Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for CEBPB
Z-value: 0.16
Motif logo
Transcription factors associated with CEBPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPB | hg19_v2_chr20_+_48807351_48807384 | 0.27 | 4.4e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 33.5 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.1 | 21.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 16.4 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 0.7 | 15.5 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 3.5 | 14.1 | GO:1903803 | glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803) |
| 4.6 | 13.8 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.7 | 13.5 | GO:0097186 | amelogenesis(GO:0097186) |
| 2.4 | 12.0 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 2.4 | 11.9 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 2.3 | 11.4 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 33.5 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 27.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 1.8 | 23.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 18.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 15.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 11.7 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.1 | 11.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.9 | 11.4 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 11.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 3.4 | 10.1 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 33.5 | GO:0004372 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.0 | 22.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.8 | 14.3 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.2 | 13.8 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 3.4 | 13.5 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
| 1.9 | 13.5 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
| 0.1 | 12.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 12.1 | GO:0005179 | hormone activity(GO:0005179) |
| 2.4 | 12.0 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 1.5 | 11.9 | GO:0001849 | complement component C1q binding(GO:0001849) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 21.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.4 | 16.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 14.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.5 | 13.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 11.9 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 11.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 7.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 7.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 6.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 30.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.9 | 21.3 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.5 | 19.3 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 1.6 | 14.3 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.6 | 12.3 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.3 | 11.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.4 | 11.1 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 9.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.5 | 9.1 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.4 | 9.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |