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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CREB5_CREM_JUNB
Z-value: 0.55
Motif logo
Transcription factors associated with CREB5_CREM_JUNB
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CREB5
|
ENSG00000146592.12 | cAMP responsive element binding protein 5 |
|
CREM
|
ENSG00000095794.15 | cAMP responsive element modulator |
|
JUNB
|
ENSG00000171223.4 | JunB proto-oncogene, AP-1 transcription factor subunit |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREM | hg19_v2_chr10_+_35456444_35456498 | 0.17 | 1.4e-02 | Click! |
| CREB5 | hg19_v2_chr7_+_28725585_28725608, hg19_v2_chr7_+_28452130_28452154 | 0.12 | 7.9e-02 | Click! |
| JUNB | hg19_v2_chr19_+_12902289_12902310 | -0.03 | 6.8e-01 | Click! |
Activity profile of CREB5_CREM_JUNB motif
Sorted Z-values of CREB5_CREM_JUNB motif
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB5_CREM_JUNB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.8 | 107.6 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 7.3 | 21.9 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 5.8 | 29.2 | GO:0030070 | insulin processing(GO:0030070) |
| 5.8 | 17.4 | GO:2000705 | dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705) |
| 5.0 | 20.0 | GO:0008628 | hormone-mediated apoptotic signaling pathway(GO:0008628) |
| 4.9 | 14.7 | GO:1901350 | cell-cell signaling involved in cell-cell junction organization(GO:1901350) |
| 4.8 | 23.9 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 4.4 | 17.4 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 3.8 | 11.4 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 3.4 | 27.4 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 3.3 | 26.6 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
| 3.1 | 6.1 | GO:0043400 | cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) |
| 3.0 | 9.1 | GO:1990502 | dense core granule maturation(GO:1990502) |
| 2.9 | 17.5 | GO:0061000 | negative regulation of dendritic spine development(GO:0061000) |
| 2.9 | 25.8 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 2.7 | 23.9 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 2.6 | 13.0 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 2.6 | 18.2 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 2.4 | 7.3 | GO:2000118 | regulation of sodium-dependent phosphate transport(GO:2000118) |
| 2.4 | 37.6 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 2.2 | 6.6 | GO:0046066 | dGDP metabolic process(GO:0046066) |
| 2.1 | 12.5 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 2.1 | 16.6 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 2.0 | 29.8 | GO:0046325 | negative regulation of glucose import(GO:0046325) |
| 2.0 | 7.9 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 1.9 | 5.8 | GO:1990637 | response to prolactin(GO:1990637) |
| 1.9 | 28.7 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 1.9 | 16.7 | GO:0003190 | atrioventricular valve formation(GO:0003190) |
| 1.8 | 20.1 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 1.8 | 12.8 | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
| 1.8 | 18.2 | GO:0045054 | constitutive secretory pathway(GO:0045054) |
| 1.8 | 31.6 | GO:0071850 | mitotic cell cycle arrest(GO:0071850) |
| 1.7 | 30.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.7 | 5.0 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
| 1.7 | 10.0 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 1.6 | 6.5 | GO:0070426 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
| 1.6 | 6.4 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 1.6 | 4.8 | GO:1990519 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 1.6 | 11.0 | GO:1902474 | positive regulation of protein localization to synapse(GO:1902474) |
| 1.6 | 11.0 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 1.5 | 53.1 | GO:0034035 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 1.5 | 10.6 | GO:0006655 | phosphatidylglycerol biosynthetic process(GO:0006655) |
| 1.5 | 4.5 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 1.5 | 17.4 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 1.4 | 4.3 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 1.4 | 5.7 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 1.4 | 12.6 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 1.4 | 5.6 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 1.4 | 6.8 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 1.3 | 2.7 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 1.3 | 8.0 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 1.3 | 10.6 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 1.3 | 3.9 | GO:0021779 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 1.3 | 52.9 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 1.2 | 6.2 | GO:0044856 | plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906) |
| 1.2 | 19.6 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 1.2 | 10.7 | GO:0038007 | netrin-activated signaling pathway(GO:0038007) |
| 1.2 | 4.6 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 1.1 | 19.2 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 1.1 | 8.8 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 1.1 | 46.8 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 1.1 | 9.6 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 1.1 | 3.2 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 1.0 | 8.1 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 1.0 | 4.0 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 1.0 | 2.0 | GO:0051795 | positive regulation of catagen(GO:0051795) |
| 1.0 | 9.9 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 1.0 | 6.9 | GO:0051414 | response to cortisol(GO:0051414) |
| 1.0 | 2.9 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.9 | 7.6 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.9 | 2.8 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.9 | 30.7 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.9 | 2.8 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.9 | 12.0 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.9 | 7.4 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.9 | 2.8 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 0.9 | 16.2 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.9 | 8.9 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.9 | 18.7 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.8 | 2.5 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) |
| 0.8 | 4.2 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) minus-end-directed organelle transport along microtubule(GO:0072385) |
| 0.8 | 4.2 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.8 | 3.3 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
| 0.8 | 2.4 | GO:0061534 | gamma-aminobutyric acid secretion, neurotransmission(GO:0061534) |
| 0.8 | 11.8 | GO:0061162 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.8 | 2.3 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.8 | 2.3 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.8 | 15.5 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.8 | 17.7 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.8 | 2.3 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.7 | 4.5 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.7 | 2.2 | GO:1901876 | regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) |
| 0.7 | 1.4 | GO:0035751 | regulation of lysosomal lumen pH(GO:0035751) |
| 0.7 | 2.8 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 0.7 | 7.0 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.7 | 4.7 | GO:2000370 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) positive regulation of clathrin-mediated endocytosis(GO:2000370) |
| 0.7 | 1.3 | GO:0010966 | regulation of phosphate transport(GO:0010966) |
| 0.5 | 2.7 | GO:2000322 | regulation of glucocorticoid receptor signaling pathway(GO:2000322) negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.5 | 1.6 | GO:0061034 | olfactory bulb mitral cell layer development(GO:0061034) |
| 0.5 | 6.5 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.5 | 2.1 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.5 | 10.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.5 | 13.8 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.5 | 3.5 | GO:0042797 | 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 0.5 | 1.9 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.5 | 1.4 | GO:0097252 | oligodendrocyte apoptotic process(GO:0097252) |
| 0.5 | 1.4 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.5 | 10.0 | GO:0021542 | dentate gyrus development(GO:0021542) |
| 0.5 | 1.4 | GO:0006014 | D-ribose metabolic process(GO:0006014) |
| 0.4 | 5.4 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.4 | 7.1 | GO:1901841 | regulation of high voltage-gated calcium channel activity(GO:1901841) |
| 0.4 | 1.8 | GO:0045053 | protein retention in Golgi apparatus(GO:0045053) |
| 0.4 | 6.5 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.4 | 5.2 | GO:0034472 | snRNA 3'-end processing(GO:0034472) |
| 0.4 | 5.2 | GO:0001553 | luteinization(GO:0001553) |
| 0.4 | 2.5 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.4 | 8.8 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.4 | 10.4 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.4 | 4.1 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.4 | 7.7 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949) |
| 0.4 | 4.1 | GO:0000050 | urea cycle(GO:0000050) |
| 0.4 | 9.2 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.4 | 13.1 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.4 | 19.5 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway(GO:0007223) |
| 0.4 | 11.0 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.4 | 7.1 | GO:0060856 | establishment of blood-brain barrier(GO:0060856) |
| 0.4 | 3.9 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.4 | 1.1 | GO:0002949 | tRNA threonylcarbamoyladenosine modification(GO:0002949) |
| 0.4 | 1.5 | GO:1900736 | regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
| 0.4 | 4.3 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.4 | 2.5 | GO:0007341 | penetration of zona pellucida(GO:0007341) |
| 0.4 | 3.9 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.4 | 2.8 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.3 | 2.8 | GO:0046626 | regulation of insulin receptor signaling pathway(GO:0046626) |
| 0.3 | 6.5 | GO:0007567 | parturition(GO:0007567) |
| 0.3 | 2.0 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 0.3 | 0.3 | GO:0010825 | positive regulation of centrosome duplication(GO:0010825) positive regulation of centriole replication(GO:0046601) |
| 0.3 | 1.9 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.3 | 9.1 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.3 | 2.4 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.3 | 3.2 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.3 | 1.1 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.3 | 10.2 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.3 | 0.8 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.3 | 2.5 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.3 | 0.8 | GO:0045212 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) |
| 0.3 | 2.7 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.3 | 8.5 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
| 0.3 | 2.7 | GO:1904152 | regulation of retrograde protein transport, ER to cytosol(GO:1904152) |
| 0.3 | 1.1 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
| 0.3 | 2.7 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.3 | 2.0 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.3 | 4.6 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.3 | 2.0 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.2 | 4.2 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.2 | 2.0 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.2 | 1.0 | GO:1902218 | regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 0.2 | 1.0 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.2 | 0.7 | GO:1904781 | positive regulation of protein localization to centrosome(GO:1904781) |
| 0.2 | 0.7 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 0.2 | 1.6 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.2 | 2.7 | GO:0015871 | choline transport(GO:0015871) |
| 0.2 | 5.3 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 0.2 | 0.2 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.2 | 1.7 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.2 | 1.3 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.2 | 3.7 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
| 0.2 | 13.8 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.2 | 0.4 | GO:0032414 | positive regulation of ion transmembrane transporter activity(GO:0032414) |
| 0.2 | 0.6 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.2 | 0.6 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.2 | 1.9 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.2 | 5.5 | GO:1904380 | endoplasmic reticulum mannose trimming(GO:1904380) |
| 0.2 | 6.8 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.2 | 0.9 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
| 0.2 | 2.1 | GO:0002052 | positive regulation of neuroblast proliferation(GO:0002052) |
| 0.2 | 2.3 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.2 | 0.8 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.2 | 14.6 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.2 | 2.5 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation(GO:1904706) |
| 0.2 | 1.1 | GO:0014827 | intestine smooth muscle contraction(GO:0014827) |
| 0.2 | 1.1 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
| 0.2 | 5.9 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.2 | 2.4 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.1 | 8.2 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.1 | 1.6 | GO:0051412 | response to corticosterone(GO:0051412) |
| 0.1 | 3.2 | GO:0003094 | glomerular filtration(GO:0003094) |
| 0.1 | 11.9 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.1 | 1.3 | GO:0032966 | negative regulation of collagen biosynthetic process(GO:0032966) positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416) negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
| 0.1 | 6.1 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 0.4 | GO:0048073 | regulation of eye pigmentation(GO:0048073) positive regulation of eye pigmentation(GO:0048075) |
| 0.1 | 0.5 | GO:0038170 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.1 | 3.1 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.1 | 2.6 | GO:0014898 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898) |
| 0.1 | 0.9 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.1 | 1.6 | GO:0022615 | protein to membrane docking(GO:0022615) |
| 0.1 | 0.4 | GO:1903208 | positive regulation of mast cell cytokine production(GO:0032765) neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208) |
| 0.1 | 2.3 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 1.2 | GO:0070141 | response to UV-A(GO:0070141) |
| 0.1 | 0.3 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
| 0.1 | 3.2 | GO:0030517 | negative regulation of axon extension(GO:0030517) |
| 0.1 | 4.2 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.1 | 3.1 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 3.4 | GO:0050779 | RNA destabilization(GO:0050779) |
| 0.1 | 1.7 | GO:0021535 | cell migration in hindbrain(GO:0021535) |
| 0.1 | 1.7 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.1 | 11.1 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.1 | 1.4 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.1 | 0.5 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.1 | 0.7 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.1 | 7.0 | GO:0035308 | negative regulation of protein dephosphorylation(GO:0035308) |
| 0.1 | 0.9 | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) |
| 0.1 | 0.1 | GO:0042746 | regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746) |
| 0.1 | 3.6 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 1.1 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.1 | 7.9 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.1 | 6.4 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) |
| 0.1 | 1.7 | GO:0006853 | carnitine shuttle(GO:0006853) positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
| 0.1 | 0.5 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 1.3 | GO:1904778 | protein localization to cell cortex(GO:0072697) regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.1 | 3.3 | GO:0016236 | macroautophagy(GO:0016236) |
| 0.1 | 0.2 | GO:0033686 | positive regulation of luteinizing hormone secretion(GO:0033686) |
| 0.1 | 7.0 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 2.1 | GO:0018108 | peptidyl-tyrosine phosphorylation(GO:0018108) peptidyl-tyrosine modification(GO:0018212) |
| 0.1 | 2.0 | GO:0040020 | regulation of meiotic nuclear division(GO:0040020) |
| 0.1 | 1.5 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 3.6 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.1 | 5.1 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
| 0.1 | 5.0 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.1 | 5.2 | GO:0048477 | oogenesis(GO:0048477) |
| 0.1 | 5.5 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 3.2 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 0.9 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
| 0.1 | 1.2 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 0.1 | 0.5 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 9.0 | GO:0000187 | activation of MAPK activity(GO:0000187) |
| 0.1 | 6.0 | GO:0098781 | ncRNA transcription(GO:0098781) |
| 0.1 | 2.1 | GO:0001541 | ovarian follicle development(GO:0001541) |
| 0.1 | 0.3 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.1 | 1.7 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.1 | 0.8 | GO:0003016 | respiratory system process(GO:0003016) |
| 0.1 | 2.7 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.1 | 0.3 | GO:0032411 | positive regulation of transporter activity(GO:0032411) |
| 0.0 | 0.1 | GO:1901895 | negative regulation of calcium-transporting ATPase activity(GO:1901895) |
| 0.0 | 4.2 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 0.2 | GO:0032747 | interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747) |
| 0.0 | 0.6 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.0 | 1.0 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.0 | 0.1 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.0 | 1.2 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.0 | 0.3 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 1.1 | GO:0016239 | positive regulation of macroautophagy(GO:0016239) |
| 0.0 | 3.5 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 1.0 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 0.8 | GO:0030318 | melanocyte differentiation(GO:0030318) |
| 0.0 | 2.5 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 7.7 | GO:0007517 | muscle organ development(GO:0007517) |
| 0.0 | 0.5 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 0.6 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 0.6 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.6 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 0.3 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 1.1 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 2.0 | GO:0006024 | aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024) |
| 0.0 | 0.3 | GO:0008213 | protein methylation(GO:0006479) protein alkylation(GO:0008213) |
| 0.0 | 0.1 | GO:0061035 | regulation of chondrocyte differentiation(GO:0032330) regulation of cartilage development(GO:0061035) |
| 0.0 | 9.8 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.0 | 1.5 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.2 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.0 | 1.3 | GO:0043473 | pigmentation(GO:0043473) |
| 0.0 | 1.6 | GO:0098916 | chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916) |
| 0.0 | 0.6 | GO:0006954 | inflammatory response(GO:0006954) |
| 0.0 | 0.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 0.1 | GO:0032354 | response to follicle-stimulating hormone(GO:0032354) |
| 0.0 | 0.7 | GO:0030282 | bone mineralization(GO:0030282) |
| 0.0 | 0.1 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.6 | 30.6 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 3.5 | 10.4 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 3.4 | 13.8 | GO:0031673 | H zone(GO:0031673) |
| 2.7 | 27.4 | GO:0045180 | basal cortex(GO:0045180) |
| 2.7 | 23.9 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 2.4 | 31.3 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 2.2 | 35.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.7 | 21.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 1.5 | 28.7 | GO:0031045 | dense core granule(GO:0031045) |
| 1.4 | 11.2 | GO:0005818 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 1.3 | 9.4 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 1.2 | 17.4 | GO:0042583 | chromaffin granule(GO:0042583) |
| 1.1 | 3.3 | GO:0043159 | acrosomal matrix(GO:0043159) |
| 1.1 | 18.2 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.9 | 19.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.9 | 6.5 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.9 | 18.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.9 | 12.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.8 | 26.6 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.8 | 22.7 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.8 | 2.3 | GO:0044393 | microspike(GO:0044393) |
| 0.7 | 11.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.7 | 5.5 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.6 | 9.4 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.6 | 3.8 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.6 | 14.7 | GO:0005921 | gap junction(GO:0005921) |
| 0.6 | 5.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.6 | 4.0 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.6 | 41.9 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.6 | 2.8 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.5 | 7.9 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.5 | 27.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.5 | 7.0 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.5 | 3.5 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.5 | 8.2 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.5 | 7.0 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.4 | 8.1 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.4 | 2.6 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.4 | 3.9 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.4 | 2.0 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.4 | 30.1 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.4 | 5.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.4 | 2.3 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.4 | 64.6 | GO:0030426 | growth cone(GO:0030426) |
| 0.4 | 2.3 | GO:0031082 | BLOC complex(GO:0031082) |
| 0.4 | 4.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.3 | 28.8 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.3 | 2.9 | GO:0034464 | BBSome(GO:0034464) |
| 0.3 | 1.0 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.3 | 79.9 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.3 | 1.7 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.3 | 1.6 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.3 | 19.5 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.3 | 2.3 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.2 | 3.7 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.2 | 1.5 | GO:0043196 | varicosity(GO:0043196) |
| 0.2 | 1.9 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.2 | 0.7 | GO:0034271 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.2 | 1.2 | GO:0032021 | NELF complex(GO:0032021) |
| 0.2 | 1.1 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.2 | 72.4 | GO:0045121 | membrane raft(GO:0045121) |
| 0.2 | 2.6 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.2 | 19.8 | GO:0043204 | perikaryon(GO:0043204) |
| 0.2 | 1.2 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.2 | 1.0 | GO:0032389 | MutLalpha complex(GO:0032389) |
| 0.2 | 5.5 | GO:0032589 | neuron projection membrane(GO:0032589) |
| 0.2 | 2.1 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.2 | 16.9 | GO:0005776 | autophagosome(GO:0005776) |
| 0.2 | 0.9 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.2 | 2.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 1.8 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.2 | 8.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.2 | 5.5 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.2 | 5.0 | GO:0016592 | mediator complex(GO:0016592) |
| 0.2 | 17.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 2.4 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 8.0 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 2.0 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.1 | 0.6 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 19.8 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 5.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 10.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 12.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 2.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 1.4 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 5.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 13.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 13.5 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 2.8 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 4.7 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 1.6 | GO:0005923 | bicellular tight junction(GO:0005923) apical junction complex(GO:0043296) occluding junction(GO:0070160) |
| 0.1 | 3.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 3.3 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 1.9 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 0.7 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 2.1 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 3.0 | GO:0005605 | basal lamina(GO:0005605) |
| 0.1 | 29.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 5.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.1 | 1.0 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 2.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 4.7 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.1 | 4.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 1.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.1 | 0.1 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 21.1 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.1 | 3.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 1.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 2.3 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.1 | 12.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 1.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 8.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 5.8 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 0.3 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 3.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 5.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 5.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 3.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 6.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 4.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 7.4 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 1.1 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 0.4 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 1.7 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.0 | 0.1 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.0 | 0.9 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 4.0 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.1 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 0.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 4.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 11.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 1.1 | GO:0030133 | transport vesicle(GO:0030133) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 32.6 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 4.5 | 13.6 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 3.9 | 11.8 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 3.5 | 10.6 | GO:0004605 | phosphatidate cytidylyltransferase activity(GO:0004605) |
| 2.9 | 8.8 | GO:0016434 | rRNA (cytosine) methyltransferase activity(GO:0016434) |
| 2.9 | 20.1 | GO:0030250 | cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250) |
| 2.8 | 16.6 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 2.7 | 16.1 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 2.6 | 12.8 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 2.3 | 53.1 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 1.9 | 5.7 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 1.9 | 20.9 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 1.8 | 11.0 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 1.8 | 10.7 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 1.7 | 20.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 1.6 | 22.7 | GO:0030957 | Tat protein binding(GO:0030957) |
| 1.6 | 4.8 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 1.4 | 5.8 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 1.3 | 13.2 | GO:0042731 | PH domain binding(GO:0042731) |
| 1.3 | 31.3 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 1.3 | 6.5 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 1.2 | 17.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 1.2 | 29.9 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 1.2 | 3.5 | GO:0000995 | polymerase III regulatory region sequence-specific DNA binding(GO:0000992) transcription factor activity, core RNA polymerase III binding(GO:0000995) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) |
| 1.2 | 30.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 1.1 | 4.5 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 1.1 | 21.4 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 1.1 | 7.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 1.0 | 3.1 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 1.0 | 32.2 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 1.0 | 31.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.0 | 6.8 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.9 | 2.8 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.9 | 23.9 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.8 | 2.5 | GO:0004040 | amidase activity(GO:0004040) fucose binding(GO:0042806) |
| 0.8 | 9.6 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.7 | 13.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.7 | 7.7 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.7 | 4.2 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.7 | 2.1 | GO:0017129 | triglyceride binding(GO:0017129) |
| 0.7 | 15.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.7 | 9.0 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.7 | 21.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.7 | 2.0 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.7 | 2.7 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.7 | 5.2 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.6 | 6.5 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.6 | 6.2 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.6 | 19.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.6 | 6.1 | GO:0031748 | D1 dopamine receptor binding(GO:0031748) |
| 0.6 | 27.9 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.6 | 15.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.6 | 4.1 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
| 0.6 | 10.6 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.6 | 2.9 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.6 | 6.8 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.5 | 27.3 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.5 | 16.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.5 | 9.1 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.5 | 16.1 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.5 | 43.5 | GO:0051213 | dioxygenase activity(GO:0051213) |
| 0.5 | 1.9 | GO:0031716 | calcitonin receptor binding(GO:0031716) |
| 0.5 | 2.4 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.5 | 6.6 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.5 | 6.6 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.5 | 5.5 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.4 | 17.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.4 | 13.0 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.4 | 1.7 | GO:0032558 | adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564) |
| 0.4 | 10.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.4 | 10.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.4 | 21.9 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.4 | 5.6 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.4 | 1.4 | GO:0035473 | lipase binding(GO:0035473) |
| 0.4 | 9.0 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.4 | 1.1 | GO:0034353 | RNA pyrophosphohydrolase activity(GO:0034353) |
| 0.3 | 1.7 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.3 | 25.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.3 | 3.4 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.3 | 41.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.3 | 1.3 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.3 | 1.6 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.3 | 1.0 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.3 | 7.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.3 | 0.9 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.3 | 0.9 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.3 | 2.3 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.3 | 11.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 3.4 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.3 | 1.5 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.3 | 5.9 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.3 | 36.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.3 | 9.4 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.2 | 4.7 | GO:0005521 | lamin binding(GO:0005521) |
| 0.2 | 2.7 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.2 | 13.7 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.2 | 1.1 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.2 | 1.8 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.2 | 5.0 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 5.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 3.1 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.2 | 1.8 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.2 | 60.3 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.2 | 19.2 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.2 | 4.1 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.2 | 0.8 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.2 | 0.8 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.2 | 6.8 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.2 | 2.7 | GO:0060590 | ATPase regulator activity(GO:0060590) |
| 0.2 | 1.0 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
| 0.2 | 2.3 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.2 | 2.5 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.2 | 46.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 2.0 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.2 | 3.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.2 | 3.2 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.2 | 4.2 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.2 | 1.7 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 1.5 | GO:0051378 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.1 | 1.0 | GO:0032135 | DNA insertion or deletion binding(GO:0032135) single base insertion or deletion binding(GO:0032138) |
| 0.1 | 0.5 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.1 | 20.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 5.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 22.5 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 4.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 1.9 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 0.5 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.1 | 1.8 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 9.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 5.0 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.1 | 1.0 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 1.5 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.8 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.1 | 1.3 | GO:0036041 | long-chain fatty acid binding(GO:0036041) |
| 0.1 | 5.1 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.1 | 0.7 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.1 | 4.1 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 3.6 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 1.5 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 2.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 3.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 2.0 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 1.5 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.1 | 2.0 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.1 | 0.5 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.1 | 5.2 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 7.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 1.0 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 1.4 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 2.1 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 1.5 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 0.7 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.0 | 0.9 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 3.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.8 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 1.4 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.0 | 0.1 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 0.0 | 0.2 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 1.3 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.1 | GO:0016499 | orexin receptor activity(GO:0016499) |
| 0.0 | 3.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 2.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.6 | GO:0042166 | neurotransmitter binding(GO:0042165) acetylcholine binding(GO:0042166) |
| 0.0 | 0.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 1.2 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 3.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 1.8 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.0 | 12.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 2.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.4 | GO:0008173 | RNA methyltransferase activity(GO:0008173) |
| 0.0 | 0.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 21.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.7 | 21.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.7 | 40.1 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.6 | 27.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.6 | 22.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.6 | 33.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.5 | 8.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.5 | 26.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.5 | 18.0 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.4 | 4.5 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.4 | 10.6 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.4 | 3.7 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.4 | 13.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 4.6 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.3 | 3.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.3 | 6.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.3 | 13.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.3 | 5.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 13.3 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.2 | 12.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 8.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 9.2 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 1.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 8.1 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.2 | 6.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 4.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.7 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 3.2 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 5.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 0.8 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 3.4 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 4.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 0.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 2.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 3.6 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 2.7 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 1.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 0.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 1.1 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 0.4 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 3.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 9.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 5.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 4.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 4.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.3 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.3 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 56.9 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 1.9 | 53.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 1.5 | 32.8 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 1.1 | 22.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 1.0 | 12.5 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 1.0 | 16.2 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.9 | 12.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.9 | 29.4 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.9 | 23.9 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.8 | 20.4 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.8 | 14.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.8 | 20.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.6 | 16.1 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.5 | 16.8 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.5 | 8.3 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.4 | 7.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.4 | 4.5 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.4 | 12.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 2.0 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.3 | 5.9 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.2 | 4.2 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.2 | 5.1 | REACTOME SHC RELATED EVENTS | Genes involved in SHC-related events |
| 0.2 | 8.1 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.2 | 2.3 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.2 | 6.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 10.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 5.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 9.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 4.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 3.4 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 1.6 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 1.9 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 2.7 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 7.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.7 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 2.1 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 7.4 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 2.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 2.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 3.1 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 2.0 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 1.3 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.1 | 1.7 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 9.1 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 17.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 2.0 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | Genes involved in Synthesis of bile acids and bile salts |
| 0.1 | 1.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.0 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 7.2 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.1 | 2.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 5.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.2 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 0.8 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 2.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 4.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 2.0 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.4 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.7 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.6 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.9 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 7.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 1.1 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 0.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |