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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CREB1
Z-value: 1.36
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Transcription factors associated with CREB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB1 | hg19_v2_chr2_+_208394794_208394834 | 0.58 | 8.3e-21 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.4 | 115.0 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 1.4 | 104.3 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 1.0 | 70.9 | GO:0031124 | mRNA 3'-end processing(GO:0031124) |
| 1.8 | 69.1 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 17.0 | 68.1 | GO:0034476 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
| 4.5 | 67.4 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 15.6 | 62.5 | GO:0046833 | snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833) |
| 20.8 | 62.4 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 1.3 | 60.2 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 2.5 | 50.2 | GO:0034134 | toll-like receptor 2 signaling pathway(GO:0034134) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 104.3 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 25.5 | 102.1 | GO:0042025 | host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
| 8.4 | 92.7 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.9 | 88.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 13.5 | 67.4 | GO:0032021 | NELF complex(GO:0032021) |
| 1.0 | 67.3 | GO:0030684 | preribosome(GO:0030684) |
| 7.4 | 66.4 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.6 | 63.0 | GO:0005643 | nuclear pore(GO:0005643) |
| 15.6 | 62.5 | GO:0005846 | nuclear cap binding complex(GO:0005846) |
| 6.7 | 53.3 | GO:0042382 | paraspeckles(GO:0042382) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 130.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 5.7 | 102.1 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 1.6 | 76.2 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 71.0 | GO:0003682 | chromatin binding(GO:0003682) |
| 3.6 | 68.1 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.2 | 66.4 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 7.8 | 62.5 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.1 | 61.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 58.4 | GO:0005524 | ATP binding(GO:0005524) |
| 0.9 | 57.7 | GO:0035064 | methylated histone binding(GO:0035064) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 70.8 | PID E2F PATHWAY | E2F transcription factor network |
| 1.5 | 50.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 41.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.0 | 23.0 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 1.4 | 21.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.7 | 19.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.2 | 17.8 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.4 | 12.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 3.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 2.8 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 126.9 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 2.9 | 102.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 7.6 | 68.1 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 3.9 | 62.5 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 1.4 | 53.3 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.7 | 52.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 4.2 | 50.2 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.5 | 45.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 36.8 | REACTOME TRANSLATION | Genes involved in Translation |
| 1.0 | 34.2 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |