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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for CBFB

Z-value: 0.45

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Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
CBFB
ENSG00000067955.9 core-binding factor subunit beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBFBhg19_v2_chr16_+_67062996_670630190.252.6e-04Click!

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_114310237 12.86 ENST00000539119.1
REXO2
RNA exonuclease 2
chr11_+_114310102 12.54 ENST00000265881.5
REXO2
RNA exonuclease 2
chr11_+_114310164 12.20 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
REXO2
RNA exonuclease 2
chr3_-_99569821 6.46 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr2_-_64881018 5.22 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr5_-_137878887 5.09 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr3_+_157154578 4.36 ENST00000295927.3
PTX3
pentraxin 3, long
chr17_+_32582293 4.31 ENST00000580907.1
ENST00000225831.4
CCL2
chemokine (C-C motif) ligand 2
chr3_-_189840223 3.77 ENST00000427335.2
LEPREL1
leprecan-like 1
chr10_-_29811456 3.75 ENST00000535393.1
SVIL
supervillin
chr11_+_18343800 2.76 ENST00000453096.2
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr12_-_4754339 2.67 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr11_-_66103867 2.32 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr11_-_18343669 2.24 ENST00000396253.3
ENST00000349215.3
ENST00000438420.2
HPS5
Hermansky-Pudlak syndrome 5
chr15_-_64665911 2.23 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr21_-_36421401 2.20 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr14_-_61116168 1.98 ENST00000247182.6
SIX1
SIX homeobox 1
chr19_-_14049184 1.96 ENST00000339560.5
PODNL1
podocan-like 1
chr19_-_14048804 1.92 ENST00000254320.3
ENST00000586075.1
PODNL1
podocan-like 1
chr7_+_120628731 1.87 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr20_+_43343886 1.69 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr12_+_15125954 1.65 ENST00000266395.2
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr20_+_54987168 1.63 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr11_-_58343319 1.46 ENST00000395074.2
LPXN
leupaxin
chr1_+_196621002 1.42 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chrX_-_49041242 1.42 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3
prickle homolog 3 (Drosophila)
chr20_+_54987305 1.35 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr3_+_98482175 1.26 ENST00000485391.1
ENST00000492254.1
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr21_-_36421626 1.26 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr1_-_179112173 1.23 ENST00000408940.3
ENST00000504405.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr21_-_36421535 1.23 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
RUNX1
runt-related transcription factor 1
chr1_+_196621156 1.18 ENST00000359637.2
CFH
complement factor H
chr11_-_66104237 1.05 ENST00000530056.1
RIN1
Ras and Rab interactor 1
chr2_+_207024306 1.03 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr5_+_131409476 1.01 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr12_+_25205568 0.98 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chrX_-_153718988 0.98 ENST00000263512.4
ENST00000393587.4
ENST00000453912.1
SLC10A3
solute carrier family 10, member 3
chr6_+_52051171 0.88 ENST00000340057.1
IL17A
interleukin 17A
chr4_+_74347400 0.85 ENST00000226355.3
AFM
afamin
chr1_-_179112189 0.83 ENST00000512653.1
ENST00000344730.3
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr12_+_25205446 0.79 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chrX_+_115567767 0.76 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr4_-_156297949 0.75 ENST00000515654.1
MAP9
microtubule-associated protein 9
chr9_-_35080013 0.70 ENST00000378643.3
FANCG
Fanconi anemia, complementation group G
chr9_-_123342415 0.70 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr1_+_89246647 0.67 ENST00000544045.1
PKN2
protein kinase N2
chr14_-_24977457 0.66 ENST00000250378.3
ENST00000206446.4
CMA1
chymase 1, mast cell
chr6_-_34524093 0.65 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr1_+_39876151 0.62 ENST00000530275.1
KIAA0754
KIAA0754
chr5_+_35856951 0.61 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr11_-_66103932 0.61 ENST00000311320.4
RIN1
Ras and Rab interactor 1
chr1_+_209859510 0.57 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr6_+_27925019 0.57 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr6_+_29068386 0.55 ENST00000377171.3
OR2J1
olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
chr6_-_34524049 0.54 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr12_-_68553512 0.49 ENST00000229135.3
IFNG
interferon, gamma
chr1_+_47264711 0.47 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
CYP4B1
cytochrome P450, family 4, subfamily B, polypeptide 1
chr16_+_53088885 0.42 ENST00000566029.1
ENST00000447540.1
CHD9
chromodomain helicase DNA binding protein 9
chr15_+_49715293 0.34 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr12_-_14849470 0.30 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr6_+_45296391 0.19 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr1_-_184723942 0.18 ENST00000318130.8
EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr14_+_22748980 0.18 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr14_+_22919081 0.16 ENST00000390473.1
TRDJ1
T cell receptor delta joining 1
chr14_+_85996507 0.15 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chrX_-_70838306 0.11 ENST00000373691.4
ENST00000373693.3
CXCR3
chemokine (C-X-C motif) receptor 3
chr2_+_234826016 0.10 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr8_-_60031762 0.04 ENST00000361421.1
TOX
thymocyte selection-associated high mobility group box
chr20_+_44637526 0.02 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_-_240775447 0.00 ENST00000318160.4
GREM2
gremlin 2, DAN family BMP antagonist

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
0.9 37.6 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.9 4.4 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.7 4.0 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.7 2.0 GO:0061055 myotome development(GO:0061055) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.5 2.4 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.3 5.1 GO:0006449 regulation of translational termination(GO:0006449)
0.3 4.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 0.7 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.2 1.5 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2 1.2 GO:0010454 negative regulation of cell fate commitment(GO:0010454) lung goblet cell differentiation(GO:0060480)
0.1 0.7 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 2.8 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.3 GO:0060437 lung growth(GO:0060437)
0.1 2.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 4.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 2.7 GO:0007340 acrosome reaction(GO:0007340)
0.1 0.5 GO:0018879 biphenyl metabolic process(GO:0018879)
0.1 0.6 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 3.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.7 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 1.3 GO:0097503 sialylation(GO:0097503)
0.0 1.7 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 2.1 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.2 GO:0097466 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.6 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 1.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.9 GO:0051180 vitamin transport(GO:0051180)
0.0 1.8 GO:0007338 single fertilization(GO:0007338)
0.0 2.2 GO:0043473 pigmentation(GO:0043473)
0.0 3.0 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.7 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.8 GO:0003333 amino acid transmembrane transport(GO:0003333)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.7 GO:0036449 microtubule minus-end(GO:0036449)
0.4 37.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 2.8 GO:0000439 core TFIIH complex(GO:0000439)
0.2 2.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.7 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 2.2 GO:0031082 BLOC complex(GO:0031082)
0.1 1.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 4.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.5 GO:0002102 podosome(GO:0002102)
0.0 1.8 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 3.5 GO:0072562 blood microparticle(GO:0072562)
0.0 5.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
1.0 37.6 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.8 5.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.5 4.4 GO:0001849 complement component C1q binding(GO:0001849)
0.3 1.3 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.2 1.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 0.9 GO:0008431 vitamin E binding(GO:0008431)
0.2 0.6 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.2 0.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 2.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 2.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 4.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.7 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.8 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 2.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.8 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 3.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 4.9 GO:0001047 core promoter binding(GO:0001047)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697)
0.0 3.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 5.2 GO:0003713 transcription coactivator activity(GO:0003713)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 5.3 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 4.0 PID RAS PATHWAY Regulation of Ras family activation
0.1 0.5 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 3.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.7 PID CONE PATHWAY Visual signal transduction: Cones
0.1 4.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID IL27 PATHWAY IL27-mediated signaling events
0.0 3.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.2 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 2.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 2.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 3.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.7 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 5.1 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.7 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.3 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 1.0 REACTOME TRANSLATION Genes involved in Translation
0.0 0.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type