ISMARA results: CGUACCG

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for CGUACCG

Z-value: 0.03

Motif logo

miRNA associated with seed CGUACCG

Name	miRBASE accession
hsa-miR-126-3p.1 miRBase	MIMAT0000445

Activity profile of CGUACCG motif

Sorted Z-values of CGUACCG motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_57756087 Show fit	1.85	ENST00000274289.3	PLK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	polo-like kinase 2
chr2_-_227664474 Show fit	0.92	ENST00000305123.5	IRS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	insulin receptor substrate 1
chr8_+_38854418 Show fit	0.69	ENST00000481513.1 ENST00000487273.2	ADAM9 Ensembl NCBI GeneCards UniProt NextProt Show fit	ADAM metallopeptidase domain 9
chr16_+_56965960 Show fit	0.49	ENST00000439977.2 ENST00000344114.4 ENST00000300302.5 ENST00000379792.2	HERPUD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr1_+_15736359 Show fit	0.48	ENST00000375980.4	EFHD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	EF-hand domain family, member D2
chr1_-_89591749 Show fit	0.36	ENST00000370466.3	GBP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	guanylate binding protein 2, interferon-inducible
chr10_-_735553 Show fit	0.25	ENST00000280886.6 ENST00000423550.1	DIP2C Ensembl NCBI GeneCards UniProt NextProt Show fit	DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr17_-_1359443 Show fit	0.22	ENST00000574295.1 ENST00000398970.5 ENST00000300574.2	CRK Ensembl NCBI GeneCards UniProt NextProt Show fit	v-crk avian sarcoma virus CT10 oncogene homolog
chr9_+_139553306 Show fit	0.19	ENST00000371699.1	EGFL7 Ensembl NCBI GeneCards UniProt NextProt Show fit	EGF-like-domain, multiple 7
chr15_+_85923856 Show fit	0.03	ENST00000560302.1 ENST00000394518.2 ENST00000361243.2 ENST00000560256.1	AKAP13 Ensembl NCBI GeneCards UniProt NextProt Show fit	A kinase (PRKA) anchor protein 13

Showing 1 to 10 of 10 entries

Network of associatons between targets according to the STRING database.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	GO:0061000	negative regulation of dendritic spine development(GO:0061000)
0.1	0.9	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2	0.7	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.5	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0	0.2	GO:0001878	response to yeast(GO:0001878)
0.0	0.0	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)

Showing 1 to 6 of 6 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:0005814	centriole(GO:0005814)
0.2	0.9	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.7	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.1	0.5	GO:1990037	Lewy body core(GO:1990037)

Showing 1 to 4 of 4 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.8	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.9	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.7	GO:0043236	laminin binding(GO:0043236)

Showing 1 to 3 of 3 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	PID S1P S1P2 PATHWAY	S1P2 pathway

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.5	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4

Showing 1 to 2 of 2 entries