ISMARA results: ELF2_GABPA

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ELF2_GABPA_ELF5

Z-value: 1.36

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Transcription factors associated with ELF2_GABPA_ELF5

Gene Symbol	Gene ID	Gene Info
ELF2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000109381.15	E74 like ETS transcription factor 2
GABPA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000154727.6	GA binding protein transcription factor subunit alpha
ELF5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000135374.5	E74 like ETS transcription factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ELF2	hg19_v2_chr4_-_140005443_140005650	0.39	3.4e-09	Click!
ELF5	hg19_v2_chr11_-_34535332_34535352	-0.32	1.3e-06	Click!
GABPA	hg19_v2_chr21_+_27107672_27107698	0.30	5.7e-06	Click!

Activity profile of ELF2_GABPA_ELF5 motif

Sorted Z-values of ELF2_GABPA_ELF5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_32687971 Show fit	250.23	ENST00000373586.1	EIF3I Ensembl NCBI GeneCards UniProt NextProt Show fit	eukaryotic translation initiation factor 3, subunit I
chr20_-_49575058 Show fit	227.86	ENST00000371584.4 ENST00000371583.5 ENST00000413082.1	DPM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr12_-_110888103 Show fit	205.96	ENST00000426440.1 ENST00000228825.7	ARPC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	actin related protein 2/3 complex, subunit 3, 21kDa
chr14_-_69864993 Show fit	203.36	ENST00000555373.1	ERH Ensembl NCBI GeneCards UniProt NextProt Show fit	enhancer of rudimentary homolog (Drosophila)
chr2_-_73964447 Show fit	198.19	ENST00000272424.5 ENST00000409716.2 ENST00000318190.7	TPRKB Ensembl NCBI GeneCards UniProt NextProt Show fit	TP53RK binding protein
chr12_+_69080734 Show fit	184.07	ENST00000378905.2	NUP107 Ensembl NCBI GeneCards UniProt NextProt Show fit	nucleoporin 107kDa
chr1_+_40506392 Show fit	163.00	ENST00000414893.1 ENST00000414281.1 ENST00000420216.1 ENST00000372792.2 ENST00000372798.1 ENST00000340450.3 ENST00000372805.3 ENST00000435719.1 ENST00000427843.1 ENST00000417287.1 ENST00000424977.1 ENST00000446031.1	CAP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	CAP, adenylate cyclase-associated protein 1 (yeast)
chr7_+_141438393 Show fit	155.66	ENST00000484178.1 ENST00000473783.1 ENST00000481508.1	SSBP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	single-stranded DNA binding protein 1, mitochondrial
chr5_+_110074685 Show fit	154.37	ENST00000355943.3 ENST00000447245.2	SLC25A46 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 25, member 46
chr19_-_10450287 Show fit	150.78	ENST00000589261.1 ENST00000590569.1 ENST00000589580.1 ENST00000589249.1	ICAM3 Ensembl NCBI GeneCards UniProt NextProt Show fit	intercellular adhesion molecule 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ELF2_GABPA_ELF5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
25.0	2321.9	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
5.6	1580.8	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
15.6	1464.7	GO:0002181	cytoplasmic translation(GO:0002181)
28.3	1386.4	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
13.5	1025.1	GO:0071349	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
14.6	989.6	GO:0070125	mitochondrial translational elongation(GO:0070125)
11.4	856.4	GO:0045047	protein targeting to ER(GO:0045047)
17.9	804.9	GO:0009452	7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
10.2	726.4	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
15.5	665.7	GO:0070979	protein K11-linked ubiquitination(GO:0070979)

Showing 1 to 10 of 1,049 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	3679.6	GO:0070062	extracellular exosome(GO:0070062)
16.9	1813.2	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
3.2	1223.5	GO:0005635	nuclear envelope(GO:0005635)
3.2	1057.6	GO:0016607	nuclear speck(GO:0016607)
10.0	897.8	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
6.3	897.1	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
8.9	894.8	GO:0035578	azurophil granule lumen(GO:0035578)
27.7	857.7	GO:0030687	preribosome, large subunit precursor(GO:0030687)
11.9	785.9	GO:0015935	small ribosomal subunit(GO:0015935)
87.2	784.6	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Showing 1 to 10 of 402 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.0	3197.5	GO:0003723	RNA binding(GO:0003723)
13.4	2787.3	GO:0003735	structural constituent of ribosome(GO:0003735)
21.2	1359.0	GO:0003743	translation initiation factor activity(GO:0003743)
43.8	1313.2	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
10.0	941.0	GO:0003697	single-stranded DNA binding(GO:0003697)
3.7	788.0	GO:0051015	actin filament binding(GO:0051015)
28.8	633.4	GO:0000339	RNA cap binding(GO:0000339)
13.1	564.8	GO:0061650	ubiquitin-like protein conjugating enzyme activity(GO:0061650)
10.7	559.0	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
4.7	542.1	GO:0047485	protein N-terminus binding(GO:0047485)

Showing 1 to 10 of 689 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.4	855.8	PID RAC1 PATHWAY	RAC1 signaling pathway
8.3	698.3	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
10.0	658.4	PID ATR PATHWAY	ATR signaling pathway
6.6	629.8	PID E2F PATHWAY	E2F transcription factor network
13.9	582.6	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
6.7	517.6	PID ILK PATHWAY	Integrin-linked kinase signaling
6.6	488.1	PID P53 REGULATION PATHWAY	p53 pathway
7.7	478.4	PID AURORA B PATHWAY	Aurora B signaling
4.4	440.6	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
8.0	393.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions

Showing 1 to 10 of 125 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
21.0	2807.8	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
35.3	2609.8	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
24.1	1833.9	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
14.5	1489.3	REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	Genes involved in Processing of Capped Intron-Containing Pre-mRNA
25.6	920.2	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
5.4	784.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
9.7	774.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
16.7	699.5	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
11.8	695.1	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
22.2	642.5	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER

Showing 1 to 10 of 187 entries

Results for ELF2_GABPA_ELF5

Z-value: 1.36

Motif logo

Transcription factors associated with ELF2_GABPA_ELF5

Activity-expression correlation:

Activity profile of ELF2_GABPA_ELF5 motif

Sorted Z-values of ELF2_GABPA_ELF5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ELF2_GABPA_ELF5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: