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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CUGGCUG
Z-value: 0.75
Motif logo
miRNA associated with seed CUGGCUG
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_40390930 Show fit | 4.05 |
ENST00000333407.6
|
family with sequence similarity 83, member F |
|
| chr13_+_27131887 Show fit | 3.55 |
ENST00000335327.5
|
WAS protein family, member 3 |
|
| chr11_-_12030629 Show fit | 3.53 |
ENST00000396505.2
|
dickkopf WNT signaling pathway inhibitor 3 |
|
| chr2_+_149632783 Show fit | 3.28 |
ENST00000435030.1
|
kinesin family member 5C |
|
| chr11_+_45868957 Show fit | 3.22 |
ENST00000443527.2
|
cryptochrome 2 (photolyase-like) |
|
| chr8_-_9008206 Show fit | 3.13 |
ENST00000310455.3
|
protein phosphatase 1, regulatory subunit 3B |
|
| chr6_+_36853607 Show fit | 2.92 |
ENST00000480824.2
ENST00000355190.3 ENST00000373685.1 |
chromosome 6 open reading frame 89 |
|
| chr14_-_77787198 Show fit | 2.77 |
ENST00000261534.4
|
protein-O-mannosyltransferase 2 |
|
| chr8_+_26435359 Show fit | 2.60 |
ENST00000311151.5
|
dihydropyrimidinase-like 2 |
|
| chr1_-_57045228 Show fit | 2.36 |
ENST00000371250.3
|
phosphatidic acid phosphatase type 2B |
Network of associatons between targets according to the STRING database.
First level regulatory network of CUGGCUG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 3.5 | GO:1990262 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 0.1 | 3.5 | GO:0031643 | positive regulation of myelination(GO:0031643) |
| 0.1 | 3.3 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 1.1 | 3.2 | GO:2000118 | regulation of sodium-dependent phosphate transport(GO:2000118) |
| 0.2 | 3.1 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.4 | 2.9 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
| 0.6 | 2.8 | GO:1904098 | regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100) |
| 0.2 | 2.2 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
| 0.2 | 2.2 | GO:0021702 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.2 | 2.1 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.3 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.3 | 3.1 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 2.3 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 2.1 | GO:0005776 | autophagosome(GO:0005776) |
| 0.1 | 2.0 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 2.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.6 | 1.9 | GO:0071020 | post-spliceosomal complex(GO:0071020) |
| 0.0 | 1.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.2 | 1.8 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.0 | 1.6 | GO:0030496 | midbody(GO:0030496) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 3.2 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.0 | 3.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.5 | 2.8 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.9 | 2.6 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.2 | 2.6 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.7 | 2.1 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.2 | 1.8 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 1.8 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 1.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 3.4 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 3.1 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.1 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.1 | 1.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 1.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 1.4 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 1.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.8 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 3.1 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 2.9 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.7 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 2.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 2.2 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 1.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.8 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 1.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |