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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for CLOCK

Z-value: 1.15

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Transcription factors associated with CLOCK

Gene Symbol Gene ID Gene Info
CLOCK
ENSG00000134852.10 clock circadian regulator

Activity profile of CLOCK motif

Sorted Z-values of CLOCK motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_64014379 41.56 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_-_26233423 37.74 ENST00000357865.2
STMN1
stathmin 1
chr5_+_138609782 35.70 ENST00000361059.2
ENST00000514694.1
ENST00000504203.1
ENST00000502929.1
ENST00000394800.2
ENST00000509644.1
ENST00000505016.1
MATR3
matrin 3
chr17_-_47492164 30.72 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
PHB
prohibitin
chr2_+_242289502 29.31 ENST00000451310.1
SEPT2
septin 2
chr2_+_198365122 28.86 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr12_+_57624085 26.81 ENST00000553474.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_-_58146128 26.74 ENST00000551800.1
ENST00000549606.1
ENST00000257904.6
CDK4
cyclin-dependent kinase 4
chr12_+_64798095 26.28 ENST00000332707.5
XPOT
exportin, tRNA
chr2_+_201170770 26.26 ENST00000409988.3
ENST00000409385.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr16_-_81129845 26.08 ENST00000569885.1
ENST00000566566.1
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr20_+_44441304 25.90 ENST00000352551.5
UBE2C
ubiquitin-conjugating enzyme E2C
chr15_-_49447771 25.73 ENST00000558843.1
ENST00000542928.1
ENST00000561248.1
COPS2
COP9 signalosome subunit 2
chr12_-_58146048 25.40 ENST00000547281.1
ENST00000546489.1
ENST00000552388.1
ENST00000540325.1
ENST00000312990.6
CDK4
cyclin-dependent kinase 4
chr20_+_44441215 24.92 ENST00000356455.4
ENST00000405520.1
UBE2C
ubiquitin-conjugating enzyme E2C
chr4_+_57302297 24.80 ENST00000399688.3
ENST00000512576.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr1_-_26232951 24.77 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr2_+_201170596 24.20 ENST00000439084.1
ENST00000409718.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chrX_+_23685653 24.07 ENST00000379331.3
PRDX4
peroxiredoxin 4
chr11_+_114310102 24.01 ENST00000265881.5
REXO2
RNA exonuclease 2
chr17_-_48474828 23.95 ENST00000576448.1
ENST00000225972.7
LRRC59
leucine rich repeat containing 59
chr2_+_201171242 23.77 ENST00000360760.5
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr9_+_112542591 23.17 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
PALM2
PALM2-AKAP2
AKAP2
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr2_+_216176761 23.00 ENST00000540518.1
ENST00000435675.1
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr11_-_122931881 22.88 ENST00000526110.1
ENST00000227378.3
HSPA8
heat shock 70kDa protein 8
chr11_+_18416103 22.73 ENST00000543445.1
ENST00000430553.2
ENST00000396222.2
ENST00000535451.1
LDHA
lactate dehydrogenase A
chr11_+_114310237 22.71 ENST00000539119.1
REXO2
RNA exonuclease 2
chr5_+_138609441 22.58 ENST00000509990.1
ENST00000506147.1
ENST00000512107.1
MATR3
matrin 3
chr2_+_198365095 22.51 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr11_+_114310164 22.43 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
REXO2
RNA exonuclease 2
chrX_+_23685563 22.37 ENST00000379341.4
PRDX4
peroxiredoxin 4
chr12_+_57624119 22.17 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_159894319 22.04 ENST00000320307.4
TAGLN2
transgelin 2
chr1_-_11120057 21.83 ENST00000376957.2
SRM
spermidine synthase
chr4_+_57301896 21.15 ENST00000514888.1
ENST00000264221.2
ENST00000505164.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr12_-_76477707 21.10 ENST00000551992.1
NAP1L1
nucleosome assembly protein 1-like 1
chr17_+_49243639 21.03 ENST00000512737.1
ENST00000503064.1
NME1-NME2
NME1-NME2 readthrough
chr17_+_40985407 20.97 ENST00000586114.1
ENST00000590720.1
ENST00000585805.1
ENST00000541124.1
ENST00000441946.2
ENST00000591152.1
ENST00000589469.1
ENST00000293362.3
ENST00000592169.1
PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr11_+_18416133 20.82 ENST00000227157.4
ENST00000478970.2
ENST00000495052.1
LDHA
lactate dehydrogenase A
chr9_+_112542572 20.31 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr14_-_58893832 20.28 ENST00000556007.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr17_-_40075219 20.17 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
ACLY
ATP citrate lyase
chr20_+_44441271 20.03 ENST00000335046.3
ENST00000243893.6
UBE2C
ubiquitin-conjugating enzyme E2C
chr2_+_216176540 20.02 ENST00000236959.9
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr12_-_21810726 19.85 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr17_+_49243792 19.49 ENST00000393183.3
ENST00000393190.1
NME1-NME2
NME1-NME2 readthrough
chr1_+_84944926 19.40 ENST00000370656.1
ENST00000370654.5
RPF1
ribosome production factor 1 homolog (S. cerevisiae)
chr12_-_21810765 19.17 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr14_-_58894223 18.91 ENST00000555593.1
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr5_+_34656569 18.84 ENST00000428746.2
RAI14
retinoic acid induced 14
chr5_+_135394840 18.56 ENST00000503087.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr3_+_52719936 18.33 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr17_-_5342380 18.28 ENST00000225698.4
C1QBP
complement component 1, q subcomponent binding protein
chr2_+_201171372 18.24 ENST00000409140.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr11_+_65770227 17.97 ENST00000527348.1
BANF1
barrier to autointegration factor 1
chr12_+_57623869 17.51 ENST00000414700.3
ENST00000557703.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr7_-_94285402 17.29 ENST00000428696.2
ENST00000445866.2
SGCE
sarcoglycan, epsilon
chr19_+_50180317 17.14 ENST00000534465.1
PRMT1
protein arginine methyltransferase 1
chr2_-_106013400 16.77 ENST00000409807.1
FHL2
four and a half LIM domains 2
chr2_-_175113088 16.60 ENST00000409546.1
ENST00000428402.2
OLA1
Obg-like ATPase 1
chr17_-_61850894 16.51 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr5_+_34656331 16.36 ENST00000265109.3
RAI14
retinoic acid induced 14
chr7_+_56019486 16.29 ENST00000446692.1
ENST00000285298.4
ENST00000443449.1
GBAS
MRPS17
glioblastoma amplified sequence
mitochondrial ribosomal protein S17
chr12_+_109535373 16.27 ENST00000242576.2
UNG
uracil-DNA glycosylase
chr10_+_60028818 16.08 ENST00000333926.5
CISD1
CDGSH iron sulfur domain 1
chr2_+_187350883 15.86 ENST00000337859.6
ZC3H15
zinc finger CCCH-type containing 15
chr1_+_166808692 15.65 ENST00000367876.4
POGK
pogo transposable element with KRAB domain
chr1_+_38478378 15.48 ENST00000373014.4
UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr2_-_47143160 15.43 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr6_-_30712313 15.29 ENST00000376377.2
ENST00000259874.5
IER3
immediate early response 3
chr2_-_10587897 15.27 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr7_-_44163107 15.15 ENST00000406581.2
ENST00000452185.1
ENST00000436844.1
ENST00000418438.1
POLD2
polymerase (DNA directed), delta 2, accessory subunit
chr1_+_182992545 14.68 ENST00000258341.4
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr12_+_57623477 14.56 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr6_-_17706618 14.53 ENST00000262077.2
ENST00000537253.1
NUP153
nucleoporin 153kDa
chr5_+_172386419 14.23 ENST00000265100.2
ENST00000519239.1
RPL26L1
ribosomal protein L26-like 1
chr2_-_175113301 14.19 ENST00000344357.5
ENST00000284719.3
OLA1
Obg-like ATPase 1
chr6_-_153304148 14.13 ENST00000229758.3
FBXO5
F-box protein 5
chr1_-_86174065 14.10 ENST00000370574.3
ENST00000431532.2
ZNHIT6
zinc finger, HIT-type containing 6
chr9_+_131445928 14.09 ENST00000372692.4
SET
SET nuclear oncogene
chr17_-_47492236 14.00 ENST00000434917.2
ENST00000300408.3
ENST00000511832.1
ENST00000419140.2
PHB
prohibitin
chr12_-_46766577 13.90 ENST00000256689.5
SLC38A2
solute carrier family 38, member 2
chr2_-_47142884 13.89 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chrX_-_16887963 13.71 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr1_+_214776516 13.52 ENST00000366955.3
CENPF
centromere protein F, 350/400kDa
chr5_+_110074685 13.37 ENST00000355943.3
ENST00000447245.2
SLC25A46
solute carrier family 25, member 46
chr2_+_187350973 13.35 ENST00000544130.1
ZC3H15
zinc finger CCCH-type containing 15
chr15_-_49447835 13.24 ENST00000388901.5
ENST00000299259.6
COPS2
COP9 signalosome subunit 2
chr6_-_114292449 13.16 ENST00000519065.1
HDAC2
histone deacetylase 2
chr22_-_42343117 13.05 ENST00000407253.3
ENST00000215980.5
CENPM
centromere protein M
chr1_+_38478432 12.98 ENST00000537711.1
UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr12_+_109535923 12.74 ENST00000336865.2
UNG
uracil-DNA glycosylase
chr2_+_201171064 12.46 ENST00000451764.2
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr2_+_118572226 12.41 ENST00000263239.2
DDX18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr13_+_50656307 12.19 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr11_-_118972575 11.97 ENST00000432443.2
DPAGT1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr21_-_27542972 11.90 ENST00000346798.3
ENST00000439274.2
ENST00000354192.3
ENST00000348990.5
ENST00000357903.3
ENST00000358918.3
ENST00000359726.3
APP
amyloid beta (A4) precursor protein
chr5_+_95066823 11.87 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr10_-_120938303 11.81 ENST00000356951.3
ENST00000298510.2
PRDX3
peroxiredoxin 3
chr6_-_114292284 11.80 ENST00000520895.1
ENST00000521163.1
ENST00000524334.1
ENST00000368632.2
ENST00000398283.2
HDAC2
histone deacetylase 2
chr1_+_24018269 11.76 ENST00000374550.3
RPL11
ribosomal protein L11
chr8_-_62627057 11.70 ENST00000519234.1
ENST00000379449.6
ENST00000379454.4
ENST00000518068.1
ENST00000517856.1
ENST00000356457.5
ASPH
aspartate beta-hydroxylase
chr1_+_111991474 11.59 ENST00000369722.3
ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr11_+_69455855 11.50 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr2_-_44223138 11.37 ENST00000260665.7
LRPPRC
leucine-rich pentatricopeptide repeat containing
chr14_+_64854958 11.16 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr15_-_101835414 11.04 ENST00000254193.6
SNRPA1
small nuclear ribonucleoprotein polypeptide A'
chr10_-_71993176 10.99 ENST00000373232.3
PPA1
pyrophosphatase (inorganic) 1
chr15_+_96875657 10.83 ENST00000559679.1
ENST00000394171.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr8_+_109455845 10.70 ENST00000220853.3
EMC2
ER membrane protein complex subunit 2
chr1_-_38061522 10.61 ENST00000373062.3
GNL2
guanine nucleotide binding protein-like 2 (nucleolar)
chr21_-_46237883 10.59 ENST00000397893.3
SUMO3
small ubiquitin-like modifier 3
chr11_+_65769946 10.48 ENST00000533166.1
BANF1
barrier to autointegration factor 1
chr2_-_179315490 10.41 ENST00000487082.1
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr16_+_53088885 10.34 ENST00000566029.1
ENST00000447540.1
CHD9
chromodomain helicase DNA binding protein 9
chr9_-_34637718 10.20 ENST00000378892.1
ENST00000277010.4
SIGMAR1
sigma non-opioid intracellular receptor 1
chr6_+_44214824 10.20 ENST00000371646.5
ENST00000353801.3
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr1_+_111992064 10.11 ENST00000483994.1
ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr19_+_21688366 10.03 ENST00000358491.4
ENST00000597078.1
ZNF429
zinc finger protein 429
chr5_-_176900610 10.01 ENST00000477391.2
ENST00000393565.1
ENST00000309007.5
DBN1
drebrin 1
chr6_+_44187334 10.01 ENST00000313248.7
ENST00000427851.2
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr3_-_183967296 9.97 ENST00000455059.1
ENST00000445626.2
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr2_+_64069459 9.93 ENST00000445915.2
ENST00000475462.1
UGP2
UDP-glucose pyrophosphorylase 2
chr16_+_14980632 9.83 ENST00000565655.1
NOMO1
NODAL modulator 1
chr11_+_71938925 9.82 ENST00000538751.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr4_+_57333756 9.81 ENST00000510663.1
ENST00000504757.1
SRP72
signal recognition particle 72kDa
chr1_-_43833628 9.76 ENST00000413844.2
ENST00000372458.3
ELOVL1
ELOVL fatty acid elongase 1
chr4_+_41258786 9.73 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr12_-_49318715 9.62 ENST00000444214.2
FKBP11
FK506 binding protein 11, 19 kDa
chr11_-_47664072 9.58 ENST00000542981.1
ENST00000530428.1
ENST00000302503.3
MTCH2
mitochondrial carrier 2
chr14_-_58894332 9.44 ENST00000395159.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr9_-_2844058 9.44 ENST00000397885.2
KIAA0020
KIAA0020
chr20_+_31407692 9.28 ENST00000375571.5
MAPRE1
microtubule-associated protein, RP/EB family, member 1
chr4_+_17579110 9.22 ENST00000606142.1
LAP3
leucine aminopeptidase 3
chr17_+_65713925 9.16 ENST00000253247.4
NOL11
nucleolar protein 11
chr6_-_32811771 9.16 ENST00000395339.3
ENST00000374882.3
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr13_+_27998681 9.13 ENST00000381140.4
GTF3A
general transcription factor IIIA
chr4_+_17578815 8.99 ENST00000226299.4
LAP3
leucine aminopeptidase 3
chr11_-_122932730 8.89 ENST00000532182.1
ENST00000524590.1
ENST00000528292.1
ENST00000533540.1
ENST00000525463.1
HSPA8
heat shock 70kDa protein 8
chr1_-_9129895 8.81 ENST00000473209.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr4_-_103266626 8.77 ENST00000356736.4
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr20_-_49547910 8.76 ENST00000396032.3
ADNP
activity-dependent neuroprotector homeobox
chr9_-_130890662 8.75 ENST00000277462.5
ENST00000338961.6
PTGES2
prostaglandin E synthase 2
chr6_+_44187242 8.64 ENST00000393844.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr1_+_26496362 8.64 ENST00000374266.5
ENST00000270812.5
ZNF593
zinc finger protein 593
chr7_+_100464760 8.64 ENST00000200457.4
TRIP6
thyroid hormone receptor interactor 6
chr1_-_36107445 8.50 ENST00000373237.3
PSMB2
proteasome (prosome, macropain) subunit, beta type, 2
chr6_-_153304697 8.46 ENST00000367241.3
FBXO5
F-box protein 5
chr5_+_172386517 8.45 ENST00000519522.1
RPL26L1
ribosomal protein L26-like 1
chr2_+_68384976 8.43 ENST00000263657.2
PNO1
partner of NOB1 homolog (S. cerevisiae)
chr6_+_44191507 8.39 ENST00000371724.1
ENST00000371713.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr1_+_24019099 8.38 ENST00000443624.1
ENST00000458455.1
RPL11
ribosomal protein L11
chr22_+_18593446 8.28 ENST00000316027.6
TUBA8
tubulin, alpha 8
chr3_-_50329990 8.18 ENST00000417626.2
IFRD2
interferon-related developmental regulator 2
chr3_+_124449213 8.17 ENST00000232607.2
ENST00000536109.1
ENST00000538242.1
ENST00000413078.2
UMPS
uridine monophosphate synthetase
chr1_-_40041925 8.08 ENST00000372862.3
PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr6_-_160210604 8.07 ENST00000420894.2
ENST00000539756.1
ENST00000544255.1
TCP1
t-complex 1
chr8_-_103424986 7.94 ENST00000521922.1
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr2_-_216257849 7.89 ENST00000456923.1
FN1
fibronectin 1
chr1_-_235292250 7.78 ENST00000366607.4
TOMM20
translocase of outer mitochondrial membrane 20 homolog (yeast)
chrX_+_51636629 7.67 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
MAGED1
melanoma antigen family D, 1
chr1_+_32479430 7.64 ENST00000327300.7
ENST00000492989.1
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr22_+_20105259 7.63 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RANBP1
RAN binding protein 1
chr1_-_40042073 7.62 ENST00000372858.3
PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr16_+_771663 7.61 ENST00000568916.1
FAM173A
family with sequence similarity 173, member A
chr19_+_36036477 7.58 ENST00000222284.5
ENST00000392204.2
TMEM147
transmembrane protein 147
chr13_-_95953589 7.56 ENST00000538287.1
ENST00000376887.4
ENST00000412704.1
ENST00000536256.1
ENST00000431522.1
ABCC4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
chr19_+_36036583 7.54 ENST00000392205.1
TMEM147
transmembrane protein 147
chr6_-_97345689 7.51 ENST00000316149.7
NDUFAF4
NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
chr10_-_16859361 7.49 ENST00000377921.3
RSU1
Ras suppressor protein 1
chr8_-_117768023 7.48 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr2_-_179315453 7.45 ENST00000432031.2
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr5_+_145826867 7.45 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr6_-_47277634 7.35 ENST00000296861.2
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr11_-_76091986 7.18 ENST00000260045.3
PRKRIR
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr12_+_6309963 7.10 ENST00000382515.2
CD9
CD9 molecule
chr3_+_133293278 6.96 ENST00000508481.1
ENST00000420115.2
ENST00000504867.1
ENST00000507408.1
ENST00000511392.1
ENST00000515421.1
CDV3
CDV3 homolog (mouse)
chr9_-_6015607 6.96 ENST00000259569.5
RANBP6
RAN binding protein 6
chr16_-_69364467 6.95 ENST00000288022.1
PDF
peptide deformylase (mitochondrial)
chr3_+_133292574 6.92 ENST00000264993.3
CDV3
CDV3 homolog (mouse)
chr6_+_44191290 6.90 ENST00000371755.3
ENST00000371740.5
ENST00000371731.1
ENST00000393841.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr21_-_46238034 6.88 ENST00000332859.6
SUMO3
small ubiquitin-like modifier 3
chr10_-_16859442 6.86 ENST00000602389.1
ENST00000345264.5
RSU1
Ras suppressor protein 1
chr5_+_102455968 6.83 ENST00000358359.3
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr3_-_160283348 6.83 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr17_+_7476136 6.74 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
EIF4A1
eukaryotic translation initiation factor 4A1
chr5_+_70883117 6.71 ENST00000340941.6
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr6_+_149539767 6.68 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
TAB2
RP1-111D6.3
TGF-beta activated kinase 1/MAP3K7 binding protein 2
RP1-111D6.3
chr2_+_32853093 6.66 ENST00000448773.1
ENST00000317907.4
TTC27
tetratricopeptide repeat domain 27
chr12_+_108079509 6.63 ENST00000412830.3
ENST00000547995.1
PWP1
PWP1 homolog (S. cerevisiae)
chr17_-_7590745 6.54 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
TP53
tumor protein p53
chr1_+_110163709 6.52 ENST00000369840.2
ENST00000527846.1
AMPD2
adenosine monophosphate deaminase 2
chr3_-_98312548 6.49 ENST00000264193.2
CPOX
coproporphyrinogen oxidase
chr8_-_103424916 6.40 ENST00000220959.4
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr7_+_26191809 6.38 ENST00000056233.3
NFE2L3
nuclear factor, erythroid 2-like 3
chr11_-_94227029 6.35 ENST00000323977.3
ENST00000536754.1
ENST00000323929.3
MRE11A
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
chr19_+_50180409 6.25 ENST00000391851.4
PRMT1
protein arginine methyltransferase 1
chr20_+_48552908 6.24 ENST00000244061.2
RNF114
ring finger protein 114
chr5_-_115177247 6.24 ENST00000500945.2
ATG12
autophagy related 12
chr1_-_154909329 6.20 ENST00000368467.3
PMVK
phosphomevalonate kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of CLOCK

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
13.6 68.1 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
11.8 11.8 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
11.6 81.1 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
10.8 43.0 GO:0046452 dihydrofolate metabolic process(GO:0046452)
10.4 52.1 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
9.3 46.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
8.9 70.8 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) positive regulation of exit from mitosis(GO:0031536)
7.5 22.6 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
7.5 44.7 GO:2000323 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259) negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
6.8 33.9 GO:0015862 uridine transport(GO:0015862)
6.4 31.8 GO:1902904 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
6.3 50.6 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
5.9 53.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
5.6 11.2 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
5.5 82.6 GO:0006089 lactate metabolic process(GO:0006089)
5.2 26.1 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
5.0 20.1 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
5.0 25.0 GO:0061198 fungiform papilla formation(GO:0061198)
4.8 28.8 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
4.6 13.9 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
4.6 18.3 GO:1901165 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of trophoblast cell migration(GO:1901165)
4.5 13.4 GO:0090149 mitochondrial membrane fission(GO:0090149)
3.9 15.6 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
3.9 11.7 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
3.8 15.3 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
3.7 11.0 GO:0071344 diphosphate metabolic process(GO:0071344)
3.4 16.8 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
3.2 9.7 GO:0007412 axon target recognition(GO:0007412)
3.1 50.2 GO:0000338 protein deneddylation(GO:0000338)
3.1 12.5 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
3.1 9.3 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
2.7 13.7 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
2.7 8.2 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
2.7 10.8 GO:0009956 radial pattern formation(GO:0009956)
2.7 18.6 GO:1902915 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
2.6 7.9 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
2.6 7.8 GO:0035927 RNA import into mitochondrion(GO:0035927)
2.4 11.9 GO:0071873 response to norepinephrine(GO:0071873) cellular response to norepinephrine stimulus(GO:0071874)
2.4 14.1 GO:0048254 snoRNA localization(GO:0048254)
2.3 13.9 GO:0032328 alanine transport(GO:0032328)
2.3 27.5 GO:0015074 DNA integration(GO:0015074)
2.2 29.0 GO:0045008 depyrimidination(GO:0045008)
2.2 6.6 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
2.1 6.3 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
2.1 6.2 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
2.0 9.9 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
2.0 11.9 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
1.9 7.6 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
1.8 5.4 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
1.8 72.0 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
1.7 8.7 GO:0019348 dolichol metabolic process(GO:0019348)
1.7 8.6 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
1.7 10.0 GO:0010643 cell communication by chemical coupling(GO:0010643)
1.7 5.0 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
1.7 11.6 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
1.7 16.5 GO:0006983 ER overload response(GO:0006983)
1.6 9.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
1.6 14.5 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
1.6 4.8 GO:0050894 determination of affect(GO:0050894)
1.6 4.8 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
1.6 4.7 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
1.6 15.6 GO:0071578 zinc II ion transmembrane import(GO:0071578)
1.5 12.2 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
1.5 3.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
1.5 10.6 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
1.5 4.4 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
1.3 18.7 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
1.3 9.2 GO:0008295 spermidine biosynthetic process(GO:0008295)
1.3 8.8 GO:0033484 nitric oxide homeostasis(GO:0033484)
1.2 18.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
1.2 6.0 GO:0006740 NADPH regeneration(GO:0006740)
1.2 38.1 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
1.2 10.7 GO:0006552 leucine catabolic process(GO:0006552)
1.2 11.7 GO:0007000 nucleolus organization(GO:0007000)
1.2 7.0 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
1.1 11.5 GO:0070141 response to UV-A(GO:0070141)
1.1 3.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
1.0 13.5 GO:0051382 kinetochore assembly(GO:0051382)
1.0 13.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
1.0 17.9 GO:0042473 outer ear morphogenesis(GO:0042473)
1.0 5.7 GO:0034201 response to oleic acid(GO:0034201)
0.9 8.5 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.9 2.8 GO:0048627 myoblast development(GO:0048627)
0.9 5.4 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.9 8.9 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.9 15.1 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.9 13.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.9 14.7 GO:0070831 basement membrane assembly(GO:0070831)
0.8 5.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.8 8.3 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.8 4.9 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.8 1.6 GO:0044030 regulation of DNA methylation(GO:0044030)
0.8 16.1 GO:0043457 regulation of cellular respiration(GO:0043457)
0.7 2.2 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.7 19.4 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.7 7.1 GO:0030913 paranodal junction assembly(GO:0030913)
0.7 2.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.7 8.1 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.7 2.7 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.7 32.6 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.6 6.5 GO:0051597 response to methylmercury(GO:0051597)
0.6 14.1 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.6 10.8 GO:0006020 inositol metabolic process(GO:0006020)
0.6 29.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.6 6.9 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.6 3.9 GO:0090032 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.6 5.0 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.5 19.2 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.5 7.6 GO:0032310 prostaglandin secretion(GO:0032310)
0.5 3.7 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.5 22.2 GO:0051031 tRNA transport(GO:0051031)
0.5 4.1 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.5 8.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.5 13.0 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.5 4.4 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.5 6.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.5 27.5 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.5 6.4 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.5 9.1 GO:0044804 nucleophagy(GO:0044804)
0.4 13.3 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.4 1.2 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.4 38.6 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.4 2.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.4 11.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.4 1.1 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.4 1.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.4 5.8 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.4 25.8 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.4 1.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.4 2.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.4 3.5 GO:0006188 IMP biosynthetic process(GO:0006188)
0.3 2.7 GO:0000012 single strand break repair(GO:0000012)
0.3 2.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3 6.9 GO:0071294 cellular response to zinc ion(GO:0071294)
0.3 4.3 GO:0031167 rRNA methylation(GO:0031167)
0.2 3.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 5.1 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.2 1.9 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593) negative regulation of lamellipodium organization(GO:1902744)
0.2 4.9 GO:0018126 protein hydroxylation(GO:0018126)
0.2 22.7 GO:0006334 nucleosome assembly(GO:0006334)
0.2 3.3 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.2 9.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 12.4 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.2 9.0 GO:0006270 DNA replication initiation(GO:0006270)
0.2 1.0 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 37.2 GO:0002576 platelet degranulation(GO:0002576)
0.2 1.5 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 6.7 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.2 4.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.2 10.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 11.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.4 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 3.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 2.6 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.1 2.7 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.1 4.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 2.2 GO:0006012 galactose metabolic process(GO:0006012)
0.1 21.3 GO:0006457 protein folding(GO:0006457)
0.1 4.1 GO:1901998 toxin transport(GO:1901998)
0.1 0.6 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 1.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 5.6 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.1 1.1 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.1 1.3 GO:0043584 nose development(GO:0043584)
0.1 8.5 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.1 1.6 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 2.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 10.6 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 13.4 GO:0007224 smoothened signaling pathway(GO:0007224)
0.1 14.2 GO:2001020 regulation of response to DNA damage stimulus(GO:2001020)
0.1 1.8 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 0.8 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 2.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 5.5 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 3.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 1.4 GO:0035150 regulation of tube size(GO:0035150) regulation of blood vessel size(GO:0050880)
0.1 3.8 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 1.4 GO:0006308 DNA catabolic process(GO:0006308)
0.1 0.3 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.0 0.3 GO:0051252 regulation of RNA metabolic process(GO:0051252)
0.0 1.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.5 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 1.4 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 5.5 GO:0006364 rRNA processing(GO:0006364)
0.0 0.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.1 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.0 1.7 GO:0006401 RNA catabolic process(GO:0006401)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
12.2 48.6 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
10.1 81.1 GO:0070552 BRISC complex(GO:0070552)
8.7 26.1 GO:0005960 glycine cleavage complex(GO:0005960)
8.7 52.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
4.5 31.8 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
3.9 15.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
3.8 15.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
3.7 14.7 GO:0005606 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
3.5 21.0 GO:0008537 proteasome activator complex(GO:0008537)
3.1 9.2 GO:0034455 t-UTP complex(GO:0034455)
2.4 70.8 GO:0005680 anaphase-promoting complex(GO:0005680)
2.1 10.7 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
2.1 38.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
2.1 29.3 GO:0097227 sperm annulus(GO:0097227)
2.0 16.3 GO:0016012 sarcoglycan complex(GO:0016012)
1.9 11.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
1.9 11.7 GO:0070545 PeBoW complex(GO:0070545)
1.9 33.9 GO:0034709 methylosome(GO:0034709)
1.8 14.1 GO:0070761 pre-snoRNP complex(GO:0070761)
1.7 8.6 GO:0045323 interleukin-1 receptor complex(GO:0045323)
1.7 5.0 GO:0070939 Dsl1p complex(GO:0070939)
1.5 9.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
1.5 18.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
1.5 12.2 GO:0097539 ciliary transition fiber(GO:0097539)
1.5 38.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
1.5 14.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.3 58.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
1.3 17.9 GO:0070578 RISC-loading complex(GO:0070578)
1.2 31.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
1.2 9.8 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
1.2 86.0 GO:0005637 nuclear inner membrane(GO:0005637)
1.2 10.7 GO:0072546 ER membrane protein complex(GO:0072546)
1.1 9.2 GO:1990111 spermatoproteasome complex(GO:1990111)
1.1 7.8 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
1.0 6.2 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
1.0 86.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
1.0 50.2 GO:0008180 COP9 signalosome(GO:0008180)
0.9 8.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.9 3.8 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.9 11.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.9 6.3 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.8 7.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.8 7.5 GO:0000439 core TFIIH complex(GO:0000439)
0.7 11.0 GO:0005686 U2 snRNP(GO:0005686)
0.7 8.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.7 2.0 GO:0001740 Barr body(GO:0001740)
0.6 7.9 GO:0005577 fibrinogen complex(GO:0005577)
0.6 16.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.5 7.6 GO:0031088 platelet dense granule membrane(GO:0031088)
0.5 3.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.4 2.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.4 4.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.4 4.8 GO:0071004 U2-type prespliceosome(GO:0071004)
0.4 5.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.4 42.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 18.8 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4 5.0 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.3 33.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.3 36.4 GO:0000776 kinetochore(GO:0000776)
0.3 77.4 GO:0043209 myelin sheath(GO:0043209)
0.3 2.3 GO:0072487 MSL complex(GO:0072487)
0.3 33.0 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 13.9 GO:0031430 M band(GO:0031430)
0.3 4.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 8.8 GO:0005921 gap junction(GO:0005921)
0.3 3.6 GO:0005869 dynactin complex(GO:0005869)
0.3 18.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 27.6 GO:0005643 nuclear pore(GO:0005643)
0.3 3.3 GO:0005652 nuclear lamina(GO:0005652)
0.3 2.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.3 28.5 GO:0000793 condensed chromosome(GO:0000793)
0.2 9.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 3.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 7.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 2.9 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.2 17.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 1.1 GO:0033503 HULC complex(GO:0033503)
0.2 13.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 2.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 17.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 24.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 8.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 4.6 GO:0009925 basal plasma membrane(GO:0009925)
0.1 5.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 21.0 GO:0042383 sarcolemma(GO:0042383)
0.1 30.4 GO:0005802 trans-Golgi network(GO:0005802)
0.1 114.8 GO:0005730 nucleolus(GO:0005730)
0.1 28.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 9.8 GO:0030175 filopodium(GO:0030175)
0.1 33.8 GO:0005874 microtubule(GO:0005874)
0.1 3.3 GO:0044391 ribosomal subunit(GO:0044391)
0.1 1.7 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 4.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 3.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 11.2 GO:0005819 spindle(GO:0005819)
0.1 0.5 GO:0097470 ribbon synapse(GO:0097470)
0.1 1.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 2.6 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.6 GO:0031082 BLOC complex(GO:0031082)
0.0 0.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.6 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
11.6 81.1 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
11.2 44.7 GO:0031871 proteinase activated receptor binding(GO:0031871)
10.8 75.8 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
7.9 47.4 GO:0019238 cyclohydrolase activity(GO:0019238)
7.3 21.9 GO:0017130 poly(C) RNA binding(GO:0017130)
7.3 58.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
7.3 21.8 GO:0004766 spermidine synthase activity(GO:0004766)
6.5 26.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
6.5 19.4 GO:0042134 rRNA primary transcript binding(GO:0042134)
6.1 18.3 GO:0030984 kininogen binding(GO:0030984)
5.2 15.6 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
4.8 28.8 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
4.3 42.7 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
4.0 20.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
4.0 12.0 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
3.5 27.7 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
3.3 10.0 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
3.3 9.9 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
3.3 9.8 GO:0005047 signal recognition particle binding(GO:0005047)
3.0 21.0 GO:0061133 endopeptidase activator activity(GO:0061133)
2.9 31.8 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
2.9 8.6 GO:0031177 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
2.7 11.0 GO:0004427 inorganic diphosphatase activity(GO:0004427)
2.4 9.7 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
2.2 8.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
2.2 10.8 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
2.1 10.7 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
2.1 23.3 GO:0031386 protein tag(GO:0031386)
2.0 46.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
2.0 17.9 GO:0070883 pre-miRNA binding(GO:0070883)
1.9 72.0 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
1.9 7.6 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
1.8 5.4 GO:0004832 valine-tRNA ligase activity(GO:0004832)
1.8 25.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.6 67.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.6 33.9 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
1.6 4.8 GO:0031877 somatostatin receptor binding(GO:0031877)
1.6 11.0 GO:0030620 U2 snRNA binding(GO:0030620)
1.6 71.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.5 10.6 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
1.5 9.1 GO:0019776 Atg8 ligase activity(GO:0019776)
1.4 38.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.4 4.2 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
1.3 12.7 GO:0008097 5S rRNA binding(GO:0008097)
1.2 18.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
1.2 9.8 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
1.2 11.9 GO:0051425 PTB domain binding(GO:0051425)
1.2 55.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
1.2 28.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
1.2 7.0 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.1 5.6 GO:0097322 7SK snRNA binding(GO:0097322)
1.0 3.1 GO:0033149 FFAT motif binding(GO:0033149)
0.9 14.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.9 5.4 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.9 4.4 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.9 4.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.8 13.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.8 15.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.8 4.9 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.8 36.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.8 7.8 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.8 83.2 GO:0051087 chaperone binding(GO:0051087)
0.7 13.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.7 1.4 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.7 2.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.7 19.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.7 2.7 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.7 2.6 GO:0004461 lactose synthase activity(GO:0004461)
0.6 18.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.6 8.1 GO:0004985 opioid receptor activity(GO:0004985)
0.6 13.1 GO:0000339 RNA cap binding(GO:0000339)
0.6 12.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.6 17.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6 4.6 GO:0008172 S-methyltransferase activity(GO:0008172)
0.6 2.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.6 10.0 GO:0005522 profilin binding(GO:0005522)
0.5 6.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.5 2.2 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.5 1.6 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.5 20.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.5 5.7 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.5 5.0 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.5 3.7 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.4 9.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.4 8.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.4 4.7 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290) O-acetyltransferase activity(GO:0016413)
0.4 10.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 7.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 6.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 9.4 GO:0070840 dynein complex binding(GO:0070840)
0.4 3.5 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 7.0 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 3.2 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.4 10.3 GO:0004386 helicase activity(GO:0004386)
0.4 6.7 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.3 16.3 GO:0019843 rRNA binding(GO:0019843)
0.3 3.1 GO:0043426 MRF binding(GO:0043426)
0.3 9.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 2.6 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.3 1.9 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.3 18.2 GO:0030145 manganese ion binding(GO:0030145)
0.3 10.8 GO:0001972 retinoic acid binding(GO:0001972)
0.3 10.9 GO:0004407 histone deacetylase activity(GO:0004407)
0.3 3.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 8.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.3 7.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.3 18.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 16.8 GO:0050681 androgen receptor binding(GO:0050681)
0.2 112.3 GO:0045296 cadherin binding(GO:0045296)
0.2 8.5 GO:0000287 magnesium ion binding(GO:0000287)
0.2 3.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 35.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 7.0 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 3.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 2.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 10.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 2.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 3.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.2 5.6 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.2 6.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 13.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 2.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 14.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 4.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.8 GO:0039552 RIG-I binding(GO:0039552)
0.1 6.9 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 6.2 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 0.4 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 5.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 2.2 GO:0030515 snoRNA binding(GO:0030515)
0.1 25.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.9 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 4.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 1.1 GO:0003678 DNA helicase activity(GO:0003678)
0.1 6.1 GO:0050661 NADP binding(GO:0050661)
0.1 0.3 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.1 7.7 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 1.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 10.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.1 GO:0016504 peptidase activator activity(GO:0016504)
0.1 14.3 GO:0015631 tubulin binding(GO:0015631)
0.1 5.6 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1 0.6 GO:0048156 tau protein binding(GO:0048156)
0.0 2.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 16.7 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 1.5 GO:0005178 integrin binding(GO:0005178)
0.0 0.6 GO:0035064 methylated histone binding(GO:0035064)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 74.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
2.3 55.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7 99.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.6 14.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.5 41.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.5 16.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.5 41.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.4 11.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 30.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.4 7.1 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.4 9.8 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.3 13.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.3 31.8 PID CDC42 PATHWAY CDC42 signaling events
0.3 32.0 PID CMYB PATHWAY C-MYB transcription factor network
0.3 16.1 PID PLK1 PATHWAY PLK1 signaling events
0.3 14.4 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.3 11.9 PID GLYPICAN 1PATHWAY Glypican 1 network
0.2 9.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 14.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.2 9.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.2 10.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 9.3 PID E2F PATHWAY E2F transcription factor network
0.2 26.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 7.7 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 3.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 2.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 9.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 4.7 SIG CHEMOTAXIS Genes related to chemotaxis
0.1 3.2 PID IFNG PATHWAY IFN-gamma pathway
0.0 2.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.0 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 1.2 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 93.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
3.2 28.5 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
2.5 70.8 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
1.7 47.9 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
1.7 38.1 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
1.5 27.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.3 33.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.3 40.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.3 15.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.1 25.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.1 61.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
1.1 6.7 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
1.0 25.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
1.0 15.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
1.0 27.1 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.9 61.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.9 18.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.8 6.5 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.7 5.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.7 31.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.6 29.2 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.6 10.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.5 7.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.5 31.9 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.5 4.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.5 14.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 18.5 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.5 16.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 6.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4 3.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.4 10.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.4 9.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.4 7.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.4 23.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 11.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.4 7.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 52.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.3 2.8 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 13.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.3 6.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 9.8 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.3 22.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 13.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 17.7 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.3 9.9 REACTOME TRANSLATION Genes involved in Translation
0.2 5.9 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 6.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 6.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 6.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 5.7 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.2 10.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 6.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 3.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 6.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 4.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 7.6 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.1 2.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.5 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.1 6.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 3.6 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 5.6 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 10.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.9 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 8.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 3.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.9 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 4.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.4 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 1.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.4 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes