Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for ELF3_EHF
Z-value: 0.57
Motif logo
Transcription factors associated with ELF3_EHF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELF3 | hg19_v2_chr1_+_201979645_201979721 | 0.30 | 7.9e-06 | Click! |
| EHF | hg19_v2_chr11_+_34642656_34642682 | 0.13 | 6.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF3_EHF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 55.3 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 1.8 | 35.7 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.7 | 32.8 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 6.5 | 32.5 | GO:0036369 | transcription factor catabolic process(GO:0036369) |
| 1.6 | 30.2 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 2.3 | 30.0 | GO:1900112 | regulation of histone H3-K9 trimethylation(GO:1900112) |
| 1.0 | 25.0 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 2.2 | 24.1 | GO:0006930 | substrate-dependent cell migration, cell extension(GO:0006930) |
| 1.0 | 23.9 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 1.4 | 23.6 | GO:0006265 | DNA topological change(GO:0006265) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 139.7 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.6 | 64.1 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 3.2 | 57.3 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.4 | 56.2 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 36.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 35.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 26.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.8 | 21.9 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 1.8 | 21.3 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.3 | 19.9 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 181.1 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 37.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 7.2 | 36.2 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.6 | 35.0 | GO:0004112 | cyclic-nucleotide phosphodiesterase activity(GO:0004112) |
| 0.4 | 34.8 | GO:0019905 | syntaxin binding(GO:0019905) |
| 6.3 | 31.5 | GO:0001132 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
| 4.5 | 27.0 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.1 | 24.3 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.8 | 23.2 | GO:0071949 | FAD binding(GO:0071949) |
| 2.0 | 21.7 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 42.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.6 | 33.1 | PID ATM PATHWAY | ATM pathway |
| 0.8 | 28.6 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.3 | 26.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 25.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 24.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 23.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 22.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.6 | 21.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.3 | 17.5 | PID ERBB4 PATHWAY | ErbB4 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 135.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.4 | 25.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.8 | 24.7 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.4 | 24.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.6 | 19.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.3 | 17.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 17.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.6 | 16.2 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.4 | 15.2 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.3 | 13.1 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |