GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)


Results for CCAGCAU

Z-value: 0.16

Motif logo

miRNA associated with seed CCAGCAU

NamemiRBASE accession

Activity profile of CCAGCAU motif

Sorted Z-values of CCAGCAU motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_116601044 2.25 ENST00000368608.3
TSPY-like 1
chr12_+_113229737 1.64 ENST00000551052.1
rabphilin 3A homolog (mouse)
chr22_-_44258360 1.50 ENST00000330884.4
sulfotransferase family 4A, member 1
chr9_-_111929560 1.24 ENST00000561981.2
ferric-chelate reductase 1-like
chr2_-_2334888 1.13 ENST00000428368.2
myelin transcription factor 1-like
chr7_-_87849340 1.04 ENST00000419179.1
chr1_+_244214577 1.01 ENST00000358704.4
zinc finger and BTB domain containing 18
chr12_-_54982420 0.96 ENST00000257905.8
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr3_+_238273 0.93 ENST00000256509.2
cell adhesion molecule L1-like
chr17_+_43971643 0.93 ENST00000344290.5
microtubule-associated protein tau
chr11_-_115375107 0.88 ENST00000545380.1
cell adhesion molecule 1
chr3_+_49591881 0.87 ENST00000296452.4
bassoon presynaptic cytomatrix protein
chr17_-_40950698 0.86 ENST00000328434.7
cytochrome c oxidase assembly factor 3
chr6_-_116575226 0.86 ENST00000420283.1
TSPY-like 4
chr1_-_154531095 0.82 ENST00000292211.4
ubiquitin-conjugating enzyme E2Q family member 1
chr5_+_141488070 0.78 ENST00000253814.4
Nedd4 family interacting protein 1
chr3_-_9291063 0.75 ENST00000383836.3
SLIT-ROBO Rho GTPase activating protein 3
chr1_+_109792641 0.73 ENST00000271332.3
cadherin, EGF LAG seven-pass G-type receptor 2
chr1_+_229440129 0.72 ENST00000366688.3
S-phase response (cyclin related)
chr19_+_40854559 0.70 ENST00000598962.1
phospholipase D family, member 3
chr14_+_23775971 0.66 ENST00000250405.5
BCL2-like 2
chr6_+_63921351 0.62 ENST00000370659.1
FK506 binding protein 1C
chr18_-_53255766 0.62 ENST00000566286.1
transcription factor 4
chr11_+_111473108 0.61 ENST00000304987.3
salt-inducible kinase 2
chr11_-_129062093 0.60 ENST00000310343.9
Rho GTPase activating protein 32
chr1_+_164528866 0.60 ENST00000420696.2
pre-B-cell leukemia homeobox 1
chr10_-_75634260 0.58 ENST00000372765.1
calcium/calmodulin-dependent protein kinase II gamma
chr11_-_73309228 0.57 ENST00000356467.4
family with sequence similarity 168, member A
chr5_+_86564739 0.56 ENST00000456692.2
RAS p21 protein activator (GTPase activating protein) 1
chr10_-_118502070 0.51 ENST00000369209.3
heat shock 70kDa protein 12A
chr8_+_6565854 0.50 ENST00000285518.6
1-acylglycerol-3-phosphate O-acyltransferase 5
chr3_-_123304017 0.47 ENST00000383657.5
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
chr3_-_134093395 0.44 ENST00000249883.5
angiomotin like 2
chr15_-_75249793 0.41 ENST00000322177.5
ribonuclease P/MRP 25kDa subunit
chr8_+_21915368 0.40 ENST00000265800.5
dematin actin binding protein
chr4_-_153457197 0.38 ENST00000281708.4
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_+_41992489 0.37 ENST00000264451.7
solute carrier family 30 (zinc transporter), member 9
chr11_+_113930291 0.34 ENST00000335953.4
zinc finger and BTB domain containing 16
chr5_+_43602750 0.31 ENST00000505678.2
nicotinamide nucleotide transhydrogenase
chr2_-_166930131 0.31 ENST00000303395.4
sodium channel, voltage-gated, type I, alpha subunit
chr16_-_69419871 0.30 ENST00000603068.1
telomeric repeat binding factor 2
chr6_+_37787262 0.29 ENST00000287218.4
zinc finger, AN1-type domain 3
chr12_+_74931551 0.29 ENST00000519948.2
ataxin 7-like 3B
chr13_-_77900814 0.29 ENST00000544440.2
MYC binding protein 2, E3 ubiquitin protein ligase
chr20_-_1373726 0.29 ENST00000400137.4
FK506 binding protein 1A, 12kDa
chr8_-_98290087 0.28 ENST00000322128.3
TSPY-like 5
chr7_+_74072011 0.27 ENST00000324896.4
general transcription factor IIi
chr3_+_100428268 0.26 ENST00000240851.4
TRK-fused gene
chr20_-_41818373 0.26 ENST00000373187.1
protein tyrosine phosphatase, receptor type, T
chr17_-_4269768 0.26 ENST00000396981.2
ubiquitin-conjugating enzyme E2G 1
chr2_-_152684977 0.24 ENST00000428992.2
ADP-ribosylation factor-like 5A
chr17_+_46125707 0.24 ENST00000584137.1
nuclear factor, erythroid 2-like 1
chr12_-_113574028 0.23 ENST00000546530.1
RAS protein activator like 1 (GAP1 like)
chr15_+_79165151 0.23 ENST00000331268.5
mortality factor 4 like 1
chr9_-_123964114 0.23 ENST00000373840.4
RAB14, member RAS oncogene family
chr3_-_142166904 0.22 ENST00000264951.4
5'-3' exoribonuclease 1
chr2_-_85555385 0.21 ENST00000377386.3
trans-golgi network protein 2
chr3_-_28390581 0.20 ENST00000479665.1
5-azacytidine induced 2
chr9_-_80646374 0.20 ENST00000286548.4
guanine nucleotide binding protein (G protein), q polypeptide
chr1_-_78148324 0.19 ENST00000370801.3
zinc finger, ZZ-type containing 3
chr1_+_201798269 0.18 ENST00000361565.4
importin 9
chr13_-_107220455 0.17 ENST00000400198.3
arginine and glutamate rich 1
chr19_+_45754505 0.16 ENST00000262891.4
MAP/microtubule affinity-regulating kinase 4
chr12_+_862089 0.16 ENST00000315939.6
WNK lysine deficient protein kinase 1
chr7_-_14942944 0.16 ENST00000403951.2
diacylglycerol kinase, beta 90kDa
chr5_+_140560980 0.15 ENST00000361016.2
protocadherin beta 16
chr9_-_136933134 0.14 ENST00000303407.7
bromodomain containing 3
chr2_-_183731882 0.12 ENST00000295113.4
frizzled-related protein
chr1_-_154155595 0.12 ENST00000328159.4
tropomyosin 3
chr14_+_65171099 0.11 ENST00000247226.7
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr9_+_35749203 0.11 ENST00000456972.2
RGP1 retrograde golgi transport homolog (S. cerevisiae)
chr9_+_140032842 0.10 ENST00000371561.3
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr4_-_149365827 0.10 ENST00000344721.4
nuclear receptor subfamily 3, group C, member 2
chr7_+_139044621 0.10 ENST00000354926.4
C7orf55-LUC7L2 readthrough
chr7_-_26240357 0.10 ENST00000354667.4
heterogeneous nuclear ribonucleoprotein A2/B1
chr10_+_105726862 0.10 ENST00000335753.4
STE20-like kinase
chrX_-_107975917 0.10 ENST00000563887.1
Uncharacterized protein
chr22_-_22221900 0.08 ENST00000215832.6
mitogen-activated protein kinase 1
chr3_+_183873098 0.07 ENST00000313143.3
dishevelled segment polarity protein 3
chr7_-_158622210 0.07 ENST00000251527.5
extended synaptotagmin-like protein 2
chr2_-_220094294 0.07 ENST00000436856.1
autophagy related 9A
chr2_-_69870835 0.07 ENST00000409085.4
AP2 associated kinase 1
chr1_-_35658736 0.07 ENST00000357214.5
splicing factor proline/glutamine-rich
chr1_+_7831323 0.07 ENST00000054666.6
vesicle-associated membrane protein 3
chr4_+_48018781 0.07 ENST00000295461.5
NIPA-like domain containing 1
chr17_+_61086917 0.06 ENST00000424789.2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr20_-_39317868 0.06 ENST00000373313.2
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr1_+_153606513 0.06 ENST00000368694.3
chromatin target of PRMT1
chr7_+_72349920 0.06 ENST00000395270.1
POM121 transmembrane nucleoporin
chr18_-_31803435 0.05 ENST00000589544.1
nucleolar protein 4
chr15_+_45422131 0.05 ENST00000321429.4
dual oxidase 1
chr15_+_85359911 0.05 ENST00000258888.5
alpha-kinase 3
chr9_-_86571628 0.04 ENST00000376344.3
chromosome 9 open reading frame 64
chr3_-_176914238 0.04 ENST00000430069.1
transducin (beta)-like 1 X-linked receptor 1
chr1_-_205091115 0.04 ENST00000264515.6
retinoblastoma binding protein 5
chr10_+_73975742 0.04 ENST00000299381.4
anaphase promoting complex subunit 16
chr14_-_76127519 0.03 ENST00000256319.6
chromosome 14 open reading frame 1
chr10_+_28966271 0.03 ENST00000375533.3
BMP and activin membrane-bound inhibitor
chr4_-_55991752 0.03 ENST00000263923.4
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr2_-_105946491 0.02 ENST00000393359.2
transforming growth factor, beta receptor associated protein 1
chr8_+_38614807 0.02 ENST00000330691.6
transforming, acidic coiled-coil containing protein 1
chr2_+_210444142 0.02 ENST00000360351.4
microtubule-associated protein 2
chr2_+_48010221 0.02 ENST00000234420.5
mutS homolog 6
chr8_+_120079478 0.01 ENST00000332843.2
collectin sub-family member 10 (C-type lectin)
chr3_+_107241783 0.00 ENST00000415149.2
bobby sox homolog (Drosophila)
chr1_+_32645269 0.00 ENST00000373610.3
taxilin alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of CCAGCAU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 0.9 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.9 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.2 0.9 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 1.0 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 0.7 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.1 0.3 GO:0031627 telomeric loop formation(GO:0031627) negative regulation of t-circle formation(GO:1904430)
0.1 0.7 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 0.4 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.2 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.1 0.8 GO:0070459 prolactin secretion(GO:0070459)
0.1 0.3 GO:0051138 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.1 0.4 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 0.3 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.2 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.0 1.5 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.1 GO:0043449 olfactory learning(GO:0008355) cellular alkene metabolic process(GO:0043449)
0.0 0.9 GO:0035640 exploration behavior(GO:0035640)
0.0 0.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.3 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 1.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.6 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.8 GO:0048665 neuron fate specification(GO:0048665)
0.0 0.1 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 3.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.6 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.0 1.2 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.0 0.1 GO:0044805 late nucleophagy(GO:0044805)
0.0 0.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.4 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.1 GO:0035283 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.2 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.0 0.1 GO:0060029 convergent extension involved in organogenesis(GO:0060029)
0.0 0.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:1903859 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.0 0.9 GO:0035418 protein localization to synapse(GO:0035418)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 0.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0042335 cuticle development(GO:0042335)
0.0 0.0 GO:0060613 fat pad development(GO:0060613)
0.0 0.6 GO:0045739 positive regulation of DNA repair(GO:0045739)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0045298 tubulin complex(GO:0045298)
0.1 1.0 GO:0044326 dendritic spine neck(GO:0044326)
0.1 0.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.3 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.9 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.9 GO:0099738 cell cortex region(GO:0099738)
0.0 1.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0043194 voltage-gated sodium channel complex(GO:0001518) axon initial segment(GO:0043194)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.1 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 0.7 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 1.6 GO:0008430 selenium binding(GO:0008430)
0.1 1.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.7 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.6 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.6 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.2 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.7 GO:0051400 BH domain binding(GO:0051400)
0.0 0.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 1.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 1.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.8 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.6 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.8 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)