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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for EMX2
Z-value: 0.02
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Transcription factors associated with EMX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EMX2 | hg19_v2_chr10_+_119301928_119301955 | -0.10 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EMX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.2 | GO:0042119 | neutrophil activation(GO:0042119) |
| 0.1 | 5.6 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.3 | 5.3 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.1 | 5.2 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.2 | 5.0 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.1 | 4.8 | GO:0030261 | chromosome condensation(GO:0030261) |
| 1.2 | 4.7 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.3 | 4.7 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.0 | 4.7 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.0 | 4.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 5.6 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 5.4 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.9 | 4.7 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 4.7 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 3.9 | GO:0032982 | myosin filament(GO:0032982) |
| 0.7 | 3.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.2 | 3.3 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 2.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 2.3 | GO:0030673 | axolemma(GO:0030673) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.6 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 7.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 6.9 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 6.6 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.2 | 5.3 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.1 | 5.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 1.2 | 4.7 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.3 | 4.7 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.5 | 4.2 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.3 | 3.7 | GO:0031432 | titin binding(GO:0031432) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 4.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 3.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 3.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.3 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 1.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 1.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 1.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.3 | 4.8 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 4.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 4.5 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 3.7 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.1 | 3.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 3.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.3 | 3.4 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 3.4 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 3.3 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |