ISMARA results: BPTF

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for BPTF

Z-value: 1.39

Motif logo

Transcription factors associated with BPTF

Gene Symbol	Gene ID	Gene Info
BPTF Ensembl NCBI GeneCards UniProt NextProt	ENSG00000171634.12	bromodomain PHD finger transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
BPTF	hg19_v2_chr17_+_65821780_65821826	0.61	1.5e-23	Click!

Activity profile of BPTF motif

Sorted Z-values of BPTF motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_216176540 Show fit	75.19	ENST00000236959.9	ATIC Ensembl NCBI GeneCards UniProt NextProt Show fit	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr3_+_127323739 Show fit	64.79	ENST00000491422.1	MCM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	minichromosome maintenance complex component 2
chr14_-_55658323 Show fit	64.15	ENST00000554067.1 ENST00000247191.2	DLGAP5 Ensembl NCBI GeneCards UniProt NextProt Show fit	discs, large (Drosophila) homolog-associated protein 5
chr17_+_4699439 Show fit	63.99	ENST00000270586.3	PSMB6 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, beta type, 6
chr1_-_150207017 Show fit	54.50	ENST00000369119.3	ANP32E Ensembl NCBI GeneCards UniProt NextProt Show fit	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr6_+_34725263 Show fit	53.22	ENST00000374018.1 ENST00000374017.3	SNRPC Ensembl NCBI GeneCards UniProt NextProt Show fit	small nuclear ribonucleoprotein polypeptide C
chr2_+_216176761 Show fit	52.90	ENST00000540518.1 ENST00000435675.1	ATIC Ensembl NCBI GeneCards UniProt NextProt Show fit	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr14_+_56127989 Show fit	52.01	ENST00000555573.1	KTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	kinectin 1 (kinesin receptor)
chr9_+_75766652 Show fit	49.53	ENST00000257497.6	ANXA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	annexin A1
chr7_+_56019486 Show fit	47.62	ENST00000446692.1 ENST00000285298.4 ENST00000443449.1	GBAS Ensembl NCBI GeneCards UniProt NextProt Show fit MRPS17 Ensembl NCBI GeneCards UniProt NextProt Show fit	glioblastoma amplified sequence mitochondrial ribosomal protein S17

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of BPTF

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	363.1	GO:0031145	anaphase-promoting complex-dependent catabolic process(GO:0031145)
3.0	221.3	GO:0070126	mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
1.4	149.9	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
1.9	149.3	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
2.9	129.5	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
32.0	128.1	GO:0046452	dihydrofolate metabolic process(GO:0046452)
21.3	127.8	GO:0007079	mitotic chromosome movement towards spindle pole(GO:0007079)
1.2	120.7	GO:0006413	translational initiation(GO:0006413)
3.1	105.3	GO:0033522	histone H2A ubiquitination(GO:0033522)
2.2	103.9	GO:0006370	7-methylguanosine mRNA capping(GO:0006370)

Showing 1 to 10 of 534 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	306.4	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
1.5	262.0	GO:0005681	spliceosomal complex(GO:0005681)
2.2	239.1	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
3.2	154.7	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.3	149.0	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
4.9	133.2	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
13.0	104.4	GO:0034715	pICln-Sm protein complex(GO:0034715)
10.4	104.2	GO:0000243	commitment complex(GO:0000243)
6.1	102.9	GO:0031616	spindle pole centrosome(GO:0031616)
3.4	102.4	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)

Showing 1 to 10 of 268 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	450.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.3	257.7	GO:0003723	RNA binding(GO:0003723)
1.4	143.6	GO:0003697	single-stranded DNA binding(GO:0003697)
4.7	141.0	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6	138.0	GO:0051015	actin filament binding(GO:0051015)
0.4	125.6	GO:0045296	cadherin binding(GO:0045296)
1.9	124.8	GO:0003743	translation initiation factor activity(GO:0003743)
0.7	123.1	GO:0004721	phosphoprotein phosphatase activity(GO:0004721)
20.1	120.7	GO:0019238	cyclohydrolase activity(GO:0019238)
4.9	102.4	GO:0001055	RNA polymerase II activity(GO:0001055)

Showing 1 to 10 of 367 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	179.3	PID ATR PATHWAY	ATR signaling pathway
2.1	129.7	PID FOXM1 PATHWAY	FOXM1 transcription factor network
2.1	128.1	PID AURORA B PATHWAY	Aurora B signaling
2.8	123.6	PID BARD1 PATHWAY	BARD1 signaling events
3.1	102.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
2.7	100.7	PID AURORA A PATHWAY	Aurora A signaling
1.0	85.3	PID E2F PATHWAY	E2F transcription factor network
0.8	76.8	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.1	63.0	PID ILK PATHWAY	Integrin-linked kinase signaling
1.0	61.2	PID CERAMIDE PATHWAY	Ceramide signaling pathway

Showing 1 to 10 of 74 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	413.9	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
3.5	358.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
11.4	193.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
2.1	188.7	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
1.0	165.8	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
3.8	127.8	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
1.6	123.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
6.6	105.4	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
2.9	104.2	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
4.0	102.8	REACTOME KINESINS	Genes involved in Kinesins

Showing 1 to 10 of 145 entries

Results for BPTF

Z-value: 1.39

Motif logo

Transcription factors associated with BPTF

Activity-expression correlation:

Activity profile of BPTF motif

Sorted Z-values of BPTF motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of BPTF

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: