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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CREB3L2
Z-value: 0.73
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Transcription factors associated with CREB3L2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB3L2 | hg19_v2_chr7_-_137686791_137686821 | 0.60 | 5.1e-23 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB3L2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 41.5 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.5 | 39.6 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 5.4 | 37.8 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 2.8 | 36.1 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 3.0 | 33.3 | GO:0031584 | activation of phospholipase D activity(GO:0031584) apical protein localization(GO:0045176) |
| 0.2 | 30.9 | GO:0006414 | translational elongation(GO:0006414) |
| 0.1 | 30.8 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
| 0.9 | 27.5 | GO:0032786 | positive regulation of DNA-templated transcription, elongation(GO:0032786) |
| 1.3 | 26.1 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 2.2 | 22.0 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 44.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 4.7 | 37.8 | GO:0070552 | BRISC complex(GO:0070552) |
| 3.0 | 36.1 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.6 | 34.7 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 1.2 | 33.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 30.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 26.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 2.5 | 24.9 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.2 | 24.9 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.7 | 21.1 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.0 | 40.1 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 5.4 | 37.8 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 1.3 | 33.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 1.1 | 30.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 1.6 | 30.8 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.6 | 29.1 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.9 | 25.3 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 25.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 3.1 | 22.0 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 7.2 | 21.6 | GO:0004488 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 28.2 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.3 | 16.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 12.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 11.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 10.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 10.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 8.7 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.4 | 8.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 7.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 7.2 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 48.7 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.6 | 44.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 27.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.0 | 25.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.5 | 22.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.6 | 21.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 21.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 1.2 | 20.4 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.5 | 20.3 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.4 | 19.7 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |