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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for DBP
Z-value: 0.11
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Transcription factors associated with DBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DBP | hg19_v2_chr19_-_49140609_49140643 | 0.19 | 4.8e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_57037284 Show fit | 14.42 |
ENST00000551570.1
|
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide |
|
| chr4_-_176733897 Show fit | 11.11 |
ENST00000393658.2
|
glycoprotein M6A |
|
| chr20_+_11898507 Show fit | 8.76 |
ENST00000378226.2
|
BTB (POZ) domain containing 3 |
|
| chr11_+_121461097 Show fit | 8.57 |
ENST00000527934.1
|
sortilin-related receptor, L(DLR class) A repeats containing |
|
| chr4_+_158142750 Show fit | 7.07 |
ENST00000505888.1
ENST00000449365.1 |
glutamate receptor, ionotropic, AMPA 2 |
|
| chr8_+_85618155 Show fit | 6.62 |
ENST00000523850.1
ENST00000521376.1 |
RALY RNA binding protein-like |
|
| chr5_-_111091948 Show fit | 6.55 |
ENST00000447165.2
|
neuronal regeneration related protein |
|
| chr3_-_33700589 Show fit | 6.10 |
ENST00000461133.3
ENST00000496954.2 |
cytoplasmic linker associated protein 2 |
|
| chr8_-_54755459 Show fit | 5.96 |
ENST00000524234.1
ENST00000521275.1 ENST00000396774.2 |
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
|
| chr7_-_150946015 Show fit | 5.56 |
ENST00000262188.8
|
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DBP
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.4 | GO:0090383 | phagosome acidification(GO:0090383) |
| 1.8 | 14.4 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 0.3 | 11.3 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 1.2 | 9.2 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 8.9 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.1 | 8.7 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 2.9 | 8.6 | GO:1905246 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 2.5 | 7.6 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.1 | 6.9 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.2 | 6.8 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 14.4 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
| 0.6 | 13.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.7 | 10.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.5 | 10.4 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 0.4 | 9.7 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.9 | 9.2 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 9.1 | GO:0031252 | cell leading edge(GO:0031252) |
| 1.5 | 8.7 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 8.6 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 8.3 | GO:0000139 | Golgi membrane(GO:0000139) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 17.9 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 2.4 | 14.4 | GO:0043532 | angiostatin binding(GO:0043532) |
| 0.1 | 10.5 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 9.4 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.1 | 9.3 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) |
| 0.5 | 8.6 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.2 | 7.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.6 | 7.0 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.5 | 6.5 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.2 | 6.0 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 7.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 7.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 7.1 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.2 | 5.4 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 4.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 3.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 3.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 3.1 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 2.1 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.4 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.6 | 14.4 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.3 | 6.5 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.3 | 5.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 5.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 5.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.2 | 5.1 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 4.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 4.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 4.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |