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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CBFB
Z-value: 0.45
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Transcription factors associated with CBFB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CBFB | hg19_v2_chr16_+_67062996_67063019 | 0.25 | 2.6e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_114310237 Show fit | 12.86 |
ENST00000539119.1
|
RNA exonuclease 2 |
|
| chr11_+_114310102 Show fit | 12.54 |
ENST00000265881.5
|
RNA exonuclease 2 |
|
| chr11_+_114310164 Show fit | 12.20 |
ENST00000544196.1
ENST00000539754.1 ENST00000539275.1 |
RNA exonuclease 2 |
|
| chr3_-_99569821 Show fit | 6.46 |
ENST00000487087.1
|
filamin A interacting protein 1-like |
|
| chr2_-_64881018 Show fit | 5.22 |
ENST00000313349.3
|
SERTA domain containing 2 |
|
| chr5_-_137878887 Show fit | 5.09 |
ENST00000507939.1
ENST00000572514.1 ENST00000499810.2 ENST00000360541.5 |
eukaryotic translation termination factor 1 |
|
| chr3_+_157154578 Show fit | 4.36 |
ENST00000295927.3
|
pentraxin 3, long |
|
| chr17_+_32582293 Show fit | 4.31 |
ENST00000580907.1
ENST00000225831.4 |
chemokine (C-C motif) ligand 2 |
|
| chr3_-_189840223 Show fit | 3.77 |
ENST00000427335.2
|
leprecan-like 1 |
|
| chr10_-_29811456 Show fit | 3.75 |
ENST00000535393.1
|
supervillin |
Network of associatons between targets according to the STRING database.
First level regulatory network of CBFB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 37.6 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.3 | 5.1 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 0.3 | 4.7 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.9 | 4.4 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.1 | 4.4 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 1.4 | 4.3 | GO:1901624 | negative regulation of lymphocyte chemotaxis(GO:1901624) |
| 0.7 | 4.0 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.1 | 3.8 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 3.0 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.1 | 2.8 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 37.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 5.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 4.4 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.5 | 3.7 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 3.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.3 | 2.8 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.2 | 2.7 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 2.2 | GO:0031082 | BLOC complex(GO:0031082) |
| 0.0 | 1.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 1.5 | GO:0002102 | podosome(GO:0002102) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 37.6 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 5.2 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.8 | 5.1 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.0 | 4.9 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.5 | 4.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 1.4 | 4.3 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.1 | 4.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 3.8 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 3.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 2.8 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 4.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 4.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 3.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 1.7 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.9 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.7 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.1 | 4.3 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 3.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.8 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 2.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 2.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 1.3 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 1.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 1.0 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.0 | 0.8 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |