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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CLOCK
Z-value: 1.15
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Transcription factors associated with CLOCK
Network of associatons between targets according to the STRING database.
First level regulatory network of CLOCK
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 82.6 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 11.6 | 81.1 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 1.8 | 72.0 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 8.9 | 70.8 | GO:0010994 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) positive regulation of exit from mitosis(GO:0031536) |
| 13.6 | 68.1 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 5.9 | 53.5 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 10.4 | 52.1 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 6.3 | 50.6 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 3.1 | 50.2 | GO:0000338 | protein deneddylation(GO:0000338) |
| 9.3 | 46.4 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 114.8 | GO:0005730 | nucleolus(GO:0005730) |
| 1.0 | 86.4 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 1.2 | 86.0 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 10.1 | 81.1 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.3 | 77.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 2.4 | 70.8 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 1.3 | 58.3 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 8.7 | 52.1 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 1.0 | 50.2 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 12.2 | 48.6 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 112.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.8 | 83.2 | GO:0051087 | chaperone binding(GO:0051087) |
| 11.6 | 81.1 | GO:0008732 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 10.8 | 75.8 | GO:0004459 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 1.9 | 72.0 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 1.6 | 71.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.6 | 67.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 7.3 | 58.3 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 1.2 | 55.6 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 7.9 | 47.4 | GO:0019238 | cyclohydrolase activity(GO:0019238) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 99.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 4.1 | 74.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 2.3 | 55.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.5 | 41.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.5 | 41.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.3 | 32.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 31.8 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.4 | 30.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 26.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.5 | 16.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 93.6 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 2.5 | 70.8 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 1.1 | 61.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.9 | 61.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.3 | 52.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.7 | 47.9 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 1.3 | 40.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.7 | 38.1 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 1.3 | 33.0 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.5 | 31.9 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |