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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for E2F8

Z-value: 1.41

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Transcription factors associated with E2F8

Gene Symbol Gene ID Gene Info
E2F8
ENSG00000129173.8 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F8hg19_v2_chr11_-_19263145_192631760.548.9e-18Click!

Activity profile of E2F8 motif

Sorted Z-values of E2F8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_10262857 66.70 ENST00000304567.5
RRM2
ribonucleotide reductase M2
chr4_-_174254823 60.08 ENST00000438704.2
HMGB2
high mobility group box 2
chr2_-_136633940 54.93 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr6_+_135502466 40.00 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr6_+_135502408 39.23 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr3_+_127317066 38.14 ENST00000265056.7
MCM2
minichromosome maintenance complex component 2
chr14_-_55658252 37.74 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr22_+_35796108 36.13 ENST00000382011.5
ENST00000416905.1
MCM5
minichromosome maintenance complex component 5
chr10_-_17659234 36.06 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr8_+_128748308 34.77 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr1_-_159893507 34.66 ENST00000368096.1
TAGLN2
transgelin 2
chr12_+_104682496 33.13 ENST00000378070.4
TXNRD1
thioredoxin reductase 1
chr20_+_42295745 32.24 ENST00000396863.4
ENST00000217026.4
MYBL2
v-myb avian myeloblastosis viral oncogene homolog-like 2
chr1_-_43638168 31.87 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr8_+_128748466 31.80 ENST00000524013.1
ENST00000520751.1
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr15_-_64673630 31.71 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr7_+_135242652 31.59 ENST00000285968.6
ENST00000440390.2
NUP205
nucleoporin 205kDa
chr9_+_131445928 31.44 ENST00000372692.4
SET
SET nuclear oncogene
chr22_+_35796056 31.02 ENST00000216122.4
MCM5
minichromosome maintenance complex component 5
chr12_-_57146095 30.65 ENST00000550770.1
ENST00000338193.6
PRIM1
primase, DNA, polypeptide 1 (49kDa)
chr14_-_55658323 30.14 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr15_+_64428529 29.42 ENST00000560861.1
SNX1
sorting nexin 1
chr14_+_51706886 28.87 ENST00000457354.2
TMX1
thioredoxin-related transmembrane protein 1
chr2_-_152146385 28.00 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr10_-_27443155 27.97 ENST00000427324.1
ENST00000326799.3
YME1L1
YME1-like 1 ATPase
chr11_+_71938925 27.95 ENST00000538751.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr22_+_19467261 27.81 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
CDC45
cell division cycle 45
chr4_-_1713977 27.55 ENST00000318386.4
SLBP
stem-loop binding protein
chr4_-_1714037 26.66 ENST00000488267.1
ENST00000429429.2
ENST00000480936.1
SLBP
stem-loop binding protein
chr12_-_54071181 26.53 ENST00000338662.5
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr22_+_40742497 26.31 ENST00000216194.7
ADSL
adenylosuccinate lyase
chr1_-_43637915 26.22 ENST00000236051.2
EBNA1BP2
EBNA1 binding protein 2
chrX_-_153707246 25.17 ENST00000407062.1
LAGE3
L antigen family, member 3
chr1_+_156024552 24.96 ENST00000368304.5
ENST00000368302.3
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr22_+_40742512 24.49 ENST00000454266.2
ENST00000342312.6
ADSL
adenylosuccinate lyase
chr11_+_17298297 24.21 ENST00000529010.1
NUCB2
nucleobindin 2
chrX_+_131157322 24.13 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4
Serine/threonine-protein kinase MST4
chr2_-_215674374 24.08 ENST00000449967.2
ENST00000421162.1
ENST00000260947.4
BARD1
BRCA1 associated RING domain 1
chrX_-_129299847 23.97 ENST00000319908.3
ENST00000287295.3
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr16_-_66864806 23.69 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chrX_+_131157290 23.22 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chr1_+_156024525 23.20 ENST00000368305.4
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr14_+_64854958 23.11 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr13_-_113862401 23.00 ENST00000375459.1
PCID2
PCI domain containing 2
chr11_+_17298255 22.66 ENST00000531172.1
ENST00000533738.2
ENST00000323688.6
NUCB2
nucleobindin 2
chr1_-_6295975 22.35 ENST00000343813.5
ENST00000362035.3
ICMT
isoprenylcysteine carboxyl methyltransferase
chr10_-_17659357 22.18 ENST00000326961.6
ENST00000361271.3
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr7_-_140714739 21.30 ENST00000467334.1
ENST00000324787.5
MRPS33
mitochondrial ribosomal protein S33
chr10_-_43892279 21.19 ENST00000443950.2
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr16_-_103572 20.92 ENST00000293860.5
POLR3K
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
chr6_+_10748019 20.57 ENST00000543878.1
ENST00000461342.1
ENST00000475942.1
ENST00000379530.3
ENST00000473276.1
ENST00000481240.1
ENST00000467317.1
SYCP2L
TMEM14B
synaptonemal complex protein 2-like
transmembrane protein 14B
chr4_-_84035868 20.54 ENST00000426923.2
ENST00000509973.1
PLAC8
placenta-specific 8
chr3_-_25824925 20.54 ENST00000396649.3
ENST00000428257.1
ENST00000280700.5
NGLY1
N-glycanase 1
chr10_-_27443294 20.52 ENST00000396296.3
ENST00000375972.3
ENST00000376016.3
ENST00000491542.2
YME1L1
YME1-like 1 ATPase
chr4_+_113558272 20.46 ENST00000509061.1
ENST00000508577.1
ENST00000513553.1
LARP7
La ribonucleoprotein domain family, member 7
chr22_-_42086477 20.26 ENST00000402458.1
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr2_-_58468437 20.25 ENST00000403676.1
ENST00000427708.2
ENST00000403295.3
ENST00000446381.1
ENST00000417361.1
ENST00000233741.4
ENST00000402135.3
ENST00000540646.1
ENST00000449070.1
FANCL
Fanconi anemia, complementation group L
chr15_+_66797627 20.03 ENST00000565627.1
ENST00000564179.1
ZWILCH
zwilch kinetochore protein
chr4_-_84035905 19.90 ENST00000311507.4
PLAC8
placenta-specific 8
chr18_-_47018869 19.66 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr7_+_75932863 19.44 ENST00000429938.1
HSPB1
heat shock 27kDa protein 1
chr5_+_34757309 19.23 ENST00000397449.1
RAI14
retinoic acid induced 14
chr18_-_47018897 19.20 ENST00000418495.1
RPL17
ribosomal protein L17
chrX_+_24072833 18.92 ENST00000253039.4
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr11_+_125496124 18.68 ENST00000533778.2
ENST00000534070.1
CHEK1
checkpoint kinase 1
chrX_-_153707545 18.49 ENST00000357360.4
LAGE3
L antigen family, member 3
chr11_+_35201826 18.40 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr15_-_34635314 18.12 ENST00000557912.1
ENST00000328848.4
NOP10
NOP10 ribonucleoprotein
chr6_+_10747986 18.04 ENST00000379542.5
TMEM14B
transmembrane protein 14B
chr22_+_20105259 18.00 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RANBP1
RAN binding protein 1
chr19_+_57874835 17.57 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
TRAPPC2P1
ZNF547
AC003002.4
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr5_+_133707252 17.54 ENST00000506787.1
ENST00000507277.1
UBE2B
ubiquitin-conjugating enzyme E2B
chr4_+_57845043 16.94 ENST00000433463.1
ENST00000314595.5
POLR2B
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr5_+_31532373 16.90 ENST00000325366.9
ENST00000355907.3
ENST00000507818.2
C5orf22
chromosome 5 open reading frame 22
chr16_+_103816 16.89 ENST00000383018.3
ENST00000417493.1
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr22_+_20105012 16.87 ENST00000331821.3
ENST00000411892.1
RANBP1
RAN binding protein 1
chr4_-_140223614 16.79 ENST00000394223.1
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr17_+_56769924 16.59 ENST00000461271.1
ENST00000583539.1
ENST00000337432.4
ENST00000421782.2
RAD51C
RAD51 paralog C
chr4_+_57845024 16.58 ENST00000431623.2
ENST00000441246.2
POLR2B
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr17_-_56084578 16.45 ENST00000582730.2
ENST00000584773.1
ENST00000585096.1
ENST00000258962.4
SRSF1
serine/arginine-rich splicing factor 1
chr8_-_131455835 16.44 ENST00000518721.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr4_-_39367949 16.41 ENST00000503784.1
ENST00000349703.2
ENST00000381897.1
RFC1
replication factor C (activator 1) 1, 145kDa
chr20_-_2451395 16.37 ENST00000339610.6
ENST00000381342.2
ENST00000438552.2
SNRPB
small nuclear ribonucleoprotein polypeptides B and B1
chr11_+_125495862 15.98 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
CHEK1
checkpoint kinase 1
chr3_+_133293278 15.90 ENST00000508481.1
ENST00000420115.2
ENST00000504867.1
ENST00000507408.1
ENST00000511392.1
ENST00000515421.1
CDV3
CDV3 homolog (mouse)
chr3_+_171758344 15.79 ENST00000336824.4
ENST00000423424.1
FNDC3B
fibronectin type III domain containing 3B
chr12_-_15942309 15.69 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr3_-_185542761 15.47 ENST00000457616.2
ENST00000346192.3
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr1_-_205719295 15.39 ENST00000367142.4
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr12_-_102455846 15.35 ENST00000545679.1
CCDC53
coiled-coil domain containing 53
chr5_-_79950371 14.88 ENST00000511032.1
ENST00000504396.1
ENST00000505337.1
DHFR
dihydrofolate reductase
chr12_-_15942503 14.83 ENST00000281172.5
EPS8
epidermal growth factor receptor pathway substrate 8
chr4_-_106629796 14.63 ENST00000416543.1
ENST00000515819.1
ENST00000420368.2
ENST00000503746.1
ENST00000340139.5
ENST00000433009.1
INTS12
integrator complex subunit 12
chr14_-_100841670 14.57 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr18_-_47017956 14.55 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr3_-_185542817 14.44 ENST00000382199.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr1_-_26232522 14.30 ENST00000399728.1
STMN1
stathmin 1
chr3_-_125313934 14.16 ENST00000296220.5
OSBPL11
oxysterol binding protein-like 11
chrX_+_41192595 13.95 ENST00000399959.2
DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr4_-_140223670 13.93 ENST00000394228.1
ENST00000539387.1
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr1_-_24306835 13.85 ENST00000484146.2
SRSF10
serine/arginine-rich splicing factor 10
chr7_+_128379346 13.63 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
CALU
calumenin
chr1_+_158979792 13.54 ENST00000359709.3
ENST00000430894.2
IFI16
interferon, gamma-inducible protein 16
chr3_+_197677047 13.28 ENST00000448864.1
RPL35A
ribosomal protein L35a
chr8_+_29953163 13.01 ENST00000518192.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr17_+_66243715 12.98 ENST00000359904.3
AMZ2
archaelysin family metallopeptidase 2
chr3_+_44803209 12.90 ENST00000326047.4
KIF15
kinesin family member 15
chr7_+_128379449 12.89 ENST00000479257.1
CALU
calumenin
chr5_+_82767583 12.89 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
VCAN
versican
chr8_+_48873453 12.09 ENST00000523944.1
MCM4
minichromosome maintenance complex component 4
chr22_+_38071615 12.07 ENST00000215909.5
LGALS1
lectin, galactoside-binding, soluble, 1
chr6_+_135502501 12.00 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr12_-_102455902 11.88 ENST00000240079.6
CCDC53
coiled-coil domain containing 53
chr15_-_64673665 11.76 ENST00000300035.4
KIAA0101
KIAA0101
chr8_+_48873479 11.72 ENST00000262105.2
MCM4
minichromosome maintenance complex component 4
chr17_+_61904766 11.64 ENST00000581842.1
ENST00000582130.1
ENST00000584320.1
ENST00000585123.1
ENST00000580864.1
PSMC5
proteasome (prosome, macropain) 26S subunit, ATPase, 5
chr2_+_238395803 11.55 ENST00000264605.3
MLPH
melanophilin
chr3_-_79816965 11.41 ENST00000464233.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr17_+_39975455 11.25 ENST00000455106.1
FKBP10
FK506 binding protein 10, 65 kDa
chr3_-_119396193 11.19 ENST00000484810.1
ENST00000497116.1
ENST00000261070.2
COX17
COX17 cytochrome c oxidase copper chaperone
chr5_+_82767487 11.07 ENST00000343200.5
ENST00000342785.4
VCAN
versican
chrX_+_52240504 11.06 ENST00000399805.2
XAGE1B
X antigen family, member 1B
chr17_-_9479128 10.97 ENST00000574431.1
STX8
syntaxin 8
chr6_-_111804905 10.68 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr14_-_20801427 10.59 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
CCNB1IP1
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr2_-_130939115 10.46 ENST00000441135.1
ENST00000339679.7
ENST00000426662.2
ENST00000443958.2
ENST00000351288.6
ENST00000453750.1
ENST00000452225.2
SMPD4
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
chr2_-_86790593 10.42 ENST00000263856.4
ENST00000409225.2
CHMP3
charged multivesicular body protein 3
chr2_+_63816295 10.38 ENST00000539945.1
ENST00000544381.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr12_+_56521840 10.37 ENST00000394048.5
ESYT1
extended synaptotagmin-like protein 1
chr17_-_29151794 10.30 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr12_-_123011536 10.11 ENST00000331738.7
ENST00000354654.2
RSRC2
arginine/serine-rich coiled-coil 2
chr12_+_3069037 9.84 ENST00000397122.2
TEAD4
TEA domain family member 4
chr20_-_2644832 9.79 ENST00000380851.5
ENST00000380843.4
IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
chr11_+_47236489 9.67 ENST00000256996.4
ENST00000378603.3
ENST00000378600.3
ENST00000378601.3
DDB2
damage-specific DNA binding protein 2, 48kDa
chr19_+_2270283 9.55 ENST00000588673.2
OAZ1
ornithine decarboxylase antizyme 1
chr1_-_28241226 9.38 ENST00000373912.3
ENST00000373909.3
RPA2
replication protein A2, 32kDa
chr17_+_57642886 9.29 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DHX40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr16_+_2732476 9.28 ENST00000301738.4
ENST00000564195.1
KCTD5
potassium channel tetramerization domain containing 5
chr18_-_47018769 9.25 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr17_+_39975544 9.24 ENST00000544340.1
FKBP10
FK506 binding protein 10, 65 kDa
chr1_+_89150245 9.06 ENST00000370513.5
PKN2
protein kinase N2
chrX_+_55026763 8.95 ENST00000374987.3
APEX2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr14_+_24899141 8.84 ENST00000556842.1
ENST00000553935.1
KHNYN
KH and NYN domain containing
chrX_-_10588459 8.79 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chrX_-_135338503 8.78 ENST00000370663.5
MAP7D3
MAP7 domain containing 3
chr17_-_30668887 8.77 ENST00000581747.1
ENST00000583334.1
ENST00000580558.1
C17orf75
chromosome 17 open reading frame 75
chr13_-_41345277 8.56 ENST00000323563.6
MRPS31
mitochondrial ribosomal protein S31
chr3_+_124449213 8.40 ENST00000232607.2
ENST00000536109.1
ENST00000538242.1
ENST00000413078.2
UMPS
uridine monophosphate synthetase
chr14_-_51135036 8.09 ENST00000324679.4
SAV1
salvador homolog 1 (Drosophila)
chr2_+_238395879 8.08 ENST00000445024.2
ENST00000338530.4
ENST00000409373.1
MLPH
melanophilin
chr22_+_35653445 8.01 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr12_+_108079509 8.01 ENST00000412830.3
ENST00000547995.1
PWP1
PWP1 homolog (S. cerevisiae)
chr20_-_524340 7.61 ENST00000400227.3
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chr12_+_1738363 7.53 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr1_-_6453399 7.43 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr7_-_56119238 7.42 ENST00000275605.3
ENST00000395471.3
PSPH
phosphoserine phosphatase
chr12_+_123011776 7.22 ENST00000450485.2
ENST00000333479.7
KNTC1
kinetochore associated 1
chr17_+_76165213 7.14 ENST00000590201.1
SYNGR2
synaptogyrin 2
chr1_+_201798269 7.05 ENST00000361565.4
IPO9
importin 9
chr12_+_111843749 7.03 ENST00000341259.2
SH2B3
SH2B adaptor protein 3
chr13_-_30169807 6.97 ENST00000380752.5
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr7_+_856246 6.97 ENST00000389574.3
ENST00000457378.2
ENST00000452783.2
ENST00000435699.1
ENST00000440380.1
ENST00000439679.1
ENST00000424128.1
SUN1
Sad1 and UNC84 domain containing 1
chrX_-_10588595 6.65 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr2_+_232575128 6.59 ENST00000412128.1
PTMA
prothymosin, alpha
chr3_-_194393206 6.58 ENST00000265245.5
LSG1
large 60S subunit nuclear export GTPase 1
chr15_+_44119159 6.46 ENST00000263795.6
ENST00000381246.2
ENST00000452115.1
WDR76
WD repeat domain 76
chr6_+_43603552 6.45 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr8_+_29952914 6.36 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr1_-_89458287 6.34 ENST00000370485.2
CCBL2
cysteine conjugate-beta lyase 2
chr6_-_2962331 6.21 ENST00000380524.1
SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chrX_-_53449593 6.08 ENST00000375340.6
ENST00000322213.4
SMC1A
structural maintenance of chromosomes 1A
chr2_+_130939235 6.07 ENST00000425361.1
ENST00000457492.1
MZT2B
mitotic spindle organizing protein 2B
chr17_-_46623441 5.90 ENST00000330070.4
HOXB2
homeobox B2
chr6_-_32157947 5.64 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr8_-_81083731 5.52 ENST00000379096.5
TPD52
tumor protein D52
chr19_-_19249255 5.31 ENST00000587583.2
ENST00000450333.2
ENST00000587096.1
ENST00000162044.9
ENST00000592369.1
ENST00000587915.1
TMEM161A
transmembrane protein 161A
chr12_-_123011476 5.17 ENST00000528279.1
ENST00000344591.4
ENST00000526560.2
RSRC2
arginine/serine-rich coiled-coil 2
chr21_-_43346790 5.17 ENST00000329623.7
C2CD2
C2 calcium-dependent domain containing 2
chr19_-_47291843 5.14 ENST00000542575.2
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr1_+_33283043 5.11 ENST00000373476.1
ENST00000373475.5
ENST00000529027.1
ENST00000398243.3
S100PBP
S100P binding protein
chr11_+_134201911 5.07 ENST00000389881.3
GLB1L2
galactosidase, beta 1-like 2
chr20_+_60174827 5.04 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr6_+_26251835 4.91 ENST00000356350.2
HIST1H2BH
histone cluster 1, H2bh
chr7_-_22259845 4.91 ENST00000420196.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr1_+_150245099 4.81 ENST00000369099.3
C1orf54
chromosome 1 open reading frame 54
chr4_-_4543700 4.76 ENST00000505286.1
ENST00000306200.2
STX18
syntaxin 18
chr1_-_21503337 4.73 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr19_+_50887585 4.49 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr2_+_63816087 4.46 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr4_-_129209944 4.41 ENST00000520121.1
PGRMC2
progesterone receptor membrane component 2
chr17_+_37894570 4.38 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr15_+_40731920 4.27 ENST00000561234.1
BAHD1
bromo adjacent homology domain containing 1
chr2_-_70780572 4.11 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr15_-_89456630 4.10 ENST00000268150.8
MFGE8
milk fat globule-EGF factor 8 protein
chrX_-_54522558 4.06 ENST00000375135.3
FGD1
FYVE, RhoGEF and PH domain containing 1
chr11_+_65029233 3.96 ENST00000265465.3
POLA2
polymerase (DNA directed), alpha 2, accessory subunit
chr10_-_121632266 3.94 ENST00000360003.3
ENST00000369077.3
MCMBP
minichromosome maintenance complex binding protein
chr14_+_105992906 3.83 ENST00000392519.2
TMEM121
transmembrane protein 121
chr2_+_132233664 3.80 ENST00000321253.6
TUBA3D
tubulin, alpha 3d
chr16_-_71264558 3.74 ENST00000448089.2
ENST00000393550.2
ENST00000448691.1
ENST00000393567.2
ENST00000321489.5
ENST00000539973.1
ENST00000288168.10
ENST00000545267.1
ENST00000541601.1
ENST00000538248.1
HYDIN
HYDIN, axonemal central pair apparatus protein

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
30.4 91.2 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
16.9 50.8 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
11.7 116.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
11.3 67.9 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
11.1 66.6 GO:0072131 kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
10.8 54.2 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
10.2 30.7 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
9.3 28.0 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
9.3 27.8 GO:0031938 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
8.1 48.5 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
7.6 30.5 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
6.8 20.5 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
6.0 60.1 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
5.8 17.5 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
5.8 34.7 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
4.9 19.4 GO:0099640 axo-dendritic protein transport(GO:0099640)
4.7 38.0 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
4.7 23.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
4.6 23.0 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
3.8 15.4 GO:0019046 release from viral latency(GO:0019046)
3.7 33.1 GO:0001887 selenium compound metabolic process(GO:0001887)
3.6 18.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
3.4 24.0 GO:1904044 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) response to aldosterone(GO:1904044)
3.3 16.6 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
3.3 16.4 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
3.2 19.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
3.0 12.1 GO:0002317 plasma cell differentiation(GO:0002317)
3.0 24.1 GO:0085020 protein K6-linked ubiquitination(GO:0085020)
2.9 14.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
2.9 66.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
2.9 14.3 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
2.8 2.8 GO:0033364 mast cell secretory granule organization(GO:0033364)
2.8 8.4 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
2.8 14.0 GO:0042256 mature ribosome assembly(GO:0042256)
2.7 8.0 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
2.3 18.4 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
2.2 40.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
2.0 28.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
2.0 14.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
2.0 5.9 GO:0021569 rhombomere 3 development(GO:0021569)
1.9 9.5 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
1.9 70.3 GO:0006270 DNA replication initiation(GO:0006270)
1.9 7.4 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
1.9 31.6 GO:0051292 nuclear pore complex assembly(GO:0051292)
1.8 5.3 GO:0050923 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
1.7 7.0 GO:1903826 arginine transmembrane transport(GO:1903826)
1.7 7.0 GO:0034398 telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
1.5 6.1 GO:0072402 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
1.4 31.3 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
1.4 9.9 GO:0051026 chiasma assembly(GO:0051026)
1.4 9.8 GO:0006102 isocitrate metabolic process(GO:0006102)
1.4 1.4 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.4 4.1 GO:0044278 cell wall disruption in other organism(GO:0044278)
1.3 19.6 GO:0030050 vesicle transport along actin filament(GO:0030050)
1.3 10.4 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
1.3 48.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
1.3 11.6 GO:0090261 positive regulation of inclusion body assembly(GO:0090261)
1.3 5.1 GO:1903803 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
1.3 31.4 GO:0006337 nucleosome disassembly(GO:0006337)
1.2 18.7 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
1.2 14.8 GO:0006108 malate metabolic process(GO:0006108)
1.2 10.8 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
1.2 15.4 GO:0035372 protein localization to microtubule(GO:0035372)
1.2 2.3 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
1.1 20.5 GO:0006516 glycoprotein catabolic process(GO:0006516)
1.0 10.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
1.0 3.0 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
1.0 24.0 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.9 28.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.9 71.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.9 11.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.8 26.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.8 4.8 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.8 10.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.8 16.4 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.7 20.9 GO:0006379 mRNA cleavage(GO:0006379)
0.7 35.7 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.7 9.7 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.7 4.4 GO:0071407 cellular response to organic cyclic compound(GO:0071407)
0.7 14.6 GO:0016180 snRNA processing(GO:0016180)
0.6 10.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.6 20.2 GO:0036297 interstrand cross-link repair(GO:0036297)
0.6 13.7 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.6 1.7 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.5 0.5 GO:0021997 neural plate axis specification(GO:0021997)
0.5 2.1 GO:1904457 glucosylceramide catabolic process(GO:0006680) termination of signal transduction(GO:0023021) beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457)
0.5 1.9 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.5 59.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.4 1.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.4 30.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4 32.2 GO:0043525 positive regulation of neuron apoptotic process(GO:0043525)
0.4 7.0 GO:0051170 nuclear import(GO:0051170)
0.4 5.5 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.4 29.9 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.4 43.7 GO:0008033 tRNA processing(GO:0008033)
0.4 8.1 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.4 6.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.4 14.5 GO:0008333 endosome to lysosome transport(GO:0008333)
0.3 27.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.3 4.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.3 13.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.3 4.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.3 0.9 GO:2000521 negative regulation of immunological synapse formation(GO:2000521)
0.3 6.6 GO:0006351 transcription, DNA-templated(GO:0006351) nucleic acid-templated transcription(GO:0097659)
0.3 2.1 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.3 4.4 GO:0034063 stress granule assembly(GO:0034063)
0.3 22.4 GO:0018410 C-terminal protein amino acid modification(GO:0018410)
0.3 1.9 GO:0072718 response to cisplatin(GO:0072718)
0.3 21.2 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.3 4.9 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.3 29.1 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.2 1.9 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.2 3.5 GO:0070307 lens fiber cell development(GO:0070307)
0.2 9.0 GO:0006284 base-excision repair(GO:0006284)
0.2 5.4 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.2 9.1 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.2 5.6 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 23.6 GO:0006413 translational initiation(GO:0006413)
0.2 5.3 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.2 1.8 GO:0055091 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) phospholipid homeostasis(GO:0055091)
0.1 12.7 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.1 12.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 10.3 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.1 4.5 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 3.0 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 9.9 GO:0046785 microtubule polymerization(GO:0046785)
0.1 3.7 GO:0021591 ventricular system development(GO:0021591)
0.1 12.9 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 2.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 20.3 GO:0002576 platelet degranulation(GO:0002576)
0.1 3.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 5.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 2.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 6.6 GO:0042254 ribosome biogenesis(GO:0042254)
0.1 8.9 GO:0044764 multi-organism cellular process(GO:0044764)
0.1 0.7 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.4 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.9 GO:0006491 N-glycan processing(GO:0006491)
0.0 4.8 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.2 GO:0033683 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296) nucleotide-excision repair, DNA incision(GO:0033683)
0.0 1.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 7.7 GO:0043687 post-translational protein modification(GO:0043687)
0.0 1.7 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 0.8 GO:0035329 hippo signaling(GO:0035329)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
16.7 66.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
14.5 188.0 GO:0042555 MCM complex(GO:0042555)
10.7 32.2 GO:0031523 Myb complex(GO:0031523)
9.6 48.2 GO:0071986 Ragulator complex(GO:0071986)
9.3 27.8 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
8.8 70.6 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
8.7 43.7 GO:0000408 EKC/KEOPS complex(GO:0000408)
7.9 31.6 GO:0044611 nuclear pore inner ring(GO:0044611)
6.9 34.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
6.8 27.2 GO:1990423 RZZ complex(GO:1990423)
6.3 18.9 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
6.0 24.1 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
4.7 28.5 GO:0030905 retromer, tubulation complex(GO:0030905)
4.3 12.9 GO:0005873 plus-end kinesin complex(GO:0005873)
4.0 67.9 GO:0031616 spindle pole centrosome(GO:0031616)
3.5 17.5 GO:0033503 HULC complex(GO:0033503)
3.0 18.1 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
2.9 20.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
2.6 18.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
2.4 26.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
2.3 16.4 GO:0005663 DNA replication factor C complex(GO:0005663)
2.0 30.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.9 58.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
1.7 23.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
1.6 14.6 GO:0032039 integrator complex(GO:0032039)
1.5 26.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
1.2 11.1 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
1.2 9.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.2 10.7 GO:0042575 DNA polymerase complex(GO:0042575)
1.1 8.0 GO:0016589 NURF complex(GO:0016589)
1.1 4.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.1 33.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
1.1 29.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
1.0 6.1 GO:0030893 meiotic cohesin complex(GO:0030893)
1.0 6.1 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
1.0 11.6 GO:0031595 nuclear proteasome complex(GO:0031595)
0.8 23.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.8 10.4 GO:0000815 ESCRT III complex(GO:0000815)
0.7 10.4 GO:0043601 replisome(GO:0030894) nuclear replisome(GO:0043601)
0.7 16.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.7 1.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.7 72.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.6 10.4 GO:0044232 organelle membrane contact site(GO:0044232)
0.6 1.9 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.6 16.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.6 16.4 GO:0002102 podosome(GO:0002102)
0.6 14.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.5 7.0 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.5 71.9 GO:0016363 nuclear matrix(GO:0016363)
0.5 4.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.5 30.7 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4 30.6 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.4 61.3 GO:0001650 fibrillar center(GO:0001650)
0.4 55.2 GO:0000793 condensed chromosome(GO:0000793)
0.4 40.4 GO:0035578 azurophil granule lumen(GO:0035578)
0.4 0.7 GO:0033186 CAF-1 complex(GO:0033186)
0.4 15.0 GO:1904115 axon cytoplasm(GO:1904115)
0.3 1.3 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.3 2.8 GO:0042588 zymogen granule(GO:0042588)
0.3 46.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.3 15.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 1.8 GO:0033063 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.3 22.2 GO:0005811 lipid particle(GO:0005811)
0.3 6.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.3 4.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 25.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.3 15.7 GO:0031201 SNARE complex(GO:0031201)
0.2 31.5 GO:0005796 Golgi lumen(GO:0005796)
0.2 15.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 2.2 GO:0000439 core TFIIH complex(GO:0000439)
0.2 4.7 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 3.0 GO:0031105 septin complex(GO:0031105)
0.2 6.6 GO:0015030 Cajal body(GO:0015030)
0.2 63.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 12.7 GO:0031902 late endosome membrane(GO:0031902)
0.1 2.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 4.9 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.1 7.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 22.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 4.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 9.1 GO:0030496 midbody(GO:0030496)
0.1 13.3 GO:0005819 spindle(GO:0005819)
0.1 1.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 3.1 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 5.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 31.0 GO:0005730 nucleolus(GO:0005730)
0.0 0.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 14.7 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 10.4 GO:0005635 nuclear envelope(GO:0005635)
0.0 2.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 2.1 GO:0000502 proteasome complex(GO:0000502)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 3.8 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 14.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
16.7 66.7 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
15.0 60.1 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
14.1 70.6 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
11.2 123.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
11.0 33.1 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
7.8 132.3 GO:0003688 DNA replication origin binding(GO:0003688)
7.7 23.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
6.5 19.4 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
6.3 50.8 GO:0016842 amidine-lyase activity(GO:0016842)
6.1 48.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
5.8 34.7 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
5.7 28.5 GO:1990460 leptin receptor binding(GO:1990460)
5.0 35.1 GO:0050733 RS domain binding(GO:0050733)
4.5 22.4 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
4.0 12.1 GO:0048030 disaccharide binding(GO:0048030)
3.0 18.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
3.0 9.0 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
3.0 14.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
2.9 14.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
2.8 28.0 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
2.5 17.8 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
2.5 14.9 GO:0051870 methotrexate binding(GO:0051870)
2.4 9.8 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
2.1 94.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
2.1 16.6 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
2.0 10.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
1.9 9.5 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
1.9 11.4 GO:0008046 axon guidance receptor activity(GO:0008046)
1.9 11.2 GO:0016531 copper chaperone activity(GO:0016531)
1.8 23.7 GO:0008641 small protein activating enzyme activity(GO:0008641)
1.7 7.0 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
1.7 87.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
1.5 6.1 GO:0036033 mediator complex binding(GO:0036033)
1.4 28.9 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
1.4 20.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
1.2 36.6 GO:0005540 hyaluronic acid binding(GO:0005540)
1.1 65.6 GO:0070888 E-box binding(GO:0070888)
1.1 31.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
1.1 11.6 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
1.0 10.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
1.0 11.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
1.0 26.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 10.4 GO:0098505 single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505)
0.9 29.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.8 39.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.7 7.4 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.7 5.1 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.7 21.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.7 20.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.7 19.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.7 10.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.6 5.1 GO:0004565 beta-galactosidase activity(GO:0004565)
0.6 15.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.6 1.8 GO:0017129 triglyceride binding(GO:0017129)
0.6 30.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 2.2 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.5 56.3 GO:0032947 protein complex scaffold(GO:0032947)
0.5 2.1 GO:0004348 glucosylceramidase activity(GO:0004348)
0.5 4.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.5 102.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 9.3 GO:0097602 cullin family protein binding(GO:0097602)
0.5 1.9 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.5 30.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.4 22.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.4 7.0 GO:0043495 protein anchor(GO:0043495)
0.4 17.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 9.1 GO:0004697 protein kinase C activity(GO:0004697)
0.4 4.9 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3 23.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 68.1 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.2 7.5 GO:0005109 frizzled binding(GO:0005109)
0.2 13.3 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.2 9.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 3.6 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.2 13.5 GO:0003777 microtubule motor activity(GO:0003777)
0.2 2.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 8.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 6.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 9.1 GO:0003684 damaged DNA binding(GO:0003684)
0.1 1.7 GO:0036122 BMP binding(GO:0036122)
0.1 0.9 GO:0019863 IgE binding(GO:0019863)
0.1 2.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 25.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 4.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 19.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.7 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 58.3 GO:0003682 chromatin binding(GO:0003682)
0.1 8.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 4.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 5.5 GO:0008289 lipid binding(GO:0008289)
0.1 5.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 13.0 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 24.1 GO:0045296 cadherin binding(GO:0045296)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 8.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 2.8 GO:0005518 collagen binding(GO:0005518)
0.0 4.6 GO:0002020 protease binding(GO:0002020)
0.0 8.3 GO:0015631 tubulin binding(GO:0015631)
0.0 1.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 5.3 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 157.8 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
1.4 20.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.4 77.4 PID AURORA A PATHWAY Aurora A signaling
1.2 28.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
1.1 128.9 PID E2F PATHWAY E2F transcription factor network
1.1 44.3 PID BARD1 PATHWAY BARD1 signaling events
1.0 46.9 PID ATR PATHWAY ATR signaling pathway
0.8 19.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.8 14.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.7 16.4 PID ARF 3PATHWAY Arf1 pathway
0.6 40.1 PID LKB1 PATHWAY LKB1 signaling events
0.6 18.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5 28.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.5 30.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.4 22.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 31.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.4 13.0 PID RAS PATHWAY Regulation of Ras family activation
0.3 15.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.3 16.4 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 23.8 PID CMYB PATHWAY C-MYB transcription factor network
0.2 7.0 PID EPO PATHWAY EPO signaling pathway
0.2 9.1 PID RHOA PATHWAY RhoA signaling pathway
0.2 4.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 4.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 6.4 PID NOTCH PATHWAY Notch signaling pathway
0.1 5.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 5.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 9.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 3.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 6.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 9.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
13.2 211.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
4.4 70.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
3.3 39.1 REACTOME POL SWITCHING Genes involved in Polymerase switching
3.0 81.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
3.0 60.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
3.0 50.8 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.9 23.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
1.9 32.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
1.7 10.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.6 73.2 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
1.5 66.6 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
1.4 33.8 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
1.1 24.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
1.0 33.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.0 18.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
1.0 9.5 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.9 31.6 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.8 18.6 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.7 112.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.6 28.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.5 10.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.5 11.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.5 91.6 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.5 6.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.4 9.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 14.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 31.1 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.4 11.0 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.4 10.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 30.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 23.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 8.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.3 12.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.3 9.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 15.8 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.3 27.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.3 4.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.3 5.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 5.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 19.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 3.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 6.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.2 15.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 10.0 REACTOME DNA REPAIR Genes involved in DNA Repair
0.2 26.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.9 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 5.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 19.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 5.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 10.6 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.1 1.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.7 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification