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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for EPAS1_BCL3

Z-value: 1.26

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Transcription factors associated with EPAS1_BCL3

Gene Symbol Gene ID Gene Info
ENSG00000116016.9 endothelial PAS domain protein 1
ENSG00000069399.8 BCL3 transcription coactivator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EPAS1hg19_v2_chr2_+_46524537_465245530.559.6e-19Click!
BCL3hg19_v2_chr19_+_45251804_45251840-0.228.7e-04Click!

Activity profile of EPAS1_BCL3 motif

Sorted Z-values of EPAS1_BCL3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_35629702 124.39 ENST00000351325.4
FXYD domain containing ion transport regulator 1
chr15_-_60690932 71.07 ENST00000559818.1
annexin A2
chr20_+_10199468 57.06 ENST00000254976.2
ENST00000304886.2
synaptosomal-associated protein, 25kDa
chr16_-_70719925 54.56 ENST00000338779.6
metastasis suppressor 1-like
chr3_-_58572760 51.71 ENST00000447756.2
family with sequence similarity 107, member A
chr1_+_6845384 45.50 ENST00000303635.7
calmodulin binding transcription activator 1
chr6_+_31620191 44.56 ENST00000375918.2
ENST00000375920.4
apolipoprotein M
chr8_+_21915368 43.97 ENST00000265800.5
ENST00000517418.1
dematin actin binding protein
chr19_+_56915668 42.39 ENST00000333201.9
ENST00000391778.3
zinc finger protein 583
chr4_-_5894777 37.87 ENST00000324989.7
collapsin response mediator protein 1
chr8_-_134309335 37.07 ENST00000522890.1
ENST00000323851.7
ENST00000518176.1
ENST00000354944.5
ENST00000537882.1
ENST00000522476.1
ENST00000518066.1
ENST00000521544.1
ENST00000518480.1
ENST00000523892.1
N-myc downstream regulated 1
chr2_+_20646824 36.93 ENST00000272233.4
ras homolog family member B
chr8_-_27462822 36.61 ENST00000522098.1
clusterin
chr16_+_6069072 36.17 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr4_+_158141806 36.10 ENST00000393815.2
glutamate receptor, ionotropic, AMPA 2
chr2_+_203499901 35.45 ENST00000303116.6
ENST00000392238.2
family with sequence similarity 117, member B
chr19_+_35630022 35.33 ENST00000589209.1
FXYD domain containing ion transport regulator 1
chr7_+_154002189 32.48 ENST00000332007.3
dipeptidyl-peptidase 6
chr16_+_22825475 32.33 ENST00000261374.3
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr17_+_73750699 30.60 ENST00000584939.1
integrin, beta 4
chr11_-_134281812 30.16 ENST00000392580.1
ENST00000312527.4
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr22_+_41956767 30.10 ENST00000306149.7
cold shock domain containing C2, RNA binding
chr4_-_174320687 30.02 ENST00000296506.3
stimulator of chondrogenesis 1
chr19_-_37019562 29.69 ENST00000523638.1
zinc finger protein 260
chr3_-_195310802 29.57 ENST00000421243.1
ENST00000453131.1
apolipoprotein D
chr7_+_87257854 29.29 ENST00000394654.3
RUN domain containing 3B
chr12_-_16761007 28.85 ENST00000354662.1
ENST00000441439.2
LIM domain only 3 (rhombotin-like 2)
chr14_-_21493649 28.77 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG family member 2
chr16_+_6069586 28.64 ENST00000547372.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_-_21978312 28.60 ENST00000359708.4
ENST00000290101.4
RAP1 GTPase activating protein
chr3_-_52479043 28.13 ENST00000231721.2
ENST00000475739.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr22_+_39853258 27.99 ENST00000341184.6
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr11_-_125366089 27.65 ENST00000366139.3
ENST00000278919.3
fasciculation and elongation protein zeta 1 (zygin I)
chr19_+_45445491 27.48 ENST00000592954.1
ENST00000419266.2
ENST00000589057.1
apolipoprotein C-IV
APOC4-APOC2 readthrough (NMD candidate)
chr1_+_184356188 27.18 ENST00000235307.6
chromosome 1 open reading frame 21
chr19_-_38714847 26.85 ENST00000420980.2
ENST00000355526.4
D4, zinc and double PHD fingers family 1
chr7_+_121513143 26.61 ENST00000393386.2
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr7_+_87257701 26.55 ENST00000338056.3
ENST00000493037.1
RUN domain containing 3B
chr12_+_121088291 26.36 ENST00000351200.2
calcium binding protein 1
chr8_+_10530155 25.64 ENST00000521818.1
chromosome 8 open reading frame 74
chr1_+_110453608 25.41 ENST00000369801.1
colony stimulating factor 1 (macrophage)
chr11_+_10472223 24.79 ENST00000396554.3
ENST00000524866.1
adenosine monophosphate deaminase 3
chr17_+_1665345 24.71 ENST00000576406.1
ENST00000571149.1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr8_+_21916710 24.67 ENST00000523266.1
ENST00000519907.1
dematin actin binding protein
chr7_+_95401877 24.33 ENST00000524053.1
ENST00000324972.6
ENST00000537881.1
ENST00000437599.1
ENST00000359388.4
ENST00000413338.1
dynein, cytoplasmic 1, intermediate chain 1
chr8_+_21916680 24.25 ENST00000358242.3
ENST00000415253.1
dematin actin binding protein
chr15_+_74422585 24.23 ENST00000561740.1
ENST00000435464.1
ENST00000453268.2
immunoglobulin superfamily containing leucine-rich repeat 2
chr19_+_30863271 24.13 ENST00000355537.3
zinc finger protein 536
chr5_-_42825983 24.04 ENST00000506577.1
selenoprotein P, plasma, 1
chr1_+_27561104 23.94 ENST00000361771.3
WD and tetratricopeptide repeats 1
chr16_+_5008290 23.81 ENST00000251170.7
SEC14-like 5 (S. cerevisiae)
chr7_+_73442422 23.79 ENST00000358929.4
ENST00000431562.1
ENST00000320492.7
ENST00000438906.1
elastin
chr2_+_25016282 23.42 ENST00000260662.1
centromere protein O
chr12_+_66218212 23.31 ENST00000393578.3
ENST00000425208.2
ENST00000536545.1
ENST00000354636.3
high mobility group AT-hook 2
chr4_+_158141843 23.27 ENST00000509417.1
ENST00000296526.7
glutamate receptor, ionotropic, AMPA 2
chr17_+_17942594 23.18 ENST00000268719.4
GID complex subunit 4
chr7_+_95401851 23.08 ENST00000447467.2
dynein, cytoplasmic 1, intermediate chain 1
chr3_-_58613323 23.00 ENST00000474531.1
ENST00000465970.1
family with sequence similarity 107, member A
chr2_-_152955213 22.55 ENST00000427385.1
calcium channel, voltage-dependent, beta 4 subunit
chr7_+_29519662 22.43 ENST00000424025.2
ENST00000439711.2
ENST00000421775.2
chimerin 2
chr9_+_103790991 22.35 ENST00000374874.3
Lipid phosphate phosphatase-related protein type 1
chr6_+_126070726 22.14 ENST00000368364.3
hes-related family bHLH transcription factor with YRPW motif 2
chr2_+_25015968 22.01 ENST00000380834.2
ENST00000473706.1
centromere protein O
chr3_-_167813672 22.00 ENST00000470487.1
golgi integral membrane protein 4
chr3_-_127541679 21.89 ENST00000265052.5
monoglyceride lipase
chrX_+_101906294 21.89 ENST00000361600.5
ENST00000415986.1
ENST00000444152.1
ENST00000537097.1
G protein-coupled receptor associated sorting protein 1
chr11_-_89224508 21.75 ENST00000525196.1
NADPH oxidase 4
chr1_+_110453462 21.73 ENST00000488198.1
colony stimulating factor 1 (macrophage)
chr17_+_8213590 21.43 ENST00000361926.3
Rho guanine nucleotide exchange factor (GEF) 15
chr12_-_12491608 21.36 ENST00000545735.1
MANSC domain containing 1
chr1_+_110453109 21.32 ENST00000525659.1
colony stimulating factor 1 (macrophage)
chr1_-_21671968 21.18 ENST00000415912.2
endothelin converting enzyme 1
chr1_+_27561007 21.05 ENST00000319394.3
WD and tetratricopeptide repeats 1
chr8_-_110620284 20.92 ENST00000529690.1
syntabulin (syntaxin-interacting)
chr19_+_35630628 20.82 ENST00000588715.1
ENST00000588607.1
FXYD domain containing ion transport regulator 1
chr20_+_57875658 20.66 ENST00000371025.3
endothelin 3
chr4_+_158141899 20.49 ENST00000264426.9
ENST00000506284.1
glutamate receptor, ionotropic, AMPA 2
chr11_-_111783595 20.47 ENST00000528628.1
crystallin, alpha B
chr19_-_47975417 20.32 ENST00000236877.6
solute carrier family 8 (sodium/calcium exchanger), member 2
chr12_+_57157100 20.19 ENST00000322165.1
hydroxysteroid (17-beta) dehydrogenase 6
chr9_+_87283430 20.14 ENST00000376214.1
ENST00000376213.1
neurotrophic tyrosine kinase, receptor, type 2
chr19_-_40562063 20.14 ENST00000598845.1
ENST00000593605.1
ENST00000221355.6
ENST00000434248.1
zinc finger protein 780B
chr19_-_16582815 20.13 ENST00000455140.2
ENST00000248070.6
ENST00000594975.1
epidermal growth factor receptor pathway substrate 15-like 1
chr22_+_19705928 20.05 ENST00000383045.3
ENST00000438754.2
septin 5
chr16_+_58283814 20.01 ENST00000443128.2
ENST00000219299.4
coiled-coil domain containing 113
chr8_+_27348626 19.94 ENST00000517536.1
epoxide hydrolase 2, cytoplasmic
chr19_+_57019212 19.68 ENST00000308031.5
ENST00000591537.1
zinc finger protein 471
chr11_-_107582775 19.62 ENST00000305991.2
sarcolipin
chr17_+_64961026 19.61 ENST00000262138.3
calcium channel, voltage-dependent, gamma subunit 4
chr14_-_64970494 19.60 ENST00000608382.1
zinc finger and BTB domain containing 25
chr14_+_96505659 19.48 ENST00000555004.1
chromosome 14 open reading frame 132
chr8_+_144816303 19.41 ENST00000533004.1
FAM83H antisense RNA 1 (head to head)
chr10_-_62332357 19.21 ENST00000503366.1
ankyrin 3, node of Ranvier (ankyrin G)
chr16_-_20681177 19.04 ENST00000524149.1
acyl-CoA synthetase medium-chain family member 1
chr3_-_9291063 19.03 ENST00000383836.3
SLIT-ROBO Rho GTPase activating protein 3
chr19_-_56988677 19.00 ENST00000504904.3
ENST00000292069.6
zinc finger protein 667
chr17_+_43972010 18.98 ENST00000334239.8
ENST00000446361.3
microtubule-associated protein tau
chr17_-_10017864 18.79 ENST00000323816.4
growth arrest-specific 7
chr3_-_127542051 18.78 ENST00000398104.1
monoglyceride lipase
chr20_+_57875758 18.43 ENST00000395654.3
endothelin 3
chr19_+_45445524 18.20 ENST00000591600.1
apolipoprotein C-IV
chr12_-_6798616 18.13 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
zinc finger protein 384
chr20_+_17207665 18.01 ENST00000536609.1
proprotein convertase subtilisin/kexin type 2
chr22_-_19512893 18.00 ENST00000403084.1
ENST00000413119.2
claudin 5
chr16_+_72090053 17.90 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
haptoglobin
chr13_-_37494365 17.88 ENST00000350148.5
SMAD family member 9
chr4_-_186732048 17.86 ENST00000448662.2
ENST00000439049.1
ENST00000420158.1
ENST00000431808.1
ENST00000319471.9
sorbin and SH3 domain containing 2
chr18_+_6729725 17.71 ENST00000400091.2
ENST00000583410.1
ENST00000584387.1
Rho GTPase activating protein 28
chr19_+_41509851 17.70 ENST00000593831.1
ENST00000330446.5
cytochrome P450, family 2, subfamily B, polypeptide 6
chr20_+_17207636 17.63 ENST00000262545.2
proprotein convertase subtilisin/kexin type 2
chr3_-_127542021 17.62 ENST00000434178.2
monoglyceride lipase
chr14_-_21493884 17.42 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG family member 2
chr1_-_177133818 17.36 ENST00000424564.2
ENST00000361833.2
astrotactin 1
chr19_-_14887568 17.29 ENST00000596991.2
ENST00000594294.1
ENST00000594076.1
ENST00000595839.1
ENST00000392965.3
ENST00000601345.1
egf-like module containing, mucin-like, hormone receptor-like 2
chr14_+_71108460 17.12 ENST00000256367.2
tetratricopeptide repeat domain 9
chr6_-_11807277 17.08 ENST00000379415.2
androgen-dependent TFPI-regulating protein
chr11_-_89224638 17.06 ENST00000535633.1
ENST00000263317.4
NADPH oxidase 4
chr21_-_31312230 17.05 ENST00000399907.1
ENST00000399909.1
glutamate receptor, ionotropic, kainate 1
chr2_-_223163465 17.00 ENST00000409828.3
ENST00000350526.4
ENST00000258387.5
ENST00000409551.3
ENST00000392069.2
ENST00000344493.4
ENST00000336840.6
ENST00000392070.2
paired box 3
chr1_+_46668994 16.84 ENST00000371980.3
leucine rich adaptor protein 1
chr12_+_50451462 16.83 ENST00000447966.2
acid-sensing (proton-gated) ion channel 1
chrX_+_135229559 16.76 ENST00000394155.2
four and a half LIM domains 1
chr1_+_160765947 16.73 ENST00000263285.6
ENST00000368039.2
lymphocyte antigen 9
chr21_-_31311818 16.71 ENST00000535441.1
ENST00000309434.7
ENST00000327783.4
ENST00000389124.2
ENST00000389125.3
ENST00000399913.1
glutamate receptor, ionotropic, kainate 1
chr19_-_36297348 16.45 ENST00000589835.1
proline dehydrogenase (oxidase) 2
chr4_-_57547870 16.41 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOP homeobox
chr7_+_29519486 16.27 ENST00000409041.4
chimerin 2
chr17_-_48207157 16.24 ENST00000330175.4
ENST00000503131.1
sterile alpha motif domain containing 14
chr20_+_30946106 16.23 ENST00000375687.4
ENST00000542461.1
additional sex combs like 1 (Drosophila)
chr17_-_56406117 16.23 ENST00000268893.6
ENST00000355701.3
benzodiazepine receptor (peripheral) associated protein 1
chr2_+_238475217 16.19 ENST00000165524.1
prolactin releasing hormone
chr7_+_73442102 16.19 ENST00000445912.1
ENST00000252034.7
elastin
chr16_+_1578674 15.98 ENST00000253934.5
transmembrane protein 204
chr4_+_158142750 15.94 ENST00000505888.1
ENST00000449365.1
glutamate receptor, ionotropic, AMPA 2
chr19_+_54024251 15.75 ENST00000253144.9
zinc finger protein 331
chr16_-_21289627 15.74 ENST00000396023.2
ENST00000415987.2
crystallin, mu
chr6_-_84419101 15.60 ENST00000520302.1
ENST00000520213.1
ENST00000439399.2
ENST00000428679.2
ENST00000437520.1
synaptosomal-associated protein, 91kDa
chr13_-_37494391 15.59 ENST00000379826.4
SMAD family member 9
chr6_+_36210980 15.55 ENST00000312917.5
ENST00000388715.3
patatin-like phospholipase domain containing 1
chr19_-_36980337 15.54 ENST00000434377.2
ENST00000424129.2
ENST00000452939.1
ENST00000427002.1
zinc finger protein 566
chr4_+_62067860 15.48 ENST00000514591.1
latrophilin 3
chr7_+_73442457 15.46 ENST00000438880.1
ENST00000414324.1
ENST00000380562.4
elastin
chr12_+_7023491 15.26 ENST00000541477.1
ENST00000229277.1
enolase 2 (gamma, neuronal)
chr19_-_36980455 15.24 ENST00000454319.1
ENST00000392170.2
zinc finger protein 566
chr7_+_86273952 15.14 ENST00000536043.1
glutamate receptor, metabotropic 3
chr19_+_46171464 15.02 ENST00000590918.1
ENST00000263281.3
ENST00000304207.8
gastric inhibitory polypeptide receptor
chr7_-_50518022 14.85 ENST00000356889.4
ENST00000420829.1
ENST00000448788.1
ENST00000395556.2
ENST00000422854.1
ENST00000435566.1
ENST00000433017.1
fidgetin-like 1
chr10_-_30348439 14.77 ENST00000375377.1
KIAA1462
chr5_-_142000883 14.75 ENST00000359370.6
fibroblast growth factor 1 (acidic)
chr5_-_148033726 14.64 ENST00000354217.2
ENST00000314512.6
ENST00000362016.2
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
chr3_+_186435065 14.63 ENST00000287611.2
ENST00000265023.4
kininogen 1
chr15_+_84116106 14.53 ENST00000535412.1
ENST00000324537.5
SH3-domain GRB2-like 3
chr17_+_1665253 14.45 ENST00000254722.4
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr7_+_73442487 14.36 ENST00000380575.4
ENST00000380584.4
ENST00000458204.1
ENST00000357036.5
ENST00000417091.1
ENST00000429192.1
ENST00000442310.1
ENST00000380553.4
ENST00000380576.5
ENST00000428787.1
ENST00000320399.6
elastin
chr4_-_8873531 14.35 ENST00000400677.3
H6 family homeobox 1
chr6_-_31620403 14.25 ENST00000451898.1
ENST00000439687.2
ENST00000362049.6
ENST00000424480.1
BCL2-associated athanogene 6
chr6_-_31514516 14.25 ENST00000303892.5
ENST00000483251.1
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr10_-_135150367 14.22 ENST00000368555.3
ENST00000252939.4
ENST00000368558.1
ENST00000368556.2
calcyon neuron-specific vesicular protein
chr1_+_160765884 14.21 ENST00000392203.4
lymphocyte antigen 9
chr7_-_44365020 14.19 ENST00000395747.2
ENST00000347193.4
ENST00000346990.4
ENST00000258682.6
ENST00000353625.4
ENST00000421607.1
ENST00000424197.1
ENST00000502837.2
ENST00000350811.3
ENST00000395749.2
calcium/calmodulin-dependent protein kinase II beta
chr19_+_35630344 14.15 ENST00000455515.2
FXYD domain containing ion transport regulator 1
chr12_+_79258444 14.09 ENST00000261205.4
synaptotagmin I
chr8_+_79428539 13.98 ENST00000352966.5
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr8_-_38239732 13.91 ENST00000534155.1
ENST00000433384.2
ENST00000317025.8
ENST00000316985.3
Wolf-Hirschhorn syndrome candidate 1-like 1
chr18_+_74534479 13.83 ENST00000320610.9
zinc finger protein 236
chr11_-_32457176 13.68 ENST00000332351.3
Wilms tumor 1
chr1_+_110453514 13.67 ENST00000369802.3
ENST00000420111.2
colony stimulating factor 1 (macrophage)
chr5_-_11588907 13.65 ENST00000513598.1
ENST00000503622.1
catenin (cadherin-associated protein), delta 2
chrX_+_135229600 13.64 ENST00000370690.3
four and a half LIM domains 1
chr9_+_129089088 13.62 ENST00000361171.3
ENST00000545391.1
multivesicular body subunit 12B
chr8_-_102803163 13.60 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
neurocalcin delta
chr11_+_6280927 13.57 ENST00000334619.2
cholecystokinin B receptor
chr11_-_70507867 13.55 ENST00000412252.1
ENST00000409161.1
ENST00000409530.1
SH3 and multiple ankyrin repeat domains 2
chr20_-_50385138 13.53 ENST00000338821.5
ATPase, class II, type 9A
chr12_+_133758115 13.51 ENST00000541009.2
ENST00000592241.1
zinc finger protein 268
chr1_+_50575292 13.51 ENST00000371821.1
ENST00000371819.1
ELAV like neuron-specific RNA binding protein 4
chr16_+_6069664 13.51 ENST00000422070.4
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_-_115630900 13.48 ENST00000537070.1
ENST00000499809.1
ENST00000514294.2
ENST00000535683.1
long intergenic non-protein coding RNA 900
chr17_+_17942684 13.43 ENST00000376345.3
GID complex subunit 4
chr12_+_79258547 13.37 ENST00000457153.2
synaptotagmin I
chr12_+_5541267 13.35 ENST00000423158.3
neurotrophin 3
chr18_+_77439775 13.20 ENST00000299543.7
ENST00000075430.7
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr11_+_17756279 13.17 ENST00000265969.6
potassium voltage-gated channel, Shaw-related subfamily, member 1
chr7_+_86274145 13.16 ENST00000439827.1
ENST00000394720.2
ENST00000421579.1
glutamate receptor, metabotropic 3
chr12_-_6798523 13.13 ENST00000319770.3
zinc finger protein 384
chr7_-_38389573 13.08 ENST00000390344.2
T cell receptor gamma variable 5
chr18_+_29171689 12.97 ENST00000237014.3
transthyretin
chr2_-_37193606 12.89 ENST00000379213.2
ENST00000263918.4
striatin, calmodulin binding protein
chr12_-_6798410 12.89 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
zinc finger protein 384
chr9_-_72287191 12.79 ENST00000265381.4
amyloid beta (A4) precursor protein-binding, family A, member 1
chr17_-_37309480 12.76 ENST00000539608.1
plexin domain containing 1
chr1_+_77747656 12.71 ENST00000354567.2
adenylate kinase 5
chr1_-_149889382 12.65 ENST00000369145.1
ENST00000369146.3
synaptic vesicle glycoprotein 2A
chr19_-_43709703 12.61 ENST00000599391.1
ENST00000244295.9
pregnancy specific beta-1-glycoprotein 4
chr14_-_54420133 12.58 ENST00000559501.1
ENST00000558984.1
bone morphogenetic protein 4
chr15_+_84115868 12.58 ENST00000427482.2
SH3-domain GRB2-like 3
chr11_-_32457075 12.57 ENST00000448076.3
Wilms tumor 1
chr1_+_228353495 12.55 ENST00000366711.3
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr11_+_66278080 12.47 ENST00000318312.7
ENST00000526815.1
ENST00000537537.1
ENST00000525809.1
ENST00000455748.2
ENST00000393994.2
Bardet-Biedl syndrome 1
chr3_+_185080908 12.40 ENST00000265026.3
mitogen-activated protein kinase kinase kinase 13

Network of associatons between targets according to the STRING database.

First level regulatory network of EPAS1_BCL3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
32.4 194.7 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
23.7 71.1 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
18.8 94.1 GO:0060611 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
15.5 92.9 GO:0070560 protein secretion by platelet(GO:0070560)
14.8 74.1 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
12.6 37.9 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
12.1 36.4 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
11.4 57.1 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
10.8 32.3 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
9.9 29.8 GO:1904425 negative regulation of GTP binding(GO:1904425)
9.8 39.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
9.2 27.5 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
9.1 27.3 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
8.3 25.0 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
8.3 58.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
8.1 16.2 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
7.8 39.2 GO:0071279 cellular response to cobalt ion(GO:0071279)
7.8 23.3 GO:0019605 benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
7.6 30.3 GO:0072299 posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
7.4 22.1 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
7.1 35.6 GO:0030070 insulin processing(GO:0030070)
7.0 20.9 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
6.7 20.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
6.5 45.7 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
6.4 19.3 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
6.2 18.6 GO:0038188 cholecystokinin signaling pathway(GO:0038188)
6.1 36.6 GO:0061518 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
6.0 17.9 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
5.7 17.1 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
5.4 10.9 GO:0055073 cadmium ion homeostasis(GO:0055073)
5.3 21.3 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
5.3 21.2 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
5.3 5.3 GO:0099545 trans-synaptic signaling by trans-synaptic complex(GO:0099545)
5.2 36.3 GO:0060681 branch elongation involved in ureteric bud branching(GO:0060681)
5.0 20.2 GO:0006710 androgen catabolic process(GO:0006710)
4.9 29.5 GO:0006196 AMP catabolic process(GO:0006196)
4.8 28.9 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
4.8 19.2 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
4.7 19.0 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
4.7 14.1 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
4.6 18.5 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
4.6 23.0 GO:0099538 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
4.6 27.7 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
4.5 13.5 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
4.4 13.2 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
4.3 47.4 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
4.2 12.7 GO:0006172 ADP biosynthetic process(GO:0006172) purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183)
4.1 4.1 GO:0045807 positive regulation of endocytosis(GO:0045807)
4.0 12.0 GO:2000360 negative regulation of binding of sperm to zona pellucida(GO:2000360)
3.9 7.8 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
3.8 11.5 GO:0042938 dipeptide transport(GO:0042938)
3.7 11.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
3.6 7.2 GO:0009957 epidermal cell fate specification(GO:0009957)
3.5 17.3 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
3.5 13.8 GO:0001678 cellular glucose homeostasis(GO:0001678)
3.4 37.1 GO:0090232 peripheral nervous system myelin maintenance(GO:0032287) positive regulation of spindle checkpoint(GO:0090232)
3.3 16.7 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
3.3 26.6 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
3.2 9.5 GO:1900104 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
3.1 6.3 GO:0031133 regulation of axon diameter(GO:0031133)
3.1 49.7 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
3.1 6.2 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
3.0 6.1 GO:0061010 gall bladder development(GO:0061010)
3.0 57.6 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
3.0 8.9 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
3.0 8.9 GO:0044179 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
3.0 11.8 GO:0050968 detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
2.9 139.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
2.9 8.7 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
2.8 11.4 GO:1990936 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
2.8 8.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
2.8 5.7 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
2.8 8.4 GO:0090035 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
2.8 8.3 GO:0008078 mesoderm migration involved in gastrulation(GO:0007509) mesodermal cell migration(GO:0008078)
2.8 5.5 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
2.7 16.5 GO:0010133 proline catabolic process to glutamate(GO:0010133)
2.7 27.4 GO:0042940 D-amino acid transport(GO:0042940)
2.7 8.1 GO:0030046 parallel actin filament bundle assembly(GO:0030046) establishment of meiotic spindle localization(GO:0051295)
2.7 21.4 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
2.6 13.2 GO:0021759 globus pallidus development(GO:0021759)
2.6 18.4 GO:0050915 sensory perception of sour taste(GO:0050915)
2.6 36.2 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
2.6 12.8 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
2.5 7.5 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
2.5 50.0 GO:0090128 regulation of synapse maturation(GO:0090128)
2.5 27.4 GO:1902172 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
2.5 7.4 GO:1902722 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) positive regulation of prolactin secretion(GO:1902722)
2.4 7.2 GO:2001301 cellular response to interleukin-13(GO:0035963) lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
2.3 2.3 GO:0032276 regulation of gonadotropin secretion(GO:0032276) negative regulation of gonadotropin secretion(GO:0032277) positive regulation of gonadotropin secretion(GO:0032278) interferon-gamma biosynthetic process(GO:0042095) regulation of interferon-gamma biosynthetic process(GO:0045072) negative regulation of interferon-gamma biosynthetic process(GO:0045077) negative regulation of B cell differentiation(GO:0045578) negative regulation of macrophage differentiation(GO:0045650) regulation of follicle-stimulating hormone secretion(GO:0046880) positive regulation of follicle-stimulating hormone secretion(GO:0046881) negative regulation of follicle-stimulating hormone secretion(GO:0046882) follicle-stimulating hormone secretion(GO:0046884)
2.3 7.0 GO:0003099 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
2.3 32.5 GO:0035878 nail development(GO:0035878)
2.3 18.0 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
2.2 6.7 GO:1904300 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)
2.2 20.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
2.2 6.6 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
2.2 28.7 GO:0070327 thyroid hormone transport(GO:0070327)
2.2 13.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
2.2 10.8 GO:0018125 peptidyl-cysteine methylation(GO:0018125) minus-end-directed organelle transport along microtubule(GO:0072385)
2.1 6.4 GO:0032289 central nervous system myelin formation(GO:0032289)
2.1 23.3 GO:0015886 heme transport(GO:0015886)
2.1 6.3 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
2.0 6.1 GO:0046440 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
2.0 6.0 GO:0031049 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
2.0 7.9 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
2.0 17.6 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
1.9 5.8 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
1.9 7.6 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
1.9 5.7 GO:0060164 amygdala development(GO:0021764) regulation of timing of neuron differentiation(GO:0060164)
1.9 7.6 GO:1905229 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
1.9 41.5 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
1.9 5.6 GO:0033341 regulation of collagen binding(GO:0033341)
1.9 18.8 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
1.8 20.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.8 7.3 GO:0021997 response to chlorate(GO:0010157) neural plate axis specification(GO:0021997)
1.8 21.6 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
1.8 5.4 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
1.8 5.3 GO:2000171 negative regulation of dendrite development(GO:2000171)
1.7 34.7 GO:0061154 endothelial tube morphogenesis(GO:0061154)
1.7 3.4 GO:0086068 Purkinje myocyte to ventricular cardiac muscle cell signaling(GO:0086029) Purkinje myocyte to ventricular cardiac muscle cell communication(GO:0086068)
1.7 6.9 GO:0090527 actin filament reorganization(GO:0090527)
1.7 8.4 GO:0080009 mRNA methylation(GO:0080009)
1.7 6.7 GO:0061196 fungiform papilla development(GO:0061196)
1.6 8.1 GO:0036369 transcription factor catabolic process(GO:0036369)
1.6 3.2 GO:0030259 lipid glycosylation(GO:0030259)
1.6 21.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.6 1.6 GO:0072197 ureter urothelium development(GO:0072190) ureter morphogenesis(GO:0072197)
1.6 7.8 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
1.5 10.6 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
1.5 4.5 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.5 7.4 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
1.5 45.4 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.5 21.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.4 18.7 GO:0042738 exogenous drug catabolic process(GO:0042738)
1.4 8.5 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
1.4 5.6 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
1.4 14.9 GO:0071625 vocalization behavior(GO:0071625)
1.3 44.1 GO:0050667 homocysteine metabolic process(GO:0050667)
1.3 3.8 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
1.2 16.2 GO:0002021 response to dietary excess(GO:0002021)
1.2 5.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
1.2 7.4 GO:0048263 determination of dorsal identity(GO:0048263)
1.2 9.8 GO:2000773 negative regulation of cellular senescence(GO:2000773)
1.2 13.5 GO:0000050 urea cycle(GO:0000050)
1.2 7.2 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
1.2 4.8 GO:0003335 corneocyte development(GO:0003335)
1.2 15.4 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
1.2 3.5 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
1.2 5.8 GO:0071286 cellular response to magnesium ion(GO:0071286)
1.2 25.5 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
1.1 20.5 GO:0007021 tubulin complex assembly(GO:0007021)
1.1 17.0 GO:0014029 neural crest formation(GO:0014029)
1.1 2.2 GO:0001575 globoside metabolic process(GO:0001575)
1.1 4.4 GO:0014734 skeletal muscle hypertrophy(GO:0014734)
1.1 18.4 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
1.1 5.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
1.1 4.3 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
1.1 5.3 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
1.1 7.4 GO:0042428 serotonin metabolic process(GO:0042428)
1.0 5.2 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
1.0 25.9 GO:0032098 regulation of appetite(GO:0032098)
1.0 58.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
1.0 21.5 GO:0050930 induction of positive chemotaxis(GO:0050930)
1.0 10.1 GO:0035641 locomotory exploration behavior(GO:0035641)
1.0 36.1 GO:0030517 negative regulation of axon extension(GO:0030517)
1.0 9.0 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
1.0 2.0 GO:0043932 ossification involved in bone remodeling(GO:0043932)
1.0 6.0 GO:0072364 regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter(GO:0072364)
1.0 7.0 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
1.0 4.0 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
1.0 10.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.0 2.0 GO:1904954 Spemann organizer formation(GO:0060061) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
1.0 6.8 GO:0001951 intestinal D-glucose absorption(GO:0001951)
1.0 4.9 GO:0042420 dopamine catabolic process(GO:0042420)
1.0 4.8 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
1.0 56.8 GO:0060997 dendritic spine morphogenesis(GO:0060997)
1.0 27.9 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.0 13.4 GO:0007158 neuron cell-cell adhesion(GO:0007158)
1.0 9.5 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.9 10.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.9 15.9 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.9 3.7 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.9 3.7 GO:0061056 sclerotome development(GO:0061056)
0.9 10.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.9 2.8 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.9 5.6 GO:0098535 de novo centriole assembly(GO:0098535)
0.9 69.2 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.9 6.4 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.9 12.8 GO:0021510 spinal cord development(GO:0021510)
0.9 13.6 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.9 6.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.9 24.2 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.9 2.7 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.9 10.6 GO:0035372 protein localization to microtubule(GO:0035372)
0.9 9.7 GO:0060004 reflex(GO:0060004)
0.9 26.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.9 2.6 GO:2001023 regulation of response to drug(GO:2001023)
0.9 4.3 GO:0071233 cellular response to leucine(GO:0071233)
0.9 12.9 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.9 6.9 GO:0035107 appendage morphogenesis(GO:0035107) limb morphogenesis(GO:0035108)
0.9 2.6 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.9 23.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.8 4.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.8 11.8 GO:0097264 self proteolysis(GO:0097264)
0.8 16.0 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.8 28.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.8 2.5 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.8 7.5 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.8 5.0 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.8 27.4 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.8 3.3 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.8 5.0 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.8 5.7 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.8 49.8 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.8 8.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.8 6.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.8 7.2 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.8 2.4 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.8 7.1 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.8 15.7 GO:0016601 Rac protein signal transduction(GO:0016601)
0.8 3.9 GO:0021861 forebrain radial glial cell differentiation(GO:0021861) odontoblast differentiation(GO:0071895)
0.8 3.1 GO:0071321 positive regulation of oocyte development(GO:0060282) cellular response to cGMP(GO:0071321)
0.8 7.0 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.8 5.4 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) parathyroid gland development(GO:0060017) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.8 22.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.8 4.5 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.7 16.9 GO:0006067 ethanol metabolic process(GO:0006067)
0.7 2.9 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.7 4.3 GO:0048511 rhythmic process(GO:0048511)
0.7 32.2 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.7 10.3 GO:0007625 grooming behavior(GO:0007625)
0.7 15.8 GO:0007368 determination of left/right symmetry(GO:0007368)
0.7 14.9 GO:0007141 male meiosis I(GO:0007141)
0.7 2.7 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.7 11.4 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.7 28.8 GO:0097178 ruffle assembly(GO:0097178)
0.7 4.0 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.7 32.0 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.7 3.9 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.7 4.6 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.6 13.5 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.6 8.9 GO:0032094 response to food(GO:0032094)
0.6 7.6 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.6 1.8 GO:0035815 positive regulation of renal sodium excretion(GO:0035815)
0.6 16.4 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.6 4.8 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.6 16.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.6 4.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.6 3.6 GO:0008544 epidermis development(GO:0008544)
0.6 6.5 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.6 2.3 GO:0007341 penetration of zona pellucida(GO:0007341)
0.6 2.9 GO:0001766 membrane raft polarization(GO:0001766) regulation of myeloid dendritic cell activation(GO:0030885) membrane raft distribution(GO:0031580)
0.6 5.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.6 9.1 GO:0014072 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.6 7.9 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.6 5.0 GO:0045986 negative regulation of smooth muscle contraction(GO:0045986)
0.6 5.0 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.6 6.7 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.6 1.7 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.5 14.2 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 4.9 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.5 18.1 GO:0090383 phagosome acidification(GO:0090383)
0.5 7.4 GO:0001522 pseudouridine synthesis(GO:0001522)
0.5 3.7 GO:0016322 neuron remodeling(GO:0016322)
0.5 14.3 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.5 3.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.5 15.2 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.5 18.9 GO:0035136 forelimb morphogenesis(GO:0035136)
0.5 14.6 GO:0006783 heme biosynthetic process(GO:0006783)
0.5 5.2 GO:0032962 regulation of inositol trisphosphate biosynthetic process(GO:0032960) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.5 4.1 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.5 2.1 GO:0006568 tryptophan metabolic process(GO:0006568)
0.5 18.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5 31.2 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.5 6.1 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.5 5.0 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.5 7.5 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.5 6.5 GO:0010039 response to iron ion(GO:0010039)
0.5 12.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.5 5.5 GO:0048813 dendrite morphogenesis(GO:0048813)
0.5 2.9 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.5 7.4 GO:0007049 cell cycle(GO:0007049)
0.5 1.0 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.5 3.4 GO:0007379 segment specification(GO:0007379)
0.5 12.0 GO:0010107 potassium ion import(GO:0010107)
0.5 2.9 GO:0060746 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.5 23.4 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.5 4.8 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.5 1.9 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.5 1.4 GO:0006726 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.5 18.9 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.5 1.4 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.5 6.6 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.5 2.3 GO:0009624 response to nematode(GO:0009624)
0.4 10.1 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.4 2.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.4 11.1 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.4 3.8 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.4 8.9 GO:0008038 neuron recognition(GO:0008038)
0.4 1.6 GO:0048050 post-embryonic eye morphogenesis(GO:0048050) post-embryonic organ morphogenesis(GO:0048563)
0.4 2.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.4 1.6 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724)
0.4 2.8 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.4 7.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.4 13.6 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.4 5.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.4 7.7 GO:0048745 smooth muscle tissue development(GO:0048745)
0.3 0.7 GO:0033686 regulation of luteinizing hormone secretion(GO:0033684) positive regulation of luteinizing hormone secretion(GO:0033686)
0.3 4.8 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.3 4.7 GO:0021681 cerebellar granular layer development(GO:0021681)
0.3 8.2 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.3 7.1 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.3 1.3 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.3 1.6 GO:0032264 IMP salvage(GO:0032264)
0.3 8.6 GO:0030488 tRNA methylation(GO:0030488)
0.3 1.6 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.3 12.2 GO:0007631 feeding behavior(GO:0007631)
0.3 2.5 GO:1903859 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.3 5.3 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.3 0.9 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.3 13.3 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.3 5.3 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.3 2.5 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.3 6.4 GO:0030199 collagen fibril organization(GO:0030199)
0.3 4.1 GO:0032196 transposition(GO:0032196)
0.3 2.3 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.3 6.6 GO:0001525 angiogenesis(GO:0001525)
0.3 12.6 GO:0030279 negative regulation of ossification(GO:0030279)
0.3 7.2 GO:0003338 metanephros morphogenesis(GO:0003338)
0.3 2.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 5.8 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.3 1.6 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.3 3.8 GO:0051764 actin crosslink formation(GO:0051764)
0.3 6.7 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.3 4.3 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of adherens junction organization(GO:1903392)
0.3 7.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.3 2.6 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.3 8.3 GO:0006954 inflammatory response(GO:0006954)
0.3 13.6 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.3 8.4 GO:0051260 protein homooligomerization(GO:0051260)
0.3 3.0 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.3 1.8 GO:0044245 polysaccharide digestion(GO:0044245)
0.3 0.5 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.2 4.7 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.2 6.0 GO:0050779 RNA destabilization(GO:0050779)
0.2 2.9 GO:0030321 transepithelial chloride transport(GO:0030321)
0.2 5.5 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.2 3.8 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.2 4.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 2.5 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.2 3.6 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.2 7.2 GO:0018149 peptide cross-linking(GO:0018149)
0.2 4.4 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.2 1.7 GO:0035095 behavioral response to nicotine(GO:0035095)
0.2 15.6 GO:0006024 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)
0.2 1.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 7.7 GO:0042472 inner ear morphogenesis(GO:0042472)
0.2 1.9 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.2 11.5 GO:0016266 O-glycan processing(GO:0016266)
0.2 1.0 GO:0035524 proline transmembrane transport(GO:0035524)
0.2 3.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 1.5 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.2 6.2 GO:0016079 synaptic vesicle exocytosis(GO:0016079)
0.2 3.1 GO:0097120 receptor localization to synapse(GO:0097120)
0.2 2.4 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2 0.5 GO:0015785 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.2 4.4 GO:0042461 photoreceptor cell development(GO:0042461)
0.2 1.5 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.2 9.6 GO:0030282 bone mineralization(GO:0030282)
0.2 6.8 GO:0006839 mitochondrial transport(GO:0006839)
0.2 13.0 GO:0031295 T cell costimulation(GO:0031295)
0.1 4.0 GO:0016579 protein deubiquitination(GO:0016579)
0.1 1.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.0 GO:0051259 protein oligomerization(GO:0051259)
0.1 4.8 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.4 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 6.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 1.1 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 6.2 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.3 GO:0015732 prostaglandin transport(GO:0015732)
0.1 1.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 3.3 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.1 5.2 GO:0061045 negative regulation of wound healing(GO:0061045)
0.1 2.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 3.3 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.1 5.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 5.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 0.4 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1 6.6 GO:0055072 iron ion homeostasis(GO:0055072)
0.1 1.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 2.2 GO:0031214 biomineral tissue development(GO:0031214)
0.1 2.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 1.2 GO:0043010 camera-type eye development(GO:0043010)
0.1 1.3 GO:0097435 fibril organization(GO:0097435)
0.1 0.1 GO:0010644 cell communication by electrical coupling(GO:0010644)
0.1 2.9 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 1.6 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 24.9 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.1 12.6 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 9.9 GO:0051262 protein tetramerization(GO:0051262)
0.1 1.3 GO:0001502 cartilage condensation(GO:0001502)
0.1 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 1.2 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 2.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 2.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.6 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 0.5 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 1.1 GO:0050905 neuromuscular process(GO:0050905)
0.1 1.4 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 7.8 GO:2001252 positive regulation of chromosome organization(GO:2001252)
0.1 1.5 GO:0048536 spleen development(GO:0048536)
0.1 2.7 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 5.0 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 1.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 2.4 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.1 3.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 4.0 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 3.7 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.0 3.4 GO:0035303 regulation of dephosphorylation(GO:0035303)
0.0 2.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 1.1 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.6 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.0 0.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.8 GO:0042255 ribosome assembly(GO:0042255)
0.0 1.4 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 1.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.9 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.6 GO:0048738 cardiac muscle tissue development(GO:0048738)
0.0 1.0 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
19.2 95.8 GO:0098843 postsynaptic endocytic zone(GO:0098843)
15.7 94.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
14.9 44.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
14.3 57.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
14.2 71.1 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
9.7 194.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
8.9 26.6 GO:0072534 perineuronal net(GO:0072534)
8.0 80.2 GO:0071953 elastic fiber(GO:0071953)
5.5 27.5 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
5.3 112.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
5.3 21.3 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
5.3 21.2 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
4.6 27.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
4.5 17.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
4.0 36.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
3.8 19.0 GO:0045298 tubulin complex(GO:0045298)
3.3 39.2 GO:0043203 axon hillock(GO:0043203)
3.2 9.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
3.0 50.3 GO:0043020 NADPH oxidase complex(GO:0043020)
2.9 8.6 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
2.8 8.4 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
2.7 13.4 GO:0097123 cyclin A1-CDK2 complex(GO:0097123)
2.6 10.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
2.5 7.4 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
2.3 9.1 GO:0070876 SOSS complex(GO:0070876)
2.3 6.8 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
2.2 8.7 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
2.1 6.4 GO:0071546 pi-body(GO:0071546)
2.1 19.3 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
2.1 6.4 GO:0005588 collagen type V trimer(GO:0005588)
2.1 10.6 GO:0005602 complement component C1 complex(GO:0005602)
2.1 12.8 GO:1990769 proximal neuron projection(GO:1990769)
2.1 20.9 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
2.0 7.9 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
1.9 13.6 GO:0000813 ESCRT I complex(GO:0000813)
1.9 11.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.9 5.6 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
1.9 5.6 GO:0098536 deuterosome(GO:0098536)
1.8 27.5 GO:0042627 chylomicron(GO:0042627)
1.8 10.8 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
1.7 20.8 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
1.7 13.6 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
1.7 5.0 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
1.6 20.9 GO:0097433 dense body(GO:0097433)
1.6 36.9 GO:0071141 SMAD protein complex(GO:0071141)
1.6 47.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
1.6 10.9 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
1.5 12.2 GO:0072687 meiotic spindle(GO:0072687)
1.5 13.1 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
1.4 12.5 GO:0034464 BBSome(GO:0034464)
1.4 2.8 GO:0032009 early phagosome(GO:0032009)
1.4 5.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
1.4 5.4 GO:0032279 asymmetric synapse(GO:0032279)
1.3 20.5 GO:0097512 cardiac myofibril(GO:0097512)
1.3 70.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.2 27.9 GO:0030056 hemidesmosome(GO:0030056)
1.2 30.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.1 27.5 GO:0030673 axolemma(GO:0030673)
1.1 26.9 GO:0071565 nBAF complex(GO:0071565)
1.0 15.6 GO:0005905 clathrin-coated pit(GO:0005905)
1.0 18.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
1.0 6.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.0 12.0 GO:0034362 low-density lipoprotein particle(GO:0034362)
1.0 14.9 GO:0005883 neurofilament(GO:0005883)
1.0 4.9 GO:0016600 flotillin complex(GO:0016600)
0.9 43.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.9 22.1 GO:0016580 Sin3 complex(GO:0016580)
0.9 7.3 GO:0044294 dendritic growth cone(GO:0044294)
0.9 132.4 GO:0043204 perikaryon(GO:0043204)
0.9 12.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.9 19.6 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.8 10.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.8 57.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.8 20.0 GO:0034451 centriolar satellite(GO:0034451)
0.8 5.5 GO:0060091 kinocilium(GO:0060091)
0.8 11.6 GO:0030478 actin cap(GO:0030478)
0.8 18.1 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.7 9.5 GO:0005858 axonemal dynein complex(GO:0005858)
0.7 4.3 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.7 46.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.7 67.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.7 5.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.7 86.7 GO:0031901 early endosome membrane(GO:0031901)
0.7 2.0 GO:0070110 ciliary neurotrophic factor receptor complex(GO:0070110)
0.7 7.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.6 4.5 GO:0097209 epidermal lamellar body(GO:0097209)
0.6 1.9 GO:0060198 clathrin-sculpted vesicle(GO:0060198)
0.6 18.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.6 7.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.6 2.3 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.6 5.8 GO:0043198 dendritic shaft(GO:0043198)
0.5 54.3 GO:0044306 neuron projection terminus(GO:0044306)
0.5 5.4 GO:0031209 SCAR complex(GO:0031209)
0.5 136.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.5 4.6 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.5 9.9 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.5 24.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.5 3.8 GO:0005610 laminin-5 complex(GO:0005610)
0.5 13.2 GO:0051233 spindle midzone(GO:0051233)
0.4 4.0 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.4 11.3 GO:0009986 cell surface(GO:0009986)
0.4 3.9 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.4 5.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.4 3.4 GO:0016012 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.4 8.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 56.5 GO:0030027 lamellipodium(GO:0030027)
0.4 11.5 GO:0098862 cluster of actin-based cell projections(GO:0098862)
0.4 7.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 68.2 GO:0005802 trans-Golgi network(GO:0005802)
0.4 2.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 39.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.3 4.4 GO:0033268 node of Ranvier(GO:0033268)
0.3 14.8 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 34.9 GO:0005796 Golgi lumen(GO:0005796)
0.3 3.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.3 52.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 39.6 GO:0030426 growth cone(GO:0030426)
0.3 47.6 GO:0031225 anchored component of membrane(GO:0031225)
0.3 40.3 GO:0098793 presynapse(GO:0098793)
0.3 65.5 GO:0019898 extrinsic component of membrane(GO:0019898)
0.3 12.9 GO:0016235 aggresome(GO:0016235)
0.3 15.3 GO:0031526 brush border membrane(GO:0031526)
0.3 2.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 7.3 GO:0032421 stereocilium bundle(GO:0032421)
0.3 3.2 GO:0031906 late endosome lumen(GO:0031906)
0.3 5.0 GO:0030658 transport vesicle membrane(GO:0030658)
0.3 58.8 GO:0043025 neuronal cell body(GO:0043025)
0.2 22.4 GO:0030424 axon(GO:0030424)
0.2 7.5 GO:0032587 ruffle membrane(GO:0032587)
0.2 17.7 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.2 6.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 9.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 2.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 2.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.2 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.2 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 12.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 91.6 GO:0000139 Golgi membrane(GO:0000139)
0.1 7.2 GO:0001533 cornified envelope(GO:0001533)
0.1 2.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 0.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 8.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 47.6 GO:0016607 nuclear speck(GO:0016607)
0.1 5.8 GO:0044297 cell body(GO:0044297)
0.1 7.5 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 4.8 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.1 5.5 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 8.7 GO:0030496 midbody(GO:0030496)
0.1 6.6 GO:0005884 actin filament(GO:0005884)
0.1 13.4 GO:0072562 blood microparticle(GO:0072562)
0.1 1.6 GO:0032982 myosin filament(GO:0032982)
0.1 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 2.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 4.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 119.9 GO:0031224 intrinsic component of membrane(GO:0031224)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
15.3 91.8 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
11.8 71.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
10.1 30.2 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
7.9 95.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
7.8 39.1 GO:0031708 endothelin B receptor binding(GO:0031708)
7.5 22.5 GO:0015439 heme-transporting ATPase activity(GO:0015439)
6.2 18.6 GO:0004951 cholecystokinin receptor activity(GO:0004951)
6.1 42.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
6.1 30.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
5.7 28.3 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
5.5 22.1 GO:0035939 microsatellite binding(GO:0035939)
5.5 55.3 GO:0019826 oxygen sensor activity(GO:0019826)
5.5 27.5 GO:0030348 syntaxin-3 binding(GO:0030348)
5.5 27.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
5.4 32.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
5.4 32.3 GO:0042577 lipid phosphatase activity(GO:0042577)
5.2 25.9 GO:0001594 trace-amine receptor activity(GO:0001594)
5.0 20.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
4.7 19.0 GO:0099609 microtubule lateral binding(GO:0099609)
4.6 23.0 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
4.5 13.6 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
4.5 27.0 GO:0005119 smoothened binding(GO:0005119)
4.5 58.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
4.3 17.3 GO:0004047 aminomethyltransferase activity(GO:0004047)
4.1 12.4 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
4.1 16.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
3.9 15.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
3.9 15.4 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
3.8 11.5 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
3.7 203.2 GO:0017080 sodium channel regulator activity(GO:0017080)
3.7 18.4 GO:0044736 acid-sensing ion channel activity(GO:0044736)
3.6 10.9 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
3.5 31.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
3.4 17.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
3.3 13.4 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
3.3 66.4 GO:0051787 misfolded protein binding(GO:0051787)
3.2 9.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
3.2 157.6 GO:0030507 spectrin binding(GO:0030507)
3.1 79.5 GO:0017075 syntaxin-1 binding(GO:0017075)
3.0 24.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
3.0 17.9 GO:0030492 hemoglobin binding(GO:0030492)
3.0 8.9 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
3.0 11.8 GO:0097603 temperature-gated ion channel activity(GO:0097603)
2.9 8.6 GO:0016429 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
2.8 8.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
2.8 19.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
2.8 8.4 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
2.8 13.9 GO:0070697 activin receptor binding(GO:0070697)
2.8 8.3 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
2.8 8.3 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
2.6 10.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
2.6 13.2 GO:0008420 CTD phosphatase activity(GO:0008420)
2.6 34.0 GO:0038132 neuregulin binding(GO:0038132)
2.6 23.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
2.5 42.2 GO:0038191 neuropilin binding(GO:0038191)
2.4 7.2 GO:0047977 hepoxilin-epoxide hydrolase activity(GO:0047977)
2.4 7.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
2.3 49.3 GO:0031005 filamin binding(GO:0031005)
2.3 7.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
2.2 8.9 GO:0042954 lipoprotein transporter activity(GO:0042954)
2.2 30.9 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
2.2 8.7 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
2.2 13.0 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
2.1 14.9 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
2.1 23.2 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
2.1 14.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
2.0 8.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
2.0 6.0 GO:0035501 MH1 domain binding(GO:0035501)
2.0 6.0 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
1.9 11.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.9 13.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.8 9.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
1.8 17.6 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
1.7 15.4 GO:0048495 Roundabout binding(GO:0048495)
1.7 6.9 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
1.7 16.9 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
1.7 5.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
1.7 6.6 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
1.6 11.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.6 13.0 GO:0070324 thyroid hormone binding(GO:0070324)
1.6 4.9 GO:0005330 dopamine:sodium symporter activity(GO:0005330)
1.6 6.4 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
1.6 20.9 GO:0008517 folic acid transporter activity(GO:0008517)
1.6 7.9 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
1.6 7.9 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
1.6 20.2 GO:0036122 BMP binding(GO:0036122)
1.5 4.6 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
1.5 6.2 GO:0004948 calcitonin receptor activity(GO:0004948)
1.5 16.8 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.5 30.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.5 4.5 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
1.5 7.4 GO:0004994 somatostatin receptor activity(GO:0004994)
1.5 32.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
1.5 5.8 GO:0048763 calcium-induced calcium release activity(GO:0048763)
1.4 18.3 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
1.4 5.5 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
1.4 16.4 GO:0004017 adenylate kinase activity(GO:0004017)
1.3 6.7 GO:0004992 platelet activating factor receptor activity(GO:0004992)
1.3 1.3 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
1.3 40.5 GO:0043015 gamma-tubulin binding(GO:0043015)
1.3 3.8 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
1.3 13.8 GO:0004568 chitinase activity(GO:0004568) chitin binding(GO:0008061)
1.3 23.8 GO:0044548 S100 protein binding(GO:0044548)
1.2 21.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.2 30.3 GO:0004383 guanylate cyclase activity(GO:0004383)
1.2 26.5 GO:0004806 triglyceride lipase activity(GO:0004806)
1.2 19.3 GO:0048156 tau protein binding(GO:0048156)
1.2 23.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
1.2 7.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
1.2 10.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
1.2 5.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
1.1 10.2 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
1.1 11.2 GO:0015643 toxic substance binding(GO:0015643)
1.1 7.6 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
1.1 5.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
1.1 6.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
1.1 5.4 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
1.1 7.4 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
1.0 3.1 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
1.0 16.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.0 5.0 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
1.0 26.9 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
1.0 16.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
1.0 2.0 GO:0016015 morphogen activity(GO:0016015)
1.0 12.6 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
1.0 43.8 GO:0003785 actin monomer binding(GO:0003785)
0.9 17.7 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.9 3.7 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.9 7.3 GO:0004111 creatine kinase activity(GO:0004111)
0.9 2.7 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.9 10.8 GO:0031489 myosin V binding(GO:0031489)
0.9 5.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.9 5.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.9 121.5 GO:0005319 lipid transporter activity(GO:0005319)
0.9 15.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.9 10.3 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.8 16.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.8 5.8 GO:0004046 aminoacylase activity(GO:0004046)
0.8 5.8 GO:0017022 myosin binding(GO:0017022)
0.8 4.0 GO:0004995 tachykinin receptor activity(GO:0004995)
0.8 19.2 GO:0071837 HMG box domain binding(GO:0071837)
0.8 12.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.8 5.5 GO:0045159 myosin II binding(GO:0045159)
0.8 12.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.8 5.4 GO:0043559 insulin binding(GO:0043559)
0.8 8.4 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.8 7.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.8 7.5 GO:0019215 intermediate filament binding(GO:0019215)
0.7 6.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.7 5.7 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.7 13.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.7 77.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.7 66.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.7 26.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.7 2.1 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.7 26.3 GO:0017046 peptide hormone binding(GO:0017046)
0.7 6.7 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.6 1.9 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.6 9.4 GO:0005003 ephrin receptor activity(GO:0005003)
0.6 7.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.6 1.8 GO:0047783 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.6 1.8 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.6 3.0 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.6 23.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.6 18.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.6 18.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.6 2.9 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.6 8.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.6 6.9 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.6 9.5 GO:0045505 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) dynein intermediate chain binding(GO:0045505)
0.5 6.6 GO:0070412 R-SMAD binding(GO:0070412)
0.5 4.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.5 10.3 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.5 2.7 GO:0070573 metallodipeptidase activity(GO:0070573)
0.5 3.8 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.5 5.3 GO:0048185 activin binding(GO:0048185)
0.5 4.8 GO:0005542 folic acid binding(GO:0005542)
0.5 11.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.5 9.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.5 5.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.5 5.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.5 2.5 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.5 4.4 GO:0017081 chloride channel regulator activity(GO:0017081)
0.5 7.8 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.5 59.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.5 26.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.5 156.3 GO:0005096 GTPase activator activity(GO:0005096)
0.5 2.3 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.5 10.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.5 24.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.5 3.2 GO:0071253 connexin binding(GO:0071253)
0.4 11.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 6.2 GO:0033691 sialic acid binding(GO:0033691)
0.4 6.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.4 2.2 GO:0097016 L27 domain binding(GO:0097016)
0.4 15.1 GO:0005109 frizzled binding(GO:0005109)
0.4 18.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 7.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 2.9 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.4 3.5 GO:0004969 histamine receptor activity(GO:0004969)
0.4 2.3 GO:0034711 inhibin binding(GO:0034711)
0.4 38.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.4 5.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 8.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 7.8 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.4 5.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 16.2 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.3 4.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.3 2.8 GO:0035325 Toll-like receptor binding(GO:0035325)
0.3 1.0 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.3 7.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 7.6 GO:0002162 dystroglycan binding(GO:0002162)
0.3 4.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.3 11.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.3 4.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.3 1.6 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.3 4.7 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.3 4.7 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.3 37.2 GO:0044325 ion channel binding(GO:0044325)
0.3 28.2 GO:0051117 ATPase binding(GO:0051117)
0.3 3.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.3 10.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 2.4 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.3 14.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 4.9 GO:0043295 glutathione binding(GO:0043295)
0.3 4.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 13.7 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.3 10.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 3.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 1.0 GO:0005499 vitamin D binding(GO:0005499)
0.2 58.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 4.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.2 15.0 GO:0019003 GDP binding(GO:0019003)
0.2 1.3 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.2 15.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 11.4 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.2 4.8 GO:0003774 motor activity(GO:0003774)
0.2 8.6 GO:0005158 insulin receptor binding(GO:0005158)
0.2 4.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 1.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 13.4 GO:0008013 beta-catenin binding(GO:0008013)
0.2 1.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 4.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 1.6 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.2 2.6 GO:0004177 aminopeptidase activity(GO:0004177)
0.2 1.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 2.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.2 34.8 GO:0008022 protein C-terminus binding(GO:0008022)
0.2 9.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.1 3.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 2.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 3.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 2.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 7.1 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 2.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.1 0.5 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.1 1.6 GO:0043495 protein anchor(GO:0043495)
0.1 1.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 3.8 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 2.1 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 0.9 GO:0019863 IgE binding(GO:0019863)
0.1 0.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 4.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 10.6 GO:0030246 carbohydrate binding(GO:0030246)
0.1 5.6 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 3.3 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.4 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 2.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.8 GO:0046961 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.9 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 3.5 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 4.8 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.1 3.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 3.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 1.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.7 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.9 GO:0005507 copper ion binding(GO:0005507)
0.0 2.8 GO:0022857 transmembrane transporter activity(GO:0022857)
0.0 0.6 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 96.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.9 110.2 PID NCADHERIN PATHWAY N-cadherin signaling events
1.5 10.8 PID EPHB FWD PATHWAY EPHB forward signaling
1.4 26.6 PID ALK2 PATHWAY ALK2 signaling events
1.1 19.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.0 25.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
1.0 17.9 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
1.0 140.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.9 163.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.8 76.6 PID SHP2 PATHWAY SHP2 signaling
0.8 53.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.8 60.0 PID ENDOTHELIN PATHWAY Endothelins
0.8 18.4 PID IL1 PATHWAY IL1-mediated signaling events
0.7 29.9 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.7 35.2 PID BMP PATHWAY BMP receptor signaling
0.6 18.4 PID RAS PATHWAY Regulation of Ras family activation
0.6 21.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.6 28.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.6 14.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.5 12.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 24.8 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.5 30.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 9.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.4 5.0 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.3 86.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 5.8 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.3 10.1 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.3 12.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 9.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.3 7.8 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.3 19.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.3 8.2 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.3 1.8 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.3 12.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.3 9.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 9.5 PID FGF PATHWAY FGF signaling pathway
0.2 4.0 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 1.5 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.2 4.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 3.8 ST GA13 PATHWAY G alpha 13 Pathway
0.2 7.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 4.7 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 4.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 4.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 4.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 1.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 8.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 6.4 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.2 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 3.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 2.4 PID IL27 PATHWAY IL27-mediated signaling events
0.1 6.6 PID AP1 PATHWAY AP-1 transcription factor network
0.1 4.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 5.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 1.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 28.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 4.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 1.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 4.3 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 1.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 2.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 9.7 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 1.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.3 PID TNF PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 84.5 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
4.5 107.8 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
2.9 5.7 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
2.7 34.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
2.6 15.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
2.5 45.9 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
2.3 56.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.8 23.8 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
1.8 19.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.8 3.5 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
1.8 49.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
1.5 43.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.5 21.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
1.4 36.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
1.3 25.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
1.3 30.2 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.3 25.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
1.2 29.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
1.2 31.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
1.2 11.0 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.1 9.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
1.0 17.7 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.9 28.0 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.9 40.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.8 29.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.8 26.0 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.8 29.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.8 15.0 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.8 24.7 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.8 6.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.8 25.0 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.7 16.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.7 8.0 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.7 31.0 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.7 5.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.7 4.9 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.7 35.7 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.7 21.5 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.7 9.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.7 27.2 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.6 24.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.6 14.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.6 35.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.6 20.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 17.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.6 6.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.6 10.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.6 43.3 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.6 18.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.6 29.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.5 3.8 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.5 97.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.5 7.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.5 20.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.5 23.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.5 5.8 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.5 11.4 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.5 18.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.5 2.8 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.5 19.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.5 10.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.4 4.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.4 43.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.4 12.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.4 7.0 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.4 8.0 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.4 10.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.4 10.5 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.4 22.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 6.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.4 17.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.3 11.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.3 5.8 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.3 12.2 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.3 4.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.3 10.0 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.3 39.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.3 11.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 5.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 11.4 REACTOME SIGNALING BY FGFR MUTANTS Genes involved in Signaling by FGFR mutants
0.2 8.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 24.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 4.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 2.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 13.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 2.0 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 5.4 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.2 4.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.2 5.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 1.8 REACTOME ION CHANNEL TRANSPORT Genes involved in Ion channel transport
0.2 8.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.2 1.2 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.2 3.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 6.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 11.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 12.5 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 4.9 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 5.3 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.1 2.1 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.1 1.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 0.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 6.8 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.1 1.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 0.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 1.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression