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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CAGUGCA
Z-value: 0.61
Motif logo
miRNA associated with seed CAGUGCA
Network of associatons between targets according to the STRING database.
First level regulatory network of CAGUGCA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 26.2 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 1.0 | 13.6 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 3.9 | 11.6 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 2.9 | 11.4 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.2 | 10.6 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.1 | 10.4 | GO:0032392 | DNA geometric change(GO:0032392) |
| 1.0 | 9.7 | GO:0007144 | female meiosis I(GO:0007144) |
| 1.2 | 9.6 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.2 | 9.1 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 1.3 | 9.0 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 25.3 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 17.8 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.2 | 15.4 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.7 | 13.6 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.2 | 12.9 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 12.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 12.0 | GO:0005643 | nuclear pore(GO:0005643) |
| 1.6 | 9.3 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.2 | 9.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.5 | 8.6 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 13.6 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 0.1 | 13.3 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 1.1 | 11.6 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.1 | 11.6 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 1.5 | 10.6 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 2.1 | 10.4 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.2 | 10.0 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.4 | 9.9 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 1.9 | 9.3 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.0 | 9.3 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.3 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 13.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 12.9 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.3 | 11.4 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 10.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.7 | 9.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.4 | 9.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 9.4 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 9.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 8.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 20.2 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 1.0 | 17.6 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.4 | 17.0 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.4 | 13.6 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.5 | 11.6 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 11.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.5 | 10.9 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.4 | 9.7 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.6 | 8.6 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.4 | 8.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |