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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CREB5_CREM_JUNB
Z-value: 0.55
Motif logo
Transcription factors associated with CREB5_CREM_JUNB
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CREB5
|
ENSG00000146592.12 | cAMP responsive element binding protein 5 |
|
CREM
|
ENSG00000095794.15 | cAMP responsive element modulator |
|
JUNB
|
ENSG00000171223.4 | JunB proto-oncogene, AP-1 transcription factor subunit |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREM | hg19_v2_chr10_+_35456444_35456498 | 0.17 | 1.4e-02 | Click! |
| CREB5 | hg19_v2_chr7_+_28725585_28725608, hg19_v2_chr7_+_28452130_28452154 | 0.12 | 7.9e-02 | Click! |
| JUNB | hg19_v2_chr19_+_12902289_12902310 | -0.03 | 6.8e-01 | Click! |
Activity profile of CREB5_CREM_JUNB motif
Sorted Z-values of CREB5_CREM_JUNB motif
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB5_CREM_JUNB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.8 | 107.6 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 7.3 | 21.9 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 5.8 | 29.2 | GO:0030070 | insulin processing(GO:0030070) |
| 5.8 | 17.4 | GO:2000705 | dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705) |
| 5.0 | 20.0 | GO:0008628 | hormone-mediated apoptotic signaling pathway(GO:0008628) |
| 4.9 | 14.7 | GO:1901350 | cell-cell signaling involved in cell-cell junction organization(GO:1901350) |
| 4.8 | 23.9 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 4.4 | 17.4 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 3.8 | 11.4 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 3.4 | 27.4 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 3.3 | 26.6 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
| 3.1 | 6.1 | GO:0043400 | cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) |
| 3.0 | 9.1 | GO:1990502 | dense core granule maturation(GO:1990502) |
| 2.9 | 17.5 | GO:0061000 | negative regulation of dendritic spine development(GO:0061000) |
| 2.9 | 25.8 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 2.7 | 23.9 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 2.6 | 13.0 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 2.6 | 18.2 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 2.4 | 7.3 | GO:2000118 | regulation of sodium-dependent phosphate transport(GO:2000118) |
| 2.4 | 37.6 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 2.2 | 6.6 | GO:0046066 | dGDP metabolic process(GO:0046066) |
| 2.1 | 12.5 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 2.1 | 16.6 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 2.0 | 29.8 | GO:0046325 | negative regulation of glucose import(GO:0046325) |
| 2.0 | 7.9 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 1.9 | 5.8 | GO:1990637 | response to prolactin(GO:1990637) |
| 1.9 | 28.7 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 1.9 | 16.7 | GO:0003190 | atrioventricular valve formation(GO:0003190) |
| 1.8 | 20.1 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 1.8 | 12.8 | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
| 1.8 | 18.2 | GO:0045054 | constitutive secretory pathway(GO:0045054) |
| 1.8 | 31.6 | GO:0071850 | mitotic cell cycle arrest(GO:0071850) |
| 1.7 | 30.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.7 | 5.0 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
| 1.7 | 10.0 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 1.6 | 6.5 | GO:0070426 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
| 1.6 | 6.4 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 1.6 | 4.8 | GO:1990519 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 1.6 | 11.0 | GO:1902474 | positive regulation of protein localization to synapse(GO:1902474) |
| 1.6 | 11.0 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 1.5 | 53.1 | GO:0034035 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 1.5 | 10.6 | GO:0006655 | phosphatidylglycerol biosynthetic process(GO:0006655) |
| 1.5 | 4.5 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 1.5 | 17.4 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 1.4 | 4.3 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 1.4 | 5.7 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 1.4 | 12.6 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 1.4 | 5.6 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 1.4 | 6.8 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 1.3 | 2.7 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 1.3 | 8.0 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 1.3 | 10.6 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 1.3 | 3.9 | GO:0021779 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 1.3 | 52.9 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 1.2 | 6.2 | GO:0044856 | plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906) |
| 1.2 | 19.6 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 1.2 | 10.7 | GO:0038007 | netrin-activated signaling pathway(GO:0038007) |
| 1.2 | 4.6 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 1.1 | 19.2 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 1.1 | 8.8 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 1.1 | 46.8 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 1.1 | 9.6 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 1.1 | 3.2 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 1.0 | 8.1 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 1.0 | 4.0 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 1.0 | 2.0 | GO:0051795 | positive regulation of catagen(GO:0051795) |
| 1.0 | 9.9 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 1.0 | 6.9 | GO:0051414 | response to cortisol(GO:0051414) |
| 1.0 | 2.9 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.9 | 7.6 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.9 | 2.8 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.9 | 30.7 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.9 | 2.8 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.9 | 12.0 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.9 | 7.4 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.9 | 2.8 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 0.9 | 16.2 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.9 | 8.9 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.9 | 18.7 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.8 | 2.5 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) |
| 0.8 | 4.2 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) minus-end-directed organelle transport along microtubule(GO:0072385) |
| 0.8 | 4.2 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.8 | 3.3 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
| 0.8 | 2.4 | GO:0061534 | gamma-aminobutyric acid secretion, neurotransmission(GO:0061534) |
| 0.8 | 11.8 | GO:0061162 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.8 | 2.3 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.8 | 2.3 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.8 | 15.5 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.8 | 17.7 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.8 | 2.3 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.7 | 4.5 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.7 | 2.2 | GO:1901876 | regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) |
| 0.7 | 1.4 | GO:0035751 | regulation of lysosomal lumen pH(GO:0035751) |
| 0.7 | 2.8 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 0.7 | 7.0 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.7 | 4.7 | GO:2000370 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) positive regulation of clathrin-mediated endocytosis(GO:2000370) |
| 0.7 | 1.3 | GO:0010966 | regulation of phosphate transport(GO:0010966) |
| 0.5 | 2.7 | GO:2000322 | regulation of glucocorticoid receptor signaling pathway(GO:2000322) negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.5 | 1.6 | GO:0061034 | olfactory bulb mitral cell layer development(GO:0061034) |
| 0.5 | 6.5 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.5 | 2.1 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.5 | 10.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.5 | 13.8 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.5 | 3.5 | GO:0042797 | 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 0.5 | 1.9 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.5 | 1.4 | GO:0097252 | oligodendrocyte apoptotic process(GO:0097252) |
| 0.5 | 1.4 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.5 | 10.0 | GO:0021542 | dentate gyrus development(GO:0021542) |
| 0.5 | 1.4 | GO:0006014 | D-ribose metabolic process(GO:0006014) |
| 0.4 | 5.4 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.4 | 7.1 | GO:1901841 | regulation of high voltage-gated calcium channel activity(GO:1901841) |
| 0.4 | 1.8 | GO:0045053 | protein retention in Golgi apparatus(GO:0045053) |
| 0.4 | 6.5 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.4 | 5.2 | GO:0034472 | snRNA 3'-end processing(GO:0034472) |
| 0.4 | 5.2 | GO:0001553 | luteinization(GO:0001553) |
| 0.4 | 2.5 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.4 | 8.8 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.4 | 10.4 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.4 | 4.1 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.4 | 7.7 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949) |
| 0.4 | 4.1 | GO:0000050 | urea cycle(GO:0000050) |
| 0.4 | 9.2 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.4 | 13.1 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.4 | 19.5 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway(GO:0007223) |
| 0.4 | 11.0 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.4 | 7.1 | GO:0060856 | establishment of blood-brain barrier(GO:0060856) |
| 0.4 | 3.9 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.4 | 1.1 | GO:0002949 | tRNA threonylcarbamoyladenosine modification(GO:0002949) |
| 0.4 | 1.5 | GO:1900736 | regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
| 0.4 | 4.3 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.4 | 2.5 | GO:0007341 | penetration of zona pellucida(GO:0007341) |
| 0.4 | 3.9 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.4 | 2.8 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.3 | 2.8 | GO:0046626 | regulation of insulin receptor signaling pathway(GO:0046626) |
| 0.3 | 6.5 | GO:0007567 | parturition(GO:0007567) |
| 0.3 | 2.0 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 0.3 | 0.3 | GO:0010825 | positive regulation of centrosome duplication(GO:0010825) positive regulation of centriole replication(GO:0046601) |
| 0.3 | 1.9 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.3 | 9.1 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.3 | 2.4 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.3 | 3.2 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.3 | 1.1 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.3 | 10.2 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.3 | 0.8 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.3 | 2.5 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.3 | 0.8 | GO:0045212 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) |
| 0.3 | 2.7 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.3 | 8.5 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
| 0.3 | 2.7 | GO:1904152 | regulation of retrograde protein transport, ER to cytosol(GO:1904152) |
| 0.3 | 1.1 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
| 0.3 | 2.7 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.3 | 2.0 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.3 | 4.6 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.3 | 2.0 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.2 | 4.2 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.2 | 2.0 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.2 | 1.0 | GO:1902218 | regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 0.2 | 1.0 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.2 | 0.7 | GO:1904781 | positive regulation of protein localization to centrosome(GO:1904781) |
| 0.2 | 0.7 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 0.2 | 1.6 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.2 | 2.7 | GO:0015871 | choline transport(GO:0015871) |
| 0.2 | 5.3 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 0.2 | 0.2 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.2 | 1.7 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.2 | 1.3 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.2 | 3.7 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
| 0.2 | 13.8 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.2 | 0.4 | GO:0032414 | positive regulation of ion transmembrane transporter activity(GO:0032414) |
| 0.2 | 0.6 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.2 | 0.6 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.2 | 1.9 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.2 | 5.5 | GO:1904380 | endoplasmic reticulum mannose trimming(GO:1904380) |
| 0.2 | 6.8 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.2 | 0.9 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
| 0.2 | 2.1 | GO:0002052 | positive regulation of neuroblast proliferation(GO:0002052) |
| 0.2 | 2.3 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.2 | 0.8 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.2 | 14.6 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.2 | 2.5 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation(GO:1904706) |
| 0.2 | 1.1 | GO:0014827 | intestine smooth muscle contraction(GO:0014827) |
| 0.2 | 1.1 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
| 0.2 | 5.9 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.2 | 2.4 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.1 | 8.2 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.1 | 1.6 | GO:0051412 | response to corticosterone(GO:0051412) |
| 0.1 | 3.2 | GO:0003094 | glomerular filtration(GO:0003094) |
| 0.1 | 11.9 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.1 | 1.3 | GO:0032966 | negative regulation of collagen biosynthetic process(GO:0032966) positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416) negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
| 0.1 | 6.1 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 0.4 | GO:0048073 | regulation of eye pigmentation(GO:0048073) positive regulation of eye pigmentation(GO:0048075) |
| 0.1 | 0.5 | GO:0038170 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.1 | 3.1 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.1 | 2.6 | GO:0014898 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898) |
| 0.1 | 0.9 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.1 | 1.6 | GO:0022615 | protein to membrane docking(GO:0022615) |
| 0.1 | 0.4 | GO:1903208 | positive regulation of mast cell cytokine production(GO:0032765) neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208) |
| 0.1 | 2.3 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 1.2 | GO:0070141 | response to UV-A(GO:0070141) |
| 0.1 | 0.3 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
| 0.1 | 3.2 | GO:0030517 | negative regulation of axon extension(GO:0030517) |
| 0.1 | 4.2 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.1 | 3.1 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 3.4 | GO:0050779 | RNA destabilization(GO:0050779) |
| 0.1 | 1.7 | GO:0021535 | cell migration in hindbrain(GO:0021535) |
| 0.1 | 1.7 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.1 | 11.1 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.1 | 1.4 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.1 | 0.5 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.1 | 0.7 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.1 | 7.0 | GO:0035308 | negative regulation of protein dephosphorylation(GO:0035308) |
| 0.1 | 0.9 | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) |
| 0.1 | 0.1 | GO:0042746 | regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746) |
| 0.1 | 3.6 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 1.1 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.1 | 7.9 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.1 | 6.4 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) |
| 0.1 | 1.7 | GO:0006853 | carnitine shuttle(GO:0006853) positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
| 0.1 | 0.5 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 1.3 | GO:1904778 | protein localization to cell cortex(GO:0072697) regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.1 | 3.3 | GO:0016236 | macroautophagy(GO:0016236) |
| 0.1 | 0.2 | GO:0033686 | positive regulation of luteinizing hormone secretion(GO:0033686) |
| 0.1 | 7.0 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 2.1 | GO:0018108 | peptidyl-tyrosine phosphorylation(GO:0018108) peptidyl-tyrosine modification(GO:0018212) |
| 0.1 | 2.0 | GO:0040020 | regulation of meiotic nuclear division(GO:0040020) |
| 0.1 | 1.5 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 3.6 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.1 | 5.1 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
| 0.1 | 5.0 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.1 | 5.2 | GO:0048477 | oogenesis(GO:0048477) |
| 0.1 | 5.5 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 3.2 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 0.9 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
| 0.1 | 1.2 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 0.1 | 0.5 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 9.0 | GO:0000187 | activation of MAPK activity(GO:0000187) |
| 0.1 | 6.0 | GO:0098781 | ncRNA transcription(GO:0098781) |
| 0.1 | 2.1 | GO:0001541 | ovarian follicle development(GO:0001541) |
| 0.1 | 0.3 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.1 | 1.7 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.1 | 0.8 | GO:0003016 | respiratory system process(GO:0003016) |
| 0.1 | 2.7 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.1 | 0.3 | GO:0032411 | positive regulation of transporter activity(GO:0032411) |
| 0.0 | 0.1 | GO:1901895 | negative regulation of calcium-transporting ATPase activity(GO:1901895) |
| 0.0 | 4.2 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 0.2 | GO:0032747 | interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747) |
| 0.0 | 0.6 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.0 | 1.0 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.0 | 0.1 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.0 | 1.2 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.0 | 0.3 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 1.1 | GO:0016239 | positive regulation of macroautophagy(GO:0016239) |
| 0.0 | 3.5 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 1.0 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 0.8 | GO:0030318 | melanocyte differentiation(GO:0030318) |
| 0.0 | 2.5 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 7.7 | GO:0007517 | muscle organ development(GO:0007517) |
| 0.0 | 0.5 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 0.6 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 0.6 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.6 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 0.3 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 1.1 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 2.0 | GO:0006024 | aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024) |
| 0.0 | 0.3 | GO:0008213 | protein methylation(GO:0006479) protein alkylation(GO:0008213) |
| 0.0 | 0.1 | GO:0061035 | regulation of chondrocyte differentiation(GO:0032330) regulation of cartilage development(GO:0061035) |
| 0.0 | 9.8 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.0 | 1.5 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.2 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.0 | 1.3 | GO:0043473 | pigmentation(GO:0043473) |
| 0.0 | 1.6 | GO:0098916 | chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916) |
| 0.0 | 0.6 | GO:0006954 | inflammatory response(GO:0006954) |
| 0.0 | 0.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 0.1 | GO:0032354 | response to follicle-stimulating hormone(GO:0032354) |
| 0.0 | 0.7 | GO:0030282 | bone mineralization(GO:0030282) |
| 0.0 | 0.1 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.6 | 30.6 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 3.5 | 10.4 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 3.4 | 13.8 | GO:0031673 | H zone(GO:0031673) |
| 2.7 | 27.4 | GO:0045180 | basal cortex(GO:0045180) |
| 2.7 | 23.9 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 2.4 | 31.3 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 2.2 | 35.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.7 | 21.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 1.5 | 28.7 | GO:0031045 | dense core granule(GO:0031045) |
| 1.4 | 11.2 | GO:0005818 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 1.3 | 9.4 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 1.2 | 17.4 | GO:0042583 | chromaffin granule(GO:0042583) |
| 1.1 | 3.3 | GO:0043159 | acrosomal matrix(GO:0043159) |
| 1.1 | 18.2 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.9 | 19.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.9 | 6.5 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.9 | 18.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.9 | 12.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.8 | 26.6 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.8 | 22.7 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.8 | 2.3 | GO:0044393 | microspike(GO:0044393) |
| 0.7 | 11.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.7 | 5.5 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.6 | 9.4 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.6 | 3.8 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.6 | 14.7 | GO:0005921 | gap junction(GO:0005921) |
| 0.6 | 5.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.6 | 4.0 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.6 | 41.9 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.6 | 2.8 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.5 | 7.9 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.5 | 27.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.5 | 7.0 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.5 | 3.5 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.5 | 8.2 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.5 | 7.0 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.4 | 8.1 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.4 | 2.6< |