ISMARA results: DBX2

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for DBX2_HLX

Z-value: 0.51

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Transcription factors associated with DBX2_HLX

Gene Symbol	Gene ID	Gene Info
DBX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000185610.6	developing brain homeobox 2
HLX Ensembl NCBI GeneCards UniProt NextProt	ENSG00000136630.11	H2.0 like homeobox

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HLX	hg19_v2_chr1_+_221051699_221051699	0.06	4.0e-01	Click!

Activity profile of DBX2_HLX motif

Sorted Z-values of DBX2_HLX motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_138340049 Show fit	21.20	ENST00000464668.1	FAIM Ensembl NCBI GeneCards UniProt NextProt Show fit	Fas apoptotic inhibitory molecule
chr4_+_113568207 Show fit	20.78	ENST00000511529.1	LARP7 Ensembl NCBI GeneCards UniProt NextProt Show fit	La ribonucleoprotein domain family, member 7
chr3_+_138340067 Show fit	13.30	ENST00000479848.1	FAIM Ensembl NCBI GeneCards UniProt NextProt Show fit	Fas apoptotic inhibitory molecule
chr8_-_27695552 Show fit	12.16	ENST00000522944.1 ENST00000301905.4	PBK Ensembl NCBI GeneCards UniProt NextProt Show fit	PDZ binding kinase
chr1_+_81771806 Show fit	11.45	ENST00000370721.1 ENST00000370727.1 ENST00000370725.1 ENST00000370723.1 ENST00000370728.1 ENST00000370730.1	LPHN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	latrophilin 2
chr1_-_89357179 Show fit	11.31	ENST00000448623.1 ENST00000418217.1 ENST00000370500.5	GTF2B Ensembl NCBI GeneCards UniProt NextProt Show fit	general transcription factor IIB
chr8_+_98900132 Show fit	10.62	ENST00000520016.1	MATN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	matrilin 2
chr5_-_146781153 Show fit	10.45	ENST00000520473.1	DPYSL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	dihydropyrimidinase-like 3
chr11_+_35201826 Show fit	10.27	ENST00000531873.1	CD44 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD44 molecule (Indian blood group)
chr1_-_45988542 Show fit	9.98	ENST00000424390.1	PRDX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	peroxiredoxin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of DBX2_HLX

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	18.4	GO:0097577	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.5	17.2	GO:0051894	positive regulation of focal adhesion assembly(GO:0051894)
0.6	13.6	GO:0051764	actin crosslink formation(GO:0051764)
0.2	13.4	GO:0032873	negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.3	12.8	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.5	12.4	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.3	11.4	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
1.9	11.3	GO:1904798	positive regulation of core promoter binding(GO:1904798)
0.4	10.8	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2	10.6	GO:0008347	glial cell migration(GO:0008347)

Showing 1 to 10 of 214 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	18.4	GO:0044326	dendritic spine neck(GO:0044326)
0.2	18.1	GO:0005901	caveola(GO:0005901)
0.0	17.9	GO:0005925	focal adhesion(GO:0005925)
0.0	14.9	GO:0005730	nucleolus(GO:0005730)
1.1	12.9	GO:0031595	nuclear proteasome complex(GO:0031595)
0.2	11.8	GO:0031941	filamentous actin(GO:0031941)
0.1	11.2	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
1.0	10.9	GO:0097550	transcriptional preinitiation complex(GO:0097550)
0.0	10.8	GO:0030529	intracellular ribonucleoprotein complex(GO:0030529)
0.0	10.4	GO:0005788	endoplasmic reticulum lumen(GO:0005788)

Showing 1 to 10 of 121 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	19.2	GO:0003723	RNA binding(GO:0003723)
0.1	19.1	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
0.6	17.7	GO:0005540	hyaluronic acid binding(GO:0005540)
0.4	16.8	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.4	16.1	GO:0008536	Ran GTPase binding(GO:0008536)
0.2	14.0	GO:0003743	translation initiation factor activity(GO:0003743)
1.2	12.9	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.0	12.1	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1	11.0	GO:0019208	phosphatase regulator activity(GO:0019208)
0.4	10.9	GO:0017025	TBP-class protein binding(GO:0017025)

Showing 1 to 10 of 162 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	27.5	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.3	20.0	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	19.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.4	14.0	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	13.6	PID EPHB FWD PATHWAY	EPHB forward signaling
0.3	13.5	PID BARD1 PATHWAY	BARD1 signaling events
0.1	12.9	PID E2F PATHWAY	E2F transcription factor network
0.3	11.5	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2	11.2	PID AURORA B PATHWAY	Aurora B signaling
0.2	10.0	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor

Showing 1 to 10 of 41 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	23.9	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.8	22.8	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.3	16.6	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.2	12.8	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4	10.5	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.5	10.3	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	10.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	10.2	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.2	9.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.4	9.4	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines

Showing 1 to 10 of 76 entries

Results for DBX2_HLX

Z-value: 0.51

Motif logo

Transcription factors associated with DBX2_HLX

Activity-expression correlation:

Activity profile of DBX2_HLX motif

Sorted Z-values of DBX2_HLX motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of DBX2_HLX

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: