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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for DLX3_EVX1_MEOX1
Z-value: 1.10
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Transcription factors associated with DLX3_EVX1_MEOX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EVX1 | hg19_v2_chr7_+_27282319_27282394 | -0.54 | 4.8e-18 | Click! |
| MEOX1 | hg19_v2_chr17_-_41739283_41739322, hg19_v2_chr17_-_41738931_41739040 | -0.44 | 1.6e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX3_EVX1_MEOX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 42.0 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 2.1 | 31.7 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 2.4 | 24.4 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.3 | 18.5 | GO:0008542 | visual learning(GO:0008542) |
| 2.8 | 14.1 | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 0.8 | 14.0 | GO:0071850 | mitotic cell cycle arrest(GO:0071850) |
| 1.1 | 13.5 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.3 | 13.2 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.4 | 10.9 | GO:0072663 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 1.5 | 10.7 | GO:1901314 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 46.0 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.2 | 31.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.7 | 26.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 19.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 17.6 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 15.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.7 | 13.6 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.1 | 13.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 12.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 10.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 42.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 31.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 1.3 | 24.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.6 | 14.1 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 13.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.0 | 13.6 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 2.6 | 13.2 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.2 | 10.9 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 10.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.2 | 9.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 54.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.4 | 15.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 12.5 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.1 | 12.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 9.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 8.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 8.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 8.0 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.3 | 7.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 5.8 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 42.0 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 1.2 | 31.7 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 1.6 | 24.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.5 | 14.1 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.2 | 13.6 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.6 | 13.2 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.2 | 9.6 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.7 | 9.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 8.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 7.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |