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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CCAGUGU
Z-value: 0.27
Motif logo
miRNA associated with seed CCAGUGU
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_182992545 Show fit | 9.54 |
ENST00000258341.4
|
laminin, gamma 1 (formerly LAMB2) |
|
| chrX_-_99891796 Show fit | 8.16 |
ENST00000373020.4
|
tetraspanin 6 |
|
| chr7_+_116165754 Show fit | 8.08 |
ENST00000405348.1
|
caveolin 1, caveolae protein, 22kDa |
|
| chr8_+_104311059 Show fit | 7.65 |
ENST00000358755.4
ENST00000523739.1 ENST00000540287.1 |
frizzled family receptor 6 |
|
| chr9_-_128003606 Show fit | 6.17 |
ENST00000324460.6
|
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
|
| chr7_-_131241361 Show fit | 5.47 |
ENST00000378555.3
ENST00000322985.9 ENST00000541194.1 ENST00000537928.1 |
podocalyxin-like |
|
| chr9_+_110045537 Show fit | 5.23 |
ENST00000358015.3
|
RAD23 homolog B (S. cerevisiae) |
|
| chr7_+_100770328 Show fit | 5.05 |
ENST00000223095.4
ENST00000445463.2 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
|
| chr15_-_34394119 Show fit | 5.04 |
ENST00000256545.4
|
ER membrane protein complex subunit 7 |
|
| chr22_-_36784035 Show fit | 4.91 |
ENST00000216181.5
|
myosin, heavy chain 9, non-muscle |
Network of associatons between targets according to the STRING database.
First level regulatory network of CCAGUGU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.5 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.1 | 8.3 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
| 0.6 | 8.2 | GO:0039532 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039532) |
| 2.7 | 8.1 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 1.9 | 7.7 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 1.7 | 6.7 | GO:0035905 | ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
| 2.1 | 6.2 | GO:0021589 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 1.4 | 5.5 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.2 | 5.2 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 1.7 | 5.0 | GO:2000097 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 2.4 | 9.5 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
| 0.6 | 8.1 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.2 | 7.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.3 | 6.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.7 | 5.5 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.3 | 5.2 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.6 | 5.0 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 1.6 | 4.9 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 4.8 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 8.1 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.1 | 8.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.3 | 6.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 5.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 5.6 | GO:0005525 | GTP binding(GO:0005525) |
| 0.5 | 5.3 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.1 | 5.2 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.2 | 5.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 5.0 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 5.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 8.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.2 | 7.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 6.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 6.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 3.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 3.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 2.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.6 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 8.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 8.0 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 7.6 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 6.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 5.2 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.3 | 4.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 4.0 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 3.4 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.3 | 3.2 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |