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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ETV7
Z-value: 0.38
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Transcription factors associated with ETV7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV7 | hg19_v2_chr6_-_36355513_36355578 | -0.28 | 2.6e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.8 | GO:0010038 | response to metal ion(GO:0010038) |
| 2.1 | 19.0 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.2 | 18.5 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 0.2 | 18.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 3.3 | 16.3 | GO:1904579 | response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) |
| 3.8 | 15.3 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 1.5 | 14.9 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
| 2.8 | 14.2 | GO:0046203 | spermidine catabolic process(GO:0046203) |
| 0.7 | 14.0 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.3 | 12.9 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.6 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.6 | 18.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.4 | 17.1 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.7 | 15.1 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 1.1 | 14.8 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.6 | 14.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.8 | 13.8 | GO:0034709 | methylosome(GO:0034709) |
| 1.0 | 13.4 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.8 | 13.1 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.2 | 12.9 | GO:0031430 | M band(GO:0031430) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 42.6 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 22.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 17.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 4.7 | 14.2 | GO:0034038 | deoxyhypusine synthase activity(GO:0034038) |
| 0.5 | 14.2 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.8 | 13.9 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.7 | 13.1 | GO:0043495 | protein anchor(GO:0043495) |
| 0.2 | 12.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 3.0 | 12.2 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 0.1 | 11.1 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 11.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 10.2 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.3 | 8.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 8.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 5.5 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 5.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 4.9 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 4.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 4.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 31.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 25.2 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.4 | 21.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.3 | 19.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 16.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.4 | 13.8 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.4 | 13.4 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.4 | 13.1 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.5 | 12.8 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 12.0 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |