GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)


Results for BRCA1

Z-value: 0.41

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
ENSG00000012048.15 BRCA1 DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_60097524 6.65 ENST00000342503.4
reticulon 1
chr14_-_60097297 6.07 ENST00000395090.1
reticulon 1
chr1_+_10271674 5.25 ENST00000377086.1
kinesin family member 1B
chr6_+_123100620 4.56 ENST00000368444.3
fatty acid binding protein 7, brain
chr8_-_81083341 4.24 ENST00000519303.2
tumor protein D52
chr5_-_68665084 3.56 ENST00000509462.1
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr2_+_223725652 3.54 ENST00000357430.3
acyl-CoA synthetase long-chain family member 3
chr1_-_170043709 3.24 ENST00000367767.1
kinesin-associated protein 3
chr5_+_140186647 3.15 ENST00000512229.2
protocadherin alpha 4
chr1_+_159141397 2.39 ENST00000368124.4
cell adhesion molecule 3
chr5_-_68665469 2.28 ENST00000217893.5
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr6_+_42981922 2.25 ENST00000326974.4
kelch domain containing 3
chr7_-_23510086 2.16 ENST00000258729.3
insulin-like growth factor 2 mRNA binding protein 3
chr5_-_68665296 2.09 ENST00000512152.1
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr11_+_117947724 2.08 ENST00000534111.1
transmembrane protease, serine 4
chr11_+_117947782 2.03 ENST00000522307.1
transmembrane protease, serine 4
chr3_-_127455200 1.88 ENST00000398101.3
monoglyceride lipase
chr4_-_48782259 1.80 ENST00000507711.1
chr18_-_49557 1.73 ENST00000308911.6
Tubulin beta-8 chain-like protein LOC260334
chr3_-_176914238 1.72 ENST00000430069.1
transducin (beta)-like 1 X-linked receptor 1
chr11_-_71823266 1.71 ENST00000538919.1
anaphase promoting complex subunit 15
chr12_-_12491608 1.50 ENST00000545735.1
MANSC domain containing 1
chr7_+_73868439 1.32 ENST00000424337.2
GTF2I repeat domain containing 1
chr1_-_173020056 1.28 ENST00000239468.2
tumor necrosis factor (ligand) superfamily, member 18
chr1_-_227505289 1.28 ENST00000366765.3
CDC42 binding protein kinase alpha (DMPK-like)
chr13_-_31038370 1.27 ENST00000399489.1
high mobility group box 1
chr13_+_30002846 1.25 ENST00000542829.1
microtubule associated tumor suppressor candidate 2
chr10_+_92631709 1.21 ENST00000413330.1
ribonuclease P/MRP 30kDa subunit
chr19_+_45394477 1.20 ENST00000252487.5
translocase of outer mitochondrial membrane 40 homolog (yeast)
chrX_-_10851762 1.16 ENST00000380785.1
midline 1 (Opitz/BBB syndrome)
chr17_-_41738931 1.16 ENST00000329168.3
mesenchyme homeobox 1
chrX_+_10124977 1.15 ENST00000380833.4
chloride channel, voltage-sensitive 4
chr11_-_27722021 1.13 ENST00000356660.4
brain-derived neurotrophic factor
chr8_-_116681221 1.07 ENST00000395715.3
trichorhinophalangeal syndrome I
chr20_-_48530230 1.05 ENST00000422556.1
spermatogenesis associated 2
chr17_+_74372662 1.03 ENST00000591651.1
sphingosine kinase 1
chr10_+_28822636 0.97 ENST00000442148.1
WW domain containing adaptor with coiled-coil
chr10_-_102289611 0.95 ENST00000299166.4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr14_-_75179774 0.92 ENST00000555249.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr10_-_69597810 0.90 ENST00000483798.2
DnaJ (Hsp40) homolog, subfamily C, member 12
chr20_+_9049682 0.85 ENST00000334005.3
phospholipase C, beta 4
chr8_+_22462532 0.81 ENST00000389279.3
cell cycle and apoptosis regulator 2
chr18_-_23671139 0.77 ENST00000579061.1
synovial sarcoma translocation, chromosome 18
chr6_-_42981651 0.77 ENST00000244711.3
male-enhanced antigen 1
chr2_-_152118352 0.77 ENST00000331426.5
RNA binding motif protein 43
chr15_-_88799948 0.74 ENST00000394480.2
neurotrophic tyrosine kinase, receptor, type 3
chr10_-_95209 0.74 ENST00000332708.5
tubulin, beta 8 class VIII
chr17_-_7082861 0.67 ENST00000269299.3
asialoglycoprotein receptor 1
chr15_+_67430339 0.64 ENST00000439724.3
SMAD family member 3
chr10_-_61900762 0.63 ENST00000355288.2
ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_41739283 0.59 ENST00000393661.2
mesenchyme homeobox 1
chr17_-_42019836 0.50 ENST00000225992.3
pancreatic polypeptide
chr1_-_160232312 0.50 ENST00000440682.1
DDB1 and CUL4 associated factor 8
chr19_+_46850320 0.49 ENST00000391919.1
protein phosphatase 5, catalytic subunit
chr14_+_32030582 0.49 ENST00000550649.1
nucleotide binding protein-like
chr18_+_55888767 0.49 ENST00000431212.2
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr8_-_16859690 0.48 ENST00000180166.5
fibroblast growth factor 20
chr17_-_60142609 0.46 ENST00000397786.2
mediator complex subunit 13
chr1_-_217250231 0.42 ENST00000493748.1
estrogen-related receptor gamma
chr19_+_46850251 0.41 ENST00000012443.4
protein phosphatase 5, catalytic subunit
chr4_-_140005443 0.40 ENST00000510408.1
E74-like factor 2 (ets domain transcription factor)
chr10_-_95504 0.34 ENST00000447903.2
tubulin, beta 8 class VIII
chr1_+_63063152 0.29 ENST00000371129.3
angiopoietin-like 3
chr3_+_185303962 0.29 ENST00000296257.5
SUMO1/sentrin/SMT3 specific peptidase 2
chr5_+_139493665 0.26 ENST00000331327.3
purine-rich element binding protein A
chr17_+_21730180 0.23 ENST00000584398.1
ubiquitin B pseudogene 4
chr12_-_117318788 0.19 ENST00000550505.1
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr12_-_117319236 0.17 ENST00000257572.5
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr4_+_619347 0.16 ENST00000255622.6
phosphodiesterase 6B, cGMP-specific, rod, beta
chr11_+_47291645 0.16 ENST00000395336.3
MAP-kinase activating death domain
chrX_+_49644470 0.13 ENST00000508866.2
ubiquitin specific peptidase 27, X-linked
chr9_+_35792151 0.11 ENST00000342694.2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr13_-_50018140 0.08 ENST00000410043.1
calcium binding protein 39-like
chr13_+_30002741 0.07 ENST00000380808.2
microtubule associated tumor suppressor candidate 2
chr20_-_34025999 0.05 ENST00000374369.3
growth differentiation factor 5
chr13_-_50018241 0.05 ENST00000409308.1
calcium binding protein 39-like
chr17_-_56296580 0.05 ENST00000313863.6
Meckel syndrome, type 1
chr11_+_47291193 0.02 ENST00000428807.1
MAP-kinase activating death domain
chr7_-_99716952 0.02 ENST00000523306.1
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_-_160232291 0.01 ENST00000368074.1
DDB1 and CUL4 associated factor 8

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:1904647 response to rotenone(GO:1904647)
1.2 3.5 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
1.1 3.2 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.6 7.9 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.4 1.7 GO:0001757 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.4 1.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.3 1.0 GO:0046521 sphingoid catabolic process(GO:0046521)
0.3 1.3 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.3 1.3 GO:0002840 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.3 1.7 GO:0060613 fat pad development(GO:0060613)
0.3 1.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 1.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.2 0.7 GO:0048687 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.2 1.0 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.2 1.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.2 4.6 GO:0060134 prepulse inhibition(GO:0060134)
0.2 0.6 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 0.9 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.8 GO:1901978 positive regulation of cell cycle checkpoint(GO:1901978)
0.1 0.6 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 1.8 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 1.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.5 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 1.7 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 1.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 2.3 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.3 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.0 2.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 1.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 4.0 GO:0030183 B cell differentiation(GO:0030183)
0.0 3.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.2 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 2.2 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.0 0.5 GO:0032098 regulation of appetite(GO:0032098)
0.0 1.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.4 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.0 0.4 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 1.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.5 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0 4.6 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.9 GO:0043647 inositol phosphate metabolic process(GO:0043647)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.9 GO:0070761 pre-snoRNP complex(GO:0070761)
0.8 3.2 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.3 0.8 GO:0044609 DBIRD complex(GO:0044609)
0.2 1.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 1.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.9 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.1 GO:0072687 meiotic spindle(GO:0072687)
0.1 5.3 GO:1904115 axon cytoplasm(GO:1904115)
0.1 0.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 12.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 1.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 3.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 3.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.7 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.6 GO:0043194 axon initial segment(GO:0043194)
0.0 0.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 2.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.5 GO:0005771 multivesicular body(GO:0005771)
0.0 5.8 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 1.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.8 GO:0030427 site of polarized growth(GO:0030427)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.9 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.4 1.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.2 1.3 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.2 3.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 1.0 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 8.5 GO:0019894 kinesin binding(GO:0019894)
0.1 1.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.2 GO:0015288 porin activity(GO:0015288)
0.1 0.6 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.7 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 1.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.7 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.3 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 4.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 2.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 1.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.7 GO:0005030 GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
0.1 0.9 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.1 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.5 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 1.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.9 PID MYC PATHWAY C-MYC pathway
0.0 1.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.0 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.9 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.3 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 8.0 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 3.2 REACTOME KINESINS Genes involved in Kinesins
0.1 1.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 4.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.0 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 0.9 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport