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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ETV3
Z-value: 1.22
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Transcription factors associated with ETV3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV3 | hg19_v2_chr1_-_157108266_157108347 | 0.47 | 1.2e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 27.0 | 81.1 | GO:0007439 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) |
| 1.6 | 67.7 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.8 | 64.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 2.7 | 48.4 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 1.5 | 44.8 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 4.8 | 43.6 | GO:0006531 | aspartate metabolic process(GO:0006531) |
| 3.4 | 43.6 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 2.4 | 43.5 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 5.2 | 41.4 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 1.3 | 41.3 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 175.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 23.9 | 95.7 | GO:1990745 | EARP complex(GO:1990745) |
| 0.1 | 54.3 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 53.8 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.4 | 51.5 | GO:0016605 | PML body(GO:0016605) |
| 0.4 | 49.0 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.6 | 43.4 | GO:0015030 | Cajal body(GO:0015030) |
| 10.4 | 41.4 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.3 | 40.1 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.3 | 39.1 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 150.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 147.5 | GO:0046872 | metal ion binding(GO:0046872) |
| 0.1 | 127.2 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.2 | 85.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 2.9 | 67.7 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 10.1 | 50.5 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 6.9 | 48.4 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 2.0 | 44.8 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 14.5 | 43.6 | GO:0004515 | nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
| 2.0 | 43.5 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 46.3 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.5 | 45.2 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.8 | 41.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.5 | 40.2 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.4 | 37.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.6 | 37.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.4 | 36.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.8 | 33.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 33.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 28.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 108.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 54.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 2.2 | 41.4 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.5 | 39.5 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.4 | 33.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 31.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 2.0 | 31.6 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 3.0 | 29.7 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.6 | 27.5 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.3 | 22.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |