Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for ETV4_ETS2
Z-value: 0.28
Motif logo
Transcription factors associated with ETV4_ETS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV4 | hg19_v2_chr17_-_41623691_41623715, hg19_v2_chr17_-_41623075_41623101 | 0.35 | 1.4e-07 | Click! |
| ETS2 | hg19_v2_chr21_+_40177143_40177231, hg19_v2_chr21_+_40177755_40177875 | -0.04 | 6.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV4_ETS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 35.5 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.4 | 25.4 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 1.2 | 23.4 | GO:0019336 | phenol-containing compound catabolic process(GO:0019336) |
| 0.2 | 22.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.3 | 21.2 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 2.8 | 19.6 | GO:0033590 | response to cobalamin(GO:0033590) |
| 0.4 | 19.6 | GO:0003281 | ventricular septum development(GO:0003281) |
| 6.2 | 18.6 | GO:1903336 | negative regulation of vacuolar transport(GO:1903336) |
| 4.6 | 18.4 | GO:0034445 | regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) |
| 0.9 | 18.4 | GO:0031167 | rRNA methylation(GO:0031167) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 23.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.9 | 20.6 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.4 | 20.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.3 | 19.5 | GO:0031904 | endosome lumen(GO:0031904) |
| 1.4 | 19.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 6.1 | 18.4 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.2 | 18.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 17.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.6 | 17.5 | GO:0002080 | acrosomal membrane(GO:0002080) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 47.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 44.9 | GO:0003677 | DNA binding(GO:0003677) |
| 5.9 | 29.4 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.2 | 28.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.6 | 22.6 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.2 | 21.9 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.9 | 20.3 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 2.8 | 19.8 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.5 | 18.9 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 1.7 | 18.8 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 46.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 32.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 31.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.4 | 26.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.4 | 23.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.5 | 21.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 21.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.3 | 21.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.4 | 20.8 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 19.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 39.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.3 | 26.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.5 | 21.3 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.3 | 19.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.9 | 15.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.6 | 14.5 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 14.4 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 12.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 12.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.2 | 11.5 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |