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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for EOMES
Z-value: 1.05
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Transcription factors associated with EOMES
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_55658252 Show fit | 24.21 |
ENST00000395425.2
|
discs, large (Drosophila) homolog-associated protein 5 |
|
| chr9_+_91926103 Show fit | 23.75 |
ENST00000314355.6
|
CDC28 protein kinase regulatory subunit 2 |
|
| chr14_-_55658323 Show fit | 20.83 |
ENST00000554067.1
ENST00000247191.2 |
discs, large (Drosophila) homolog-associated protein 5 |
|
| chr7_-_96339132 Show fit | 19.10 |
ENST00000413065.1
|
split hand/foot malformation (ectrodactyly) type 1 |
|
| chr6_+_34204642 Show fit | 18.64 |
ENST00000347617.6
ENST00000401473.3 ENST00000311487.5 ENST00000447654.1 ENST00000395004.3 |
high mobility group AT-hook 1 |
|
| chr1_-_167906277 Show fit | 16.99 |
ENST00000271373.4
|
mitochondrial pyruvate carrier 2 |
|
| chr14_+_54863739 Show fit | 16.64 |
ENST00000541304.1
|
cyclin-dependent kinase inhibitor 3 |
|
| chr1_+_87170577 Show fit | 16.48 |
ENST00000482504.1
|
SH3-domain GRB2-like endophilin B1 |
|
| chr1_+_162531294 Show fit | 16.26 |
ENST00000367926.4
ENST00000271469.3 |
UDP-N-acteylglucosamine pyrophosphorylase 1 |
|
| chr10_-_58120996 Show fit | 16.26 |
ENST00000361148.6
ENST00000395405.1 ENST00000373944.3 |
ZW10 interacting kinetochore protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of EOMES
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 45.0 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 7.5 | 37.7 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 4.8 | 33.6 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.6 | 27.5 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 8.6 | 25.7 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 8.2 | 24.6 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 6.1 | 24.5 | GO:1902361 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
| 0.3 | 22.2 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.6 | 19.8 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.2 | 19.4 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 45.0 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 3.4 | 33.6 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 30.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.5 | 27.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.4 | 27.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 2.6 | 25.5 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.9 | 24.5 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 1.3 | 23.7 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.2 | 20.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.5 | 20.5 | GO:0000421 | autophagosome membrane(GO:0000421) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 69.4 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.4 | 50.1 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 29.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 25.2 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.3 | 24.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 3.1 | 24.5 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 3.0 | 24.4 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 4.0 | 24.0 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 3.4 | 23.8 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 1.3 | 23.7 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 89.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 41.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 23.2 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.3 | 22.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 17.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.3 | 14.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 12.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 9.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 8.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 8.6 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 52.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.3 | 28.9 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 1.5 | 25.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 24.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.6 | 24.0 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.9 | 21.5 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.8 | 19.2 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.5 | 19.2 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 2.1 | 18.6 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.3 | 17.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |