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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for BHLHE22_BHLHA15_BHLHE23

Z-value: 0.21

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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23

Gene Symbol Gene ID Gene Info
BHLHE22
ENSG00000180828.1 basic helix-loop-helix family member e22
BHLHA15
ENSG00000180535.3 basic helix-loop-helix family member a15
BHLHE23
ENSG00000125533.4 basic helix-loop-helix family member e23

Activity profile of BHLHE22_BHLHA15_BHLHE23 motif

Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_121379739 18.86 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chrX_+_128913906 12.09 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr10_+_5135981 9.66 ENST00000380554.3
AKR1C3
aldo-keto reductase family 1, member C3
chr1_+_244214577 8.78 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr5_-_111312622 7.71 ENST00000395634.3
NREP
neuronal regeneration related protein
chr19_-_54876558 7.62 ENST00000391742.2
ENST00000434277.2
LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr3_-_18480260 5.90 ENST00000454909.2
SATB1
SATB homeobox 1
chr11_+_65405556 5.55 ENST00000534313.1
ENST00000533361.1
ENST00000526137.1
SIPA1
signal-induced proliferation-associated 1
chr6_-_112115074 5.35 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chr6_+_135502501 5.07 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr3_-_114477787 4.65 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr19_+_18208603 4.60 ENST00000262811.6
MAST3
microtubule associated serine/threonine kinase 3
chr3_-_114477962 4.53 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr7_-_55930443 4.31 ENST00000388975.3
SEPT14
septin 14
chr20_+_57226841 4.18 ENST00000358029.4
ENST00000361830.3
STX16
syntaxin 16
chrX_+_107288197 3.58 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chrX_+_107288239 3.42 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr7_-_27205136 2.86 ENST00000396345.1
ENST00000343483.6
HOXA9
homeobox A9
chr14_-_107283278 2.83 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr4_+_160188889 2.77 ENST00000264431.4
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr1_+_50569575 2.27 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr8_-_23315190 2.23 ENST00000356206.6
ENST00000358689.4
ENST00000417069.2
ENTPD4
ectonucleoside triphosphate diphosphohydrolase 4
chr5_-_169725231 1.87 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_+_156607829 1.79 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chr10_+_51565188 1.45 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
NCOA4
nuclear receptor coactivator 4
chr10_+_51565108 1.39 ENST00000438493.1
ENST00000452682.1
NCOA4
nuclear receptor coactivator 4
chr1_+_104293028 1.39 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr6_+_69942298 1.33 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr3_+_113251143 1.29 ENST00000264852.4
ENST00000393830.3
SIDT1
SID1 transmembrane family, member 1
chr4_-_153456153 1.22 ENST00000603548.1
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr13_+_49551020 1.16 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chrX_+_105855160 1.16 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr9_+_2158485 1.12 ENST00000417599.1
ENST00000382185.1
ENST00000382183.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_219110149 1.11 ENST00000456575.1
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr4_-_74088800 1.11 ENST00000509867.2
ANKRD17
ankyrin repeat domain 17
chr9_+_2158443 1.04 ENST00000302401.3
ENST00000324954.5
ENST00000423555.1
ENST00000382186.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_+_159272111 1.00 ENST00000368114.1
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr19_-_37019562 0.98 ENST00000523638.1
ZNF260
zinc finger protein 260
chr1_+_110881945 0.96 ENST00000602849.1
ENST00000487146.2
RBM15
RNA binding motif protein 15
chr18_-_52989525 0.94 ENST00000457482.3
TCF4
transcription factor 4
chr1_-_205091115 0.92 ENST00000264515.6
ENST00000367164.1
RBBP5
retinoblastoma binding protein 5
chr19_-_11450249 0.91 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr15_-_55700522 0.84 ENST00000564092.1
ENST00000310958.6
CCPG1
cell cycle progression 1
chr1_+_12524965 0.81 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr3_-_150264272 0.79 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
SERP1
stress-associated endoplasmic reticulum protein 1
chr2_-_163099885 0.73 ENST00000443424.1
FAP
fibroblast activation protein, alpha
chr22_+_36113919 0.72 ENST00000249044.2
APOL5
apolipoprotein L, 5
chr6_+_37400974 0.65 ENST00000455891.1
ENST00000373451.4
CMTR1
cap methyltransferase 1
chr7_+_116502527 0.59 ENST00000361183.3
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr16_-_4896205 0.55 ENST00000589389.1
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr4_+_114214125 0.54 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr1_+_170633047 0.51 ENST00000239461.6
ENST00000497230.2
PRRX1
paired related homeobox 1
chr4_+_144354644 0.50 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr8_+_21823726 0.47 ENST00000433566.4
XPO7
exportin 7
chr7_-_38403077 0.42 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr16_+_72142195 0.41 ENST00000563819.1
ENST00000567142.2
DHX38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr4_+_2814011 0.41 ENST00000502260.1
ENST00000435136.2
SH3BP2
SH3-domain binding protein 2
chr17_+_7211280 0.38 ENST00000419711.2
ENST00000571955.1
ENST00000573714.1
EIF5A
eukaryotic translation initiation factor 5A
chr2_-_163100045 0.38 ENST00000188790.4
FAP
fibroblast activation protein, alpha
chr3_+_137728842 0.36 ENST00000183605.5
CLDN18
claudin 18
chr12_-_30887948 0.36 ENST00000433722.2
CAPRIN2
caprin family member 2
chr2_-_183387283 0.35 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chrX_+_107334895 0.35 ENST00000372232.3
ENST00000345734.3
ENST00000372254.3
ATG4A
autophagy related 4A, cysteine peptidase
chr15_-_55700457 0.34 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1
cell cycle progression 1
chr7_+_116502605 0.33 ENST00000458284.2
ENST00000490693.1
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr2_-_182545603 0.32 ENST00000295108.3
NEUROD1
neuronal differentiation 1
chr15_-_65503801 0.29 ENST00000261883.4
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr4_-_87028478 0.28 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr7_-_41742697 0.28 ENST00000242208.4
INHBA
inhibin, beta A
chr8_-_67976509 0.27 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr17_+_60758814 0.25 ENST00000579432.1
ENST00000446119.2
MRC2
mannose receptor, C type 2
chr12_-_40013553 0.24 ENST00000308666.3
ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
chr1_+_180897269 0.24 ENST00000367587.1
KIAA1614
KIAA1614
chr11_-_44972476 0.23 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr3_-_33700589 0.21 ENST00000461133.3
ENST00000496954.2
CLASP2
cytoplasmic linker associated protein 2
chr7_-_97881429 0.20 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
TECPR1
tectonin beta-propeller repeat containing 1
chr15_-_55700216 0.19 ENST00000569205.1
CCPG1
cell cycle progression 1
chr4_-_70505358 0.19 ENST00000457664.2
ENST00000604629.1
ENST00000604021.1
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr19_-_52227221 0.19 ENST00000222115.1
ENST00000540069.2
HAS1
hyaluronan synthase 1
chr10_-_48416849 0.18 ENST00000249598.1
GDF2
growth differentiation factor 2
chr12_-_108714412 0.18 ENST00000412676.1
ENST00000550573.1
CMKLR1
chemokine-like receptor 1
chr2_-_183387064 0.16 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chrX_-_15402498 0.16 ENST00000297904.3
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr2_-_165424973 0.13 ENST00000543549.1
GRB14
growth factor receptor-bound protein 14
chr4_+_2813946 0.13 ENST00000442312.2
SH3BP2
SH3-domain binding protein 2
chr8_-_38239732 0.10 ENST00000534155.1
ENST00000433384.2
ENST00000317025.8
ENST00000316985.3
WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr4_-_159094194 0.10 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B
family with sequence similarity 198, member B
chr2_+_181845843 0.10 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr4_+_74301880 0.09 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr9_+_125796806 0.09 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr10_+_18629628 0.09 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr3_-_33700933 0.08 ENST00000480013.1
CLASP2
cytoplasmic linker associated protein 2
chr8_+_67976593 0.07 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr10_-_94257512 0.07 ENST00000371581.5
IDE
insulin-degrading enzyme
chr4_+_55095264 0.06 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr1_+_100810575 0.05 ENST00000542213.1
CDC14A
cell division cycle 14A
chr11_-_44972418 0.04 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
TP53I11
tumor protein p53 inducible protein 11
chr14_+_24540046 0.04 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6
copine VI (neuronal)
chr15_-_63448973 0.04 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chr5_+_175299743 0.02 ENST00000502265.1
CPLX2
complexin 2
chr18_+_32290218 0.01 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE22_BHLHA15_BHLHE23

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0016095 polyprenol catabolic process(GO:0016095)
1.7 5.1 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
1.1 5.6 GO:0042631 cellular response to water deprivation(GO:0042631)
1.1 18.9 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.9 2.8 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.6 1.1 GO:0097325 melanocyte proliferation(GO:0097325)
0.5 12.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.5 5.3 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.4 2.2 GO:0009191 ribonucleoside diphosphate catabolic process(GO:0009191)
0.4 5.9 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.4 7.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.3 1.0 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.3 1.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.3 1.4 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.3 2.9 GO:0042118 endothelial cell activation(GO:0042118)
0.2 4.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.2 1.2 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.2 1.3 GO:0033227 dsRNA transport(GO:0033227)
0.2 9.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 0.9 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.2 0.5 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 1.8 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 1.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.7 GO:0080009 mRNA methylation(GO:0080009)
0.1 0.3 GO:0051697 protein delipidation(GO:0051697)
0.1 0.3 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1 2.8 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 0.5 GO:0048664 neuron fate determination(GO:0048664)
0.1 1.1 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.1 0.8 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.1 1.2 GO:0060009 Sertoli cell development(GO:0060009)
0.0 2.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 7.3 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.9 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.3 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.1 GO:0072276 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.2 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 1.9 GO:0045576 mast cell activation(GO:0045576)
0.0 0.3 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.9 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.5 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.2 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.2 GO:0030213 negative regulation of fibroblast migration(GO:0010764) hyaluronan biosynthetic process(GO:0030213)
0.0 5.0 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 7.0 GO:0002250 adaptive immune response(GO:0002250)
0.0 2.2 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.2 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.4 1.9 GO:0036398 TCR signalosome(GO:0036398)
0.4 1.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2 2.8 GO:0044754 autolysosome(GO:0044754)
0.2 1.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 5.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 7.9 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.1 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.3 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 2.2 GO:0071564 npBAF complex(GO:0071564)
0.1 0.9 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.9 GO:0042588 zymogen granule(GO:0042588)
0.1 4.2 GO:0031201 SNARE complex(GO:0031201)
0.1 7.6 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 0.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 2.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 19.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 7.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 5.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 2.5 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.9 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.7 GO:0047718 enone reductase activity(GO:0035671) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.9 5.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.6 2.8 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.5 5.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.4 2.2 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.2 1.3 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 0.5 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.2 1.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.7 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.1 1.0 GO:0019763 immunoglobulin receptor activity(GO:0019763) IgE binding(GO:0019863)
0.1 19.4 GO:0017124 SH3 domain binding(GO:0017124)
0.1 4.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.9 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 2.3 GO:0017091 AU-rich element binding(GO:0017091)
0.1 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 9.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 2.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.7 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.1 1.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 5.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 2.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 2.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 1.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 5.0 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 4.3 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.5 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0017070 U6 snRNA binding(GO:0017070)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 28.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 5.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 5.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 7.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 3.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 PID MYC PATHWAY C-MYC pathway
0.0 2.2 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 4.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 5.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 5.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 3.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 5.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells