ISMARA results: EGR3

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for EGR3_EGR2

Z-value: 0.15

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Transcription factors associated with EGR3_EGR2

Gene Symbol	Gene ID	Gene Info
EGR3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000179388.8	early growth response 3
EGR2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000122877.9	early growth response 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EGR3	hg19_v2_chr8_-_22550815_22550844	0.29	1.2e-05	Click!
EGR2	hg19_v2_chr10_-_64576105_64576133	-0.19	4.7e-03	Click!

Activity profile of EGR3_EGR2 motif

Sorted Z-values of EGR3_EGR2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_124609823 Show fit	36.04	ENST00000412681.2	NRGN Ensembl NCBI GeneCards UniProt NextProt Show fit	neurogranin (protein kinase C substrate, RC3)
chr11_+_124609742 Show fit	35.85	ENST00000284292.6	NRGN Ensembl NCBI GeneCards UniProt NextProt Show fit	neurogranin (protein kinase C substrate, RC3)
chrX_-_47479246 Show fit	21.49	ENST00000295987.7 ENST00000340666.4	SYN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synapsin I
chr3_-_149688655 Show fit	20.12	ENST00000461930.1 ENST00000423691.2 ENST00000490975.1 ENST00000461868.1 ENST00000452853.2	PFN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	profilin 2
chr20_+_44035200 Show fit	19.61	ENST00000372717.1 ENST00000360981.4	DBNDD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	dysbindin (dystrobrevin binding protein 1) domain containing 2
chr16_+_23847267 Show fit	19.29	ENST00000321728.7	PRKCB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase C, beta
chr15_+_84115868 Show fit	18.40	ENST00000427482.2	SH3GL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	SH3-domain GRB2-like 3
chr15_+_84116106 Show fit	17.80	ENST00000535412.1 ENST00000324537.5	SH3GL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	SH3-domain GRB2-like 3
chr12_+_79258444 Show fit	16.56	ENST00000261205.4	SYT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin I
chr3_-_149688896 Show fit	16.07	ENST00000239940.7	PFN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	profilin 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR3_EGR2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	80.7	GO:1900273	positive regulation of long-term synaptic potentiation(GO:1900273)
4.8	58.0	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
11.5	34.4	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
10.5	31.5	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
3.2	25.8	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
2.6	23.5	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
2.5	22.4	GO:0097091	synaptic vesicle clustering(GO:0097091)
4.4	21.8	GO:1903285	negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
1.4	21.6	GO:0090168	Golgi reassembly(GO:0090168)
1.3	21.1	GO:0051639	actin filament network formation(GO:0051639)

Showing 1 to 10 of 273 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	97.5	GO:0043195	terminal bouton(GO:0043195)
5.9	71.4	GO:0044327	dendritic spine head(GO:0044327)
0.3	42.3	GO:0031901	early endosome membrane(GO:0031901)
0.6	38.7	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
6.3	31.5	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
1.4	19.3	GO:0031209	SCAR complex(GO:0031209)
0.0	18.3	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
1.2	17.8	GO:0005641	nuclear envelope lumen(GO:0005641)
1.2	17.8	GO:0005916	fascia adherens(GO:0005916)
1.3	16.1	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)

Showing 1 to 10 of 154 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	71.6	GO:0070300	phosphatidic acid binding(GO:0070300)
1.0	46.9	GO:0003785	actin monomer binding(GO:0003785)
11.5	34.4	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
6.3	31.5	GO:0030348	syntaxin-3 binding(GO:0030348)
1.2	30.1	GO:0017075	syntaxin-1 binding(GO:0017075)
4.4	21.8	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.1	21.5	GO:0000287	magnesium ion binding(GO:0000287)
0.3	21.1	GO:0048365	Rac GTPase binding(GO:0048365)
0.2	21.1	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
2.0	18.1	GO:0032051	clathrin light chain binding(GO:0032051)

Showing 1 to 10 of 206 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	77.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.8	40.3	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
1.6	35.9	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.5	33.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.4	31.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.6	22.0	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.2	14.0	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.3	11.4	PID AURORA A PATHWAY	Aurora A signaling
0.2	11.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.3	10.4	PID NCADHERIN PATHWAY	N-cadherin signaling events

Showing 1 to 10 of 47 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	58.3	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
2.0	56.8	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
3.0	53.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
1.2	35.9	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
1.4	34.0	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.3	23.2	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.4	22.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	21.0	REACTOME AMYLOIDS	Genes involved in Amyloids
0.2	18.2	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
0.7	17.9	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP

Showing 1 to 10 of 81 entries

Results for EGR3_EGR2

Z-value: 0.15

Motif logo

Transcription factors associated with EGR3_EGR2

Activity-expression correlation:

Activity profile of EGR3_EGR2 motif

Sorted Z-values of EGR3_EGR2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR3_EGR2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: