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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for CDX2

Z-value: 0.26

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Transcription factors associated with CDX2

Gene Symbol Gene ID Gene Info
CDX2
ENSG00000165556.9 caudal type homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CDX2hg19_v2_chr13_-_28545276_28545276-0.045.2e-01Click!

Activity profile of CDX2 motif

Sorted Z-values of CDX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_112127981 11.30 ENST00000486726.2
RP11-231E6.1
RP11-231E6.1
chr3_-_123710199 7.13 ENST00000184183.4
ROPN1
rhophilin associated tail protein 1
chr3_-_123710893 6.91 ENST00000467907.1
ENST00000459660.1
ENST00000495093.1
ENST00000460743.1
ENST00000405845.3
ENST00000484329.1
ENST00000479867.1
ENST00000496145.1
ROPN1
rhophilin associated tail protein 1
chr3_+_125687987 6.49 ENST00000514116.1
ENST00000251776.4
ENST00000504401.1
ENST00000513830.1
ENST00000508088.1
ROPN1B
rhophilin associated tail protein 1B
chr1_+_151739131 5.20 ENST00000400999.1
OAZ3
ornithine decarboxylase antizyme 3
chrX_+_64708615 4.61 ENST00000338957.4
ENST00000423889.3
ZC3H12B
zinc finger CCCH-type containing 12B
chr4_+_174089904 4.34 ENST00000265000.4
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr18_+_3252265 4.25 ENST00000580887.1
ENST00000536605.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr7_+_64838786 3.99 ENST00000450302.2
ZNF92
zinc finger protein 92
chr7_+_64838712 3.84 ENST00000328747.7
ENST00000431504.1
ENST00000357512.2
ZNF92
zinc finger protein 92
chr5_+_72143988 3.62 ENST00000506351.2
TNPO1
transportin 1
chr14_+_52456327 3.62 ENST00000556760.1
C14orf166
chromosome 14 open reading frame 166
chr12_+_56546363 3.55 ENST00000551834.1
ENST00000552568.1
MYL6B
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr14_+_52456193 3.31 ENST00000261700.3
C14orf166
chromosome 14 open reading frame 166
chr20_+_4702548 3.29 ENST00000305817.2
PRND
prion protein 2 (dublet)
chr9_+_100174232 3.23 ENST00000355295.4
TDRD7
tudor domain containing 7
chr6_+_134274322 3.03 ENST00000367871.1
ENST00000237264.4
TBPL1
TBP-like 1
chr15_-_55541227 3.00 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr9_+_134065506 2.94 ENST00000483497.2
NUP214
nucleoporin 214kDa
chr19_+_21579908 2.93 ENST00000596302.1
ENST00000392288.2
ENST00000594390.1
ENST00000355504.4
ZNF493
zinc finger protein 493
chr12_+_56546223 2.87 ENST00000550443.1
ENST00000207437.5
MYL6B
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr1_+_151735431 2.85 ENST00000321531.5
ENST00000315067.8
OAZ3
ornithine decarboxylase antizyme 3
chr1_+_158979686 2.78 ENST00000368132.3
ENST00000295809.7
IFI16
interferon, gamma-inducible protein 16
chr1_+_158979792 2.77 ENST00000359709.3
ENST00000430894.2
IFI16
interferon, gamma-inducible protein 16
chr17_-_76921459 2.70 ENST00000262768.7
TIMP2
TIMP metallopeptidase inhibitor 2
chrX_-_15619076 2.67 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chr2_+_109204909 2.65 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr16_+_25228242 2.60 ENST00000219660.5
AQP8
aquaporin 8
chrX_-_135962876 2.59 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX
RNA binding motif protein, X-linked
chr9_-_95055956 2.56 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS
isoleucyl-tRNA synthetase
chr9_+_100174344 2.42 ENST00000422139.2
TDRD7
tudor domain containing 7
chrX_+_105937068 2.41 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr16_-_20338748 2.28 ENST00000575582.1
ENST00000341642.5
ENST00000381362.4
ENST00000572347.1
ENST00000572478.1
ENST00000302555.5
GP2
glycoprotein 2 (zymogen granule membrane)
chr12_-_71551652 2.20 ENST00000546561.1
TSPAN8
tetraspanin 8
chr2_+_233415363 2.20 ENST00000409514.1
ENST00000409098.1
ENST00000409495.1
ENST00000409167.3
ENST00000409322.1
ENST00000409394.1
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chr16_-_20339123 2.19 ENST00000381360.5
GP2
glycoprotein 2 (zymogen granule membrane)
chr10_+_13652047 2.17 ENST00000601460.1
RP11-295P9.3
Uncharacterized protein
chr18_+_3252206 2.03 ENST00000578562.2
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr9_-_95056010 2.01 ENST00000443024.2
IARS
isoleucyl-tRNA synthetase
chr2_+_187371440 1.99 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr1_+_26798955 1.97 ENST00000361427.5
HMGN2
high mobility group nucleosomal binding domain 2
chrX_-_101771645 1.94 ENST00000289373.4
TMSB15A
thymosin beta 15a
chrX_+_70503433 1.86 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chr3_+_148545586 1.80 ENST00000282957.4
ENST00000468341.1
CPB1
carboxypeptidase B1 (tissue)
chr1_+_220267429 1.78 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr12_+_25205568 1.73 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr16_+_68119764 1.72 ENST00000570212.1
ENST00000562926.1
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr2_+_109204743 1.69 ENST00000332345.6
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_+_32812568 1.65 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr1_+_74701062 1.62 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr18_-_5396271 1.58 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr3_+_171757346 1.58 ENST00000421757.1
ENST00000415807.2
ENST00000392699.1
FNDC3B
fibronectin type III domain containing 3B
chr19_+_48497901 1.54 ENST00000339841.2
ELSPBP1
epididymal sperm binding protein 1
chr2_+_219081817 1.51 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr1_+_53480598 1.50 ENST00000430330.2
ENST00000408941.3
ENST00000478274.2
ENST00000484100.1
ENST00000435345.2
ENST00000488965.1
SCP2
sterol carrier protein 2
chr16_-_21431078 1.48 ENST00000458643.2
NPIPB3
nuclear pore complex interacting protein family, member B3
chr7_-_41742697 1.48 ENST00000242208.4
INHBA
inhibin, beta A
chr1_+_73771844 1.47 ENST00000440762.1
ENST00000444827.1
ENST00000415686.1
ENST00000411903.1
RP4-598G3.1
RP4-598G3.1
chr19_+_21106081 1.47 ENST00000300540.3
ENST00000595854.1
ENST00000601284.1
ENST00000328178.8
ENST00000599885.1
ENST00000596476.1
ENST00000345030.6
ZNF85
zinc finger protein 85
chr3_+_149191723 1.46 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr19_+_48497962 1.44 ENST00000596043.1
ENST00000597519.1
ELSPBP1
epididymal sperm binding protein 1
chr14_+_53173890 1.42 ENST00000445930.2
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr3_+_157827841 1.41 ENST00000295930.3
ENST00000471994.1
ENST00000464171.1
ENST00000312179.6
ENST00000475278.2
RSRC1
arginine/serine-rich coiled-coil 1
chr14_+_53173910 1.41 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr12_-_57146095 1.38 ENST00000550770.1
ENST00000338193.6
PRIM1
primase, DNA, polypeptide 1 (49kDa)
chr2_+_208423840 1.37 ENST00000539789.1
CREB1
cAMP responsive element binding protein 1
chr10_-_21661870 1.35 ENST00000433460.1
RP11-275N1.1
RP11-275N1.1
chr3_+_63953415 1.33 ENST00000484332.1
ATXN7
ataxin 7
chr12_-_71551868 1.33 ENST00000247829.3
TSPAN8
tetraspanin 8
chr2_+_208423891 1.32 ENST00000448277.1
ENST00000457101.1
CREB1
cAMP responsive element binding protein 1
chr11_-_3400442 1.29 ENST00000429541.2
ENST00000532539.1
ZNF195
zinc finger protein 195
chr1_+_89246647 1.28 ENST00000544045.1
PKN2
protein kinase N2
chr2_+_27440229 1.27 ENST00000264705.4
ENST00000403525.1
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr16_+_16472912 1.23 ENST00000530217.2
NPIPA7
nuclear pore complex interacting protein family, member A7
chr1_-_160231451 1.19 ENST00000495887.1
DCAF8
DDB1 and CUL4 associated factor 8
chr16_-_15472151 1.18 ENST00000360151.4
ENST00000543801.1
NPIPA5
nuclear pore complex interacting protein family, member A5
chr2_-_176046391 1.18 ENST00000392541.3
ENST00000409194.1
ATP5G3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr11_-_3400330 1.18 ENST00000427810.2
ENST00000005082.9
ENST00000534569.1
ENST00000438262.2
ENST00000528796.1
ENST00000528410.1
ENST00000529678.1
ENST00000354599.6
ENST00000526601.1
ENST00000525502.1
ENST00000533036.1
ENST00000399602.4
ZNF195
zinc finger protein 195
chr7_+_134464414 1.16 ENST00000361901.2
CALD1
caldesmon 1
chr4_-_164534657 1.13 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr16_-_75498553 1.13 ENST00000569276.1
ENST00000357613.4
ENST00000561878.1
ENST00000566980.1
ENST00000567194.1
TMEM170A
RP11-77K12.1
transmembrane protein 170A
Uncharacterized protein
chr8_-_81083890 1.12 ENST00000518937.1
TPD52
tumor protein D52
chr16_+_14805546 1.11 ENST00000552140.1
NPIPA3
nuclear pore complex interacting protein family, member A3
chr7_+_80275953 1.06 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36
CD36 molecule (thrombospondin receptor)
chr3_-_67705006 1.06 ENST00000492795.1
ENST00000493112.1
ENST00000307227.5
SUCLG2
succinate-CoA ligase, GDP-forming, beta subunit
chr17_-_46690839 1.06 ENST00000498634.2
HOXB8
homeobox B8
chr7_+_134464376 1.04 ENST00000454108.1
ENST00000361675.2
CALD1
caldesmon 1
chr17_+_45286706 1.04 ENST00000393450.1
ENST00000572303.1
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr22_-_32651326 1.02 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr17_-_40288449 0.99 ENST00000552162.1
ENST00000550504.1
RAB5C
RAB5C, member RAS oncogene family
chr7_+_80275621 0.96 ENST00000426978.1
ENST00000432207.1
CD36
CD36 molecule (thrombospondin receptor)
chr4_-_72649763 0.95 ENST00000513476.1
GC
group-specific component (vitamin D binding protein)
chr5_-_148442584 0.90 ENST00000394358.2
ENST00000512049.1
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr3_-_172241250 0.87 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr7_-_80141328 0.81 ENST00000398291.3
GNAT3
guanine nucleotide binding protein, alpha transducing 3
chr12_+_64173583 0.81 ENST00000261234.6
TMEM5
transmembrane protein 5
chr7_-_16872932 0.80 ENST00000419572.2
ENST00000412973.1
AGR2
anterior gradient 2
chr19_+_21265028 0.80 ENST00000291770.7
ZNF714
zinc finger protein 714
chr7_-_26578407 0.77 ENST00000242109.3
KIAA0087
KIAA0087
chr4_-_140222358 0.74 ENST00000505036.1
ENST00000544855.1
ENST00000539002.1
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr7_+_57509877 0.71 ENST00000420713.1
ZNF716
zinc finger protein 716
chr4_-_15939963 0.68 ENST00000259988.2
FGFBP1
fibroblast growth factor binding protein 1
chr19_-_43032532 0.66 ENST00000403461.1
ENST00000352591.5
ENST00000358394.3
ENST00000403444.3
ENST00000308072.4
ENST00000599389.1
ENST00000351134.3
ENST00000161559.6
CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr5_-_148033693 0.62 ENST00000377888.3
ENST00000360693.3
HTR4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
chr17_-_46806540 0.62 ENST00000290295.7
HOXB13
homeobox B13
chr5_-_148033726 0.61 ENST00000354217.2
ENST00000314512.6
ENST00000362016.2
HTR4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
chr10_+_75504105 0.60 ENST00000535742.1
ENST00000546025.1
ENST00000345254.4
ENST00000540668.1
ENST00000339365.2
ENST00000411652.2
SEC24C
SEC24 family member C
chr5_+_86564739 0.60 ENST00000456692.2
ENST00000512763.1
ENST00000506290.1
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr7_-_25268104 0.58 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr5_-_138534071 0.57 ENST00000394817.2
SIL1
SIL1 nucleotide exchange factor
chr2_-_40657397 0.56 ENST00000408028.2
ENST00000332839.4
ENST00000406391.2
ENST00000542024.1
ENST00000542756.1
ENST00000405901.3
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_+_210444142 0.56 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chr7_+_80275752 0.55 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chr18_+_21032781 0.54 ENST00000339486.3
RIOK3
RIO kinase 3
chr8_-_80993010 0.53 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
TPD52
tumor protein D52
chr8_+_76452097 0.50 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr19_-_22018966 0.49 ENST00000599906.1
ENST00000354959.4
ZNF43
zinc finger protein 43
chr8_+_143761874 0.49 ENST00000301258.4
ENST00000513264.1
PSCA
prostate stem cell antigen
chr5_-_39270725 0.49 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr4_-_186317034 0.48 ENST00000505916.1
LRP2BP
LRP2 binding protein
chr4_-_39979576 0.45 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr6_+_25754927 0.44 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr8_-_81083731 0.40 ENST00000379096.5
TPD52
tumor protein D52
chr1_-_204135450 0.39 ENST00000272190.8
ENST00000367195.2
REN
renin
chr21_-_28338732 0.38 ENST00000284987.5
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr9_+_2029019 0.37 ENST00000382194.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_-_145562147 0.37 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
LARS
leucyl-tRNA synthetase
chr17_+_58018269 0.37 ENST00000591035.1
RP11-178C3.1
Uncharacterized protein
chr6_+_12958137 0.36 ENST00000457702.2
ENST00000379345.2
PHACTR1
phosphatase and actin regulator 1
chr6_-_87804815 0.34 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr3_-_38992052 0.34 ENST00000302328.3
ENST00000450244.1
ENST00000444237.2
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr5_-_111093167 0.32 ENST00000446294.2
ENST00000419114.2
NREP
neuronal regeneration related protein
chr1_-_43919346 0.32 ENST00000372430.3
ENST00000372433.1
ENST00000372434.1
ENST00000486909.1
HYI
hydroxypyruvate isomerase (putative)
chr3_+_15045419 0.32 ENST00000406272.2
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr7_-_107204918 0.30 ENST00000297135.3
COG5
component of oligomeric golgi complex 5
chr3_-_196911002 0.29 ENST00000452595.1
DLG1
discs, large homolog 1 (Drosophila)
chr8_-_13372395 0.29 ENST00000276297.4
ENST00000511869.1
DLC1
deleted in liver cancer 1
chr12_-_10959892 0.28 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr3_-_46068969 0.27 ENST00000542109.1
ENST00000395946.2
XCR1
chemokine (C motif) receptor 1
chr8_+_128426535 0.25 ENST00000465342.2
POU5F1B
POU class 5 homeobox 1B
chr16_-_21663950 0.24 ENST00000268389.4
IGSF6
immunoglobulin superfamily, member 6
chr6_-_133035185 0.21 ENST00000367928.4
VNN1
vanin 1
chr17_+_7211656 0.21 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr17_+_68071389 0.20 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr2_-_209010874 0.19 ENST00000260988.4
CRYGB
crystallin, gamma B
chr19_-_48753104 0.19 ENST00000447740.2
CARD8
caspase recruitment domain family, member 8
chr12_-_10962767 0.18 ENST00000240691.2
TAS2R9
taste receptor, type 2, member 9
chr6_-_27782548 0.18 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr19_-_48752812 0.15 ENST00000359009.4
CARD8
caspase recruitment domain family, member 8
chr20_-_7921090 0.15 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr5_-_16738451 0.14 ENST00000274203.9
ENST00000515803.1
MYO10
myosin X
chr19_+_4402659 0.14 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr1_+_12524965 0.12 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chrX_+_144908928 0.12 ENST00000408967.2
TMEM257
transmembrane protein 257
chr8_-_20040638 0.10 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr6_-_127840453 0.10 ENST00000556132.1
SOGA3
SOGA family member 3
chr1_-_54355430 0.10 ENST00000371399.1
ENST00000072644.1
ENST00000412288.1
YIPF1
Yip1 domain family, member 1
chr10_-_103599591 0.08 ENST00000348850.5
KCNIP2
Kv channel interacting protein 2
chr1_-_23495340 0.07 ENST00000418342.1
LUZP1
leucine zipper protein 1
chr11_-_4719072 0.07 ENST00000396950.3
ENST00000532598.1
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr19_+_21264980 0.05 ENST00000596053.1
ENST00000597086.1
ENST00000596143.1
ENST00000596367.1
ENST00000601416.1
ZNF714
zinc finger protein 714
chr22_-_30642782 0.04 ENST00000249075.3
LIF
leukemia inhibitory factor
chr4_-_123377880 0.02 ENST00000226730.4
IL2
interleukin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
1.6 8.0 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.8 3.0 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.6 6.9 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.5 2.7 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.5 2.7 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.5 3.0 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.5 1.5 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.5 1.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.4 2.7 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.4 1.3 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.4 2.6 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.4 6.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.3 1.9 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.3 1.5 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.3 0.8 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.3 2.4 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.2 3.6 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 1.6 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 0.7 GO:0043318 cytotoxic T cell degranulation(GO:0043316) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318) insulin catabolic process(GO:1901143)
0.2 1.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.2 5.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 0.7 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.2 0.6 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 2.8 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.5 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 0.8 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 0.4 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425) valyl-tRNA aminoacylation(GO:0006438)
0.1 1.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 8.5 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 2.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 3.0 GO:0048240 sperm capacitation(GO:0048240)
0.1 5.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.5 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.1 4.0 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 2.6 GO:0006833 water transport(GO:0006833)
0.1 7.5 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 0.6 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 0.9 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 1.1 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.6 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 0.4 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.1 1.7 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.1 1.0 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.1 0.8 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 3.3 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 1.6 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.1 3.7 GO:0016266 O-glycan processing(GO:0016266)
0.1 2.9 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 1.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 5.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.9 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 0.4 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 1.2 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.3 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.0 0.3 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 1.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 1.0 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.0 0.9 GO:0042359 vitamin D metabolic process(GO:0042359)
0.0 1.9 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.0 0.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 1.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.2 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 1.4 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.6 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 1.5 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.6 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.0 2.0 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0001842 neural fold formation(GO:0001842)
0.0 4.0 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 2.2 GO:0017148 negative regulation of translation(GO:0017148)
0.0 0.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.3 GO:0051930 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.9 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
1.0 2.9 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.5 2.6 GO:0044530 supraspliceosomal complex(GO:0044530)
0.5 5.7 GO:0033391 chromatoid body(GO:0033391)
0.5 1.5 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.5 1.5 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.4 6.4 GO:0016461 unconventional myosin complex(GO:0016461)
0.4 2.7 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.4 3.0 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.3 3.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 2.8 GO:0031595 nuclear proteasome complex(GO:0031595)
0.2 4.9 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 1.9 GO:0042382 paraspeckles(GO:0042382)
0.2 1.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.2 1.6 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 1.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 2.2 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.1 2.2 GO:0030478 actin cap(GO:0030478)
0.1 1.6 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 7.5 GO:0016459 myosin complex(GO:0016459)
0.1 2.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 1.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 6.5 GO:0031514 motile cilium(GO:0031514)
0.0 6.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 2.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.2 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 2.7 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 6.0 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.3 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 6.6 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0043219 lateral loop(GO:0043219)
0.0 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.3 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
1.6 8.0 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.5 1.5 GO:0070538 oleic acid binding(GO:0070538)
0.5 1.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 2.7 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.4 2.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.4 1.3 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 2.7 GO:1990763 arrestin family protein binding(GO:1990763)
0.3 4.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 2.9 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 1.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.3 1.0 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.3 2.8 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.2 1.0 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 1.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.2 6.9 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 0.6 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.2 6.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.2 0.9 GO:0005499 vitamin D binding(GO:0005499)
0.2 2.6 GO:0015250 water channel activity(GO:0015250)
0.1 1.6 GO:0031013 troponin I binding(GO:0031013)
0.1 0.4 GO:0004819 glutamine-tRNA ligase activity(GO:0004819) valine-tRNA ligase activity(GO:0004832)
0.1 3.0 GO:0031489 myosin V binding(GO:0031489)
0.1 0.3 GO:0032089 NACHT domain binding(GO:0032089)
0.1 2.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 3.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 2.2 GO:0000339 RNA cap binding(GO:0000339)
0.1 1.4 GO:0002162 dystroglycan binding(GO:0002162)
0.1 6.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.5 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 1.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 1.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.5 GO:0089720 caspase binding(GO:0089720)
0.0 1.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.6 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 2.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 5.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 8.7 GO:0001047 core promoter binding(GO:0001047)
0.0 4.6 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.7 GO:0031005 filamin binding(GO:0031005)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.1 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.2 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 3.9 GO:0005178 integrin binding(GO:0005178)
0.0 3.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.7 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.0 GO:0019003 GDP binding(GO:0019003)
0.0 13.5 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.3 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.0 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 2.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.3 PID AURORA A PATHWAY Aurora A signaling
0.1 2.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 4.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 2.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 1.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 4.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 4.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.0 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.3 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.2 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 2.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.6 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.2 2.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 12.5 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.2 4.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.7 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 4.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 8.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 3.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 4.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.8 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.1 1.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 1.4 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 1.5 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 2.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 2.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.6 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 1.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 3.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.3 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 2.2 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.9 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 8.7 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.6 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.0 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 2.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines