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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CCUUCAU
Z-value: 0.89
Motif logo
miRNA associated with seed CCUUCAU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-205-5p
|
MIMAT0000266 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_182992545 Show fit | 11.00 |
ENST00000258341.4
|
laminin, gamma 1 (formerly LAMB2) |
|
| chr20_+_11871371 Show fit | 10.10 |
ENST00000254977.3
|
BTB (POZ) domain containing 3 |
|
| chr12_+_56473628 Show fit | 8.08 |
ENST00000549282.1
ENST00000549061.1 ENST00000267101.3 |
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 |
|
| chr5_+_167718604 Show fit | 7.94 |
ENST00000265293.4
|
WW and C2 domain containing 1 |
|
| chr7_-_10979750 Show fit | 7.76 |
ENST00000339600.5
|
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa |
|
| chr6_+_114178512 Show fit | 7.53 |
ENST00000368635.4
|
myristoylated alanine-rich protein kinase C substrate |
|
| chr1_-_63988846 Show fit | 7.43 |
ENST00000283568.8
ENST00000371092.3 ENST00000271002.10 |
integrin beta 3 binding protein (beta3-endonexin) |
|
| chr11_-_115375107 Show fit | 6.87 |
ENST00000545380.1
ENST00000452722.3 ENST00000537058.1 ENST00000536727.1 ENST00000542447.2 ENST00000331581.6 |
cell adhesion molecule 1 |
|
| chr2_-_161350305 Show fit | 6.60 |
ENST00000348849.3
|
RNA binding motif, single stranded interacting protein 1 |
|
| chr20_-_48330377 Show fit | 6.14 |
ENST00000371711.4
|
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CCUUCAU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 11.0 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 1.5 | 10.5 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.1 | 9.0 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.3 | 8.1 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.4 | 7.8 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.2 | 7.6 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.4 | 7.5 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.2 | 7.4 | GO:0061641 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 1.7 | 6.9 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.0 | 5.8 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 11.0 | GO:0005606 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
| 0.2 | 10.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 8.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.6 | 7.8 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 7.7 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 7.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.5 | 7.5 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.1 | 7.4 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 6.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.6 | 5.0 | GO:0071439 | clathrin complex(GO:0071439) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.7 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.1 | 11.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 10.5 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.6 | 8.1 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.3 | 7.8 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 7.7 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.7 | 7.6 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.1 | 7.5 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.1 | 7.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 6.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 7.8 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 6.0 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.1 | 5.4 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.2 | 5.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.9 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 3.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 3.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 1.9 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.6 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.3 | 8.9 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.3 | 8.1 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 7.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 7.6 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.7 | 7.5 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.3 | 7.4 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.2 | 6.8 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 6.6 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 6.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |