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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CACAGUG
Z-value: 0.57
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miRNA associated with seed CACAGUG
Network of associatons between targets according to the STRING database.
First level regulatory network of CACAGUG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 12.1 | GO:0009258 | 10-formyltetrahydrofolate catabolic process(GO:0009258) |
| 0.1 | 9.7 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 0.1 | 8.7 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 2.7 | 8.2 | GO:0060535 | trachea cartilage morphogenesis(GO:0060535) |
| 2.1 | 8.2 | GO:0097476 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 2.0 | 8.0 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.0 | 7.6 | GO:0071805 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.9 | 7.4 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.0 | 7.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 7.0 | GO:0006198 | cAMP catabolic process(GO:0006198) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 15.8 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 13.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 12.6 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 11.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 9.2 | GO:0001726 | ruffle(GO:0001726) |
| 0.8 | 8.9 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.2 | 7.0 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 6.2 | GO:0030424 | axon(GO:0030424) |
| 1.5 | 6.1 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.6 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.0 | 16.6 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 15.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 4.0 | 12.1 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 0.0 | 11.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.9 | 10.9 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 9.4 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.2 | 8.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.5 | 7.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.7 | 7.8 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.6 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 9.4 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.1 | 9.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 8.1 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.3 | 7.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 6.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 6.8 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.2 | 5.8 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 5.6 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 5.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 9.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.4 | 7.4 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.4 | 7.0 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.2 | 6.9 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 6.8 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.1 | 6.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 6.2 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.2 | 5.8 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.2 | 5.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |