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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CPEB1
Z-value: 0.65
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Transcription factors associated with CPEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CPEB1 | hg19_v2_chr15_-_83240507_83240539 | -0.33 | 5.6e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CPEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.4 | 34.2 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.1 | 31.6 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 1.0 | 31.4 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.9 | 27.3 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.5 | 26.3 | GO:0031648 | protein destabilization(GO:0031648) |
| 2.0 | 19.6 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 1.9 | 19.0 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.2 | 18.7 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 2.0 | 18.3 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.4 | 18.3 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 44.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 3.8 | 34.2 | GO:0005955 | calcineurin complex(GO:0005955) |
| 1.5 | 27.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 26.2 | GO:0005769 | early endosome(GO:0005769) |
| 0.1 | 24.5 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.3 | 23.5 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 23.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 22.3 | GO:0005938 | cell cortex(GO:0005938) |
| 3.7 | 22.0 | GO:1990357 | terminal web(GO:1990357) |
| 0.0 | 21.1 | GO:0005925 | focal adhesion(GO:0005925) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 43.6 | GO:0019894 | kinesin binding(GO:0019894) |
| 3.4 | 34.2 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 32.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.2 | 32.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 32.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.8 | 29.1 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 1.1 | 21.3 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.1 | 20.9 | GO:0042393 | histone binding(GO:0042393) |
| 5.2 | 20.7 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.5 | 20.2 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 31.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.4 | 27.5 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.2 | 24.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 20.7 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 18.5 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.3 | 18.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 16.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.5 | 16.5 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.2 | 16.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 15.8 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 40.7 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 31.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 23.4 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 1.2 | 19.0 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.4 | 18.9 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.7 | 16.6 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.3 | 16.5 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.2 | 15.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.3 | 15.5 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.7 | 15.0 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |