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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for DLX5

Z-value: 0.04

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Transcription factors associated with DLX5

Gene Symbol Gene ID Gene Info
DLX5
ENSG00000105880.4 distal-less homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DLX5hg19_v2_chr7_-_96654133_96654409-0.136.1e-02Click!

Activity profile of DLX5 motif

Sorted Z-values of DLX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_74853897 3.18 ENST00000296028.3
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr3_-_105588231 3.01 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr15_+_89631647 2.42 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr7_-_86849883 2.37 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr2_+_30369859 1.75 ENST00000402003.3
YPEL5
yippee-like 5 (Drosophila)
chrX_-_16887963 1.72 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr12_+_54378923 1.72 ENST00000303460.4
HOXC10
homeobox C10
chr7_+_100770328 1.70 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr3_+_186560476 1.47 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr3_+_186560462 1.46 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr2_+_30369807 1.44 ENST00000379520.3
ENST00000379519.3
ENST00000261353.4
YPEL5
yippee-like 5 (Drosophila)
chr18_-_33709268 1.27 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr2_+_196313239 1.23 ENST00000413290.1
AC064834.1
AC064834.1
chr2_-_183387283 1.19 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr4_-_143767428 1.17 ENST00000513000.1
ENST00000509777.1
ENST00000503927.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr2_-_183387064 1.12 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr3_+_158519654 1.05 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr12_-_50616382 0.86 ENST00000552783.1
LIMA1
LIM domain and actin binding 1
chr11_+_818902 0.82 ENST00000336615.4
PNPLA2
patatin-like phospholipase domain containing 2
chrX_+_100645812 0.79 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr4_-_105416039 0.71 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr12_-_53171128 0.67 ENST00000332411.2
KRT76
keratin 76
chr4_-_7069760 0.64 ENST00000264954.4
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr19_-_14785698 0.60 ENST00000344373.4
ENST00000595472.1
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr12_+_7014126 0.59 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr2_-_183387430 0.53 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr8_-_22526597 0.53 ENST00000519513.1
ENST00000276416.6
ENST00000520292.1
ENST00000522268.1
BIN3
bridging integrator 3
chr19_-_14785674 0.52 ENST00000253673.5
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr19_-_14785622 0.51 ENST00000443157.2
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr4_+_151503077 0.49 ENST00000317605.4
MAB21L2
mab-21-like 2 (C. elegans)
chr7_-_99716952 0.48 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr6_-_112194484 0.46 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
FYN
FYN oncogene related to SRC, FGR, YES
chr11_-_102709441 0.44 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr14_-_24711470 0.44 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr3_-_52567792 0.38 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
NT5DC2
5'-nucleotidase domain containing 2
chr14_-_24711865 0.33 ENST00000399423.4
ENST00000267415.7
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr1_-_23670752 0.31 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr14_-_24711806 0.30 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr4_-_66536057 0.30 ENST00000273854.3
EPHA5
EPH receptor A5
chr11_+_76092353 0.30 ENST00000530460.1
ENST00000321844.4
RP11-111M22.2
Homo sapiens putative uncharacterized protein FLJ37770-like (LOC100506127), mRNA.
chr1_-_23670817 0.28 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr4_-_66536196 0.28 ENST00000511294.1
EPHA5
EPH receptor A5
chr1_-_23670813 0.27 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr14_+_22739823 0.27 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr11_+_73498898 0.26 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr17_-_37009882 0.25 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
RPL23
ribosomal protein L23
chr1_-_78444776 0.24 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr12_+_52695617 0.22 ENST00000293525.5
KRT86
keratin 86
chr6_-_33160231 0.21 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr13_-_36788718 0.18 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr1_+_160160346 0.18 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr13_-_36050819 0.18 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr9_+_34646624 0.17 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr2_-_220118631 0.17 ENST00000248437.4
TUBA4A
tubulin, alpha 4a
chr22_-_30960876 0.17 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_+_54569968 0.17 ENST00000391366.1
AL161915.1
Uncharacterized protein
chr3_-_105587879 0.16 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr5_-_20575959 0.16 ENST00000507958.1
CDH18
cadherin 18, type 2
chr15_+_89164520 0.15 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr9_+_34646651 0.14 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr7_-_14029283 0.14 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr11_-_26743546 0.13 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr1_-_78444738 0.13 ENST00000436586.2
ENST00000370768.2
FUBP1
far upstream element (FUSE) binding protein 1
chr1_+_160160283 0.13 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr19_+_58570605 0.12 ENST00000359978.6
ENST00000401053.4
ENST00000439855.2
ENST00000313434.5
ENST00000511556.1
ENST00000506786.1
ZNF135
zinc finger protein 135
chr11_-_102651343 0.10 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr4_-_8873531 0.10 ENST00000400677.3
HMX1
H6 family homeobox 1
chr1_-_150669500 0.08 ENST00000271732.3
GOLPH3L
golgi phosphoprotein 3-like
chr12_+_81110684 0.07 ENST00000228644.3
MYF5
myogenic factor 5
chr19_+_36605850 0.07 ENST00000221855.3
TBCB
tubulin folding cofactor B
chr12_-_10978957 0.06 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr15_+_89631381 0.06 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr9_+_116225999 0.05 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr5_-_58571935 0.04 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_39979576 0.03 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr1_-_150669604 0.02 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr11_-_71823715 0.01 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr12_+_7014064 0.01 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr12_+_7013897 0.00 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr2_-_172290482 0.00 ENST00000442541.1
ENST00000392599.2
ENST00000375258.4
METTL8
methyltransferase like 8

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:2000532 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.6 1.7 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.3 1.7 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.3 3.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.2 1.7 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.2 1.1 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.2 2.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 3.2 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 1.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.7 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.3 GO:0006258 UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499)
0.1 2.5 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.5 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.1 0.8 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.1 0.7 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.5 GO:0009826 unidimensional cell growth(GO:0009826)
0.1 0.2 GO:0060023 soft palate development(GO:0060023)
0.1 0.3 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.4 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.9 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.3 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.6 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.5 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.2 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.9 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.1 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.2 1.7 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.2 2.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 0.6 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 6.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 1.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0014802 terminal cisterna(GO:0014802)
0.0 1.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 3.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.9 GO:0045095 keratin filament(GO:0045095)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 1.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.2 2.9 GO:0033691 sialic acid binding(GO:0033691)
0.2 3.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 2.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.8 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.5 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 2.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 1.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.2 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 1.1 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID CD40 PATHWAY CD40/CD40L signaling
0.0 2.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 2.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 2.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 3.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 3.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)