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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ESRRB_ESRRG

Z-value: 0.68

Motif logo

Transcription factors associated with ESRRB_ESRRG

Gene Symbol Gene ID Gene Info
ENSG00000119715.10 estrogen related receptor beta
ENSG00000196482.12 estrogen related receptor gamma

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ESRRGhg19_v2_chr1_-_217250231_217250349-0.405.3e-10Click!

Activity profile of ESRRB_ESRRG motif

Sorted Z-values of ESRRB_ESRRG motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_176046391 81.19 ENST00000392541.3
ENST00000409194.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr1_+_169077172 60.52 ENST00000499679.3
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr20_-_62130474 59.51 ENST00000217182.3
eukaryotic translation elongation factor 1 alpha 2
chr8_+_145149930 52.60 ENST00000318911.4
cytochrome c-1
chr14_-_103987679 48.19 ENST00000553610.1
creatine kinase, brain
chr10_+_81107271 45.45 ENST00000448165.1
peptidylprolyl isomerase F
chr1_+_165600436 38.68 ENST00000367888.4
ENST00000367885.1
ENST00000367884.2
microsomal glutathione S-transferase 3
chr1_-_149889382 38.26 ENST00000369145.1
ENST00000369146.3
synaptic vesicle glycoprotein 2A
chr12_+_120875910 37.06 ENST00000551806.1
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
chr7_-_30029367 34.60 ENST00000242059.5
secernin 1
chr11_+_57480046 34.40 ENST00000378312.4
ENST00000278422.4
thioredoxin-related transmembrane protein 2
chr2_+_198365122 34.26 ENST00000604458.1
HSPE1-MOB4 readthrough
chr16_-_47177874 33.86 ENST00000562435.1
neuropilin (NRP) and tolloid (TLL)-like 2
chr10_+_81107216 33.21 ENST00000394579.3
ENST00000225174.3
peptidylprolyl isomerase F
chr14_-_21492251 33.16 ENST00000554398.1
NDRG family member 2
chr3_+_179322573 32.74 ENST00000493866.1
ENST00000472629.1
ENST00000482604.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr12_+_120875887 32.67 ENST00000229379.2
cytochrome c oxidase subunit VIa polypeptide 1
chr17_+_79670386 32.58 ENST00000333676.3
ENST00000571730.1
ENST00000541223.1
mitochondrial ribosomal protein L12
Mitochondrial dicarboxylate carrier; Uncharacterized protein; cDNA FLJ60124, highly similar to Mitochondrial dicarboxylate carrier
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr7_+_128399002 32.47 ENST00000493278.1
calumenin
chr15_+_43985725 31.81 ENST00000413453.2
creatine kinase, mitochondrial 1A
chr12_+_6976687 31.67 ENST00000396705.5
triosephosphate isomerase 1
chr3_-_42845951 30.61 ENST00000418900.2
ENST00000430190.1
HIG1 hypoxia inducible domain family, member 1A
chr12_-_57039739 30.36 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr2_+_198365095 30.23 ENST00000409468.1
heat shock 10kDa protein 1
chr15_+_43985084 29.64 ENST00000434505.1
ENST00000411750.1
creatine kinase, mitochondrial 1A
chr11_+_67798363 29.20 ENST00000525628.1
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr1_-_17380630 28.92 ENST00000375499.3
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr16_+_21964662 28.55 ENST00000561553.1
ENST00000565331.1
ubiquinol-cytochrome c reductase core protein II
chr12_+_6643676 28.48 ENST00000396856.1
ENST00000396861.1
glyceraldehyde-3-phosphate dehydrogenase
chr14_-_21492113 28.41 ENST00000554094.1
NDRG family member 2
chr1_+_169075554 28.06 ENST00000367815.4
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr3_+_179322481 27.62 ENST00000259037.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr15_+_43885252 27.34 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
creatine kinase, mitochondrial 1B
chr11_+_67798114 27.31 ENST00000453471.2
ENST00000528492.1
ENST00000526339.1
ENST00000525419.1
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr15_+_43886057 26.89 ENST00000441322.1
ENST00000413657.2
ENST00000453733.1
creatine kinase, mitochondrial 1B
chr8_+_86376081 26.67 ENST00000285379.5
carbonic anhydrase II
chr9_-_130637244 26.52 ENST00000373156.1
adenylate kinase 1
chr2_-_106054952 26.51 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
four and a half LIM domains 2
chr3_+_133465228 25.80 ENST00000482271.1
ENST00000264998.3
transferrin
chr14_-_21491477 25.42 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
NDRG family member 2
chr15_-_72523454 25.20 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
pyruvate kinase, muscle
chr10_-_101190202 25.17 ENST00000543866.1
ENST00000370508.5
glutamic-oxaloacetic transaminase 1, soluble
chrX_+_103031758 24.98 ENST00000303958.2
ENST00000361621.2
proteolipid protein 1
chr1_-_241683001 24.95 ENST00000366560.3
fumarate hydratase
chr21_-_27107344 24.93 ENST00000457143.2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr15_-_72523924 24.81 ENST00000566809.1
ENST00000567087.1
ENST00000569050.1
ENST00000568883.1
pyruvate kinase, muscle
chr21_-_27107198 24.79 ENST00000400094.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr3_+_113465866 24.66 ENST00000273398.3
ENST00000538620.1
ENST00000496747.1
ENST00000475322.1
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr8_-_100905925 24.66 ENST00000518171.1
cytochrome c oxidase subunit VIc
chr8_-_100905850 24.55 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
cytochrome c oxidase subunit VIc
chr21_-_27107283 24.15 ENST00000284971.3
ENST00000400099.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr7_-_10979750 23.94 ENST00000339600.5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chr14_-_58893832 23.79 ENST00000556007.2
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr2_-_44223138 23.73 ENST00000260665.7
leucine-rich pentatricopeptide repeat containing
chr17_-_29624343 23.63 ENST00000247271.4
oligodendrocyte myelin glycoprotein
chrX_+_103031421 23.60 ENST00000433491.1
ENST00000418604.1
ENST00000443502.1
proteolipid protein 1
chr9_-_32573130 23.53 ENST00000350021.2
ENST00000379847.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
chr4_-_140216948 23.49 ENST00000265500.4
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr2_+_86426478 23.34 ENST00000254644.8
ENST00000605125.1
ENST00000337109.4
ENST00000409180.1
mitochondrial ribosomal protein L35
chr11_+_34938119 23.34 ENST00000227868.4
ENST00000430469.2
ENST00000533262.1
pyruvate dehydrogenase complex, component X
chr22_-_39239987 23.01 ENST00000333039.2
neuronal pentraxin receptor
chr4_-_71705060 23.00 ENST00000514161.1
G-rich RNA sequence binding factor 1
chr10_+_60028818 22.60 ENST00000333926.5
CDGSH iron sulfur domain 1
chr4_-_71705027 22.06 ENST00000545193.1
G-rich RNA sequence binding factor 1
chr1_+_228270784 21.97 ENST00000541182.1
ADP-ribosylation factor 1
chr11_+_65770227 21.87 ENST00000527348.1
barrier to autointegration factor 1
chr5_-_140027175 21.77 ENST00000512088.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
chr1_-_110284384 21.60 ENST00000540225.1
glutathione S-transferase mu 3 (brain)
chr5_+_34757309 21.36 ENST00000397449.1
retinoic acid induced 14
chr20_+_3776936 21.28 ENST00000439880.2
cell division cycle 25B
chr8_+_55047763 21.04 ENST00000260102.4
ENST00000519831.1
mitochondrial ribosomal protein L15
chr8_-_100905363 20.77 ENST00000524245.1
cytochrome c oxidase subunit VIc
chr2_+_98262497 20.62 ENST00000258424.2
cytochrome c oxidase subunit Vb
chr3_-_10028366 20.59 ENST00000429759.1
ER membrane protein complex subunit 3
chr18_-_43678241 20.35 ENST00000593152.2
ENST00000589252.1
ENST00000590665.1
ENST00000398752.6
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr3_-_167452262 20.32 ENST00000487947.2
programmed cell death 10
chr12_+_6644443 19.96 ENST00000396858.1
glyceraldehyde-3-phosphate dehydrogenase
chr11_-_790060 19.91 ENST00000330106.4
cell cycle exit and neuronal differentiation 1
chr1_-_211752073 19.85 ENST00000367001.4
solute carrier family 30 (zinc transporter), member 1
chr20_+_3776371 19.73 ENST00000245960.5
cell division cycle 25B
chr17_+_66509019 19.21 ENST00000585981.1
ENST00000589480.1
ENST00000585815.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr16_+_57481349 18.99 ENST00000262507.6
ENST00000565964.1
coenzyme Q9
chr2_-_220119280 18.91 ENST00000392088.2
tubulin, alpha 4a
chrX_+_134166333 18.82 ENST00000257013.7
family with sequence similarity 127, member A
chr6_-_43027105 18.76 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
mitochondrial ribosomal protein L2
chr5_+_218356 18.63 ENST00000264932.6
ENST00000504309.1
ENST00000510361.1
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr1_-_26233423 18.26 ENST00000357865.2
stathmin 1
chr16_+_56623433 18.11 ENST00000570176.1
metallothionein 3
chr1_-_33502528 17.85 ENST00000354858.6
adenylate kinase 2
chr16_-_58768177 17.80 ENST00000434819.2
ENST00000245206.5
glutamic-oxaloacetic transaminase 2, mitochondrial
chr10_+_99185917 17.41 ENST00000334828.5
phosphoglycerate mutase 1 (brain)
chr2_+_220491973 17.25 ENST00000358055.3
solute carrier family 4 (anion exchanger), member 3
chr19_+_19626531 17.02 ENST00000507754.4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr15_+_78441663 16.92 ENST00000299518.2
ENST00000558554.1
ENST00000557826.1
ENST00000561279.1
ENST00000559186.1
ENST00000560770.1
ENST00000559881.1
ENST00000559205.1
ENST00000441490.2
isocitrate dehydrogenase 3 (NAD+) alpha
chr17_-_27503770 16.91 ENST00000533112.1
myosin XVIIIA
chr1_-_205719295 16.85 ENST00000367142.4
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr11_+_65769946 16.41 ENST00000533166.1
barrier to autointegration factor 1
chr2_-_86422095 16.31 ENST00000254636.5
inner membrane protein, mitochondrial
chr16_+_58533951 16.16 ENST00000566192.1
ENST00000565088.1
ENST00000568640.1
ENST00000563978.1
ENST00000569923.1
ENST00000356752.4
ENST00000563799.1
ENST00000562999.1
ENST00000570248.1
ENST00000562731.1
ENST00000568424.1
NDRG family member 4
chr16_-_47007545 15.88 ENST00000317089.5
DnaJ (Hsp40) homolog, subfamily A, member 2
chr16_-_19897455 15.87 ENST00000568214.1
ENST00000569479.1
G protein-coupled receptor, family C, group 5, member B
chr16_+_4674787 15.85 ENST00000262370.7
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr7_+_44836276 15.67 ENST00000451562.1
ENST00000468812.1
ENST00000489459.1
ENST00000355968.6
peptidylprolyl isomerase A (cyclophilin A)
chr1_-_153600656 15.60 ENST00000339556.4
ENST00000440685.2
S100 calcium binding protein A13
chr4_-_71705082 15.54 ENST00000439371.1
ENST00000499044.2
G-rich RNA sequence binding factor 1
chrX_-_13835147 15.49 ENST00000493677.1
ENST00000355135.2
glycoprotein M6B
chr3_-_98241760 15.49 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
claudin domain containing 1
chr8_+_124429006 15.21 ENST00000522194.1
ENST00000523356.1
WDYHV motif containing 1
chr1_+_153600869 15.05 ENST00000292169.1
ENST00000368696.3
ENST00000436839.1
S100 calcium binding protein A1
chr19_-_12912601 14.95 ENST00000334482.5
peroxiredoxin 2
chr22_+_29702996 14.86 ENST00000406549.3
ENST00000360113.2
ENST00000341313.6
ENST00000403764.1
ENST00000471961.1
ENST00000407854.1
growth arrest-specific 2 like 1
chr4_+_41614909 14.62 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIM and calponin homology domains 1
chr16_-_81040415 14.58 ENST00000564174.1
ENST00000562713.1
ENST00000570195.1
ENST00000565925.1
ENST00000565108.1
ENST00000565650.1
ENST00000486645.1
C-x(9)-C motif containing 2
chr1_+_202995611 14.49 ENST00000367240.2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr20_+_30865429 14.46 ENST00000375712.3
kinesin family member 3B
chr12_-_53320245 14.28 ENST00000552150.1
keratin 8
chr15_-_66790146 14.22 ENST00000316634.5
small nuclear RNA activating complex, polypeptide 5, 19kDa
chr7_+_56032270 14.18 ENST00000322090.3
ENST00000446778.1
glioblastoma amplified sequence
chr5_-_133340326 14.03 ENST00000425992.1
ENST00000395044.3
ENST00000395047.2
voltage-dependent anion channel 1
chr10_+_71078595 14.02 ENST00000359426.6
hexokinase 1
chr2_-_207024233 13.90 ENST00000423725.1
ENST00000233190.6
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr12_-_21810726 13.75 ENST00000396076.1
lactate dehydrogenase B
chr14_-_104387888 13.73 ENST00000286953.3
chromosome 14 open reading frame 2
chrX_+_47053208 13.65 ENST00000442035.1
ENST00000457753.1
ENST00000335972.6
ubiquitin-like modifier activating enzyme 1
chr10_-_75634326 13.60 ENST00000322635.3
ENST00000444854.2
ENST00000423381.1
ENST00000322680.3
ENST00000394762.2
calcium/calmodulin-dependent protein kinase II gamma
chr8_-_131028869 13.52 ENST00000518283.1
ENST00000519110.1
family with sequence similarity 49, member B
chr8_-_110704014 13.44 ENST00000529190.1
ENST00000422135.1
ENST00000419099.1
syntabulin (syntaxin-interacting)
chr19_-_29704448 13.36 ENST00000304863.4
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr19_+_17416609 13.35 ENST00000602206.1
mitochondrial ribosomal protein L34
chr8_+_110346546 13.34 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
enhancer of yellow 2 homolog (Drosophila)
chr12_-_21810765 13.29 ENST00000450584.1
ENST00000350669.1
lactate dehydrogenase B
chr11_+_118272328 13.00 ENST00000524422.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
chr3_-_98241358 12.94 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
claudin domain containing 1
chr12_+_119616447 12.93 ENST00000281938.2
heat shock 22kDa protein 8
chr13_-_48575401 12.84 ENST00000433022.1
ENST00000544100.1
succinate-CoA ligase, ADP-forming, beta subunit
chr16_+_4674814 12.73 ENST00000415496.1
ENST00000587747.1
ENST00000399577.5
ENST00000588994.1
ENST00000586183.1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr20_+_34700333 12.41 ENST00000441639.1
erythrocyte membrane protein band 4.1-like 1
chr19_+_35783028 12.37 ENST00000600291.1
ENST00000392213.3
myelin associated glycoprotein
chr14_-_104387831 12.31 ENST00000557040.1
ENST00000414262.2
ENST00000555030.1
ENST00000554713.1
ENST00000553430.1
chromosome 14 open reading frame 2
chr5_-_137911049 12.24 ENST00000297185.3
heat shock 70kDa protein 9 (mortalin)
chr22_+_30163340 12.23 ENST00000330029.6
ENST00000401406.3
ubiquinol-cytochrome c reductase, complex III subunit X
chr19_+_35783047 12.19 ENST00000595791.1
ENST00000597035.1
ENST00000537831.2
myelin associated glycoprotein
chr1_+_2036149 12.04 ENST00000482686.1
ENST00000400920.1
ENST00000486681.1
protein kinase C, zeta
chr16_-_85833160 11.97 ENST00000435200.2
ER membrane protein complex subunit 8
chr16_-_85833109 11.93 ENST00000253457.3
ER membrane protein complex subunit 8
chr18_-_5544241 11.91 ENST00000341928.2
ENST00000540638.2
erythrocyte membrane protein band 4.1-like 3
chr19_+_34855925 11.88 ENST00000590375.1
ENST00000356487.5
glucose-6-phosphate isomerase
chr19_+_35783037 11.86 ENST00000361922.4
myelin associated glycoprotein
chr19_+_34855874 11.81 ENST00000588991.2
glucose-6-phosphate isomerase
chrX_-_77225135 11.76 ENST00000458128.1
phosphoglycerate mutase family member 4
chr8_-_18541603 11.75 ENST00000428502.2
pleckstrin and Sec7 domain containing 3
chr11_-_111957451 11.64 ENST00000504148.2
ENST00000541231.1
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chr11_+_73498898 11.30 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
mitochondrial ribosomal protein L48
chr1_+_201924619 11.28 ENST00000367287.4
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr3_-_167452298 11.17 ENST00000475915.2
ENST00000462725.2
ENST00000461494.1
programmed cell death 10
chr19_+_34856141 11.06 ENST00000586425.1
glucose-6-phosphate isomerase
chr6_-_34360413 10.95 ENST00000607016.1
nudix (nucleoside diphosphate linked moiety X)-type motif 3
chr16_-_3767551 10.86 ENST00000246957.5
TNF receptor-associated protein 1
chr16_-_3767506 10.50 ENST00000538171.1
TNF receptor-associated protein 1
chr6_-_97345689 10.46 ENST00000316149.7
NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
chr20_+_1875942 10.42 ENST00000358771.4
signal-regulatory protein alpha
chr16_-_19533404 10.38 ENST00000353258.3
glycerophosphodiester phosphodiesterase 1
chr21_-_35288284 10.38 ENST00000290299.2
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr12_+_98987369 10.29 ENST00000401722.3
ENST00000188376.5
ENST00000228318.3
ENST00000551917.1
ENST00000548046.1
ENST00000552981.1
ENST00000551265.1
ENST00000550695.1
ENST00000547534.1
ENST00000549338.1
ENST00000548847.1
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr1_-_241520385 10.27 ENST00000366564.1
regulator of G-protein signaling 7
chr1_-_241520525 10.26 ENST00000366565.1
regulator of G-protein signaling 7
chr7_-_123197733 10.20 ENST00000470123.1
ENST00000471770.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr20_+_57430162 10.16 ENST00000450130.1
ENST00000349036.3
ENST00000423897.1
GNAS complex locus
chr1_+_84609944 10.15 ENST00000370685.3
protein kinase, cAMP-dependent, catalytic, beta
chr16_-_15472151 9.96 ENST00000360151.4
ENST00000543801.1
nuclear pore complex interacting protein family, member A5
chr7_+_48128194 9.96 ENST00000416681.1
ENST00000331803.4
ENST00000432131.1
uridine phosphorylase 1
chr9_+_131873227 9.88 ENST00000358994.4
ENST00000455292.1
protein phosphatase 2A activator, regulatory subunit 4
chr6_-_43197189 9.73 ENST00000509253.1
ENST00000393987.2
ENST00000230431.6
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr16_+_57481382 9.67 ENST00000564655.1
ENST00000567072.1
ENST00000567933.1
ENST00000563166.1
coenzyme Q9
chr15_-_41694640 9.64 ENST00000558719.1
ENST00000260361.4
ENST00000560978.1
NADH dehydrogenase (ubiquinone) complex I, assembly factor 1
chr19_+_54926601 9.61 ENST00000301194.4
tweety family member 1
chr7_+_48128816 9.60 ENST00000395564.4
uridine phosphorylase 1
chr3_+_52232102 9.58 ENST00000469224.1
ENST00000394965.2
ENST00000310271.2
ENST00000484952.1
aminolevulinate, delta-, synthase 1
chr19_+_54926621 9.53 ENST00000376530.3
ENST00000445095.1
ENST00000391739.3
ENST00000376531.3
tweety family member 1
chr19_+_46850251 9.51 ENST00000012443.4
protein phosphatase 5, catalytic subunit
chr10_-_75634260 9.42 ENST00000372765.1
ENST00000351293.3
calcium/calmodulin-dependent protein kinase II gamma
chr7_+_48128316 9.41 ENST00000341253.4
uridine phosphorylase 1
chr2_+_220492116 9.34 ENST00000373760.2
solute carrier family 4 (anion exchanger), member 3
chr19_+_46850320 9.33 ENST00000391919.1
protein phosphatase 5, catalytic subunit
chr7_-_43965937 9.27 ENST00000455877.1
ENST00000223341.7
ENST00000447717.3
ENST00000426198.1
upregulator of cell proliferation
chr3_+_184038073 9.26 ENST00000428387.1
ENST00000434061.2
eukaryotic translation initiation factor 4 gamma, 1
chr16_+_6069586 9.17 ENST00000547372.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_-_207023918 9.12 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr4_-_74088800 9.11 ENST00000509867.2
ankyrin repeat domain 17
chr2_+_192141611 9.10 ENST00000392316.1
myosin IB
chr17_-_42144949 9.07 ENST00000591247.1
LSM12 homolog (S. cerevisiae)
chr7_+_48128854 9.06 ENST00000436673.1
ENST00000429491.2
uridine phosphorylase 1
chr7_+_153584166 9.01 ENST00000404039.1
dipeptidyl-peptidase 6
chr17_-_40729681 8.97 ENST00000590760.1
ENST00000587209.1
ENST00000393795.3
ENST00000253789.5
PSMC3 interacting protein
chr14_-_21490958 8.88 ENST00000554104.1
NDRG family member 2
chr3_-_183735731 8.78 ENST00000334444.6
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr2_-_207024134 8.70 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr22_-_43036607 8.62 ENST00000505920.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr20_-_3748416 8.57 ENST00000399672.1
chromosome 20 open reading frame 27
chr11_-_57298187 8.50 ENST00000525158.1
ENST00000257245.4
ENST00000525587.1
translocase of inner mitochondrial membrane 10 homolog (yeast)

Network of associatons between targets according to the STRING database.

First level regulatory network of ESRRB_ESRRG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
26.2 78.7 GO:2000276 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
22.6 67.9 GO:0006106 fumarate metabolic process(GO:0006106)
22.1 88.6 GO:1903288 protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
16.1 48.4 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
13.4 40.1 GO:0097212 lysosomal membrane organization(GO:0097212)
12.0 48.2 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
11.6 34.7 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
10.6 31.7 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
10.1 322.9 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
9.5 38.0 GO:0046108 uridine catabolic process(GO:0006218) uridine metabolic process(GO:0046108)
8.9 26.7 GO:0042938 dipeptide transport(GO:0042938)
8.3 50.0 GO:0042866 pyruvate biosynthetic process(GO:0042866)
8.2 24.6 GO:0006172 ADP biosynthetic process(GO:0006172)
7.6 22.7 GO:1902356 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
7.5 22.5 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
7.3 29.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
7.2 7.2 GO:0006533 aspartate catabolic process(GO:0006533)
7.2 143.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
7.1 28.6 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
6.4 63.6 GO:0006600 creatine metabolic process(GO:0006600)
6.3 31.5 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
6.0 95.9 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
5.9 23.7 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
5.6 16.9 GO:1903028 positive regulation of opsonization(GO:1903028)
5.6 11.2 GO:0002352 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
5.3 21.4 GO:0009386 translational attenuation(GO:0009386)
5.3 26.5 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
4.9 29.1 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
4.7 47.5 GO:0006105 succinate metabolic process(GO:0006105)
4.6 18.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
4.4 301.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
4.3 25.8 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
4.3 38.3 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
4.3 59.5 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
4.2 16.8 GO:0019046 release from viral latency(GO:0019046)
4.1 41.0 GO:0007144 female meiosis I(GO:0007144)
4.0 19.9 GO:0021590 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
4.0 19.8 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
3.7 18.5 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
3.7 85.0 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
3.2 12.9 GO:1900034 regulation of cellular response to heat(GO:1900034)
3.2 38.3 GO:0015074 DNA integration(GO:0015074)
3.1 18.8 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
3.1 15.5 GO:0051610 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
3.1 21.7 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
3.1 12.2 GO:1903719 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
2.9 23.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
2.9 11.6 GO:0072321 chaperone-mediated protein transport(GO:0072321)
2.8 19.4 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
2.7 29.9 GO:0042407 cristae formation(GO:0042407)
2.6 25.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
2.4 28.6 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
2.4 7.1 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
2.3 13.8 GO:1903027 regulation of opsonization(GO:1903027)
2.3 9.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
2.2 10.9 GO:1901908 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
2.0 10.1 GO:0097338 response to clozapine(GO:0097338)
2.0 12.0 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
2.0 14.0 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
2.0 14.0 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
2.0 11.9 GO:0002175 protein localization to paranode region of axon(GO:0002175)
1.9 13.3 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
1.9 5.6 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
1.9 14.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
1.9 5.6 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
1.8 12.9 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
1.8 9.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
1.8 9.0 GO:0014886 transition between slow and fast fiber(GO:0014886)
1.8 5.3 GO:0006097 glyoxylate cycle(GO:0006097)
1.6 22.6 GO:0043457 regulation of cellular respiration(GO:0043457)
1.6 49.4 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
1.6 15.6 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
1.5 6.2 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.5 12.2 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
1.5 30.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
1.5 4.5 GO:1902722 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) positive regulation of prolactin secretion(GO:1902722)
1.5 3.0 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
1.5 7.3 GO:0060356 leucine import(GO:0060356)
1.5 23.3 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
1.5 33.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
1.5 10.2 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
1.4 5.7 GO:0030242 pexophagy(GO:0030242)
1.4 5.6 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
1.4 101.2 GO:0070125 mitochondrial translational elongation(GO:0070125)
1.4 19.2 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
1.3 13.4 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
1.3 13.3 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
1.3 24.6 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
1.3 20.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
1.3 16.6 GO:2001135 regulation of endocytic recycling(GO:2001135)
1.3 15.0 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
1.3 13.8 GO:2000210 positive regulation of anoikis(GO:2000210)
1.2 14.8 GO:0006089 lactate metabolic process(GO:0006089)
1.2 18.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
1.2 5.9 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
1.2 24.7 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
1.2 14.0 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
1.2 16.2 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
1.1 5.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
1.1 3.3 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
1.0 14.3 GO:0051599 response to hydrostatic pressure(GO:0051599)
1.0 6.9 GO:1904044 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) response to aldosterone(GO:1904044)
1.0 4.9 GO:1903275 regulation of sodium ion export(GO:1903273) positive regulation of sodium ion export(GO:1903275) regulation of sodium ion export from cell(GO:1903276) positive regulation of sodium ion export from cell(GO:1903278)
0.9 55.0 GO:0006378 mRNA polyadenylation(GO:0006378)
0.9 5.6 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.9 5.4 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.9 9.7 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.9 7.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.9 5.1 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.8 2.4 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900)
0.8 5.5 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.8 43.1 GO:0015701 bicarbonate transport(GO:0015701)
0.8 7.0 GO:0006783 heme biosynthetic process(GO:0006783)
0.8 6.9 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.8 7.5 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.7 9.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.7 4.1 GO:0072719 cellular response to cisplatin(GO:0072719)
0.7 3.4 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.6 8.3 GO:0019388 galactose catabolic process(GO:0019388)
0.6 14.5 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.6 8.8 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.6 29.5 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.6 3.1 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of lung blood pressure(GO:0061767) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.6 28.7 GO:1900449 regulation of neurotransmitter receptor activity(GO:0099601) regulation of glutamate receptor signaling pathway(GO:1900449)
0.6 14.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.6 15.7 GO:0042026 protein refolding(GO:0042026)
0.6 2.8 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.5 10.3 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.5 3.8 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.5 2.4 GO:0006543 glutamine catabolic process(GO:0006543)
0.5 12.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.4 8.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 11.1 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.4 0.9 GO:0052552 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.4 5.7 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.4 5.6 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.4 1.6 GO:0045915 response to selenium ion(GO:0010269) positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.4 14.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.4 1.1 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.4 4.8 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.4 2.9 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.4 1.1 GO:0046521 sphingoid catabolic process(GO:0046521)
0.4 7.1 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 3.4 GO:0016559 peroxisome fission(GO:0016559)
0.3 1.3 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.3 42.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.3 24.3 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.3 2.6 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.3 20.6 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.3 3.0 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.3 2.7 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.3 2.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 1.5 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.3 9.0 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.3 5.5 GO:0009060 aerobic respiration(GO:0009060)
0.3 5.8 GO:0002192 IRES-dependent translational initiation(GO:0002192)
0.3 6.6 GO:0008038 neuron recognition(GO:0008038)
0.3 0.8 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) positive regulation of telomeric DNA binding(GO:1904744)
0.3 2.4 GO:0007613 memory(GO:0007613)
0.3 8.2 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.3 14.5 GO:0014047 glutamate secretion(GO:0014047)
0.3 53.7 GO:0006457 protein folding(GO:0006457)
0.2 7.4 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.2 2.9 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.2 2.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.2 3.8 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.2 5.2 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.2 3.8 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.2 1.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 6.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 17.8 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.2 3.9 GO:0019372 lipoxygenase pathway(GO:0019372)
0.2 2.2 GO:0051601 exocyst localization(GO:0051601)
0.2 1.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 1.8 GO:0033623 regulation of integrin activation(GO:0033623)
0.2 2.5 GO:0051683 establishment of Golgi localization(GO:0051683)
0.2 1.3 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) protein localization to nucleolus(GO:1902570)
0.2 6.0 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.2 1.3 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.2 1.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.2 6.6 GO:0042417 dopamine metabolic process(GO:0042417)
0.2 3.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 7.2 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.1 2.7 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 7.6 GO:0006301 postreplication repair(GO:0006301)
0.1 1.8 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 3.3 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 2.8 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 3.6 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.1 9.0 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.1 4.1 GO:0032402 melanosome transport(GO:0032402)
0.1 2.7 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.1 6.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 8.9 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.1 2.3 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 2.2 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 14.6 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.1 0.4 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 1.9 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.1 1.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 2.9 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.1 0.5 GO:0090344 negative regulation of cell aging(GO:0090344)
0.0 1.1 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.5 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 2.8 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.9 GO:0045333 cellular respiration(GO:0045333)
0.0 0.7 GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 1.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.7 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.5 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 4.3 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.0 2.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.4 GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure(GO:0001976)
0.0 1.5 GO:0009791 post-embryonic development(GO:0009791)
0.0 1.2 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 4.7 GO:0043687 post-translational protein modification(GO:0043687)
0.0 0.2 GO:0060850 regulation of transcription involved in cell fate commitment(GO:0060850)
0.0 0.1 GO:0010226 response to lithium ion(GO:0010226)
0.0 0.7 GO:2001022 positive regulation of response to DNA damage stimulus(GO:2001022)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
12.9 51.4 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
12.1 36.4 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
11.0 197.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
10.3 144.8 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
10.0 139.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
7.2 64.8 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
6.9 48.4 GO:0097452 GAIT complex(GO:0097452)
6.3 31.7 GO:0070470 plasma membrane respiratory chain complex I(GO:0045272) plasma membrane respiratory chain(GO:0070470)
6.0 59.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
5.6 5.6 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
5.5 43.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
4.9 44.5 GO:0072546 ER membrane protein complex(GO:0072546)
4.8 14.5 GO:0005873 plus-end kinesin complex(GO:0005873)
4.7 93.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
4.3 25.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
4.0 240.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
3.3 13.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
3.2 128.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
3.0 21.2 GO:0061617 MICOS complex(GO:0061617)
3.0 41.5 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
3.0 32.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
2.7 18.8 GO:1990635 proximal dendrite(GO:1990635)
2.6 23.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
2.3 9.1 GO:1990246 uniplex complex(GO:1990246)
2.3 38.3 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
2.1 109.8 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.0 21.6 GO:0035686 sperm fibrous sheath(GO:0035686)
1.9 19.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.9 24.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
1.9 33.6 GO:0070469 respiratory chain(GO:0070469)
1.9 5.6 GO:0043291 RAVE complex(GO:0043291)
1.8 18.1 GO:0097449 astrocyte projection(GO:0097449)
1.6 18.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
1.6 29.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.5 350.0 GO:0043209 myelin sheath(GO:0043209)
1.5 4.5 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
1.5 13.4 GO:0097433 dense body(GO:0097433)
1.4 7.2 GO:0032021 NELF complex(GO:0032021)
1.4 5.7 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
1.4 16.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
1.3 12.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.3 11.9 GO:0033270 paranode region of axon(GO:0033270)
1.3 25.8 GO:0097228 sperm principal piece(GO:0097228)
1.3 5.1 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
1.2 8.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
1.1 24.5 GO:0030137 COPI-coated vesicle(GO:0030137)
1.1 2.2 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
1.0 3.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
1.0 7.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
1.0 5.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.9 13.3 GO:0000124 SAGA complex(GO:0000124)
0.9 2.7 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.9 3.4 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.9 11.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.9 36.6 GO:0031430 M band(GO:0031430)
0.8 6.8 GO:0031931 TORC1 complex(GO:0031931)
0.8 6.2 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.8 49.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.7 37.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 15.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.6 5.4 GO:0035253 ciliary rootlet(GO:0035253)
0.6 3.6 GO:0097512 cardiac myofibril(GO:0097512)
0.5 143.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.5 13.7 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.5 13.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.5 15.6 GO:0042629 mast cell granule(GO:0042629)
0.4 16.9 GO:0048786 presynaptic active zone(GO:0048786)
0.4 79.6 GO:0030426 growth cone(GO:0030426)
0.4 11.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.4 3.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.4 2.6 GO:0031415 NatA complex(GO:0031415)
0.4 3.0 GO:0042382 paraspeckles(GO:0042382)
0.4 11.8 GO:0005838 proteasome regulatory particle(GO:0005838)
0.3 25.6 GO:0016459 myosin complex(GO:0016459)
0.3 4.1 GO:0055037 recycling endosome(GO:0055037)
0.3 4.8 GO:0005652 nuclear lamina(GO:0005652)
0.2 2.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.2 10.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 32.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.3 GO:0033268 node of Ranvier(GO:0033268)
0.2 21.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 65.1 GO:0031965 nuclear membrane(GO:0031965)
0.2 29.7 GO:0000922 spindle pole(GO:0000922)
0.2 0.5 GO:0033553 rDNA heterochromatin(GO:0033553)
0.2 0.7 GO:0005915 zonula adherens(GO:0005915)
0.2 21.5 GO:0001650 fibrillar center(GO:0001650)
0.1 0.7 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 12.2 GO:0036064 ciliary basal body(GO:0036064)
0.1 38.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 20.4 GO:0005739 mitochondrion(GO:0005739)
0.1 6.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 7.4 GO:0005925 focal adhesion(GO:0005925)
0.1 0.8 GO:0070187 telosome(GO:0070187)
0.1 17.9 GO:0005635 nuclear envelope(GO:0005635)
0.1 1.1 GO:0097225 sperm midpiece(GO:0097225)
0.1 29.8 GO:0005874 microtubule(GO:0005874)
0.1 3.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 2.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 4.8 GO:0031519 PcG protein complex(GO:0031519)
0.1 5.8 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 5.0 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.1 9.5 GO:0000793 condensed chromosome(GO:0000793)
0.1 5.2 GO:0043679 axon terminus(GO:0043679)
0.0 1.1 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 13.8 GO:0005769 early endosome(GO:0005769)
0.0 3.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.5 GO:0030424 axon(GO:0030424)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 3.6 GO:0043202 lysosomal lumen(GO:0043202)
0.0 4.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.0 GO:0005771 multivesicular body(GO:0005771)
0.0 1.2 GO:0030133 transport vesicle(GO:0030133)
0.0 1.6 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.9 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
17.5 52.6 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
17.1 51.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
14.3 43.0 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
14.0 42.0 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
14.0 111.8 GO:0004111 creatine kinase activity(GO:0004111)
12.5 50.0 GO:0004743 pyruvate kinase activity(GO:0004743)
12.1 48.4 GO:0019828 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
11.6 34.7 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
9.5 38.0 GO:0004850 uridine phosphorylase activity(GO:0004850)
8.5 50.7 GO:0043532 angiostatin binding(GO:0043532)
7.6 22.7 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
7.3 22.0 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
7.3 29.2 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
7.0 97.9 GO:0016018 cyclosporin A binding(GO:0016018)
6.0 138.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
5.8 167.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
5.5 88.6 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
5.1 262.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
4.3 12.8 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
4.3 51.2 GO:0004017 adenylate kinase activity(GO:0004017)
4.2 16.9 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
4.0 48.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
3.9 27.0 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
3.7 25.6 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
3.3 26.7 GO:0004064 arylesterase activity(GO:0004064)
3.3 16.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
3.3 19.8 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
3.2 9.6 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
3.2 19.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
3.1 24.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
2.9 23.3 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
2.6 36.4 GO:0033691 sialic acid binding(GO:0033691)
2.6 10.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
2.6 10.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
2.5 24.6 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
2.4 43.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
2.3 13.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
2.3 61.4 GO:0003746 translation elongation factor activity(GO:0003746)
2.3 18.1 GO:0046870 cadmium ion binding(GO:0046870)
2.2 10.9 GO:0052846 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
2.1 29.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.9 14.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.9 20.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
1.8 5.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
1.8 14.0 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.7 15.0 GO:0015288 porin activity(GO:0015288)
1.5 3.0 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
1.5 70.7 GO:0004364 glutathione transferase activity(GO:0004364)
1.5 87.6 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
1.4 11.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
1.4 8.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.4 5.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
1.3 20.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
1.3 5.2 GO:0004461 lactose synthase activity(GO:0004461)
1.2 18.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
1.2 32.1 GO:0016805 dipeptidase activity(GO:0016805)
1.2 4.8 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.2 6.0 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
1.2 7.0 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
1.2 3.5 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
1.1 8.7 GO:0019871 sodium channel inhibitor activity(GO:0019871)
1.0 4.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
1.0 7.2 GO:0004046 aminoacylase activity(GO:0004046)
1.0 19.3 GO:0032794 GTPase activating protein binding(GO:0032794)
1.0 19.7 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
1.0 5.9 GO:0003998 acylphosphatase activity(GO:0003998)
0.9 10.2 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.9 5.5 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.9 4.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.9 96.0 GO:0051087 chaperone binding(GO:0051087)
0.9 2.7 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.9 2.6 GO:0032551 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
0.9 26.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.8 5.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.8 18.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.8 10.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.8 15.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.8 15.0 GO:0044548 S100 protein binding(GO:0044548)
0.7 8.8 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.7 7.7 GO:1903136 cuprous ion binding(GO:1903136)
0.7 25.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.6 8.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.6 3.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.6 9.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.6 14.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.5 10.3 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.5 3.1 GO:0034511 U3 snoRNA binding(GO:0034511)
0.5 5.6 GO:0070569 uridylyltransferase activity(GO:0070569)
0.5 12.0 GO:0004697 protein kinase C activity(GO:0004697)
0.5 2.4 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.5 2.4 GO:0004359 glutaminase activity(GO:0004359)
0.5 8.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.5 4.8 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.5 4.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.5 54.6 GO:0051082 unfolded protein binding(GO:0051082)
0.5 2.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.5 14.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.5 6.9 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.4 1.3 GO:0008097 5S rRNA binding(GO:0008097)
0.4 24.9 GO:0050681 androgen receptor binding(GO:0050681)
0.4 2.9 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.4 9.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.4 25.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.4 83.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 5.6 GO:0001671 ATPase activator activity(GO:0001671)
0.4 3.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.4 2.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.3 4.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 2.3 GO:0001727 lipid kinase activity(GO:0001727)
0.3 9.7 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.3 3.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.3 7.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.3 41.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.3 7.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.3 3.0 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 1.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.3 63.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2 3.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 0.9 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.2 28.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 1.1 GO:0051373 FATZ binding(GO:0051373)
0.2 6.9 GO:0043531 ADP binding(GO:0043531)
0.2 2.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 8.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2 7.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 14.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 4.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 3.4 GO:0005109 frizzled binding(GO:0005109)
0.1 2.7 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 17.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 6.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 7.3 GO:0019003 GDP binding(GO:0019003)
0.1 1.8 GO:0031005 filamin binding(GO:0031005)
0.1 2.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 24.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 0.8 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 1.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 8.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 3.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 3.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 6.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 6.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.9 GO:0097110 scaffold protein binding(GO:0097110)
0.1 0.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.3 GO:0005123 death receptor binding(GO:0005123)
0.0 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 5.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 2.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.7 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 3.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.5 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 41.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.3 106.4 PID HNF3A PATHWAY FOXA1 transcription factor network
1.1 41.1 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.0 18.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.9 22.0 PID ARF 3PATHWAY Arf1 pathway
0.9 11.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.9 26.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.8 101.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.8 113.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.7 16.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.7 81.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.4 7.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.3 19.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 3.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 3.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 9.3 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.2 10.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 11.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 3.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 3.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.2 3.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 6.8 PID LKB1 PATHWAY LKB1 signaling events
0.1 6.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 0.7 PID INSULIN PATHWAY Insulin Pathway
0.1 7.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.1 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 1.2 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 1.8 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 26.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 5.5 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 5.4 PID P73PATHWAY p73 transcription factor network
0.0 1.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.3 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.7 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 168.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
6.7 570.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
6.0 54.0 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
3.2 132.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
3.2 208.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
3.0 54.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
2.3 53.5 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
2.2 22.0 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
2.0 63.5 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
1.8 26.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
1.8 83.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
1.6 54.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.5 41.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.5 20.8 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
1.4 12.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
1.3 45.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
1.3 26.6 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
1.2 19.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
1.0 18.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.9 13.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.8 7.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.8 19.0 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.7 18.9 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.6 7.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.6 14.5 REACTOME KINESINS Genes involved in Kinesins
0.6 155.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.5 4.1 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.4 16.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.4 10.2 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.4 9.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.4 5.4 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.4 9.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 5.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 6.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 31.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 8.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 56.0 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.3 27.2 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.3 7.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 5.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.3 4.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.2 11.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.2 2.9 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 3.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 10.0 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 3.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 8.9 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 3.0 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.2 4.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 9.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 4.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 5.3 REACTOME RNA POL III TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 16.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.1 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 2.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.0 REACTOME GABA B RECEPTOR ACTIVATION Genes involved in GABA B receptor activation
0.1 1.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 2.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 15.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 0.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.9 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.1 1.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.7 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 3.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 5.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 2.7 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 1.8 REACTOME MITOTIC M M G1 PHASES Genes involved in Mitotic M-M/G1 phases
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions