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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for E2F3
Z-value: 1.76
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Transcription factors associated with E2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F3 | hg19_v2_chr6_+_20403997_20404034 | 0.59 | 3.8e-22 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 372.5 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 2.6 | 303.1 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
| 2.8 | 187.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 1.3 | 153.8 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 11.6 | 150.4 | GO:0000492 | box C/D snoRNP assembly(GO:0000492) |
| 1.8 | 124.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 2.1 | 115.8 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 2.3 | 106.8 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 4.6 | 101.5 | GO:0006465 | signal peptide processing(GO:0006465) |
| 4.0 | 100.3 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.5 | 282.9 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 2.4 | 253.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.6 | 197.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.1 | 196.9 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 2.7 | 167.3 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 1.7 | 142.4 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 13.4 | 106.9 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 14.5 | 101.5 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 2.1 | 100.8 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.3 | 100.0 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 537.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.3 | 172.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 4.8 | 144.4 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 3.1 | 137.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.5 | 130.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 108.6 | GO:0003723 | RNA binding(GO:0003723) |
| 0.9 | 105.6 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 3.4 | 105.1 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 1.0 | 98.2 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 3.4 | 97.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 229.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.9 | 149.9 | PID MYC PATHWAY | C-MYC pathway |
| 2.1 | 122.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.3 | 121.9 | PID E2F PATHWAY | E2F transcription factor network |
| 2.1 | 100.9 | PID ATR PATHWAY | ATR signaling pathway |
| 6.3 | 88.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 1.6 | 84.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 3.0 | 83.1 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.6 | 57.4 | PID P73PATHWAY | p73 transcription factor network |
| 0.6 | 56.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 336.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.6 | 248.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 2.9 | 246.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 3.0 | 230.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 1.1 | 195.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.7 | 162.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 2.3 | 124.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 5.6 | 101.5 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 4.0 | 100.1 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 5.5 | 98.3 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |