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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for BRCA1
Z-value: 0.41
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Transcription factors associated with BRCA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BRCA1 | hg19_v2_chr17_-_41277467_41277510 | 0.29 | 1.5e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_60097524 Show fit | 6.65 |
ENST00000342503.4
|
reticulon 1 |
|
| chr14_-_60097297 Show fit | 6.07 |
ENST00000395090.1
|
reticulon 1 |
|
| chr1_+_10271674 Show fit | 5.25 |
ENST00000377086.1
|
kinesin family member 1B |
|
| chr6_+_123100620 Show fit | 4.56 |
ENST00000368444.3
|
fatty acid binding protein 7, brain |
|
| chr8_-_81083341 Show fit | 4.24 |
ENST00000519303.2
|
tumor protein D52 |
|
| chr5_-_68665084 Show fit | 3.56 |
ENST00000509462.1
|
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa |
|
| chr2_+_223725652 Show fit | 3.54 |
ENST00000357430.3
ENST00000392066.3 |
acyl-CoA synthetase long-chain family member 3 |
|
| chr1_-_170043709 Show fit | 3.24 |
ENST00000367767.1
ENST00000361580.2 ENST00000538366.1 |
kinesin-associated protein 3 |
|
| chr5_+_140186647 Show fit | 3.15 |
ENST00000512229.2
ENST00000356878.4 ENST00000530339.1 |
protocadherin alpha 4 |
|
| chr1_+_159141397 Show fit | 2.39 |
ENST00000368124.4
ENST00000368125.4 ENST00000416746.1 |
cell adhesion molecule 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BRCA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.9 | GO:0000492 | box C/D snoRNP assembly(GO:0000492) |
| 1.8 | 5.3 | GO:1904647 | response to rotenone(GO:1904647) |
| 0.2 | 4.6 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 0.0 | 4.6 | GO:0006898 | receptor-mediated endocytosis(GO:0006898) |
| 0.0 | 4.0 | GO:0030183 | B cell differentiation(GO:0030183) |
| 1.2 | 3.5 | GO:2001245 | regulation of phosphatidylcholine biosynthetic process(GO:2001245) |
| 1.1 | 3.2 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.0 | 3.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 2.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 2.3 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 1.0 | 7.9 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 0.0 | 5.8 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.1 | 5.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 3.5 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.8 | 3.2 | GO:1990075 | kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075) |
| 0.0 | 3.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 2.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.8 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.1 | 1.7 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.6 | 7.9 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.1 | 4.1 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.2 | 3.5 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 2.2 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 1.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 1.8 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 1.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.7 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 1.5 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 2.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.3 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 1.0 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 0.9 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 0.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 4.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 3.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 3.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 2.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 2.0 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.1 | 1.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 1.7 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.3 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 1.2 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |