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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CAGUAGU
Z-value: 0.81
Motif logo
miRNA associated with seed CAGUAGU
Network of associatons between targets according to the STRING database.
First level regulatory network of CAGUAGU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 21.6 | GO:0046035 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 2.4 | 18.8 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.6 | 18.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 6.1 | 18.2 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 0.4 | 14.8 | GO:1902475 | L-alpha-amino acid transmembrane transport(GO:1902475) |
| 0.9 | 14.6 | GO:0051198 | negative regulation of glycolytic process(GO:0045820) negative regulation of cofactor metabolic process(GO:0051195) negative regulation of coenzyme metabolic process(GO:0051198) |
| 2.1 | 12.8 | GO:0044789 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.0 | 12.7 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 2.8 | 11.1 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.4 | 10.7 | GO:0060148 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 2.7 | 18.8 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.2 | 18.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.3 | 17.5 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.7 | 16.6 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.4 | 14.9 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.5 | 12.8 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 11.5 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 11.1 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 10.7 | GO:0043034 | costamere(GO:0043034) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 21.6 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.6 | 18.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 1.3 | 17.8 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 17.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 16.8 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.4 | 15.1 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.4 | 12.9 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.6 | 11.1 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 1.5 | 10.7 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 1.0 | 10.7 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) RNA strand annealing activity(GO:0033592) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.6 | 18.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.4 | 18.2 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.3 | 16.1 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.2 | 14.2 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.2 | 11.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 11.1 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.2 | 9.9 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.2 | 8.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 7.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 25.4 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.6 | 19.1 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 1.0 | 18.8 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 18.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.4 | 16.3 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.5 | 12.9 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 10.1 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 8.4 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.1 | 8.3 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.3 | 8.1 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |