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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for E2F7_E2F1
Z-value: 1.77
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | 0.73 | 1.5e-37 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_76183111 Show fit | 154.09 |
ENST00000405273.1
ENST00000590862.1 ENST00000590430.1 ENST00000586613.1 |
thymidine kinase 1, soluble |
|
| chr2_+_10262857 Show fit | 153.55 |
ENST00000304567.5
|
ribonucleotide reductase M2 |
|
| chr11_+_4116005 Show fit | 126.04 |
ENST00000300738.5
|
ribonucleotide reductase M1 |
|
| chr2_+_47630255 Show fit | 124.22 |
ENST00000406134.1
|
mutS homolog 2 |
|
| chr18_+_657733 Show fit | 119.47 |
ENST00000323250.5
ENST00000323224.7 |
thymidylate synthetase |
|
| chr2_+_47630108 Show fit | 117.56 |
ENST00000233146.2
ENST00000454849.1 ENST00000543555.1 |
mutS homolog 2 |
|
| chr7_-_99698338 Show fit | 116.37 |
ENST00000354230.3
ENST00000425308.1 |
minichromosome maintenance complex component 7 |
|
| chr11_+_4116054 Show fit | 115.75 |
ENST00000423050.2
|
ribonucleotide reductase M1 |
|
| chr6_-_52149475 Show fit | 109.53 |
ENST00000419835.2
ENST00000229854.7 ENST00000596288.1 |
minichromosome maintenance complex component 3 |
|
| chr4_-_174254823 Show fit | 103.40 |
ENST00000438704.2
|
high mobility group box 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.9 | 447.5 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 41.2 | 412.0 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 9.3 | 289.6 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 9.5 | 266.6 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 3.2 | 252.3 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 48.4 | 241.8 | GO:0010520 | meiotic gene conversion(GO:0006311) regulation of reciprocal meiotic recombination(GO:0010520) |
| 43.6 | 218.2 | GO:1900264 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 20.5 | 204.7 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 66.2 | 198.7 | GO:0036333 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 49.2 | 196.9 | GO:0019860 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) uracil metabolic process(GO:0019860) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 48.2 | 626.5 | GO:0042555 | MCM complex(GO:0042555) |
| 98.8 | 395.3 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 24.9 | 373.6 | GO:0045120 | pronucleus(GO:0045120) |
| 88.3 | 353.1 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 3.4 | 299.5 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 41.3 | 288.8 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 28.4 | 283.8 | GO:0000796 | condensin complex(GO:0000796) |
| 16.7 | 283.4 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 31.9 | 255.5 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.8 | 251.5 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.2 | 503.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 98.8 | 395.3 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.4 | 362.5 | GO:0003723 | RNA binding(GO:0003723) |
| 88.3 | 353.1 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 36.9 | 331.7 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 2.1 | 323.9 | GO:0042393 | histone binding(GO:0042393) |
| 7.8 | 318.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 22.2 | 311.2 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 9.4 | 273.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 1.3 | 268.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.2 | 1303.2 | PID E2F PATHWAY | E2F transcription factor network |
| 8.9 | 544.3 | PID ATR PATHWAY | ATR signaling pathway |
| 12.1 | 302.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 1.7 | 290.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 2.7 | 258.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 2.4 | 251.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 3.9 | 239.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.4 | 133.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 3.4 | 115.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 1.6 | 103.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 45.2 | 723.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 4.8 | 566.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 21.5 | 516.9 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 11.2 | 359.8 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 9.7 | 357.7 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 23.8 | 356.7 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 2.0 | 336.5 | REACTOME TRANSLATION | Genes involved in Translation |
| 5.4 | 315.5 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 1.6 | 244.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 15.2 | 242.5 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |