ISMARA results: ELK4_ETV5_ELK1_ELK3

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ELK4_ETV5_ELK1_ELK3_ELF4

Z-value: 1.69

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Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4

Gene Symbol	Gene ID	Gene Info
ELK4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000158711.9	ETS transcription factor ELK4
ETV5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000244405.3	ETS variant transcription factor 5
ELK1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000126767.13	ETS transcription factor ELK1
ELK3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000111145.3	ETS transcription factor ELK3
ELF4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000102034.12	E74 like ETS transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ELK4	hg19_v2_chr1_-_205601064_205601090	-0.48	5.2e-14	Click!
ELK1	hg19_v2_chrX_-_47509887_47509990	-0.44	1.1e-11	Click!
ELK3	hg19_v2_chr12_+_96588279_96588323	-0.42	1.3e-10	Click!
ELF4	hg19_v2_chrX_-_129244655_129244697, hg19_v2_chrX_-_129244454_129244488	0.41	3.3e-10	Click!
ETV5	hg19_v2_chr3_-_185826855_185826911	0.20	3.2e-03	Click!

Activity profile of ELK4_ETV5_ELK1_ELK3_ELF4 motif

Sorted Z-values of ELK4_ETV5_ELK1_ELK3_ELF4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_-_49575058 Show fit	172.85	ENST00000371584.4 ENST00000371583.5 ENST00000413082.1	DPM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr1_+_32687971 Show fit	161.32	ENST00000373586.1	EIF3I Ensembl NCBI GeneCards UniProt NextProt Show fit	eukaryotic translation initiation factor 3, subunit I
chr12_-_110888103 Show fit	159.77	ENST00000426440.1 ENST00000228825.7	ARPC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	actin related protein 2/3 complex, subunit 3, 21kDa
chr2_-_73964447 Show fit	155.91	ENST00000272424.5 ENST00000409716.2 ENST00000318190.7	TPRKB Ensembl NCBI GeneCards UniProt NextProt Show fit	TP53RK binding protein
chr14_-_69864993 Show fit	136.26	ENST00000555373.1	ERH Ensembl NCBI GeneCards UniProt NextProt Show fit	enhancer of rudimentary homolog (Drosophila)
chr5_+_110074685 Show fit	133.79	ENST00000355943.3 ENST00000447245.2	SLC25A46 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 25, member 46
chr17_+_1944790 Show fit	130.73	ENST00000575162.1	DPH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	diphthamide biosynthesis 1
chr5_-_140070897 Show fit	129.09	ENST00000448240.1 ENST00000438307.2 ENST00000415192.2 ENST00000457527.2 ENST00000307633.3 ENST00000507746.1 ENST00000431330.2	HARS Ensembl NCBI GeneCards UniProt NextProt Show fit	histidyl-tRNA synthetase
chr20_-_2451395 Show fit	127.40	ENST00000339610.6 ENST00000381342.2 ENST00000438552.2	SNRPB Ensembl NCBI GeneCards UniProt NextProt Show fit	small nuclear ribonucleoprotein polypeptides B and B1
chr2_+_201754050 Show fit	124.90	ENST00000426253.1 ENST00000416651.1 ENST00000454952.1 ENST00000409020.1 ENST00000359683.4	NIF3L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
15.3	1679.6	GO:1904667	negative regulation of ubiquitin protein ligase activity(GO:1904667)
17.5	855.9	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
12.0	852.0	GO:0070125	mitochondrial translational elongation(GO:0070125)
7.3	803.2	GO:0045047	protein targeting to ER(GO:0045047)
2.7	736.0	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
15.2	685.3	GO:0036260	7-methylguanosine mRNA capping(GO:0006370) 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
13.7	631.4	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
9.6	623.8	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
5.6	536.2	GO:0006413	translational initiation(GO:0006413)
13.8	428.0	GO:0000027	ribosomal large subunit assembly(GO:0000027)

Showing 1 to 10 of 952 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.9	958.6	GO:0015934	large ribosomal subunit(GO:0015934)
0.9	924.3	GO:0005739	mitochondrion(GO:0005739)
0.3	743.7	GO:0070062	extracellular exosome(GO:0070062)
22.5	696.6	GO:0030687	preribosome, large subunit precursor(GO:0030687)
4.2	618.7	GO:0005681	spliceosomal complex(GO:0005681)
8.9	542.0	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
11.0	517.6	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
55.5	499.5	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
13.0	495.4	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
6.8	447.8	GO:0015935	small ribosomal subunit(GO:0015935)

Showing 1 to 10 of 381 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.1	1929.8	GO:0003735	structural constituent of ribosome(GO:0003735)
1.6	1752.3	GO:0003723	RNA binding(GO:0003723)
8.1	841.0	GO:0003697	single-stranded DNA binding(GO:0003697)
14.2	767.8	GO:0003743	translation initiation factor activity(GO:0003743)
11.9	630.5	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
19.5	584.2	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
2.4	532.1	GO:0051015	actin filament binding(GO:0051015)
20.7	455.7	GO:0000339	RNA cap binding(GO:0000339)
38.2	382.3	GO:0070990	snRNP binding(GO:0070990)
33.4	367.6	GO:0036402	proteasome-activating ATPase activity(GO:0036402)

Showing 1 to 10 of 587 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.0	627.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
8.6	562.2	PID AURORA B PATHWAY	Aurora B signaling
7.7	472.1	PID ATR PATHWAY	ATR signaling pathway
8.3	375.4	PID PLK1 PATHWAY	PLK1 signaling events
2.8	229.4	PID E2F PATHWAY	E2F transcription factor network
16.2	227.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
5.0	216.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
7.4	208.3	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
7.6	205.5	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
5.5	201.9	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Showing 1 to 10 of 97 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.4	1533.5	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
20.6	1524.4	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
14.4	1093.9	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
9.4	798.5	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
13.8	757.1	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
6.6	675.8	REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	Genes involved in Processing of Capped Intron-Containing Pre-mRNA
18.5	664.9	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
15.9	621.0	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
33.9	541.9	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
8.8	536.1	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import

Showing 1 to 10 of 176 entries

Results for ELK4_ETV5_ELK1_ELK3_ELF4

Z-value: 1.69

Motif logo

Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4

Activity-expression correlation:

Activity profile of ELK4_ETV5_ELK1_ELK3_ELF4 motif

Sorted Z-values of ELK4_ETV5_ELK1_ELK3_ELF4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: