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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for EBF3
Z-value: 0.35
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Transcription factors associated with EBF3
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_153517473 Show fit | 13.64 |
ENST00000368715.1
|
S100 calcium binding protein A4 |
|
| chr1_-_113247543 Show fit | 12.36 |
ENST00000414971.1
ENST00000534717.1 |
ras homolog family member C |
|
| chr7_-_100881041 Show fit | 11.28 |
ENST00000412417.1
ENST00000414035.1 |
claudin 15 |
|
| chr8_+_22436248 Show fit | 11.08 |
ENST00000308354.7
|
PDZ and LIM domain 2 (mystique) |
|
| chr7_+_75932863 Show fit | 10.96 |
ENST00000429938.1
|
heat shock 27kDa protein 1 |
|
| chr22_-_37640277 Show fit | 10.56 |
ENST00000401529.3
ENST00000249071.6 |
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
|
| chr1_-_154943212 Show fit | 10.09 |
ENST00000368445.5
ENST00000448116.2 ENST00000368449.4 |
SHC (Src homology 2 domain containing) transforming protein 1 |
|
| chr7_-_6523688 Show fit | 9.67 |
ENST00000490996.1
|
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 |
|
| chr1_-_154943002 Show fit | 9.53 |
ENST00000606391.1
|
SHC (Src homology 2 domain containing) transforming protein 1 |
|
| chr11_-_67120974 Show fit | 9.44 |
ENST00000539074.1
ENST00000312419.3 |
polymerase (DNA-directed), delta 4, accessory subunit |
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 22.1 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.2 | 21.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 20.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 3.3 | 20.0 | GO:0046985 | positive regulation of hemoglobin biosynthetic process(GO:0046985) |
| 0.5 | 19.6 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.5 | 15.8 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 2.0 | 15.7 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
| 1.0 | 14.6 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.2 | 14.4 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 1.3 | 14.1 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.7 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.4 | 20.1 | GO:0019814 | immunoglobulin complex(GO:0019814) |
| 1.1 | 20.0 | GO:0034709 | methylosome(GO:0034709) |
| 3.3 | 19.6 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.2 | 19.1 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 18.6 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 16.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.3 | 15.5 | GO:0045171 | intercellular bridge(GO:0045171) |
| 2.1 | 14.4 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.3 | 14.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 20.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.4 | 20.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 3.3 | 20.0 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 2.8 | 19.6 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.7 | 19.4 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 14.6 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
| 3.5 | 14.1 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 0.8 | 13.6 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 3.3 | 13.1 | GO:0032217 | riboflavin transporter activity(GO:0032217) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 22.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.7 | 19.6 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.4 | 19.4 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.3 | 16.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 14.3 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.4 | 13.6 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.3 | 12.8 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.4 | 12.4 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 10.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 37.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.5 | 20.5 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.9 | 19.8 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 17.1 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 15.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.4 | 15.8 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.3 | 13.4 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.5 | 13.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 12.7 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.4 | 10.1 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |