Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for BBX
Z-value: 0.71
Motif logo
Transcription factors associated with BBX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BBX | hg19_v2_chr3_+_107241783_107241850 | 0.26 | 1.1e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_28527152 Show fit | 14.36 |
ENST00000321830.5
|
Uncharacterized protein |
|
| chr16_-_58768177 Show fit | 5.98 |
ENST00000434819.2
ENST00000245206.5 |
glutamic-oxaloacetic transaminase 2, mitochondrial |
|
| chr15_+_65823092 Show fit | 5.47 |
ENST00000566074.1
|
protein tyrosine phosphatase-like A domain containing 1 |
|
| chr4_+_155484103 Show fit | 5.25 |
ENST00000302068.4
|
fibrinogen beta chain |
|
| chr6_-_150067696 Show fit | 4.75 |
ENST00000340413.2
ENST00000367403.3 |
nucleoporin 43kDa |
|
| chr1_+_95616933 Show fit | 4.68 |
ENST00000604203.1
|
TMEM56-RWDD3 readthrough |
|
| chr5_+_74011328 Show fit | 4.03 |
ENST00000513336.1
|
hexosaminidase B (beta polypeptide) |
|
| chr4_+_155484155 Show fit | 3.86 |
ENST00000509493.1
|
fibrinogen beta chain |
|
| chr11_-_14541872 Show fit | 3.76 |
ENST00000419365.2
ENST00000530457.1 ENST00000532256.1 ENST00000533068.1 |
proteasome (prosome, macropain) subunit, alpha type, 1 |
|
| chr7_-_16872932 Show fit | 3.20 |
ENST00000419572.2
ENST00000412973.1 |
anterior gradient 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BBX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 1.0 | 6.8 | GO:0060154 | cellular process regulating host cell cycle in response to virus(GO:0060154) |
| 2.0 | 6.0 | GO:0006106 | fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) L-kynurenine metabolic process(GO:0097052) |
| 0.1 | 4.7 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.2 | 4.6 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.8 | 4.0 | GO:0007619 | courtship behavior(GO:0007619) |
| 0.6 | 4.0 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.0 | 3.8 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.6 | 3.2 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.5 | 3.2 | GO:1903899 | positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.5 | 6.8 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 6.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 6.0 | GO:0043204 | perikaryon(GO:0043204) |
| 0.3 | 4.7 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 4.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 4.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.3 | 3.8 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.2 | 3.2 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.3 | 3.1 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.6 | 6.8 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 2.0 | 6.0 | GO:0080130 | L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130) |
| 0.2 | 4.6 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.5 | 4.0 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.1 | 3.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 3.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.7 | 3.0 | GO:0019862 | IgA binding(GO:0019862) |
| 0.0 | 3.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 2.8 | GO:0015248 | sterol transporter activity(GO:0015248) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.3 | 6.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 3.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 3.1 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.7 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 6.8 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.2 | 6.0 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 4.7 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.2 | 4.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 3.8 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 3.1 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 2.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 2.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |