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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for DDIT3
Z-value: 0.75
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Transcription factors associated with DDIT3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DDIT3 | hg19_v2_chr12_-_57914275_57914304 | -0.29 | 1.4e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DDIT3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.5 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 5.5 | 16.4 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 1.6 | 12.8 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 0.8 | 9.3 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.3 | 9.1 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 0.5 | 7.4 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 1.4 | 7.1 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 1.1 | 6.9 | GO:0036111 | very long-chain fatty-acyl-CoA metabolic process(GO:0036111) |
| 1.3 | 6.7 | GO:0042816 | vitamin B6 metabolic process(GO:0042816) |
| 0.2 | 6.7 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 16.4 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 12.8 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.1 | 10.5 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.5 | 9.1 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.1 | 7.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 6.9 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 6.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 6.3 | GO:0016459 | myosin complex(GO:0016459) |
| 0.7 | 4.7 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 4.4 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 16.4 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.2 | 12.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 1.9 | 9.3 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 0.2 | 9.1 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.4 | 8.9 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.2 | 7.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.9 | 7.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 1.1 | 6.9 | GO:0033989 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594) |
| 1.0 | 6.1 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 1.2 | 5.9 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.4 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 9.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 3.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 3.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 3.2 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 2.6 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.8 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.0 | 1.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 19.4 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.4 | 12.3 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 10.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.3 | 9.1 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 7.8 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.4 | 7.4 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.1 | 7.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.4 | 6.9 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 5.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 3.6 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |