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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOSB
Z-value: 0.81
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Transcription factors associated with FOSB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSB | hg19_v2_chr19_+_45971246_45971265 | -0.20 | 3.5e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 31.3 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.2 | 28.2 | GO:0051225 | spindle assembly(GO:0051225) |
| 4.2 | 25.2 | GO:0007296 | vitellogenesis(GO:0007296) |
| 1.3 | 25.0 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.3 | 19.7 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 1.2 | 19.3 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.4 | 17.3 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 1.3 | 16.7 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 1.6 | 16.4 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 4.1 | 16.3 | GO:0006238 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 28.2 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.2 | 24.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 1.2 | 21.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 20.1 | GO:0034399 | nuclear periphery(GO:0034399) |
| 1.0 | 19.3 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.1 | 19.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.2 | 16.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 1.7 | 13.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 12.5 | GO:0016604 | nuclear body(GO:0016604) |
| 0.0 | 12.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 31.9 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.7 | 27.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.6 | 19.3 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 5.6 | 16.7 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.3 | 16.4 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 2.3 | 16.3 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.3 | 13.9 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.3 | 13.8 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 13.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 52.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 25.5 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.3 | 22.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 17.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 15.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 14.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 13.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.5 | 13.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.2 | 13.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 13.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.6 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 1.0 | 18.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.4 | 18.7 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.5 | 16.3 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.2 | 14.6 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 14.4 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.5 | 13.8 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.2 | 13.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.5 | 13.2 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 13.0 | REACTOME TRANSLATION | Genes involved in Translation |