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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for E2F2_E2F5
Z-value: 1.76
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Transcription factors associated with E2F2_E2F5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F2 | hg19_v2_chr1_-_23857698_23857733 | -0.46 | 8.6e-13 | Click! |
| E2F5 | hg19_v2_chr8_+_86099884_86099920 | 0.41 | 3.2e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F2_E2F5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 37.7 | 377.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 10.1 | 372.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 44.9 | 269.7 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 1.1 | 195.2 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 8.1 | 187.0 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 15.1 | 150.9 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 24.5 | 147.1 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 28.2 | 141.1 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 30.2 | 120.7 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 13.1 | 118.0 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 45.4 | 589.9 | GO:0042555 | MCM complex(GO:0042555) |
| 53.9 | 269.7 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 14.2 | 199.1 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 46.7 | 187.0 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 33.8 | 135.3 | GO:0000811 | GINS complex(GO:0000811) |
| 8.0 | 103.9 | GO:0045120 | pronucleus(GO:0045120) |
| 12.8 | 102.7 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 7.9 | 102.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.6 | 102.2 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.1 | 101.0 | GO:0005730 | nucleolus(GO:0005730) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.2 | 269.7 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 8.4 | 268.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 15.2 | 258.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 22.3 | 200.5 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 1.9 | 192.7 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 46.7 | 187.0 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 1.0 | 137.8 | GO:0042393 | histone binding(GO:0042393) |
| 11.3 | 135.3 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 14.6 | 131.5 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 1.0 | 125.0 | GO:0004386 | helicase activity(GO:0004386) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 587.5 | PID E2F PATHWAY | E2F transcription factor network |
| 20.8 | 290.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 2.5 | 203.7 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 3.2 | 182.1 | PID ATR PATHWAY | ATR signaling pathway |
| 7.2 | 129.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 2.9 | 97.4 | PID ATM PATHWAY | ATM pathway |
| 0.9 | 94.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.0 | 63.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 1.1 | 52.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.9 | 46.3 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 45.3 | 725.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 25.5 | 687.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 2.1 | 185.4 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 1.8 | 156.6 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 9.2 | 128.8 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 2.1 | 120.3 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 2.2 | 115.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 1.3 | 78.1 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 5.1 | 76.7 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 3.5 | 69.8 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |