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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CTCF_CTCFL
Z-value: 1.03
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Transcription factors associated with CTCF_CTCFL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CTCF | hg19_v2_chr16_+_67596310_67596353 | 0.50 | 4.3e-15 | Click! |
| CTCFL | hg19_v2_chr20_-_56100155_56100163 | -0.49 | 1.6e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CTCF_CTCFL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 62.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.5 | 51.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 1.0 | 46.7 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 5.0 | 39.9 | GO:0010994 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 12.4 | 37.1 | GO:0071344 | diphosphate metabolic process(GO:0071344) |
| 0.1 | 34.6 | GO:0008380 | RNA splicing(GO:0008380) |
| 8.6 | 34.5 | GO:0071733 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 2.3 | 34.2 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 4.8 | 33.6 | GO:1904690 | regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690) |
| 10.7 | 32.1 | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 79.9 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 1.6 | 63.7 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 6.1 | 61.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.5 | 55.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.7 | 51.9 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 51.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.4 | 44.6 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
| 0.8 | 39.8 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 1.2 | 36.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 6.8 | 34.2 | GO:0097149 | centralspindlin complex(GO:0097149) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 113.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.5 | 51.9 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.7 | 42.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.9 | 42.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.6 | 37.3 | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655) |
| 5.7 | 34.5 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.1 | 33.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 8.2 | 32.6 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 2.3 | 32.1 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.3 | 31.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 42.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.6 | 37.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.7 | 34.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.3 | 23.8 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.4 | 18.8 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.2 | 18.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 16.2 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.2 | 15.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 15.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.3 | 13.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 65.3 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.7 | 51.0 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 1.9 | 46.7 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 1.6 | 45.8 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.5 | 43.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.7 | 41.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.5 | 40.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.0 | 39.0 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.5 | 36.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.6 | 34.3 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |