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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for BHLHE22_BHLHA15_BHLHE23
Z-value: 0.21
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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000180828.1 | basic helix-loop-helix family member e22 | |
| ENSG00000180535.3 | basic helix-loop-helix family member a15 | |
| ENSG00000125533.4 | basic helix-loop-helix family member e23 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BHLHE22_BHLHA15_BHLHE23
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 18.9 | GO:0045651 | positive regulation of macrophage differentiation(GO:0045651) |
| 0.5 | 12.1 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 3.2 | 9.7 | GO:0016095 | polyprenol catabolic process(GO:0016095) |
| 0.2 | 9.2 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.4 | 7.3 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 7.3 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.0 | 7.0 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.4 | 5.9 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 1.1 | 5.6 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.5 | 5.3 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 7.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 7.6 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 7.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 5.9 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 5.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 4.2 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.2 | 2.8 | GO:0044754 | autolysosome(GO:0044754) |
| 0.1 | 2.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 2.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.4 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 2.4 | 9.7 | GO:0047718 | enone reductase activity(GO:0035671) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718) |
| 0.1 | 9.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 5.9 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.9 | 5.3 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.5 | 5.1 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 5.0 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 4.3 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.1 | 4.2 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.6 | 2.8 | GO:0031697 | beta-1 adrenergic receptor binding(GO:0031697) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 28.9 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 7.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 5.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.1 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 3.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.2 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.3 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 5.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 5.3 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 5.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 4.2 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 3.7 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 1.4 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 1.2 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |