ISMARA results: EP300

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for EP300

Z-value: 0.04

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Transcription factors associated with EP300

Gene Symbol	Gene ID	Gene Info
EP300 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000100393.9	E1A binding protein p300

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EP300	hg19_v2_chr22_+_41487711_41487798	-0.38	9.1e-09	Click!

Activity profile of EP300 motif

Sorted Z-values of EP300 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_6308881 Show fit	18.70	ENST00000382518.1 ENST00000536586.1	CD9 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD9 molecule
chrX_-_140271249 Show fit	17.14	ENST00000370526.2	LDOC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	leucine zipper, down-regulated in cancer 1
chr8_+_30300119 Show fit	17.03	ENST00000520191.1	RBPMS Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein with multiple splicing
chr14_-_69445968 Show fit	16.35	ENST00000438964.2	ACTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	actinin, alpha 1
chr1_+_10003486 Show fit	16.21	ENST00000403197.1 ENST00000377205.1	NMNAT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	nicotinamide nucleotide adenylyltransferase 1
chr2_-_110371720 Show fit	15.11	ENST00000356688.4	SEPT10 Ensembl NCBI GeneCards UniProt NextProt Show fit	septin 10
chr12_+_6309517 Show fit	14.77	ENST00000382519.4 ENST00000009180.4	CD9 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD9 molecule
chr14_-_69445793 Show fit	14.56	ENST00000538545.2 ENST00000394419.4	ACTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	actinin, alpha 1
chr14_-_69446034 Show fit	14.48	ENST00000193403.6	ACTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	actinin, alpha 1
chr11_-_46722117 Show fit	13.37	ENST00000311956.4	ARHGAP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GTPase activating protein 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of EP300

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	45.4	GO:0051639	actin filament network formation(GO:0051639)
3.0	33.5	GO:0009414	response to water deprivation(GO:0009414)
4.7	28.3	GO:0030421	defecation(GO:0030421)
4.9	19.6	GO:0035026	leading edge cell differentiation(GO:0035026)
0.6	19.2	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
3.7	18.7	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
1.1	18.6	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
2.1	17.1	GO:0043129	surfactant homeostasis(GO:0043129)
1.3	17.1	GO:0060137	maternal process involved in parturition(GO:0060137)
1.5	16.8	GO:0032287	peripheral nervous system myelin maintenance(GO:0032287)

Showing 1 to 10 of 213 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.0	45.4	GO:0005916	fascia adherens(GO:0005916)
0.3	35.3	GO:0005913	cell-cell adherens junction(GO:0005913)
1.1	33.5	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.6	25.4	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	20.5	GO:0031012	extracellular matrix(GO:0031012)
2.2	19.6	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.5	17.0	GO:0005685	U1 snRNP(GO:0005685)
0.0	16.7	GO:0005856	cytoskeleton(GO:0005856)
0.1	14.7	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	14.2	GO:0016324	apical plasma membrane(GO:0016324)

Showing 1 to 10 of 98 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	45.4	GO:0017166	vinculin binding(GO:0017166)
0.2	37.2	GO:0044325	ion channel binding(GO:0044325)
0.2	33.6	GO:0005178	integrin binding(GO:0005178)
0.2	28.9	GO:0008201	heparin binding(GO:0008201)
0.1	26.7	GO:0005525	GTP binding(GO:0005525)
0.1	23.8	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.9	19.6	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
4.8	19.2	GO:0001512	dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408)
2.3	18.7	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.2	18.4	GO:0008307	structural constituent of muscle(GO:0008307)

Showing 1 to 10 of 163 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	73.6	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.5	42.8	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.3	25.8	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	23.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	20.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.3	18.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	13.7	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.4	13.4	PID S1P S1P2 PATHWAY	S1P2 pathway
0.2	11.6	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.2	10.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	56.0	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.4	29.8	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	29.8	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.1	19.6	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.4	17.1	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.2	15.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.5	15.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.9	15.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.2	14.9	REACTOME ASPARAGINE N LINKED GLYCOSYLATION	Genes involved in Asparagine N-linked glycosylation
0.2	10.9	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere

Showing 1 to 10 of 56 entries

Results for EP300

Z-value: 0.04

Motif logo

Transcription factors associated with EP300

Activity-expression correlation:

Activity profile of EP300 motif

Sorted Z-values of EP300 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of EP300

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: