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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for EVX2

Z-value: 0.07

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Transcription factors associated with EVX2

Gene Symbol Gene ID Gene Info
EVX2
ENSG00000174279.4 even-skipped homeobox 2

Activity profile of EVX2 motif

Sorted Z-values of EVX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_111718173 13.73 ENST00000494932.1
TAGLN3
transgelin 3
chr3_+_111717600 13.63 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111718036 13.47 ENST00000455401.2
TAGLN3
transgelin 3
chr3_+_111717511 13.17 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr6_+_39760129 12.18 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr3_+_115342349 9.09 ENST00000393780.3
GAP43
growth associated protein 43
chr11_-_115375107 7.70 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1
cell adhesion molecule 1
chr17_-_9929581 7.41 ENST00000437099.2
ENST00000396115.2
GAS7
growth arrest-specific 7
chr17_-_27418537 2.77 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr1_-_151431909 2.73 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr1_-_151431647 2.29 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr18_-_33709268 2.03 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr12_+_15699286 1.46 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr4_-_41884620 1.01 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chr6_-_62996066 0.99 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr12_+_28410128 0.76 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr1_+_28261533 0.71 ENST00000411604.1
ENST00000373888.4
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr19_+_11071546 0.43 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr6_-_111927062 0.40 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr6_-_111927449 0.27 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr17_-_40337470 0.16 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr15_-_55563072 0.13 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr1_+_28261492 0.11 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr1_+_28261621 0.10 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr15_-_55562479 0.07 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr15_-_55562582 0.02 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family

Network of associatons between targets according to the STRING database.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.7 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.9 9.1 GO:0016198 axon choice point recognition(GO:0016198)
0.5 1.5 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.4 5.0 GO:0051382 kinetochore assembly(GO:0051382)
0.2 2.0 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 12.2 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 0.9 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.4 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.1 0.8 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 52.5 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 0.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.7 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 7.4 GO:0007050 cell cycle arrest(GO:0007050)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 9.1 GO:0032584 growth cone membrane(GO:0032584)
0.2 54.0 GO:0043209 myelin sheath(GO:0043209)
0.1 7.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 5.0 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 9.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.2 54.0 GO:0051015 actin filament binding(GO:0051015)
0.1 12.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 2.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.9 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 7.7 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.0 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters