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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CREB5_CREM_JUNB
Z-value: 0.55
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Transcription factors associated with CREB5_CREM_JUNB
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000146592.12 | cAMP responsive element binding protein 5 | |
| ENSG00000095794.15 | cAMP responsive element modulator | |
| ENSG00000171223.4 | JunB proto-oncogene, AP-1 transcription factor subunit |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREM | hg19_v2_chr10_+_35456444_35456498 | 0.17 | 1.4e-02 | Click! |
| CREB5 | hg19_v2_chr7_+_28725585_28725608, hg19_v2_chr7_+_28452130_28452154 | 0.12 | 7.9e-02 | Click! |
| JUNB | hg19_v2_chr19_+_12902289_12902310 | -0.03 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_44258360 Show fit | 53.11 |
ENST00000330884.4
ENST00000249130.5 |
sulfotransferase family 4A, member 1 |
|
| chrX_-_13956497 Show fit | 38.92 |
ENST00000398361.3
|
glycoprotein M6B |
|
| chrX_-_13956737 Show fit | 35.61 |
ENST00000454189.2
|
glycoprotein M6B |
|
| chr2_+_149632783 Show fit | 31.28 |
ENST00000435030.1
|
kinesin family member 5C |
|
| chr6_-_46293378 Show fit | 31.21 |
ENST00000330430.6
|
regulator of calcineurin 2 |
|
| chr8_-_27115931 Show fit | 30.71 |
ENST00000523048.1
|
stathmin-like 4 |
|
| chr20_+_10199468 Show fit | 30.59 |
ENST00000254976.2
ENST00000304886.2 |
synaptosomal-associated protein, 25kDa |
|
| chr2_-_224467093 Show fit | 28.67 |
ENST00000305409.2
|
secretogranin II |
|
| chrX_-_47479246 Show fit | 26.64 |
ENST00000295987.7
ENST00000340666.4 |
synapsin I |
|
| chr8_-_27115903 Show fit | 26.22 |
ENST00000350889.4
ENST00000519997.1 ENST00000519614.1 ENST00000522908.1 ENST00000265770.7 |
stathmin-like 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB5_CREM_JUNB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.8 | 107.6 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 1.5 | 53.1 | GO:0034035 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 1.3 | 52.9 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 1.1 | 46.8 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 2.4 | 37.6 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 1.8 | 31.6 | GO:0071850 | mitotic cell cycle arrest(GO:0071850) |
| 0.9 | 30.7 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 1.7 | 30.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 2.0 | 29.8 | GO:0046325 | negative regulation of glucose import(GO:0046325) |
| 5.8 | 29.2 | GO:0030070 | insulin processing(GO:0030070) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 79.9 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.2 | 72.4 | GO:0045121 | membrane raft(GO:0045121) |
| 0.4 | 64.6 | GO:0030426 | growth cone(GO:0030426) |
| 0.6 | 41.9 | GO:0014704 | intercalated disc(GO:0014704) |
| 2.2 | 35.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 2.4 | 31.3 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 7.6 | 30.6 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.4 | 30.1 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 29.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 28.8 | GO:0008021 | synaptic vesicle(GO:0008021) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 60.3 | GO:0015631 | tubulin binding(GO:0015631) |
| 2.3 | 53.1 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.2 | 46.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 43.5 | GO:0051213 | dioxygenase activity(GO:0051213) |
| 0.3 | 41.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.3 | 36.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 5.4 | 32.6 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 1.0 | 32.2 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 1.0 | 31.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.3 | 31.3 | GO:0002162 | dystroglycan binding(GO:0002162) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 40.1 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.6 | 33.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.6 | 27.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.5 | 26.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.6 | 22.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.7 | 21.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 1.0 | 21.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.5 | 18.0 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.4 | 13.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 13.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 56.9 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 1.9 | 53.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 1.5 | 32.8 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.9 | 29.4 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.9 | 23.9 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 1.1 | 22.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.8 | 20.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.8 | 20.4 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 17.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.5 | 16.8 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |