Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for DLX5
Z-value: 0.04
Motif logo
Transcription factors associated with DLX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DLX5 | hg19_v2_chr7_-_96654133_96654409 | -0.13 | 6.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_74853897 Show fit | 3.18 |
ENST00000296028.3
|
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
|
| chr3_-_105588231 Show fit | 3.01 |
ENST00000545639.1
ENST00000394027.3 ENST00000438603.1 ENST00000447441.1 ENST00000443752.1 |
Cbl proto-oncogene B, E3 ubiquitin protein ligase |
|
| chr15_+_89631647 Show fit | 2.42 |
ENST00000569550.1
ENST00000565066.1 ENST00000565973.1 |
abhydrolase domain containing 2 |
|
| chr7_-_86849883 Show fit | 2.37 |
ENST00000433078.1
|
transmembrane protein 243, mitochondrial |
|
| chr2_+_30369859 Show fit | 1.75 |
ENST00000402003.3
|
yippee-like 5 (Drosophila) |
|
| chrX_-_16887963 Show fit | 1.72 |
ENST00000380084.4
|
retinoblastoma binding protein 7 |
|
| chr12_+_54378923 Show fit | 1.72 |
ENST00000303460.4
|
homeobox C10 |
|
| chr7_+_100770328 Show fit | 1.70 |
ENST00000223095.4
ENST00000445463.2 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
|
| chr3_+_186560476 Show fit | 1.47 |
ENST00000320741.2
ENST00000444204.2 |
adiponectin, C1Q and collagen domain containing |
|
| chr3_+_186560462 Show fit | 1.46 |
ENST00000412955.2
|
adiponectin, C1Q and collagen domain containing |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.2 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.2 | 3.2 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 1.0 | 2.9 | GO:2000532 | renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584) |
| 0.2 | 2.8 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 2.5 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.6 | 1.7 | GO:2000097 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.3 | 1.7 | GO:0010286 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 0.2 | 1.7 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.1 | 1.3 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.0 | 1.2 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 3.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 2.5 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.2 | 1.7 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.1 | 1.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.3 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.2 | 1.1 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.0 | 0.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.9 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.2 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 2.9 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 2.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.4 | 2.8 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.2 | 2.5 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 1.7 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 1.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 1.2 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.0 | 1.1 | GO:0042162 | telomeric DNA binding(GO:0042162) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 2.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.9 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 3.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 1.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 1.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.2 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 1.1 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |