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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for CUUUGGU

Z-value: 0.07

Motif logo

logo of

miRNA associated with seed CUUUGGU

NamemiRBASE accession
hsa-miR-9-5p
MIMAT0000441

Activity profile of CUUUGGU motif

Sorted Z-values of CUUUGGU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_120170052 27.50 ENST00000295633.3
FSTL1
follistatin-like 1
chr7_-_45960850 26.01 ENST00000381083.4
ENST00000381086.5
ENST00000275521.6
IGFBP3
insulin-like growth factor binding protein 3
chr5_+_135364584 25.65 ENST00000442011.2
ENST00000305126.8
TGFBI
transforming growth factor, beta-induced, 68kDa
chr13_+_110959598 22.62 ENST00000360467.5
COL4A2
collagen, type IV, alpha 2
chr15_-_60690163 19.85 ENST00000558998.1
ENST00000560165.1
ENST00000557986.1
ENST00000559780.1
ENST00000559467.1
ENST00000559956.1
ENST00000332680.4
ENST00000396024.3
ENST00000421017.2
ENST00000560466.1
ENST00000558132.1
ENST00000559113.1
ENST00000557906.1
ENST00000558558.1
ENST00000560468.1
ENST00000559370.1
ENST00000558169.1
ENST00000559725.1
ENST00000558985.1
ENST00000451270.2
ANXA2
annexin A2
chr3_+_197476621 19.39 ENST00000241502.4
FYTTD1
forty-two-three domain containing 1
chr4_-_157892498 18.34 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr2_+_203499901 18.33 ENST00000303116.6
ENST00000392238.2
FAM117B
family with sequence similarity 117, member B
chr2_-_161350305 18.20 ENST00000348849.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr15_-_48937982 17.85 ENST00000316623.5
FBN1
fibrillin 1
chr2_-_1748214 17.75 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
PXDN
peroxidasin homolog (Drosophila)
chr12_-_10875831 16.53 ENST00000279550.7
ENST00000228251.4
YBX3
Y box binding protein 3
chr3_+_171758344 15.07 ENST00000336824.4
ENST00000423424.1
FNDC3B
fibronectin type III domain containing 3B
chr3_-_185542817 14.21 ENST00000382199.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr8_+_22224811 13.96 ENST00000381237.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr5_+_82767284 13.85 ENST00000265077.3
VCAN
versican
chr5_+_34656331 13.71 ENST00000265109.3
RAI14
retinoic acid induced 14
chr21_+_46825032 13.10 ENST00000400337.2
COL18A1
collagen, type XVIII, alpha 1
chr5_-_131563501 12.99 ENST00000401867.1
ENST00000379086.1
ENST00000418055.1
ENST00000453286.1
ENST00000166534.4
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr6_-_82462425 12.77 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr6_+_116601265 12.57 ENST00000452085.3
DSE
dermatan sulfate epimerase
chr5_-_127873659 12.54 ENST00000262464.4
FBN2
fibrillin 2
chr21_-_44846999 12.40 ENST00000270162.6
SIK1
salt-inducible kinase 1
chr1_-_154943212 12.33 ENST00000368445.5
ENST00000448116.2
ENST00000368449.4
SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr3_-_32544900 11.54 ENST00000205636.3
CMTM6
CKLF-like MARVEL transmembrane domain containing 6
chr3_+_30648066 11.49 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr9_-_117880477 11.15 ENST00000534839.1
ENST00000340094.3
ENST00000535648.1
ENST00000346706.3
ENST00000345230.3
ENST00000350763.4
TNC
tenascin C
chr2_-_218808771 11.10 ENST00000449814.1
ENST00000171887.4
TNS1
tensin 1
chr10_-_33623564 10.26 ENST00000374875.1
ENST00000374822.4
NRP1
neuropilin 1
chr10_+_75757863 10.18 ENST00000372755.3
ENST00000211998.4
ENST00000417648.2
VCL
vinculin
chr3_-_123603137 10.17 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
MYLK
myosin light chain kinase
chr5_-_149535421 10.11 ENST00000261799.4
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr2_+_36582857 10.00 ENST00000280527.2
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr2_+_46524537 9.53 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr19_+_797392 9.32 ENST00000350092.4
ENST00000349038.4
ENST00000586481.1
ENST00000585535.1
PTBP1
polypyrimidine tract binding protein 1
chr2_+_235860616 9.21 ENST00000392011.2
SH3BP4
SH3-domain binding protein 4
chr9_+_101705893 9.04 ENST00000375001.3
COL15A1
collagen, type XV, alpha 1
chr22_-_36784035 8.83 ENST00000216181.5
MYH9
myosin, heavy chain 9, non-muscle
chr15_-_101792137 8.49 ENST00000254190.3
CHSY1
chondroitin sulfate synthase 1
chrX_-_109561294 8.36 ENST00000372059.2
ENST00000262844.5
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr8_-_71519889 8.17 ENST00000521425.1
TRAM1
translocation associated membrane protein 1
chr16_-_65155833 7.85 ENST00000566827.1
ENST00000394156.3
ENST00000562998.1
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr1_+_25071848 7.82 ENST00000374379.4
CLIC4
chloride intracellular channel 4
chr13_+_73632897 7.78 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr5_+_149340282 7.71 ENST00000286298.4
SLC26A2
solute carrier family 26 (anion exchanger), member 2
chr8_-_119124045 7.64 ENST00000378204.2
EXT1
exostosin glycosyltransferase 1
chr5_+_40909354 7.39 ENST00000313164.9
C7
complement component 7
chr7_+_115850547 7.31 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
TES
testis derived transcript (3 LIM domains)
chr1_-_120612240 7.29 ENST00000256646.2
NOTCH2
notch 2
chr6_+_160390102 7.26 ENST00000356956.1
IGF2R
insulin-like growth factor 2 receptor
chr2_+_48541776 7.24 ENST00000413569.1
ENST00000340553.3
FOXN2
forkhead box N2
chr12_+_66217911 7.09 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr2_-_38604398 7.00 ENST00000443098.1
ENST00000449130.1
ENST00000378954.4
ENST00000539122.1
ENST00000419554.2
ENST00000451483.1
ENST00000406122.1
ATL2
atlastin GTPase 2
chr2_-_208030647 6.96 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr21_-_28338732 6.90 ENST00000284987.5
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr3_-_114790179 6.80 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr2_+_121103706 6.79 ENST00000295228.3
INHBB
inhibin, beta B
chr9_-_16870704 6.74 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2
basonuclin 2
chr1_-_225840747 6.66 ENST00000366843.2
ENST00000366844.3
ENAH
enabled homolog (Drosophila)
chr19_+_7968728 6.57 ENST00000397981.3
ENST00000545011.1
ENST00000397983.3
ENST00000397979.3
MAP2K7
mitogen-activated protein kinase kinase 7
chr3_+_187930719 6.48 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chrX_-_77150985 6.42 ENST00000358075.6
MAGT1
magnesium transporter 1
chr3_-_134093395 6.27 ENST00000249883.5
AMOTL2
angiomotin like 2
chr16_-_85045131 6.27 ENST00000313732.4
ZDHHC7
zinc finger, DHHC-type containing 7
chr6_-_169654139 6.24 ENST00000366787.3
THBS2
thrombospondin 2
chr10_+_60272814 6.17 ENST00000373886.3
BICC1
bicaudal C homolog 1 (Drosophila)
chr17_-_62658186 5.87 ENST00000262435.9
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr2_-_20424844 5.85 ENST00000403076.1
ENST00000254351.4
SDC1
syndecan 1
chr7_+_66386204 5.83 ENST00000341567.4
ENST00000607045.1
TMEM248
transmembrane protein 248
chr9_-_35732362 5.80 ENST00000314888.9
ENST00000540444.1
TLN1
talin 1
chr7_-_41742697 5.78 ENST00000242208.4
INHBA
inhibin, beta A
chr13_-_41240717 5.74 ENST00000379561.5
FOXO1
forkhead box O1
chr1_-_108742957 5.72 ENST00000565488.1
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr3_+_193853927 5.62 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr20_-_36793774 5.54 ENST00000361475.2
TGM2
transglutaminase 2
chr17_-_41174424 5.51 ENST00000355653.3
VAT1
vesicle amine transport 1
chr12_+_69004619 5.40 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B
RAP1B, member of RAS oncogene family
chr4_+_87856129 5.37 ENST00000395146.4
ENST00000507468.1
AFF1
AF4/FMR2 family, member 1
chr3_+_61547585 5.32 ENST00000295874.10
ENST00000474889.1
PTPRG
protein tyrosine phosphatase, receptor type, G
chr5_-_180242534 5.30 ENST00000333055.3
ENST00000513431.1
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr15_-_42264702 5.26 ENST00000220325.4
EHD4
EH-domain containing 4
chr16_+_68771128 5.24 ENST00000261769.5
ENST00000422392.2
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr3_+_154797428 5.17 ENST00000460393.1
MME
membrane metallo-endopeptidase
chr1_+_100111479 5.15 ENST00000263174.4
PALMD
palmdelphin
chr21_+_35445827 5.04 ENST00000608209.1
ENST00000381151.3
SLC5A3
SLC5A3
sodium/myo-inositol cotransporter
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr2_+_74425689 5.01 ENST00000394053.2
ENST00000409804.1
ENST00000264090.4
ENST00000394050.3
ENST00000409601.1
MTHFD2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr1_+_99127265 4.96 ENST00000306121.3
SNX7
sorting nexin 7
chr15_-_75744014 4.93 ENST00000394947.3
ENST00000565264.1
SIN3A
SIN3 transcription regulator family member A
chr13_+_113951532 4.92 ENST00000332556.4
LAMP1
lysosomal-associated membrane protein 1
chrX_-_83442915 4.82 ENST00000262752.2
ENST00000543399.1
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr12_-_14721283 4.81 ENST00000240617.5
PLBD1
phospholipase B domain containing 1
chr2_+_46926048 4.79 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chrX_+_49687216 4.78 ENST00000376088.3
CLCN5
chloride channel, voltage-sensitive 5
chr8_-_99837856 4.78 ENST00000518165.1
ENST00000419617.2
STK3
serine/threonine kinase 3
chr16_+_69221028 4.75 ENST00000336278.4
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr13_+_96329381 4.72 ENST00000602402.1
ENST00000376795.6
DNAJC3
DnaJ (Hsp40) homolog, subfamily C, member 3
chrX_+_16737718 4.71 ENST00000380155.3
SYAP1
synapse associated protein 1
chr10_-_62704005 4.71 ENST00000337910.5
RHOBTB1
Rho-related BTB domain containing 1
chr3_-_46037299 4.54 ENST00000296137.2
FYCO1
FYVE and coiled-coil domain containing 1
chr5_-_148930960 4.46 ENST00000261798.5
ENST00000377843.2
CSNK1A1
casein kinase 1, alpha 1
chr19_+_39616410 4.40 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chrX_-_131352152 4.38 ENST00000342983.2
RAP2C
RAP2C, member of RAS oncogene family
chr8_-_134309335 4.35 ENST00000522890.1
ENST00000323851.7
ENST00000518176.1
ENST00000354944.5
ENST00000537882.1
ENST00000522476.1
ENST00000518066.1
ENST00000521544.1
ENST00000518480.1
ENST00000523892.1
NDRG1
N-myc downstream regulated 1
chr3_+_44626446 4.34 ENST00000441021.1
ENST00000322734.2
ZNF660
zinc finger protein 660
chr2_-_69614373 4.31 ENST00000361060.5
ENST00000357308.4
GFPT1
glutamine--fructose-6-phosphate transaminase 1
chr11_+_101981169 4.31 ENST00000526343.1
ENST00000282441.5
ENST00000537274.1
ENST00000345877.2
YAP1
Yes-associated protein 1
chr8_+_22462145 4.28 ENST00000308511.4
ENST00000523801.1
ENST00000521301.1
CCAR2
cell cycle and apoptosis regulator 2
chr1_+_155099927 4.27 ENST00000368407.3
EFNA1
ephrin-A1
chrX_+_23352133 4.21 ENST00000379361.4
PTCHD1
patched domain containing 1
chr15_+_42787452 4.18 ENST00000249647.3
SNAP23
synaptosomal-associated protein, 23kDa
chr7_-_95225768 4.14 ENST00000005178.5
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr5_+_162864575 4.12 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1
cyclin G1
chrX_-_153718953 4.09 ENST00000369649.4
ENST00000393586.1
SLC10A3
solute carrier family 10, member 3
chr7_-_137686791 4.07 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
CREB3L2
cAMP responsive element binding protein 3-like 2
chr6_+_108881012 4.07 ENST00000343882.6
FOXO3
forkhead box O3
chr14_+_50359773 4.05 ENST00000298316.5
ARF6
ADP-ribosylation factor 6
chr1_-_94374946 4.01 ENST00000370238.3
GCLM
glutamate-cysteine ligase, modifier subunit
chr9_+_137218362 4.00 ENST00000481739.1
RXRA
retinoid X receptor, alpha
chr1_+_224544552 3.96 ENST00000465271.1
ENST00000366858.3
CNIH4
cornichon family AMPA receptor auxiliary protein 4
chrX_-_46618490 3.91 ENST00000328306.4
SLC9A7
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
chr5_-_32174369 3.89 ENST00000265070.6
GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr3_+_29322803 3.87 ENST00000396583.3
ENST00000383767.2
RBMS3
RNA binding motif, single stranded interacting protein 3
chr7_-_27224795 3.84 ENST00000006015.3
HOXA11
homeobox A11
chr8_-_89339705 3.83 ENST00000286614.6
MMP16
matrix metallopeptidase 16 (membrane-inserted)
chr5_-_160973649 3.81 ENST00000393959.1
ENST00000517547.1
GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr1_+_93811438 3.75 ENST00000370272.4
ENST00000370267.1
DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr1_-_108507631 3.73 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr7_-_23510086 3.72 ENST00000258729.3
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr17_-_1395954 3.72 ENST00000359786.5
MYO1C
myosin IC
chr3_-_179754706 3.68 ENST00000465751.1
ENST00000467460.1
PEX5L
peroxisomal biogenesis factor 5-like
chr13_-_77460525 3.68 ENST00000377474.2
ENST00000317765.2
KCTD12
potassium channel tetramerization domain containing 12
chr5_+_172410757 3.66 ENST00000519374.1
ENST00000519911.1
ENST00000265093.4
ENST00000517669.1
ATP6V0E1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
chr19_-_14629224 3.65 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr11_+_60681346 3.65 ENST00000227525.3
TMEM109
transmembrane protein 109
chr7_-_129592700 3.63 ENST00000472396.1
ENST00000355621.3
UBE2H
ubiquitin-conjugating enzyme E2H
chrX_+_109246285 3.60 ENST00000372073.1
ENST00000372068.2
ENST00000288381.4
TMEM164
transmembrane protein 164
chr18_-_500692 3.59 ENST00000400256.3
COLEC12
collectin sub-family member 12
chr22_+_38302285 3.58 ENST00000215957.6
MICALL1
MICAL-like 1
chr8_+_37654424 3.51 ENST00000315215.7
GPR124
G protein-coupled receptor 124
chr19_-_15560730 3.49 ENST00000389282.4
ENST00000263381.7
WIZ
widely interspaced zinc finger motifs
chr1_+_193091080 3.49 ENST00000367435.3
CDC73
cell division cycle 73
chr4_+_57774042 3.49 ENST00000309042.7
REST
RE1-silencing transcription factor
chr9_-_38069208 3.46 ENST00000377707.3
ENST00000377700.4
SHB
Src homology 2 domain containing adaptor protein B
chr10_-_15210666 3.45 ENST00000378165.4
NMT2
N-myristoyltransferase 2
chr2_-_26101374 3.41 ENST00000435504.4
ASXL2
additional sex combs like 2 (Drosophila)
chr1_+_206858232 3.41 ENST00000294981.4
MAPKAPK2
mitogen-activated protein kinase-activated protein kinase 2
chr1_+_7831323 3.40 ENST00000054666.6
VAMP3
vesicle-associated membrane protein 3
chr6_+_114178512 3.38 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr11_-_106889250 3.37 ENST00000526355.2
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr8_-_28243934 3.34 ENST00000521185.1
ENST00000520290.1
ENST00000344423.5
ZNF395
zinc finger protein 395
chr13_-_40177261 3.32 ENST00000379589.3
LHFP
lipoma HMGIC fusion partner
chr12_+_56521840 3.30 ENST00000394048.5
ESYT1
extended synaptotagmin-like protein 1
chr3_+_141106643 3.25 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr16_+_58059470 3.24 ENST00000219271.3
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr5_+_170814803 3.23 ENST00000521672.1
ENST00000351986.6
ENST00000393820.2
ENST00000523622.1
NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr3_+_47324424 3.20 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
KLHL18
kelch-like family member 18
chr10_-_124768300 3.20 ENST00000368886.5
IKZF5
IKAROS family zinc finger 5 (Pegasus)
chr1_-_52831796 3.20 ENST00000284376.3
ENST00000438831.1
ENST00000371586.2
CC2D1B
coiled-coil and C2 domain containing 1B
chr19_-_8070474 3.18 ENST00000407627.2
ENST00000593807.1
ELAVL1
ELAV like RNA binding protein 1
chr14_+_103058948 3.17 ENST00000262241.6
RCOR1
REST corepressor 1
chr7_-_98741642 3.17 ENST00000361368.2
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr20_+_42086525 3.16 ENST00000244020.3
SRSF6
serine/arginine-rich splicing factor 6
chr13_-_36920420 3.13 ENST00000438666.2
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr3_-_98620500 3.12 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr12_-_102874416 3.10 ENST00000392904.1
ENST00000337514.6
IGF1
insulin-like growth factor 1 (somatomedin C)
chr17_+_21187976 3.09 ENST00000342679.4
MAP2K3
mitogen-activated protein kinase kinase 3
chr2_+_32502952 3.08 ENST00000238831.4
YIPF4
Yip1 domain family, member 4
chr2_+_64681219 3.07 ENST00000238875.5
LGALSL
lectin, galactoside-binding-like
chr10_-_121632266 3.07 ENST00000360003.3
ENST00000369077.3
MCMBP
minichromosome maintenance complex binding protein
chr16_+_30710462 3.03 ENST00000262518.4
ENST00000395059.2
ENST00000344771.4
SRCAP
Snf2-related CREBBP activator protein
chr1_+_179262905 3.02 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr19_+_1752372 2.99 ENST00000382349.4
ONECUT3
one cut homeobox 3
chr1_+_113161778 2.99 ENST00000263168.3
CAPZA1
capping protein (actin filament) muscle Z-line, alpha 1
chr5_-_77590480 2.96 ENST00000519295.1
ENST00000255194.6
AP3B1
adaptor-related protein complex 3, beta 1 subunit
chr3_-_72496035 2.96 ENST00000477973.2
RYBP
RING1 and YY1 binding protein
chr1_+_26737253 2.96 ENST00000326279.6
LIN28A
lin-28 homolog A (C. elegans)
chr9_-_14314066 2.90 ENST00000397575.3
NFIB
nuclear factor I/B
chr11_+_69924397 2.89 ENST00000355303.5
ANO1
anoctamin 1, calcium activated chloride channel
chr2_+_119981384 2.88 ENST00000393108.2
ENST00000354888.5
ENST00000450943.2
ENST00000393110.2
ENST00000393106.2
ENST00000409811.1
ENST00000393107.2
STEAP3
STEAP family member 3, metalloreductase
chr19_+_3359561 2.86 ENST00000589123.1
ENST00000346156.5
ENST00000395111.3
ENST00000586919.1
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr7_-_139876812 2.86 ENST00000397560.2
JHDM1D
lysine (K)-specific demethylase 7A
chr10_+_69644404 2.85 ENST00000212015.6
SIRT1
sirtuin 1
chr16_-_79634595 2.82 ENST00000326043.4
ENST00000393350.1
MAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr15_-_56209306 2.80 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
chr19_+_16222439 2.79 ENST00000300935.3
RAB8A
RAB8A, member RAS oncogene family
chrX_-_132549506 2.77 ENST00000370828.3
GPC4
glypican 4
chr19_+_17448348 2.76 ENST00000324894.8
ENST00000358792.7
ENST00000600625.1
GTPBP3
GTP binding protein 3 (mitochondrial)
chr15_+_91411810 2.72 ENST00000268171.3
FURIN
furin (paired basic amino acid cleaving enzyme)
chr4_-_82136114 2.70 ENST00000395578.1
ENST00000418486.2
PRKG2
protein kinase, cGMP-dependent, type II
chr1_+_65613217 2.70 ENST00000545314.1
AK4
adenylate kinase 4
chr8_-_57123815 2.68 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr1_+_87170247 2.66 ENST00000370558.4
SH3GLB1
SH3-domain GRB2-like endophilin B1
chr10_+_119000604 2.66 ENST00000298472.5
SLC18A2
solute carrier family 18 (vesicular monoamine transporter), member 2
chr14_+_70078303 2.63 ENST00000342745.4
KIAA0247
KIAA0247
chr16_-_4166186 2.62 ENST00000294016.3
ADCY9
adenylate cyclase 9
chr11_-_8680383 2.62 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr11_-_10590238 2.61 ENST00000256178.3
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr5_-_131132614 2.60 ENST00000307968.7
ENST00000307954.8
FNIP1
folliculin interacting protein 1
chr2_-_166651191 2.54 ENST00000392701.3
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr1_-_109940550 2.54 ENST00000256637.6
SORT1
sortilin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of CUUUGGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 22.6 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
4.2 12.6 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
3.8 11.5 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
3.6 17.9 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
3.6 10.7 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
3.4 10.1 GO:0060437 lung growth(GO:0060437) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
3.1 12.4 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
2.9 8.8 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
2.4 7.1 GO:2000685 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
2.1 10.3 GO:1904835 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
1.9 5.8 GO:0048627 myoblast development(GO:0048627)
1.9 5.6 GO:0021558 midbrain-hindbrain boundary morphogenesis(GO:0021555) trochlear nerve development(GO:0021558)
1.8 5.5 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
1.8 12.5 GO:0071692 sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
1.7 20.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
1.7 10.5 GO:0070417 cellular response to cold(GO:0070417)
1.7 22.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
1.7 6.7 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
1.6 4.9 GO:0051595 response to methylglyoxal(GO:0051595)
1.5 7.7 GO:0034036 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
1.5 16.5 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
1.4 2.8 GO:0044111 development involved in symbiotic interaction(GO:0044111)
1.4 14.0 GO:0071578 zinc II ion transmembrane import(GO:0071578)
1.4 29.1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
1.4 4.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
1.3 4.0 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
1.3 5.3 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
1.3 5.2 GO:0071492 cellular response to UV-A(GO:0071492)
1.3 10.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.3 6.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.2 4.9 GO:0043323 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
1.2 4.8 GO:0060379 cardiac muscle cell myoblast differentiation(GO:0060379)
1.2 10.9 GO:0042415 norepinephrine metabolic process(GO:0042415)
1.2 9.7 GO:0035897 proteolysis in other organism(GO:0035897)
1.1 3.4 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
1.1 5.5 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
1.1 4.3 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
1.1 4.3 GO:0014028 notochord formation(GO:0014028)
1.1 26.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
1.1 3.2 GO:1902534 single-organism membrane invagination(GO:1902534)
1.0 5.2 GO:0010587 miRNA catabolic process(GO:0010587)
1.0 4.0 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
1.0 6.0 GO:1901096 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
1.0 3.0 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
1.0 3.9 GO:0045053 protein retention in Golgi apparatus(GO:0045053) asymmetric Golgi ribbon formation(GO:0090164)
1.0 4.8 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
1.0 14.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.9 2.8 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.9 2.7 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.9 5.3 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.9 8.7 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.9 3.5 GO:0060283 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.9 7.8 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.8 2.5 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.8 2.4 GO:0060748 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.8 19.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.8 4.8 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.8 7.8 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.8 3.1 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.8 2.3 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.8 11.5 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.8 3.0 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.7 7.3 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.7 10.2 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.7 2.2 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.7 5.7 GO:0015866 ADP transport(GO:0015866)
0.7 2.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.7 5.0 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.7 2.1 GO:0035624 receptor transactivation(GO:0035624)
0.7 2.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.7 7.6 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.7 4.8 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.7 2.7 GO:1903778 protein localization to vacuolar membrane(GO:1903778)
0.7 8.6 GO:1901978 positive regulation of cell cycle checkpoint(GO:1901978)
0.7 5.2 GO:0071680 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.6 2.6 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.6 3.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.6 3.7 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.6 0.6 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.6 3.6 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.6 2.4 GO:0042256 mature ribosome assembly(GO:0042256)
0.6 2.4 GO:0015917 aminophospholipid transport(GO:0015917)
0.6 2.9 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.6 0.6 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.6 2.8 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.6 1.7 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.5 9.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.5 3.3 GO:1901526 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.5 1.6 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.5 2.2 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.5 17.3 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.5 5.2 GO:0015791 polyol transport(GO:0015791)
0.5 1.5 GO:0051182 coenzyme transport(GO:0051182)
0.5 2.0 GO:0048861 oncostatin-M-mediated signaling pathway(GO:0038165) leukemia inhibitory factor signaling pathway(GO:0048861)
0.5 3.5 GO:0046465 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.5 8.1 GO:0036010 protein localization to endosome(GO:0036010)
0.5 7.0 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.5 1.0 GO:0043416 positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416)
0.5 2.0 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.5 7.9 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.5 1.0 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.5 17.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.5 1.5 GO:2000364 negative regulation of glucagon secretion(GO:0070093) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.5 2.5 GO:0086053 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.5 2.4 GO:0035977 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.5 1.0 GO:1904783 positive regulation of NMDA glutamate receptor activity(GO:1904783)
0.5 1.4 GO:0072560 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.5 1.9 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.5 11.4 GO:0002063 chondrocyte development(GO:0002063)
0.5 1.4 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.5 8.8 GO:0003416 endochondral bone growth(GO:0003416)
0.5 1.8 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.5 1.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5 2.7 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.4 2.7 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.4 2.2 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.4 2.6 GO:0071321 cellular response to cGMP(GO:0071321)
0.4 2.2 GO:0001999 renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) renin secretion into blood stream(GO:0002001)
0.4 3.4 GO:0044351 macropinocytosis(GO:0044351)
0.4 1.3 GO:0033206 meiotic chromosome movement towards spindle pole(GO:0016344) meiotic cytokinesis(GO:0033206)
0.4 2.9 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 0.8 GO:0060061 Spemann organizer formation(GO:0060061)
0.4 3.2 GO:0060699 regulation of endoribonuclease activity(GO:0060699)
0.4 3.6 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.4 3.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.4 1.2 GO:1903557 positive regulation of tumor necrosis factor production(GO:0032760) positive regulation of tumor necrosis factor superfamily cytokine production(GO:1903557)
0.4 30.3 GO:0002062 chondrocyte differentiation(GO:0002062)
0.4 8.9 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.4 3.5 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.4 1.5 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.4 1.1 GO:1904481 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.4 5.3 GO:0006907 pinocytosis(GO:0006907)
0.4 1.8 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.4 12.5 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.4 5.8 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.4 2.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.4 1.1 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.3 1.0 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.3 3.5 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.3 1.4 GO:0021784 postganglionic parasympathetic fiber development(GO:0021784)
0.3 3.4 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.3 1.7 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016)
0.3 1.0 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.3 3.7 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.3 1.0 GO:2000630 positive regulation of miRNA metabolic process(GO:2000630)
0.3 3.9 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.3 4.2 GO:0021794 thalamus development(GO:0021794)
0.3 2.9 GO:0015705 iodide transport(GO:0015705)
0.3 2.2 GO:0002005 angiotensin catabolic process in blood(GO:0002005)
0.3 0.6 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.3 2.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.3 4.3 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.3 0.9 GO:0070781 response to biotin(GO:0070781)
0.3 0.9 GO:0071529 cementum mineralization(GO:0071529)
0.3 9.2 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.3 0.9 GO:0006172 ADP biosynthetic process(GO:0006172)
0.3 5.0 GO:0050812 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.3 0.8 GO:0071934 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.3 1.6 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.3 1.6 GO:0060976 coronary vasculature development(GO:0060976)
0.3 1.0 GO:0016240 autophagosome docking(GO:0016240)
0.3 4.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.3 2.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.3 4.8 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.2 3.2 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.2 1.0 GO:0019086 late viral transcription(GO:0019086)
0.2 1.1 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.2 1.8 GO:0072178 nephric duct morphogenesis(GO:0072178)
0.2 0.6 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188) histone H3-K27 demethylation(GO:0071557)
0.2 1.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.2 0.8 GO:0021796 cerebral cortex regionalization(GO:0021796) oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.2 1.4 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.2 19.4 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.2 1.6 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.2 0.8 GO:0035740 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.2 28.1 GO:0030509 BMP signaling pathway(GO:0030509)
0.2 0.6 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
0.2 0.8 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.2 0.8 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.2 12.5 GO:0030574 collagen catabolic process(GO:0030574)
0.2 3.0 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.2 1.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.2 0.4 GO:0070295 renal water absorption(GO:0070295)
0.2 0.7 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.2 2.0 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 2.7 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.2 1.0 GO:0031053 primary miRNA processing(GO:0031053)
0.2 2.8 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane(GO:0098969) establishment of protein localization to postsynaptic membrane(GO:1903540)
0.2 5.4 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 5.0 GO:0046655 folic acid metabolic process(GO:0046655)
0.2 0.7 GO:0021997 response to chlorate(GO:0010157) neural plate axis specification(GO:0021997)
0.2 6.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 0.8 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 1.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.2 3.0 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.2 1.8 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 2.6 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.2 2.1 GO:0021511 spinal cord patterning(GO:0021511)
0.2 0.8 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 3.4 GO:0051764 actin crosslink formation(GO:0051764)
0.2 1.9 GO:0032717 negative regulation of interleukin-8 production(GO:0032717)
0.2 1.9 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.2 1.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 1.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 1.4 GO:0060215 primitive hemopoiesis(GO:0060215)
0.1 8.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 6.6 GO:0010761 fibroblast migration(GO:0010761)
0.1 4.7 GO:0030890 positive regulation of B cell proliferation(GO:0030890)
0.1 0.8 GO:0072501 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 3.4 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.1 0.9 GO:1903433 regulation of constitutive secretory pathway(GO:1903433)
0.1 0.4 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 1.0 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.6 GO:0060242 contact inhibition(GO:0060242)
0.1 3.7 GO:0007035 vacuolar acidification(GO:0007035)
0.1 0.6 GO:0060148 positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.1 6.0 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 3.2 GO:0097503 sialylation(GO:0097503)
0.1 1.7 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.1 2.1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 0.2 GO:1901656 glycoside transport(GO:1901656)
0.1 0.6 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.1 1.7 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.1 2.6 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 4.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.7 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 3.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.8 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.1 1.9 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 3.8 GO:0060119 inner ear receptor cell development(GO:0060119)
0.1 6.2 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 0.7 GO:0023019 signal transduction involved in regulation of gene expression(GO:0023019)
0.1 0.4 GO:0072423 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.1 1.6 GO:0008228 opsonization(GO:0008228)
0.1 2.6 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498)
0.1 1.8 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 1.9 GO:0060081 membrane hyperpolarization(GO:0060081)
0.1 1.6 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 2.0 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.4 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 2.4 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 3.6 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.1 1.1 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 12.1 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 1.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 2.8 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.1 0.3 GO:0060613 fat pad development(GO:0060613)
0.1 1.9 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.1 1.1 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.4 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.4 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 1.2 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 1.2 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 0.7 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.1 2.3 GO:0010863 positive regulation of phospholipase C activity(GO:0010863)
0.1 1.0 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 0.3 GO:0031291 Ran protein signal transduction(GO:0031291)
0.1 4.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.7 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 0.4 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.1 4.8 GO:0007588 excretion(GO:0007588)
0.1 1.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.1 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.1 1.4 GO:0015695 organic cation transport(GO:0015695)
0.1 2.4 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.9 GO:0045116 protein neddylation(GO:0045116)
0.1 1.9 GO:0051493 regulation of cytoskeleton organization(GO:0051493)
0.1 4.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.1 8.2 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 3.9 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 2.2 GO:0045445 myoblast differentiation(GO:0045445)
0.0 2.8 GO:0006400 tRNA modification(GO:0006400)
0.0 0.3 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 1.5 GO:0046039 GTP metabolic process(GO:0046039)
0.0 3.0 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 1.5 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 0.4 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.2 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.3 GO:0042426 choline catabolic process(GO:0042426)
0.0 1.8 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 1.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.2 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 1.0 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.4 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.1 GO:0006550 isoleucine catabolic process(GO:0006550)
0.0 0.1 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.1 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.2 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.2 GO:0043488 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.0 4.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 7.8 GO:0006260 DNA replication(GO:0006260)
0.0 0.0 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.2 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 1.6 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 1.9 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 1.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.4 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.6 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.8 GO:0032259 methylation(GO:0032259)
0.0 1.8 GO:0090175 Wnt signaling pathway, planar cell polarity pathway(GO:0060071) regulation of establishment of planar polarity(GO:0090175)
0.0 0.2 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0032847 regulation of cellular pH reduction(GO:0032847) positive regulation of cellular pH reduction(GO:0032849)
0.0 6.3 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 1.0 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.3 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.0 GO:0045176 apical protein localization(GO:0045176)
0.0 0.3 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 19.9 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
3.2 29.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
3.2 31.7 GO:0098651 basement membrane collagen trimer(GO:0098651)
2.1 12.3 GO:0070435 Shc-EGFR complex(GO:0070435)
1.9 5.8 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
1.8 8.8 GO:0097513 myosin II filament(GO:0097513)
1.4 4.3 GO:0044609 DBIRD complex(GO:0044609)
1.4 30.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
1.4 12.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
1.0 5.2 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
1.0 11.2 GO:0005614 interstitial matrix(GO:0005614)
0.9 4.7 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.9 10.3 GO:0097443 sorting endosome(GO:0097443)
0.9 3.7 GO:0045160 myosin I complex(GO:0045160)
0.9 4.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.8 7.4 GO:0005579 membrane attack complex(GO:0005579)
0.7 5.2 GO:0016342 catenin complex(GO:0016342)
0.7 3.4 GO:0044216 host(GO:0018995) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.7 2.7 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.7 10.2 GO:0005916 fascia adherens(GO:0005916)
0.7 2.6 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.6 3.2 GO:0031012 extracellular matrix(GO:0031012)
0.6 7.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.6 4.9 GO:0032010 phagolysosome(GO:0032010) alveolar lamellar body(GO:0097208)
0.6 1.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.6 2.8 GO:0033553 rDNA heterochromatin(GO:0033553)
0.6 1.7 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
0.5 6.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.5 2.1 GO:1990075 periciliary membrane compartment(GO:1990075)
0.5 7.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.5 5.0 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.5 1.5 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.5 2.8 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.4 3.0 GO:0071203 WASH complex(GO:0071203)
0.4 43.5 GO:0005604 basement membrane(GO:0005604)
0.4 1.2 GO:0005879 axonemal microtubule(GO:0005879)
0.4 2.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.4 1.9 GO:0005921 gap junction(GO:0005921)
0.3 3.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.3 1.0 GO:1903349 omegasome membrane(GO:1903349)
0.3 24.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 1.5 GO:0005677 chromatin silencing complex(GO:0005677)
0.3 1.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.3 4.9 GO:0005922 connexon complex(GO:0005922)
0.3 34.4 GO:0005796 Golgi lumen(GO:0005796)
0.3 3.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.3 3.7 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 2.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 6.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 4.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 3.1 GO:0042555 MCM complex(GO:0042555)
0.2 0.7 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.2 3.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 65.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 3.4 GO:0043073 germ cell nucleus(GO:0043073)
0.2 3.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 4.9 GO:0016580 Sin3 complex(GO:0016580)
0.2 3.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 2.0 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.2 0.6 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.2 1.4 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 1.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 17.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 11.4 GO:0005844 polysome(GO:0005844)
0.2 7.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 10.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 0.6 GO:0031519 PcG protein complex(GO:0031519)
0.2 4.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.9 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 10.7 GO:0005811 lipid particle(GO:0005811)
0.1 4.8 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.4 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.1 0.7 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 2.6 GO:0002102 podosome(GO:0002102)
0.1 2.9 GO:0097440 apical dendrite(GO:0097440)
0.1 4.1 GO:0000421 autophagosome membrane(GO:0000421)
0.1 4.7 GO:0042629 mast cell granule(GO:0042629)
0.1 5.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.9 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 2.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 3.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.9 GO:0043194 axon initial segment(GO:0043194)
0.1 0.7 GO:0044294 dendritic growth cone(GO:0044294)
0.1 2.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 2.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 7.5 GO:0005902 microvillus(GO:0005902)
0.1 0.4 GO:0030893 meiotic cohesin complex(GO:0030893)
0.1 2.6 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 2.9 GO:0005581 collagen trimer(GO:0005581)
0.1 1.0 GO:0000796 condensin complex(GO:0000796)
0.1 0.4 GO:0070695 FHF complex(GO:0070695)
0.1 17.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 13.5 GO:0030027 lamellipodium(GO:0030027)
0.1 6.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 56.9 GO:0005925 focal adhesion(GO:0005925)
0.1 13.6 GO:0001650 fibrillar center(GO:0001650)
0.1 2.9 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 4.2 GO:0016235 aggresome(GO:0016235)
0.1 0.1 GO:0044094 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.1 2.6 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 8.4 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 2.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 32.6 GO:0016607 nuclear speck(GO:0016607)
0.1 3.3 GO:1990391 DNA repair complex(GO:1990391)
0.1 2.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 5.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 2.1 GO:0005771 multivesicular body(GO:0005771)
0.1 0.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.5 GO:0043198 dendritic shaft(GO:0043198)
0.1 4.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 3.7 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 30.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.8 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 4.6 GO:0005643 nuclear pore(GO:0005643)
0.0 17.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 2.8 GO:0000785 chromatin(GO:0000785)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.0 1.4 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 3.0 GO:0035579 specific granule membrane(GO:0035579)
0.0 1.4 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 1.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.8 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.9 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 29.3 GO:0005615 extracellular space(GO:0005615)
0.0 0.4 GO:0000242 pericentriolar material(GO:0000242)
0.0 2.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.6 GO:0031526 brush border membrane(GO:0031526)
0.0 12.8 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.6 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
4.0 28.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
3.8 30.4 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
3.5 17.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
3.4 10.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
3.3 19.9 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
2.9 11.5 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
2.8 8.5 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
2.6 13.0 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
2.4 7.1 GO:0035501 MH1 domain binding(GO:0035501)
2.0 10.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.0 14.0 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
1.9 5.8 GO:0070699 type II activin receptor binding(GO:0070699)
1.9 7.6 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
1.8 12.3 GO:0048408 epidermal growth factor binding(GO:0048408)
1.7 5.0 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
1.5 10.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
1.3 5.3 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
1.3 7.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
1.2 5.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.2 7.3 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
1.2 3.5 GO:0070984 SET domain binding(GO:0070984)
1.1 3.4 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
1.1 11.2 GO:0045545 syndecan binding(GO:0045545)
1.0 4.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
1.0 4.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
1.0 21.0 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
1.0 1.0 GO:0051185 coenzyme transporter activity(GO:0051185)
0.9 2.7 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.9 2.6 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.8 2.5 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.8 4.0 GO:0008420 CTD phosphatase activity(GO:0008420)
0.8 11.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.7 3.7 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.7 7.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.7 2.9 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.7 2.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.7 2.9 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.7 2.1 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.7 5.7 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
0.7 2.8 GO:0043398 HLH domain binding(GO:0043398)
0.7 5.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.7 2.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.7 2.7 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.6 2.6 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.6 3.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.6 6.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.6 1.9 GO:0032427 GBD domain binding(GO:0032427)
0.6 5.0 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.6 8.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.6 2.4 GO:0035473 lipase binding(GO:0035473)
0.6 12.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.5 16.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.5 3.8 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.5 2.7 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.5 2.5 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.5 2.5 GO:0086077 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.5 33.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 1.5 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.5 2.8 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.4 3.6 GO:0005534 galactose binding(GO:0005534)
0.4 8.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.4 1.3 GO:0032767 copper-dependent protein binding(GO:0032767)
0.4 15.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.4 31.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.4 6.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.4 1.2 GO:0090556 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.4 2.4 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.4 1.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.4 9.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 2.8 GO:0050815 phosphoserine binding(GO:0050815)
0.4 4.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.4 1.9 GO:0071253 connexin binding(GO:0071253)
0.4 4.1 GO:0035497 cAMP response element binding(GO:0035497)
0.4 9.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.4 4.0 GO:0048185 activin binding(GO:0048185)
0.4 1.1 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.4 1.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 3.4 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.3 9.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.3 1.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.3 7.5 GO:0017166 vinculin binding(GO:0017166)
0.3 0.9 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.3 2.2 GO:0039706 co-receptor binding(GO:0039706)
0.3 4.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.3 2.4 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 1.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 3.0 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.3 1.5 GO:0052832 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.3 4.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 8.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.3 1.7 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.3 1.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.3 2.0 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) kainate selective glutamate receptor activity(GO:0015277) G-protein coupled glutamate receptor activity(GO:0098988)
0.3 0.8 GO:0015403 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403) uptake transmembrane transporter activity(GO:0015563)
0.3 5.2 GO:0032794 GTPase activating protein binding(GO:0032794)
0.3 0.8 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.3 7.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.3 2.8 GO:0097016 L27 domain binding(GO:0097016)
0.3 15.5 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.2 2.2 GO:0005243 gap junction channel activity(GO:0005243)
0.2 3.0 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 0.7 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 6.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 32.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 4.7 GO:0051787 misfolded protein binding(GO:0051787)
0.2 1.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 2.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 2.0 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.2 1.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.2 0.6 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.0 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.2 3.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 0.8 GO:0004348 glucosylceramidase activity(GO:0004348)
0.2 3.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 8.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 0.8 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 3.0 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.2 2.5 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2 3.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 1.0 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 0.6 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.2 4.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 2.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 3.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 0.6 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.2 28.9 GO:0008201 heparin binding(GO:0008201)
0.2 1.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.2 3.5 GO:0001221 transcription cofactor binding(GO:0001221)
0.2 4.8 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.2 1.4 GO:0019966 interleukin-1 binding(GO:0019966)
0.2 9.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 1.6 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.2 13.1 GO:0005198 structural molecule activity(GO:0005198)
0.2 4.0 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.2 4.3 GO:0070064 proline-rich region binding(GO:0070064)
0.2 1.2 GO:0016594 glycine binding(GO:0016594)
0.2 6.7 GO:0050699 WW domain binding(GO:0050699)
0.2 0.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.2 7.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 5.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 3.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 3.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 4.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 4.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.4 GO:0036033 mediator complex binding(GO:0036033)
0.1 22.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.4 GO:0048018 receptor agonist activity(GO:0048018)
0.1 4.8 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 3.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 4.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.9 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 1.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.9 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.2 GO:0016462 pyrophosphatase activity(GO:0016462)
0.1 0.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.9 GO:0017111 nucleoside-triphosphatase activity(GO:0017111)
0.1 0.7 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.8 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 1.4 GO:0019534 toxin transporter activity(GO:0019534)
0.1 0.8 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 3.8 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 2.3 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 1.8 GO:0000287 magnesium ion binding(GO:0000287)
0.1 2.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 1.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 2.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 35.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 3.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 2.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.6 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 2.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.6 GO:0033592 RNA strand annealing activity(GO:0033592)
0.1 0.9 GO:0009374 biotin binding(GO:0009374)
0.1 0.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 1.0 GO:0031996 thioesterase binding(GO:0031996)
0.1 2.0 GO:0031489 myosin V binding(GO:0031489)
0.1 6.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 1.4 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1 1.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 3.0 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 3.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 11.5 GO:0005125 cytokine activity(GO:0005125)
0.1 3.4 GO:0030145 manganese ion binding(GO:0030145)
0.1 1.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 1.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 5.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 20.9 GO:0005525 GTP binding(GO:0005525)
0.1 2.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 4.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.9 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.7 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 2.5 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.8 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 7.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 10.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 1.6 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 1.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 8.0 GO:0003779 actin binding(GO:0003779)
0.0 0.1 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.4 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.3 GO:0017022 myosin binding(GO:0017022)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 44.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
1.1 83.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.8 16.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.7 32.1 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.7 10.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.6 22.8 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.5 13.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.5 27.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.4 35.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 9.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.4 13.5 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.4 12.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 11.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.3 3.0 ST JAK STAT PATHWAY Jak-STAT Pathway
0.2 5.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.2 6.5 PID ALK1 PATHWAY ALK1 signaling events
0.2 3.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.2 40.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 10.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 8.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 17.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 12.4 PID BMP PATHWAY BMP receptor signaling
0.2 0.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 28.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 10.2 PID LKB1 PATHWAY LKB1 signaling events
0.2 2.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 6.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 1.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 0.8 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 6.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 6.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 7.0 PID NOTCH PATHWAY Notch signaling pathway
0.1 27.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.2 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 1.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 5.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 3.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 2.5 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 3.2 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 27.9 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.0 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 4.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 1.9 PID INSULIN PATHWAY Insulin Pathway
0.1 1.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 9.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 1.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 3.0 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 4.0 PID CMYB PATHWAY C-MYB transcription factor network
0.1 2.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.6 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.8 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID EPO PATHWAY EPO signaling pathway
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.4 PID ATM PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 28.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
1.0 26.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.9 12.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.9 36.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.7 12.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.7 7.3 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.7 2.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.6 18.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.6 80.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.6 18.8 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.6 3.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.5 10.8 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.5 15.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.5 6.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.4 11.1 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.4 7.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 22.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 14.3 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.3 6.6 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.3 5.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3 26.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 9.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.3 4.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 4.8 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.3 7.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 8.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 7.5 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.2 2.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 16.7 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.2 4.0 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 1.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 3.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 7.8 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.2 8.8 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.2 18.8 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.1 7.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 7.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 3.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 2.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.0 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 1.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 2.0 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 3.2 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.1 17.7 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.1 0.7 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.1 6.0 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 4.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.8 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.5 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 2.0 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.6 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 2.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 7.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 3.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 0.6 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 2.9 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 0.3 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 2.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 6.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 5.3 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.1 1.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 5.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 8.2 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 4.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 2.1 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.0 1.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.2 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 3.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.4 REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT Genes involved in SLC-mediated transmembrane transport
0.0 0.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.8 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.9 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.2 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.8 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 0.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+