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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for DLX3_EVX1_MEOX1

Z-value: 1.10

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Transcription factors associated with DLX3_EVX1_MEOX1

Gene Symbol Gene ID Gene Info
DLX3
ENSG00000064195.7 distal-less homeobox 3
EVX1
ENSG00000106038.8 even-skipped homeobox 1
MEOX1
ENSG00000005102.8 mesenchyme homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EVX1hg19_v2_chr7_+_27282319_27282394-0.544.8e-18Click!
MEOX1hg19_v2_chr17_-_41739283_41739322,
hg19_v2_chr17_-_41738931_41739040		-0.441.6e-11Click!

Activity profile of DLX3_EVX1_MEOX1 motif

Sorted Z-values of DLX3_EVX1_MEOX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_33709268 24.36 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr15_-_55563072 19.11 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr15_-_37393406 18.63 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr8_-_101963677 16.33 ENST00000395956.3
ENST00000395953.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr15_-_64673630 15.97 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr15_-_55562479 15.58 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr8_-_101963482 15.36 ENST00000419477.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr15_+_75080883 14.10 ENST00000567571.1
CSK
c-src tyrosine kinase
chr1_+_68150744 13.98 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr12_+_28410128 13.49 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr12_-_56694142 13.25 ENST00000550655.1
ENST00000548567.1
ENST00000551430.2
ENST00000351328.3
CS
citrate synthase
chr16_-_29910853 11.86 ENST00000308713.5
SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr6_+_151646800 11.04 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_197115818 9.96 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr19_+_13049413 9.44 ENST00000316448.5
ENST00000588454.1
CALR
calreticulin
chr15_+_80351910 8.92 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr18_+_3447572 8.59 ENST00000548489.2
TGIF1
TGFB-induced factor homeobox 1
chr6_+_52535878 8.21 ENST00000211314.4
TMEM14A
transmembrane protein 14A
chr7_+_116660246 8.11 ENST00000434836.1
ENST00000393443.1
ENST00000465133.1
ENST00000477742.1
ENST00000393447.4
ENST00000393444.3
ST7
suppression of tumorigenicity 7
chr7_-_14029283 8.06 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr7_-_99716952 7.83 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr5_-_148929848 7.48 ENST00000504676.1
ENST00000515435.1
CSNK1A1
casein kinase 1, alpha 1
chr15_-_55562582 7.35 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr21_-_35899113 7.32 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr2_+_171785012 7.27 ENST00000234160.4
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr3_-_33686743 6.72 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr15_-_64673665 6.62 ENST00000300035.4
KIAA0101
KIAA0101
chr6_+_34204642 6.50 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr16_-_66864806 6.47 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr3_+_159557637 6.41 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chrX_-_13835147 6.25 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr16_+_69345243 5.86 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr3_-_141747950 5.81 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr20_+_3776371 5.80 ENST00000245960.5
CDC25B
cell division cycle 25B
chr7_-_99717463 5.77 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chrX_-_118986911 5.67 ENST00000276201.2
ENST00000345865.2
UPF3B
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr7_-_14028488 5.65 ENST00000405358.4
ETV1
ets variant 1
chr11_-_107729887 5.57 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr2_+_201754050 5.36 ENST00000426253.1
ENST00000416651.1
ENST00000454952.1
ENST00000409020.1
ENST00000359683.4
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr13_-_31191642 5.36 ENST00000405805.1
HMGB1
high mobility group box 1
chr2_-_17981462 5.33 ENST00000402989.1
ENST00000428868.1
SMC6
structural maintenance of chromosomes 6
chr4_+_174089904 5.30 ENST00000265000.4
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr5_+_115177178 5.22 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr18_+_55888767 5.11 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chrX_-_77225135 5.09 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr3_+_44840679 5.09 ENST00000425755.1
KIF15
kinesin family member 15
chr2_+_201754135 4.96 ENST00000409357.1
ENST00000409129.2
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr8_+_110346546 4.82 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
ENY2
enhancer of yellow 2 homolog (Drosophila)
chr4_-_66536057 4.80 ENST00000273854.3
EPHA5
EPH receptor A5
chr8_+_22424551 4.73 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr1_-_68698197 4.70 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr1_+_101003687 4.62 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr1_-_68698222 4.61 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr20_+_60174827 4.46 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr6_-_36515177 4.44 ENST00000229812.7
STK38
serine/threonine kinase 38
chr6_+_39760129 4.41 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr13_-_46716969 4.41 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_61697862 4.22 ENST00000398571.2
USP34
ubiquitin specific peptidase 34
chr4_-_105416039 4.13 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr3_+_130569429 4.09 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr4_-_66536196 4.02 ENST00000511294.1
EPHA5
EPH receptor A5
chr13_-_95131923 4.01 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr14_-_21737551 3.97 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
HNRNPC
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr4_-_139163491 3.88 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr6_+_160211481 3.81 ENST00000367034.4
MRPL18
mitochondrial ribosomal protein L18
chr2_-_86422095 3.80 ENST00000254636.5
IMMT
inner membrane protein, mitochondrial
chr17_-_77924627 3.75 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1D16
TBC1 domain family, member 16
chr15_+_89631381 3.72 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr7_+_100860949 3.67 ENST00000305105.2
ZNHIT1
zinc finger, HIT-type containing 1
chrX_-_16887963 3.67 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr14_-_21737610 3.62 ENST00000320084.7
ENST00000449098.1
ENST00000336053.6
HNRNPC
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chrX_-_23926004 3.53 ENST00000379226.4
ENST00000379220.3
APOO
apolipoprotein O
chr12_-_89746173 3.50 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr21_-_43346790 3.49 ENST00000329623.7
C2CD2
C2 calcium-dependent domain containing 2
chrX_-_106243451 3.42 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr7_-_151217166 3.39 ENST00000496004.1
RHEB
Ras homolog enriched in brain
chr8_-_49834299 3.38 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr7_+_75931861 3.34 ENST00000248553.6
HSPB1
heat shock 27kDa protein 1
chr3_-_47950745 3.28 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr10_+_114710211 3.19 ENST00000349937.2
ENST00000369397.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr1_+_230193521 3.11 ENST00000543760.1
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr10_+_85899196 3.09 ENST00000372134.3
GHITM
growth hormone inducible transmembrane protein
chr2_-_230786679 2.98 ENST00000543084.1
ENST00000343290.5
ENST00000389044.4
ENST00000283943.5
TRIP12
thyroid hormone receptor interactor 12
chr15_-_31393910 2.96 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr22_-_41682172 2.93 ENST00000356244.3
RANGAP1
Ran GTPase activating protein 1
chr6_-_111804905 2.91 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr4_+_41614909 2.90 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIMCH1
LIM and calponin homology domains 1
chr2_-_230786619 2.80 ENST00000389045.3
ENST00000409677.1
TRIP12
thyroid hormone receptor interactor 12
chr4_+_41614720 2.70 ENST00000509277.1
LIMCH1
LIM and calponin homology domains 1
chr2_-_37544209 2.70 ENST00000234179.2
PRKD3
protein kinase D3
chr1_-_151431647 2.58 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr6_-_87804815 2.57 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr1_+_236958554 2.51 ENST00000366577.5
ENST00000418145.2
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
chr5_-_142780280 2.50 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chrM_+_12331 2.49 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr6_-_111927062 2.39 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr11_-_95657231 2.37 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
MTMR2
myotubularin related protein 2
chr19_+_11071546 2.34 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr3_+_111717600 2.32 ENST00000273368.4
TAGLN3
transgelin 3
chr8_-_103424986 2.26 ENST00000521922.1
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr15_+_96869165 2.23 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr3_-_47934234 2.21 ENST00000420772.2
MAP4
microtubule-associated protein 4
chr17_-_27418537 2.18 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr14_+_22739823 2.15 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr17_-_60142609 2.10 ENST00000397786.2
MED13
mediator complex subunit 13
chr17_-_10017864 2.08 ENST00000323816.4
GAS7
growth arrest-specific 7
chr8_-_49833978 2.06 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr3_+_111717511 2.06 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr7_-_25019760 2.02 ENST00000352860.1
ENST00000353930.1
ENST00000431825.2
ENST00000313367.2
OSBPL3
oxysterol binding protein-like 3
chr17_+_60536002 2.00 ENST00000582809.1
TLK2
tousled-like kinase 2
chr15_+_80351977 1.95 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chr12_+_15699286 1.94 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr4_+_169013666 1.88 ENST00000359299.3
ANXA10
annexin A10
chr14_+_64680854 1.82 ENST00000458046.2
SYNE2
spectrin repeat containing, nuclear envelope 2
chr12_-_10978957 1.76 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr3_+_111718173 1.76 ENST00000494932.1
TAGLN3
transgelin 3
chr12_+_54378923 1.74 ENST00000303460.4
HOXC10
homeobox C10
chr1_-_101491319 1.69 ENST00000342173.7
ENST00000488176.1
ENST00000370109.3
DPH5
diphthamide biosynthesis 5
chr8_-_103424916 1.68 ENST00000220959.4
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr10_-_48416849 1.66 ENST00000249598.1
GDF2
growth differentiation factor 2
chr12_-_118628350 1.61 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr1_-_10532531 1.61 ENST00000377036.2
ENST00000377038.3
DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr6_+_46761118 1.52 ENST00000230588.4
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr1_-_67266939 1.51 ENST00000304526.2
INSL5
insulin-like 5
chr2_-_224467093 1.50 ENST00000305409.2
SCG2
secretogranin II
chr6_-_55739542 1.50 ENST00000446683.2
BMP5
bone morphogenetic protein 5
chr10_-_101690650 1.49 ENST00000543621.1
DNMBP
dynamin binding protein
chr10_+_35484793 1.46 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr1_-_151431909 1.46 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr1_-_190446759 1.28 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr3_+_157828152 1.21 ENST00000476899.1
RSRC1
arginine/serine-rich coiled-coil 1
chr22_-_30960876 1.14 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr8_-_17533838 1.09 ENST00000400046.1
MTUS1
microtubule associated tumor suppressor 1
chr12_-_121454148 1.03 ENST00000535367.1
ENST00000538296.1
ENST00000445832.3
ENST00000536407.2
ENST00000366211.2
ENST00000539736.1
ENST00000288757.3
ENST00000537817.1
C12orf43
chromosome 12 open reading frame 43
chr3_+_115342349 1.02 ENST00000393780.3
GAP43
growth associated protein 43
chr17_-_48785216 1.00 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr12_-_53171128 0.99 ENST00000332411.2
KRT76
keratin 76
chr6_-_109702885 0.99 ENST00000504373.1
CD164
CD164 molecule, sialomucin
chr8_-_103425047 0.99 ENST00000520539.1
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr14_-_78083112 0.98 ENST00000216484.2
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr14_+_74034310 0.93 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr6_-_111927449 0.92 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr5_+_140625147 0.92 ENST00000231173.3
PCDHB15
protocadherin beta 15
chrX_-_72434628 0.91 ENST00000536638.1
ENST00000373517.3
NAP1L2
nucleosome assembly protein 1-like 2
chr5_-_16509101 0.91 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr3_-_195538760 0.88 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chrX_+_105855160 0.87 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr15_+_64680003 0.84 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr9_-_13165457 0.82 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr11_-_70672645 0.82 ENST00000423696.2
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr7_-_151217001 0.77 ENST00000262187.5
RHEB
Ras homolog enriched in brain
chr20_+_30697298 0.74 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr4_-_39979576 0.72 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr12_-_14849470 0.72 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chrX_-_100129128 0.67 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr20_+_45947246 0.64 ENST00000599904.1
AL031666.2
HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr4_+_144354644 0.61 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr1_+_50575292 0.60 ENST00000371821.1
ENST00000371819.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chrX_+_7137475 0.57 ENST00000217961.4
STS
steroid sulfatase (microsomal), isozyme S
chr13_-_45010939 0.55 ENST00000261489.2
TSC22D1
TSC22 domain family, member 1
chr4_-_87028478 0.54 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr20_+_18488137 0.48 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B
Sec23 homolog B (S. cerevisiae)
chr1_-_94586651 0.47 ENST00000535735.1
ENST00000370225.3
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr2_-_99279928 0.47 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr20_+_18447771 0.44 ENST00000377603.4
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr16_-_67517716 0.42 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr3_-_108248169 0.39 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr14_-_37051798 0.39 ENST00000258829.5
NKX2-8
NK2 homeobox 8
chr5_+_174151536 0.38 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr3_-_195538728 0.35 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr11_+_20620946 0.33 ENST00000525748.1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 5
chr12_-_68619586 0.30 ENST00000229134.4
IL26
interleukin 26
chr4_-_155533787 0.30 ENST00000407946.1
ENST00000405164.1
ENST00000336098.3
ENST00000393846.2
ENST00000404648.3
ENST00000443553.1
FGG
fibrinogen gamma chain
chr4_-_74486217 0.28 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr2_-_55647057 0.28 ENST00000436346.1
CCDC88A
coiled-coil domain containing 88A
chr12_-_14133053 0.27 ENST00000609686.1
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr12_+_41831485 0.22 ENST00000539469.2
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4
chr11_-_102709441 0.22 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr3_+_152879985 0.20 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family
chr7_-_83824169 0.19 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_-_151034734 0.16 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr17_-_39677971 0.16 ENST00000393976.2
KRT15
keratin 15
chr15_+_89631647 0.13 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr18_-_71959159 0.10 ENST00000494131.2
ENST00000397914.4
ENST00000340533.4
CYB5A
cytochrome b5 type A (microsomal)
chrX_-_110655306 0.10 ENST00000371993.2
DCX
doublecortin
chr8_+_32579341 0.07 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr15_-_68497657 0.07 ENST00000448060.2
ENST00000467889.1
CALML4
calmodulin-like 4
chr7_+_73245193 0.06 ENST00000340958.2
CLDN4
claudin 4
chr17_-_64225508 0.05 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr6_-_111136513 0.04 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr2_-_207082748 0.03 ENST00000407325.2
ENST00000411719.1
GPR1
G protein-coupled receptor 1
chr2_-_55646957 0.03 ENST00000263630.8
CCDC88A
coiled-coil domain containing 88A
chr12_-_86650077 0.03 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr17_-_33446735 0.03 ENST00000460118.2
ENST00000335858.7
RAD51D
RAD51 paralog D

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX3_EVX1_MEOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 42.0 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
3.1 9.3 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
2.8 14.1 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
2.7 2.7 GO:0089700 protein kinase D signaling(GO:0089700)
2.4 24.4 GO:0071578 zinc II ion transmembrane import(GO:0071578)
2.1 31.7 GO:0090168 Golgi reassembly(GO:0090168)
2.0 5.9 GO:0090611 mitotic cytokinesis checkpoint(GO:0044878) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
1.8 5.4 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.7 10.0 GO:0051661 maintenance of centrosome location(GO:0051661)
1.6 6.5 GO:0090402 oncogene-induced cell senescence(GO:0090402)
1.6 9.4 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
1.5 10.7 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
1.3 5.4 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
1.3 6.5 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.3 5.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
1.3 3.8 GO:0035928 rRNA import into mitochondrion(GO:0035928)
1.2 3.5 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
1.2 4.6 GO:0061743 motor learning(GO:0061743)
1.1 13.5 GO:0090160 Golgi to lysosome transport(GO:0090160)
1.1 7.5 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
1.0 5.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.9 5.5 GO:0051012 microtubule sliding(GO:0051012)
0.8 6.7 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.8 3.3 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.8 3.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.8 14.0 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.7 3.7 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.7 10.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.7 4.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.7 4.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.6 1.9 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.6 6.2 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.6 2.4 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.6 5.8 GO:0007144 female meiosis I(GO:0007144)
0.6 4.0 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.6 2.2 GO:0009956 radial pattern formation(GO:0009956)
0.6 4.4 GO:0009799 determination of left/right symmetry(GO:0007368) specification of symmetry(GO:0009799) determination of bilateral symmetry(GO:0009855)
0.5 1.6 GO:1903625 negative regulation of DNA catabolic process(GO:1903625)
0.5 5.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.5 4.2 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.5 4.8 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.5 2.3 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.4 8.8 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.4 10.9 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.4 1.2 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.4 1.9 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.3 13.2 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.3 1.0 GO:1904502 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.3 5.2 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.3 8.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 7.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.3 2.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.3 4.0 GO:0051382 kinetochore assembly(GO:0051382)
0.3 1.8 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.3 2.9 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.3 4.4 GO:0051639 actin filament network formation(GO:0051639)
0.3 18.5 GO:0008542 visual learning(GO:0008542)
0.2 1.7 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.2 2.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.2 1.7 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 3.9 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.2 3.7 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.2 4.2 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.2 0.4 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.2 7.3 GO:0042407 cristae formation(GO:0042407)
0.2 0.9 GO:2000035 regulation of stem cell division(GO:2000035)
0.2 3.0 GO:0046548 retinal rod cell development(GO:0046548)
0.2 1.0 GO:0016198 axon choice point recognition(GO:0016198)
0.2 0.7 GO:0045112 integrin biosynthetic process(GO:0045112) regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.1 3.3 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 2.5 GO:0009086 methionine biosynthetic process(GO:0009086)
0.1 5.8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 1.5 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.1 1.0 GO:0048733 sebaceous gland development(GO:0048733)
0.1 6.5 GO:0016266 O-glycan processing(GO:0016266)
0.1 2.9 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 3.0 GO:0048240 sperm capacitation(GO:0048240)
0.1 3.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 4.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 5.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.5 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 7.0 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 0.3 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 1.4 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.1 5.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.7 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 1.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 5.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.7 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 2.6 GO:0016486 peptide hormone processing(GO:0016486)
0.1 7.3 GO:0007030 Golgi organization(GO:0007030)
0.1 4.2 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.1 2.1 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 0.2 GO:0048880 sensory system development(GO:0048880)
0.0 2.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0015816 glycine transport(GO:0015816)
0.0 3.0 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.0 0.8 GO:0071625 vocalization behavior(GO:0071625)
0.0 1.6 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.2 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.9 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 2.0 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.7 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.2 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.2 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.3 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.0 0.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.6 GO:0006397 mRNA processing(GO:0006397)
0.0 0.2 GO:0032486 Rap protein signal transduction(GO:0032486) establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.8 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 1.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 46.0 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
1.7 5.1 GO:0005873 plus-end kinesin complex(GO:0005873)
1.4 10.0 GO:0036449 microtubule minus-end(GO:0036449)
1.3 5.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
1.2 9.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
1.0 7.3 GO:0061617 MICOS complex(GO:0061617)
0.8 4.8 GO:0000124 SAGA complex(GO:0000124)
0.7 3.0 GO:0035838 growing cell tip(GO:0035838)
0.7 13.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.7 6.7 GO:0045180 basal cortex(GO:0045180)
0.7 26.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.6 7.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.6 6.5 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.5 2.9 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.5 5.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.5 5.9 GO:0000815 ESCRT III complex(GO:0000815)
0.3 9.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 1.0 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.2 3.0 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 4.4 GO:0001891 phagocytic cup(GO:0001891)
0.2 2.9 GO:0042575 DNA polymerase complex(GO:0042575)
0.2 1.0 GO:0032584 growth cone membrane(GO:0032584)
0.2 5.1 GO:0097228 sperm principal piece(GO:0097228)
0.2 5.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 1.7 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.2 31.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 3.7 GO:0000812 Swr1 complex(GO:0000812)
0.2 5.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 3.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 2.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 12.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 5.1 GO:0005771 multivesicular body(GO:0005771)
0.1 0.7 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.5 GO:0031045 dense core granule(GO:0031045)
0.1 2.3 GO:0071564 npBAF complex(GO:0071564)
0.1 3.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 3.3 GO:1904115 axon cytoplasm(GO:1904115)
0.1 3.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 2.1 GO:0016592 mediator complex(GO:0016592)
0.1 5.5 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 10.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 13.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.6 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 5.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.8 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 19.7 GO:0016607 nuclear speck(GO:0016607)
0.0 2.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.8 GO:0005795 Golgi stack(GO:0005795)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 4.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 4.8 GO:0000922 spindle pole(GO:0000922)
0.0 2.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 17.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 8.6 GO:0005938 cell cortex(GO:0005938)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 15.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.5 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 2.4 GO:0008021 synaptic vesicle(GO:0008021)
0.0 3.6 GO:0005819 spindle(GO:0005819)
0.0 0.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 4.9 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 3.0 GO:0005769 early endosome(GO:0005769)
0.0 2.6 GO:0045121 membrane raft(GO:0045121)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 13.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.6 42.0 GO:0031489 myosin V binding(GO:0031489)
1.3 24.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.3 5.1 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
1.2 7.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
1.2 9.4 GO:0001849 complement component C1q binding(GO:0001849)
1.1 3.3 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
1.0 13.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.9 5.4 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.9 8.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.8 4.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.7 9.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.7 4.0 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.6 5.1 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.6 7.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.6 14.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.6 8.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.5 8.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.5 2.5 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.5 6.5 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.5 6.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 3.8 GO:0008097 5S rRNA binding(GO:0008097)
0.3 4.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.3 1.0 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.3 2.5 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 1.2 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.3 3.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 8.6 GO:0070410 co-SMAD binding(GO:0070410)
0.3 6.7 GO:0002162 dystroglycan binding(GO:0002162)
0.3 4.7 GO:0017166 vinculin binding(GO:0017166)
0.2 10.9 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 3.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 4.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2 7.9 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.2 2.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 31.7 GO:0044325 ion channel binding(GO:0044325)
0.2 1.5 GO:0042056 chemoattractant activity(GO:0042056)
0.2 2.3 GO:0030957 Tat protein binding(GO:0030957)
0.2 1.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.2 1.8 GO:0033038 bitter taste receptor activity(GO:0033038)
0.2 5.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 4.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.8 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.7 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.1 4.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.0 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 2.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.2 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.5 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.9 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 3.7 GO:0031491 nucleosome binding(GO:0031491)
0.1 2.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 3.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 4.4 GO:0019003 GDP binding(GO:0019003)
0.1 1.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 2.0 GO:0015248 sterol transporter activity(GO:0015248)
0.1 5.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 4.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 5.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 13.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.9 GO:0003774 motor activity(GO:0003774)
0.0 10.3 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 1.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 7.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 2.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 3.0 GO:0005262 calcium channel activity(GO:0005262)
0.0 3.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 4.9 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 4.0 GO:0001047 core promoter binding(GO:0001047)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 5.1 GO:0003779 actin binding(GO:0003779)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 4.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 54.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 15.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 7.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 2.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 8.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 12.5 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.2 5.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 8.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 12.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 8.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 3.5 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 9.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 5.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 1.7 PID ALK1 PATHWAY ALK1 signaling events
0.1 4.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 5.8 PID E2F PATHWAY E2F transcription factor network
0.1 3.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.6 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 2.7 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID REELIN PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 24.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
1.6 42.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
1.2 31.7 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.7 6.5 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.7 9.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.6 13.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.5 14.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.4 3.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.3 7.0 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 7.5 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.3 5.8 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 2.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.2 5.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 9.6 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 13.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.2 4.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 5.1 REACTOME KINESINS Genes involved in Kinesins
0.2 8.6 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 2.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 5.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 3.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 7.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 4.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 5.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 3.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.6 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 2.9 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 3.3 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 5.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.0 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 2.9 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway