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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for E2F2_E2F5

Z-value: 1.76

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Transcription factors associated with E2F2_E2F5

Gene Symbol Gene ID Gene Info
ENSG00000007968.6 E2F transcription factor 2
ENSG00000133740.6 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F2hg19_v2_chr1_-_23857698_23857733-0.468.6e-13Click!
E2F5hg19_v2_chr8_+_86099884_860999200.413.2e-10Click!

Activity profile of E2F2_E2F5 motif

Sorted Z-values of E2F2_E2F5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_64673630 156.03 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
chr2_+_10262857 152.65 ENST00000304567.5
ribonucleotide reductase M2
chr2_-_136633940 143.42 ENST00000264156.2
minichromosome maintenance complex component 6
chr10_+_62538089 141.94 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
cyclin-dependent kinase 1
chr10_+_62538248 127.75 ENST00000448257.2
cyclin-dependent kinase 1
chr8_-_124408652 118.04 ENST00000287394.5
ATPase family, AAA domain containing 2
chr6_+_24775153 110.76 ENST00000356509.3
ENST00000230056.3
geminin, DNA replication inhibitor
chr6_-_52149475 109.35 ENST00000419835.2
ENST00000229854.7
ENST00000596288.1
minichromosome maintenance complex component 3
chr3_+_127317066 105.24 ENST00000265056.7
minichromosome maintenance complex component 2
chr20_+_25388293 104.83 ENST00000262460.4
ENST00000429262.2
GINS complex subunit 1 (Psf1 homolog)
chr19_-_10305752 102.39 ENST00000540357.1
ENST00000359526.4
ENST00000340748.4
DNA (cytosine-5-)-methyltransferase 1
chr7_-_99699538 85.19 ENST00000343023.6
ENST00000303887.5
minichromosome maintenance complex component 7
chr7_+_26241310 84.59 ENST00000396386.2
chromobox homolog 3
chr7_+_26241325 83.12 ENST00000456948.1
ENST00000409747.1
chromobox homolog 3
chr15_-_64673665 71.84 ENST00000300035.4
KIAA0101
chr5_-_79950371 63.57 ENST00000511032.1
ENST00000504396.1
ENST00000505337.1
dihydrofolate reductase
chr1_-_26232951 60.40 ENST00000426559.2
ENST00000455785.2
stathmin 1
chr18_+_19192228 59.84 ENST00000300413.5
ENST00000579618.1
ENST00000582475.1
small nuclear ribonucleoprotein D1 polypeptide 16kDa
chr6_-_17706618 57.72 ENST00000262077.2
ENST00000537253.1
nucleoporin 153kDa
chr5_-_79950775 57.08 ENST00000439211.2
dihydrofolate reductase
chr22_+_35796108 56.60 ENST00000382011.5
ENST00000416905.1
minichromosome maintenance complex component 5
chr7_-_148581251 53.64 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
enhancer of zeste homolog 2 (Drosophila)
chr13_+_114238997 51.95 ENST00000538138.1
ENST00000375370.5
transcription factor Dp-1
chr1_+_212208919 51.89 ENST00000366991.4
ENST00000542077.1
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr15_-_66649010 51.47 ENST00000367709.4
ENST00000261881.4
TIMELESS interacting protein
chr1_-_26232522 51.02 ENST00000399728.1
stathmin 1
chr22_+_35796056 50.66 ENST00000216122.4
minichromosome maintenance complex component 5
chr7_-_148581360 50.24 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
enhancer of zeste homolog 2 (Drosophila)
chr2_+_232573222 49.18 ENST00000341369.7
ENST00000409683.1
prothymosin, alpha
chr10_+_112327425 48.63 ENST00000361804.4
structural maintenance of chromosomes 3
chr7_-_158497431 48.28 ENST00000449727.2
ENST00000409339.3
ENST00000409423.1
ENST00000356309.3
non-SMC condensin II complex, subunit G2
chr14_-_50154921 46.65 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
polymerase (DNA directed), epsilon 2, accessory subunit
chr14_+_51706886 46.53 ENST00000457354.2
thioredoxin-related transmembrane protein 1
chrX_+_123095546 46.29 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
stromal antigen 2
chr2_-_47168850 46.00 ENST00000409207.1
multiple coagulation factor deficiency 2
chr3_+_44803209 45.40 ENST00000326047.4
kinesin family member 15
chr14_-_69864993 44.78 ENST00000555373.1
enhancer of rudimentary homolog (Drosophila)
chr5_+_36152091 44.04 ENST00000274254.5
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr4_-_174256276 42.76 ENST00000296503.5
high mobility group box 2
chr2_+_48010312 41.80 ENST00000540021.1
mutS homolog 6
chr10_-_58120996 41.47 ENST00000361148.6
ENST00000395405.1
ENST00000373944.3
ZW10 interacting kinetochore protein
chr20_-_32274179 40.36 ENST00000343380.5
E2F transcription factor 1
chr2_+_48010221 39.78 ENST00000234420.5
mutS homolog 6
chr9_-_35080013 37.41 ENST00000378643.3
Fanconi anemia, complementation group G
chr11_+_64808368 36.54 ENST00000531072.1
ENST00000398846.1
SAC3 domain containing 1
chr7_-_94285511 36.30 ENST00000265735.7
sarcoglycan, epsilon
chr6_+_24775641 36.29 ENST00000378054.2
ENST00000476555.1
geminin, DNA replication inhibitor
chr7_-_94285472 35.61 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
sarcoglycan, epsilon
chr5_+_36152163 35.42 ENST00000274255.6
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr11_+_125495862 35.21 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
checkpoint kinase 1
chr19_+_36705504 35.13 ENST00000456324.1
zinc finger protein 146
chr10_+_13203543 34.58 ENST00000378714.3
ENST00000479669.1
ENST00000484800.2
minichromosome maintenance complex component 10
chr8_+_128748308 34.47 ENST00000377970.2
v-myc avian myelocytomatosis viral oncogene homolog
chr11_+_4116054 34.33 ENST00000423050.2
ribonucleotide reductase M1
chr16_-_3030407 34.02 ENST00000431515.2
ENST00000574385.1
ENST00000576268.1
ENST00000574730.1
ENST00000575632.1
ENST00000573944.1
ENST00000262300.8
protein kinase, membrane associated tyrosine/threonine 1
chr2_+_232573208 33.52 ENST00000409115.3
prothymosin, alpha
chr11_+_64808675 33.35 ENST00000529996.1
SAC3 domain containing 1
chr7_+_26240776 32.76 ENST00000337620.4
chromobox homolog 3
chr22_+_35653445 32.55 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMG box domain containing 4
chr2_-_47168906 32.09 ENST00000444761.2
ENST00000409147.1
multiple coagulation factor deficiency 2
chr19_+_36706024 31.98 ENST00000443387.2
zinc finger protein 146
chr22_+_20105259 31.24 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RAN binding protein 1
chr16_-_3030283 31.04 ENST00000572619.1
ENST00000574415.1
ENST00000440027.2
ENST00000572059.1
protein kinase, membrane associated tyrosine/threonine 1
chr7_-_94285402 30.83 ENST00000428696.2
ENST00000445866.2
sarcoglycan, epsilon
chr16_-_85722530 30.48 ENST00000253462.3
GINS complex subunit 2 (Psf2 homolog)
chr1_-_26233423 29.67 ENST00000357865.2
stathmin 1
chr3_-_133380731 29.49 ENST00000260810.5
topoisomerase (DNA) II binding protein 1
chrX_+_106871713 29.42 ENST00000372435.4
ENST00000372428.4
ENST00000372419.3
ENST00000543248.1
phosphoribosyl pyrophosphate synthetase 1
chr17_-_17184605 28.62 ENST00000268717.5
COP9 signalosome subunit 3
chr17_+_30264014 27.64 ENST00000322652.5
ENST00000580398.1
SUZ12 polycomb repressive complex 2 subunit
chr22_+_20105012 27.64 ENST00000331821.3
ENST00000411892.1
RAN binding protein 1
chr1_-_222885770 27.53 ENST00000355727.2
ENST00000340020.6
axin interactor, dorsalization associated
chr7_+_94285637 27.21 ENST00000482108.1
ENST00000488574.1
paternally expressed 10
chr12_-_31479045 26.72 ENST00000539409.1
ENST00000395766.1
family with sequence similarity 60, member A
chrX_+_118708517 24.85 ENST00000346330.3
ubiquitin-conjugating enzyme E2A
chr7_+_120591170 24.83 ENST00000431467.1
inhibitor of growth family, member 3
chr20_-_5100591 24.69 ENST00000379143.5
proliferating cell nuclear antigen
chr12_+_109535923 24.54 ENST00000336865.2
uracil-DNA glycosylase
chr6_+_135502466 23.87 ENST00000367814.4
v-myb avian myeloblastosis viral oncogene homolog
chr8_+_128748466 23.36 ENST00000524013.1
ENST00000520751.1
v-myc avian myelocytomatosis viral oncogene homolog
chrX_+_21958814 23.29 ENST00000379404.1
ENST00000415881.2
spermine synthase
chr1_-_205719295 23.22 ENST00000367142.4
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr7_+_139044621 23.19 ENST00000354926.4
C7orf55-LUC7L2 readthrough
chr17_-_56084578 23.12 ENST00000582730.2
ENST00000584773.1
ENST00000585096.1
ENST00000258962.4
serine/arginine-rich splicing factor 1
chr14_+_35452104 23.03 ENST00000216774.6
ENST00000546080.1
signal recognition particle 54kDa
chrX_+_21958674 22.82 ENST00000404933.2
spermine synthase
chr6_-_27114577 22.66 ENST00000356950.1
ENST00000396891.4
histone cluster 1, H2bk
chr9_+_106856831 22.55 ENST00000303219.8
ENST00000374787.3
structural maintenance of chromosomes 2
chr6_+_135502408 22.20 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
v-myb avian myeloblastosis viral oncogene homolog
chr10_-_13390021 22.01 ENST00000537130.1
selenophosphate synthetase 1
chr11_+_47236489 22.01 ENST00000256996.4
ENST00000378603.3
ENST00000378600.3
ENST00000378601.3
damage-specific DNA binding protein 2, 48kDa
chrX_+_118708493 21.40 ENST00000371558.2
ubiquitin-conjugating enzyme E2A
chrX_-_53449593 20.94 ENST00000375340.6
ENST00000322213.4
structural maintenance of chromosomes 1A
chr11_+_9406169 20.90 ENST00000379719.3
ENST00000527431.1
importin 7
chr14_+_35452169 20.85 ENST00000555557.1
signal recognition particle 54kDa
chr11_-_19263145 20.78 ENST00000532666.1
ENST00000527884.1
E2F transcription factor 8
chr4_+_71859156 20.57 ENST00000286648.5
ENST00000504730.1
ENST00000504952.1
deoxycytidine kinase
chr8_+_48873453 20.12 ENST00000523944.1
minichromosome maintenance complex component 4
chr8_+_48873479 19.34 ENST00000262105.2
minichromosome maintenance complex component 4
chr11_-_118966167 19.10 ENST00000530167.1
H2A histone family, member X
chrX_+_24711997 19.04 ENST00000379068.3
ENST00000379059.3
polymerase (DNA directed), alpha 1, catalytic subunit
chr2_-_38978492 18.25 ENST00000409276.1
ENST00000446327.2
ENST00000313117.6
serine/arginine-rich splicing factor 7
chr3_+_52719936 18.19 ENST00000418458.1
ENST00000394799.2
guanine nucleotide binding protein-like 3 (nucleolar)
chr16_-_12009833 17.92 ENST00000420576.2
G1 to S phase transition 1
chr19_+_16187085 17.86 ENST00000300933.4
tropomyosin 4
chr4_+_129730779 17.76 ENST00000226319.6
jade family PHD finger 1
chr4_+_129730947 17.61 ENST00000452328.2
ENST00000504089.1
jade family PHD finger 1
chr3_-_141868293 17.46 ENST00000317104.7
ENST00000494358.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_-_203103281 17.41 ENST00000392244.3
ENST00000409181.1
ENST00000409712.1
ENST00000409498.2
ENST00000409368.1
ENST00000392245.1
ENST00000392246.2
small ubiquitin-like modifier 1
chr16_-_23607598 17.32 ENST00000562133.1
ENST00000570319.1
ENST00000007516.3
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr4_-_170679024 17.30 ENST00000393381.2
chromosome 4 open reading frame 27
chr7_-_44887620 17.29 ENST00000349299.3
ENST00000521529.1
ENST00000308153.4
ENST00000350771.3
ENST00000222690.6
ENST00000381124.5
ENST00000437072.1
ENST00000446531.1
H2A histone family, member V
chr12_+_57623869 16.82 ENST00000414700.3
ENST00000557703.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr7_+_120590803 16.49 ENST00000315870.5
ENST00000339121.5
ENST00000445699.1
inhibitor of growth family, member 3
chr1_-_28241226 16.31 ENST00000373912.3
ENST00000373909.3
replication protein A2, 32kDa
chr5_+_43121698 16.29 ENST00000505606.2
ENST00000509634.1
ENST00000509341.1
zinc finger protein 131
chr16_+_29817399 16.12 ENST00000545521.1
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_+_47630108 16.09 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
mutS homolog 2
chr7_+_6048856 15.99 ENST00000223029.3
ENST00000400479.2
ENST00000395236.2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chrX_+_131157322 15.69 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
Serine/threonine-protein kinase MST4
chr5_+_140019079 15.51 ENST00000252100.6
transmembrane and coiled-coil domains 6
chrX_+_131157290 15.47 ENST00000394334.2
Serine/threonine-protein kinase MST4
chr3_+_14219858 15.41 ENST00000306024.3
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr14_+_75348592 14.96 ENST00000334220.4
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr1_+_33116743 14.93 ENST00000414241.3
ENST00000373493.5
retinoblastoma binding protein 4
chr9_+_86595626 14.76 ENST00000445877.1
ENST00000325875.3
RecQ mediated genome instability 1
chr2_-_27632390 14.76 ENST00000350803.4
ENST00000344034.4
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr5_+_43121607 14.39 ENST00000509156.1
ENST00000508259.1
ENST00000306938.4
ENST00000399534.1
zinc finger protein 131
chr12_+_57623477 14.28 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr6_-_5260963 14.13 ENST00000464010.1
ENST00000468929.1
ENST00000480566.1
LYR motif containing 4
chr5_+_138629389 13.98 ENST00000504045.1
ENST00000504311.1
ENST00000502499.1
matrin 3
chr1_-_24306835 13.82 ENST00000484146.2
serine/arginine-rich splicing factor 10
chr6_+_31633011 13.52 ENST00000375885.4
casein kinase 2, beta polypeptide
chr19_+_10765699 13.45 ENST00000590009.1
interleukin enhancer binding factor 3, 90kDa
chr3_-_185655795 13.25 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
transformer 2 beta homolog (Drosophila)
chr5_+_138629417 13.20 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
matrin 3
chr5_+_138629337 13.18 ENST00000394805.3
ENST00000512876.1
ENST00000513678.1
matrin 3
chr9_+_106856541 13.12 ENST00000286398.7
ENST00000440179.1
ENST00000374793.3
structural maintenance of chromosomes 2
chr11_+_74303575 13.09 ENST00000263681.2
polymerase (DNA-directed), delta 3, accessory subunit
chr3_-_10028366 12.52 ENST00000429759.1
ER membrane protein complex subunit 3
chr19_-_50432782 12.33 ENST00000413454.1
ENST00000596437.1
ENST00000341114.3
ENST00000595948.1
nucleoporin 62kDa
interleukin 4 induced 1
chr14_+_64854958 12.26 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr16_+_67596310 12.11 ENST00000264010.4
ENST00000401394.1
CCCTC-binding factor (zinc finger protein)
chr8_-_120868078 12.06 ENST00000313655.4
DNA replication and sister chromatid cohesion 1
chr10_-_13390270 11.85 ENST00000378614.4
ENST00000545675.1
ENST00000327347.5
selenophosphate synthetase 1
chrX_-_106243451 11.82 ENST00000355610.4
ENST00000535534.1
MORC family CW-type zinc finger 4
chr17_+_3572087 11.80 ENST00000248378.5
ENST00000397133.2
ER membrane protein complex subunit 6
chr5_+_140019004 11.66 ENST00000394671.3
ENST00000511410.1
ENST00000537378.1
transmembrane and coiled-coil domains 6
chr16_+_28962128 11.59 ENST00000564978.1
ENST00000320805.4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr6_+_88299833 11.06 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
origin recognition complex, subunit 3
chr1_-_54303934 10.96 ENST00000537333.1
NDC1 transmembrane nucleoporin
chr12_+_122326662 10.54 ENST00000261817.2
ENST00000538613.1
ENST00000542602.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr1_-_23670813 10.23 ENST00000374612.1
heterogeneous nuclear ribonucleoprotein R
chr6_-_160210604 9.95 ENST00000420894.2
ENST00000539756.1
ENST00000544255.1
t-complex 1
chr10_+_73724123 9.86 ENST00000373115.4
carbohydrate (chondroitin 6) sulfotransferase 3
chr8_-_67525473 9.80 ENST00000522677.3
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr1_-_23670817 9.79 ENST00000478691.1
heterogeneous nuclear ribonucleoprotein R
chr17_-_57184064 9.77 ENST00000262294.7
tripartite motif containing 37
chr17_-_74733404 9.72 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
serine/arginine-rich splicing factor 2
chr2_-_174830430 9.68 ENST00000310015.6
ENST00000455789.2
Sp3 transcription factor
chr6_+_30312908 9.67 ENST00000433076.2
ENST00000442966.2
ENST00000428040.2
ENST00000436442.2
ribonuclease P/MRP 21kDa subunit
chr12_+_122326630 9.60 ENST00000541212.1
ENST00000340175.5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr17_-_57184260 9.21 ENST00000376149.3
ENST00000393066.3
tripartite motif containing 37
chr17_-_73781567 9.14 ENST00000586607.1
H3 histone, family 3B (H3.3B)
chrX_+_70752917 9.09 ENST00000373719.3
O-linked N-acetylglucosamine (GlcNAc) transferase
chr14_-_68141535 9.03 ENST00000554659.1
vesicle transport through interaction with t-SNAREs 1B
chr11_-_64546202 8.90 ENST00000377390.3
ENST00000227503.9
ENST00000377394.3
ENST00000422298.2
ENST00000334944.5
splicing factor 1
chr22_-_29137771 8.73 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
checkpoint kinase 2
chr3_+_41240925 8.72 ENST00000396183.3
ENST00000349496.5
ENST00000453024.1
catenin (cadherin-associated protein), beta 1, 88kDa
chr2_-_100106419 8.55 ENST00000393445.3
ENST00000258428.3
REV1, polymerase (DNA directed)
chr3_-_141868357 8.54 ENST00000489671.1
ENST00000475734.1
ENST00000467072.1
ENST00000499676.2
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_-_235405679 8.50 ENST00000390645.2
ADP-ribosylation factor-like 4C
chr3_-_48229846 8.34 ENST00000302506.3
ENST00000351231.3
ENST00000437972.1
cell division cycle 25A
chr5_-_137548997 8.16 ENST00000505120.1
ENST00000394886.2
ENST00000394884.3
cell division cycle 23
chr18_-_54318353 8.08 ENST00000590954.1
ENST00000540155.1
thioredoxin-like 1
chr17_+_48796905 7.87 ENST00000505658.1
ENST00000393227.2
ENST00000240304.1
ENST00000311571.3
ENST00000505619.1
ENST00000544170.1
ENST00000510984.1
LUC7-like 3 (S. cerevisiae)
chr1_+_86046433 7.82 ENST00000451137.2
cysteine-rich, angiogenic inducer, 61
chr12_+_53848505 7.80 ENST00000552819.1
ENST00000455667.3
poly(rC) binding protein 2
chr6_+_35995488 7.80 ENST00000229795.3
mitogen-activated protein kinase 14
chr13_+_45694583 7.74 ENST00000340473.6
general transcription factor IIF, polypeptide 2, 30kDa
chr6_+_4021554 7.73 ENST00000337659.6
pre-mRNA processing factor 4B
chr5_+_74062806 7.62 ENST00000296802.5
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr2_-_17935059 7.62 ENST00000448223.2
ENST00000381272.4
ENST00000351948.4
structural maintenance of chromosomes 6
chr6_+_27114861 7.56 ENST00000377459.1
histone cluster 1, H2ah
chr6_+_35995531 7.34 ENST00000229794.4
mitogen-activated protein kinase 14
chr6_-_160210715 7.32 ENST00000392168.2
ENST00000321394.7
t-complex 1
chr3_-_51975942 7.21 ENST00000232888.6
ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
chr2_-_203103185 6.98 ENST00000409205.1
small ubiquitin-like modifier 1
chr16_-_12009735 6.80 ENST00000439887.2
ENST00000434724.2
G1 to S phase transition 1
chr1_-_25747283 6.75 ENST00000346452.4
ENST00000340849.4
ENST00000349438.4
ENST00000294413.7
ENST00000413854.1
ENST00000455194.1
ENST00000243186.6
ENST00000425135.1
Rh blood group, CcEe antigens
chr22_+_38201114 6.74 ENST00000340857.2
H1 histone family, member 0
chr1_-_23670752 6.62 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
heterogeneous nuclear ribonucleoprotein R
chr16_-_47495170 6.55 ENST00000320640.6
ENST00000544001.2
integrin alpha FG-GAP repeat containing 1
chr11_-_64545941 6.50 ENST00000377387.1
splicing factor 1
chr19_+_2236509 6.48 ENST00000221494.5
splicing factor 3a, subunit 2, 66kDa
chr6_+_135502501 6.24 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
v-myb avian myeloblastosis viral oncogene homolog
chr17_+_57642886 6.22 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr4_+_30721968 6.08 ENST00000361762.2
protocadherin 7
chr17_-_56065484 6.05 ENST00000581208.1
vascular endothelial zinc finger 1
chr19_+_49588690 6.03 ENST00000221448.5
small nuclear ribonucleoprotein 70kDa (U1)

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
44.9 269.7 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
37.7 377.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
34.6 103.9 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
30.2 120.7 GO:0046452 dihydrofolate metabolic process(GO:0046452)
28.6 114.5 GO:0010216 maintenance of DNA methylation(GO:0010216)
28.2 141.1 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
24.5 147.1 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
17.4 52.3 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
15.7 78.7 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
15.4 46.1 GO:0006597 spermine biosynthetic process(GO:0006597)
15.1 150.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
14.6 43.9 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
13.1 118.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
12.9 51.5 GO:0048478 replication fork protection(GO:0048478)
12.3 24.7 GO:0006272 leading strand elongation(GO:0006272)
11.7 81.6 GO:0000710 meiotic mismatch repair(GO:0000710)
11.3 33.9 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
11.1 11.1 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
10.5 115.9 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
10.1 372.0 GO:0006270 DNA replication initiation(GO:0006270)
9.6 57.8 GO:0072131 kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
9.2 92.3 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
8.2 24.7 GO:0002184 cytoplasmic translational termination(GO:0002184)
8.1 187.0 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
8.1 24.4 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
7.8 31.1 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
7.4 29.4 GO:0046101 hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
6.6 39.3 GO:0035822 gene conversion(GO:0035822)
6.3 19.0 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
5.9 35.2 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
5.3 42.8 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
5.3 16.0 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
5.0 15.0 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
4.5 9.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
4.5 35.7 GO:0010032 meiotic chromosome condensation(GO:0010032)
4.4 57.7 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
4.4 21.9 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
4.4 8.7 GO:0070602 regulation of centromeric sister chromatid cohesion(GO:0070602)
4.1 28.5 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
4.0 20.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
3.7 14.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
3.7 11.0 GO:0071789 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
3.5 17.3 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
3.4 20.6 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157)
3.3 13.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
3.1 12.3 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
2.9 8.7 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
2.8 22.0 GO:0006290 pyrimidine dimer repair(GO:0006290)
2.6 23.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
2.5 27.5 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262)
2.4 12.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
2.2 35.0 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
2.0 35.5 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
1.9 24.5 GO:0045008 depyrimidination(GO:0045008)
1.9 11.2 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
1.8 81.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
1.8 28.6 GO:0000338 protein deneddylation(GO:0000338)
1.8 86.5 GO:0006301 postreplication repair(GO:0006301)
1.7 17.3 GO:0009249 protein lipoylation(GO:0009249)
1.7 6.9 GO:0032954 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
1.7 8.5 GO:0032456 endocytic recycling(GO:0032456)
1.7 13.5 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
1.7 14.9 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.6 9.7 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
1.5 44.8 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
1.5 24.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
1.5 5.9 GO:0097167 circadian regulation of translation(GO:0097167)
1.5 5.8 GO:0031291 Ran protein signal transduction(GO:0031291)
1.4 41.3 GO:0043968 histone H2A acetylation(GO:0043968)
1.3 5.3 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
1.3 78.1 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
1.3 9.0 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
1.1 195.2 GO:0006338 chromatin remodeling(GO:0006338)
1.1 26.6 GO:0061157 mRNA destabilization(GO:0061157)
1.1 17.7 GO:0070734 histone H3-K27 methylation(GO:0070734)
1.1 7.6 GO:0000722 telomere maintenance via recombination(GO:0000722)
1.1 5.3 GO:0060356 leucine import(GO:0060356)
1.0 26.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.9 3.7 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.9 7.8 GO:0060591 apoptotic process involved in heart morphogenesis(GO:0003278) chondroblast differentiation(GO:0060591)
0.8 14.8 GO:0000732 strand displacement(GO:0000732)
0.8 18.3 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.8 2.3 GO:0061010 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088) gall bladder development(GO:0061010)
0.8 13.5 GO:0002227 innate immune response in mucosa(GO:0002227)
0.7 15.4 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.7 2.2 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.7 5.7 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.7 3.4 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.7 54.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.7 4.0 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.6 3.9 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.6 7.7 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.6 7.8 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.6 3.4 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.6 9.7 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.5 1.6 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.5 9.7 GO:0033197 response to vitamin E(GO:0033197)
0.5 49.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.5 8.2 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.5 3.3 GO:0001675 acrosome assembly(GO:0001675)
0.4 45.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.4 40.5 GO:0007062 sister chromatid cohesion(GO:0007062)
0.4 7.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.4 16.4 GO:0006342 chromatin silencing(GO:0006342)
0.4 3.3 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.4 1.2 GO:0042727 flavin-containing compound biosynthetic process(GO:0042727)
0.3 3.4 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.3 6.7 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.3 19.7 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.3 10.0 GO:0005980 glycogen catabolic process(GO:0005980)
0.3 9.9 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.3 88.0 GO:0007160 cell-matrix adhesion(GO:0007160)
0.3 7.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.2 3.9 GO:0006284 base-excision repair(GO:0006284)
0.2 17.9 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.2 1.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.2 3.2 GO:1903432 regulation of TORC1 signaling(GO:1903432)
0.2 12.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 4.1 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.1 1.8 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.1 4.8 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.1 1.8 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.1 3.9 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 25.8 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.1 11.6 GO:0016925 protein sumoylation(GO:0016925)
0.1 20.1 GO:0030336 negative regulation of cell migration(GO:0030336)
0.1 6.1 GO:0001885 endothelial cell development(GO:0001885)
0.1 5.8 GO:0001541 ovarian follicle development(GO:0001541)
0.1 21.7 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744)
0.1 3.7 GO:0046677 response to antibiotic(GO:0046677)
0.1 2.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 3.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 6.1 GO:0002576 platelet degranulation(GO:0002576)
0.0 7.2 GO:0006364 rRNA processing(GO:0006364)
0.0 0.2 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.0 GO:0042023 regulation of DNA endoreduplication(GO:0032875) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0033504 floor plate development(GO:0033504)
0.0 0.5 GO:0051865 protein autoubiquitination(GO:0051865)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
53.9 269.7 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
46.7 187.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
45.4 589.9 GO:0042555 MCM complex(GO:0042555)
33.8 135.3 GO:0000811 GINS complex(GO:0000811)
24.4 97.7 GO:0032301 MutSalpha complex(GO:0032301)
16.2 48.6 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
15.1 45.4 GO:0005873 plus-end kinesin complex(GO:0005873)
14.3 86.0 GO:0031298 replication fork protection complex(GO:0031298)
14.2 199.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
13.5 40.4 GO:0035189 Rb-E2F complex(GO:0035189)
12.8 102.7 GO:0016012 sarcoglycan complex(GO:0016012)
11.1 11.1 GO:0031261 DNA replication preinitiation complex(GO:0031261)
10.3 41.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
9.3 83.9 GO:0000796 condensin complex(GO:0000796)
9.2 46.2 GO:0033503 HULC complex(GO:0033503)
9.2 73.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
8.4 41.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
8.2 24.7 GO:0018444 translation release factor complex(GO:0018444)
8.2 24.7 GO:0070557 PCNA-p21 complex(GO:0070557)
8.0 103.9 GO:0045120 pronucleus(GO:0045120)
7.9 102.4 GO:0005721 pericentric heterochromatin(GO:0005721)
7.5 59.8 GO:0034715 pICln-Sm protein complex(GO:0034715)
7.4 29.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
7.0 20.9 GO:0030893 meiotic cohesin complex(GO:0030893)
6.8 47.5 GO:0016589 NURF complex(GO:0016589)
6.1 24.4 GO:0031510 SUMO activating enzyme complex(GO:0031510)
5.5 43.9 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
4.8 57.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
4.6 27.6 GO:0001739 sex chromatin(GO:0001739)
4.5 18.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
4.5 44.8 GO:0034709 methylosome(GO:0034709)
3.9 11.8 GO:1903349 omegasome membrane(GO:1903349)
3.9 31.1 GO:0070552 BRISC complex(GO:0070552)
3.8 19.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
3.7 48.6 GO:0001673 male germ cell nucleus(GO:0001673)
3.7 11.0 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
3.5 17.3 GO:0035061 interchromatin granule(GO:0035061)
3.4 3.4 GO:0032302 MutSbeta complex(GO:0032302)
2.6 7.7 GO:0005674 transcription factor TFIIF complex(GO:0005674)
2.4 7.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
2.2 15.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
2.1 15.0 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
2.0 12.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.9 13.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
1.7 8.7 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
1.6 12.5 GO:0072546 ER membrane protein complex(GO:0072546)
1.5 26.7 GO:0016580 Sin3 complex(GO:0016580)
1.4 78.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
1.3 25.5 GO:0071004 U2-type prespliceosome(GO:0071004)
1.3 17.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
1.2 6.9 GO:0044613 nuclear pore central transport channel(GO:0044613)
1.1 10.0 GO:0005964 phosphorylase kinase complex(GO:0005964)
1.1 5.3 GO:0033553 rDNA heterochromatin(GO:0033553)
1.1 20.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
1.0 87.1 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
1.0 9.7 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
1.0 20.9 GO:0035861 site of double-strand break(GO:0035861)
0.9 17.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.8 23.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.8 3.9 GO:0034457 Mpp10 complex(GO:0034457)
0.8 53.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.8 16.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.8 9.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.6 28.6 GO:0008180 COP9 signalosome(GO:0008180)
0.6 102.2 GO:0000775 chromosome, centromeric region(GO:0000775)
0.5 3.2 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.4 57.9 GO:0016363 nuclear matrix(GO:0016363)
0.4 29.5 GO:0000793 condensed chromosome(GO:0000793)
0.4 30.0 GO:0005643 nuclear pore(GO:0005643)
0.4 1.1 GO:1990075 periciliary membrane compartment(GO:1990075)
0.3 4.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.3 30.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.3 21.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 57.3 GO:0005819 spindle(GO:0005819)
0.3 8.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 7.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 6.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 21.6 GO:0005681 spliceosomal complex(GO:0005681)
0.2 6.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 97.3 GO:0005874 microtubule(GO:0005874)
0.2 26.2 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.2 5.9 GO:0016592 mediator complex(GO:0016592)
0.2 25.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 2.3 GO:0000785 chromatin(GO:0000785)
0.2 4.0 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 3.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 41.9 GO:0005635 nuclear envelope(GO:0005635)
0.1 6.8 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 101.0 GO:0005730 nucleolus(GO:0005730)
0.1 7.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 8.1 GO:0000502 proteasome complex(GO:0000502)
0.1 4.8 GO:0031201 SNARE complex(GO:0031201)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 5.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 30.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 7.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 7.8 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
46.7 187.0 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
24.4 97.7 GO:0032143 single thymine insertion binding(GO:0032143)
22.3 200.5 GO:1990226 histone methyltransferase binding(GO:1990226)
20.1 120.7 GO:0051870 methotrexate binding(GO:0051870)
18.0 71.9 GO:0036033 mediator complex binding(GO:0036033)
17.1 102.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
15.2 258.1 GO:0003688 DNA replication origin binding(GO:0003688)
14.6 131.5 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
11.3 33.9 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
11.3 135.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
11.2 269.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
10.7 42.8 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
9.4 28.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
8.8 43.9 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
8.4 268.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
7.1 71.0 GO:1990446 U1 snRNP binding(GO:1990446)
6.9 20.6 GO:0004137 deoxycytidine kinase activity(GO:0004137)
6.4 44.8 GO:0050733 RS domain binding(GO:0050733)
5.9 35.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
5.8 17.3 GO:0031177 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
4.9 29.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
4.4 31.1 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
4.1 24.7 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
4.1 12.3 GO:0004487 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
3.9 3.9 GO:0000405 bubble DNA binding(GO:0000405)
3.7 15.0 GO:0016748 succinyltransferase activity(GO:0016748)
3.1 24.5 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
3.0 24.4 GO:0044388 small protein activating enzyme binding(GO:0044388)
3.0 9.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
2.9 57.7 GO:0043495 protein anchor(GO:0043495)
2.7 78.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
2.7 5.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
2.5 9.9 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
2.3 16.1 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
2.2 46.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
2.0 44.8 GO:0008327 methyl-CpG binding(GO:0008327)
2.0 5.9 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
1.9 192.7 GO:0070491 repressing transcription factor binding(GO:0070491)
1.7 17.3 GO:0051525 NFAT protein binding(GO:0051525)
1.5 16.9 GO:0098505 single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505)
1.5 89.4 GO:0035064 methylated histone binding(GO:0035064)
1.3 7.8 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
1.3 14.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.3 13.9 GO:0019869 chloride channel inhibitor activity(GO:0019869)
1.2 7.2 GO:0034511 U3 snoRNA binding(GO:0034511)
1.2 11.6 GO:0031386 protein tag(GO:0031386)
1.2 8.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
1.2 55.3 GO:0008536 Ran GTPase binding(GO:0008536)
1.1 10.0 GO:0004689 phosphorylase kinase activity(GO:0004689)
1.1 38.4 GO:0036002 pre-mRNA binding(GO:0036002)
1.1 46.2 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
1.0 137.8 GO:0042393 histone binding(GO:0042393)
1.0 125.0 GO:0004386 helicase activity(GO:0004386)
0.8 4.0 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.7 6.9 GO:0051425 PTB domain binding(GO:0051425)
0.7 61.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.6 18.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.6 6.7 GO:0003680 AT DNA binding(GO:0003680)
0.6 9.7 GO:0004526 ribonuclease P activity(GO:0004526)
0.6 3.4 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.6 20.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.5 45.4 GO:0003777 microtubule motor activity(GO:0003777)
0.5 5.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.5 28.2 GO:0003684 damaged DNA binding(GO:0003684)
0.5 46.1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.5 17.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.4 11.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 19.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.4 5.6 GO:0016018 cyclosporin A binding(GO:0016018)
0.4 25.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3 69.1 GO:0008201 heparin binding(GO:0008201)
0.3 8.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 99.7 GO:0015631 tubulin binding(GO:0015631)
0.3 26.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.3 41.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.3 67.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 3.7 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 27.2 GO:0008565 protein transporter activity(GO:0008565)
0.2 3.8 GO:0048038 quinone binding(GO:0048038)
0.2 36.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 1.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 3.9 GO:0030515 snoRNA binding(GO:0030515)
0.2 17.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 12.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 12.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.2 16.0 GO:0032947 protein complex scaffold(GO:0032947)
0.1 5.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 58.4 GO:0008134 transcription factor binding(GO:0008134)
0.1 22.8 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 27.5 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 48.1 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 9.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.3 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 38.7 GO:0005198 structural molecule activity(GO:0005198)
0.1 6.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 31.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
20.8 290.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
7.2 129.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
4.9 587.5 PID E2F PATHWAY E2F transcription factor network
3.2 182.1 PID ATR PATHWAY ATR signaling pathway
2.9 97.4 PID ATM PATHWAY ATM pathway
2.5 203.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
2.2 24.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
2.0 63.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
1.1 52.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.9 46.3 PID PLK1 PATHWAY PLK1 signaling events
0.9 94.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.8 35.7 PID AURORA B PATHWAY Aurora B signaling
0.6 13.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.4 31.2 PID LKB1 PATHWAY LKB1 signaling events
0.3 26.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.3 8.7 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.3 7.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 29.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 9.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 8.6 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.4 PID NOTCH PATHWAY Notch signaling pathway
0.1 3.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 3.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
45.3 725.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
25.5 687.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
9.2 128.8 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
5.1 76.7 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
3.5 69.8 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
2.8 55.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
2.4 42.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
2.2 115.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
2.1 120.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
2.1 185.4 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
2.0 22.0 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
1.8 46.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.8 156.6 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
1.7 64.6 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
1.7 8.7 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.7 45.4 REACTOME KINESINS Genes involved in Kinesins
1.3 78.1 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
1.1 15.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
1.1 34.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.1 14.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.0 24.4 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
1.0 17.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.8 20.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.6 15.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.6 55.8 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.5 28.5 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.5 15.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.5 3.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.5 8.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.5 35.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 16.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 52.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 8.2 REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.4 10.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 9.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.3 17.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 19.2 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 46.2 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 13.5 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.2 13.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 32.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 14.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 4.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 5.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 1.8 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 19.2 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 1.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels