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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOSL1
Z-value: 0.26
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Transcription factors associated with FOSL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg19_v2_chr11_-_65667884_65667895 | 0.53 | 1.7e-17 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.3 | 71.3 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.6 | 62.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 3.2 | 60.2 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 2.0 | 59.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 7.9 | 47.4 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 6.4 | 38.5 | GO:0007296 | vitellogenesis(GO:0007296) |
| 2.0 | 35.3 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 2.0 | 34.4 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 0.9 | 31.3 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 3.5 | 28.2 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.9 | 71.3 | GO:0005638 | lamin filament(GO:0005638) |
| 1.1 | 58.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 9.0 | 53.9 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 2.9 | 53.0 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 1.3 | 47.4 | GO:0032420 | stereocilium(GO:0032420) |
| 5.3 | 42.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.4 | 37.0 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.3 | 30.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.3 | 29.6 | GO:0005604 | basement membrane(GO:0005604) |
| 4.0 | 28.2 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 172.5 | GO:0005198 | structural molecule activity(GO:0005198) |
| 1.9 | 75.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 7.7 | 53.9 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 38.0 | GO:0005525 | GTP binding(GO:0005525) |
| 0.6 | 34.1 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.5 | 32.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.0 | 31.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 1.6 | 30.6 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.2 | 30.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 4.9 | 29.2 | GO:1990254 | keratin filament binding(GO:1990254) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 70.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 2.9 | 67.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.8 | 67.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.9 | 63.8 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 1.4 | 48.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 1.4 | 44.0 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 1.4 | 39.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.7 | 38.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.8 | 35.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.6 | 35.6 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 73.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.8 | 62.1 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.7 | 61.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 2.0 | 53.9 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 1.0 | 51.8 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.5 | 38.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 1.5 | 28.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 1.0 | 26.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 1.9 | 26.1 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.8 | 24.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |