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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for CGUACCG

Z-value: 0.03

Motif logo

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miRNA associated with seed CGUACCG

NamemiRBASE accession
hsa-miR-126-3p.1
MIMAT0000445

Activity profile of CGUACCG motif

Sorted Z-values of CGUACCG motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_57756087 1.85 ENST00000274289.3
PLK2
polo-like kinase 2
chr2_-_227664474 0.92 ENST00000305123.5
IRS1
insulin receptor substrate 1
chr8_+_38854418 0.69 ENST00000481513.1
ENST00000487273.2
ADAM9
ADAM metallopeptidase domain 9
chr16_+_56965960 0.49 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr1_+_15736359 0.48 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr1_-_89591749 0.36 ENST00000370466.3
GBP2
guanylate binding protein 2, interferon-inducible
chr10_-_735553 0.25 ENST00000280886.6
ENST00000423550.1
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr17_-_1359443 0.22 ENST00000574295.1
ENST00000398970.5
ENST00000300574.2
CRK
v-crk avian sarcoma virus CT10 oncogene homolog
chr9_+_139553306 0.19 ENST00000371699.1
EGFL7
EGF-like-domain, multiple 7
chr15_+_85923856 0.03 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
AKAP13
A kinase (PRKA) anchor protein 13

Network of associatons between targets according to the STRING database.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.1 1.8 GO:0061000 negative regulation of dendritic spine development(GO:0061000)
0.1 0.9 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.5 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.2 GO:0001878 response to yeast(GO:0001878)
0.0 0.0 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.5 GO:1990037 Lewy body core(GO:1990037)
0.0 0.7 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 1.8 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.7 GO:0043236 laminin binding(GO:0043236)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID S1P S1P2 PATHWAY S1P2 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4