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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for FOSL2_SMARCC1

Z-value: 0.32

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Transcription factors associated with FOSL2_SMARCC1

Gene Symbol Gene ID Gene Info
ENSG00000075426.7 FOS like 2, AP-1 transcription factor subunit
ENSG00000173473.6 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOSL2hg19_v2_chr2_+_28615669_286157330.243.4e-04Click!
SMARCC1hg19_v2_chr3_-_47823298_478234230.236.2e-04Click!

Activity profile of FOSL2_SMARCC1 motif

Sorted Z-values of FOSL2_SMARCC1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_223889285 74.89 ENST00000433674.2
calpain 2, (m/II) large subunit
chr1_-_113247543 71.58 ENST00000414971.1
ENST00000534717.1
ras homolog family member C
chr6_-_31704282 59.93 ENST00000375784.3
ENST00000375779.2
chloride intracellular channel 1
chr22_+_23241661 45.39 ENST00000390322.2
immunoglobulin lambda joining 2
chr1_+_156096336 42.14 ENST00000504687.1
ENST00000473598.2
lamin A/C
chr1_+_156084461 41.84 ENST00000347559.2
ENST00000361308.4
ENST00000368300.4
ENST00000368299.3
lamin A/C
chr1_-_151965048 39.20 ENST00000368809.1
S100 calcium binding protein A10
chr2_+_89901292 34.61 ENST00000448155.2
immunoglobulin kappa variable 1D-39
chr1_+_156095951 33.25 ENST00000448611.2
ENST00000368297.1
lamin A/C
chr2_+_90060377 33.18 ENST00000436451.2
immunoglobulin kappa variable 6D-21 (non-functional)
chr11_-_64013288 32.90 ENST00000542235.1
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr22_+_23077065 32.57 ENST00000390310.2
immunoglobulin lambda variable 2-18
chr2_-_89459813 32.47 ENST00000390256.2
immunoglobulin kappa variable 6-21 (non-functional)
chr12_-_53343602 31.82 ENST00000546897.1
ENST00000552551.1
keratin 8
chr12_-_56122426 31.00 ENST00000551173.1
CD63 molecule
chr18_+_21452804 30.68 ENST00000269217.6
laminin, alpha 3
chr7_+_73245193 28.97 ENST00000340958.2
claudin 4
chr11_-_64013663 28.62 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr3_-_81792780 28.61 ENST00000489715.1
glucan (1,4-alpha-), branching enzyme 1
chr5_+_138089100 27.94 ENST00000520339.1
ENST00000355078.5
ENST00000302763.7
ENST00000518910.1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr10_+_17270214 27.25 ENST00000544301.1
vimentin
chr2_-_89417335 26.97 ENST00000490686.1
immunoglobulin kappa variable 1-17
chr2_-_89399845 26.40 ENST00000479981.1
immunoglobulin kappa variable 1-16
chr11_-_65667997 26.20 ENST00000312562.2
ENST00000534222.1
FOS-like antigen 1
chr15_-_60690163 25.99 ENST00000558998.1
ENST00000560165.1
ENST00000557986.1
ENST00000559780.1
ENST00000559467.1
ENST00000559956.1
ENST00000332680.4
ENST00000396024.3
ENST00000421017.2
ENST00000560466.1
ENST00000558132.1
ENST00000559113.1
ENST00000557906.1
ENST00000558558.1
ENST00000560468.1
ENST00000559370.1
ENST00000558169.1
ENST00000559725.1
ENST00000558985.1
ENST00000451270.2
annexin A2
chr1_+_26606608 25.73 ENST00000319041.6
SH3 domain binding glutamic acid-rich protein like 3
chr11_-_65667884 25.11 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOS-like antigen 1
chr2_+_90121477 24.21 ENST00000483379.1
immunoglobulin kappa variable 1D-17
chr5_+_135394840 23.98 ENST00000503087.1
transforming growth factor, beta-induced, 68kDa
chr7_+_116312411 23.93 ENST00000456159.1
ENST00000397752.3
ENST00000318493.6
met proto-oncogene
chr6_-_30712313 23.83 ENST00000376377.2
ENST00000259874.5
immediate early response 3
chr11_-_2950642 23.04 ENST00000314222.4
pleckstrin homology-like domain, family A, member 2
chr14_+_58711539 22.85 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
proteasome (prosome, macropain) subunit, alpha type, 3
chr2_+_90139056 22.32 ENST00000492446.1
immunoglobulin kappa variable 1D-16
chr17_-_79481666 22.17 ENST00000575659.1
actin, gamma 1
chr10_+_121410882 21.75 ENST00000369085.3
BCL2-associated athanogene 3
chr11_+_101983176 21.35 ENST00000524575.1
Yes-associated protein 1
chr1_-_153538011 21.18 ENST00000368707.4
S100 calcium binding protein A2
chrX_+_47441712 21.08 ENST00000218388.4
ENST00000377018.2
ENST00000456754.2
ENST00000377017.1
ENST00000441738.1
TIMP metallopeptidase inhibitor 1
chrX_+_49028265 21.06 ENST00000376322.3
ENST00000376327.5
proteolipid protein 2 (colonic epithelium-enriched)
chr7_+_55177416 20.67 ENST00000450046.1
ENST00000454757.2
epidermal growth factor receptor
chr2_+_89998789 20.48 ENST00000453166.2
immunoglobulin kappa variable 2D-28
chr17_-_73150629 20.11 ENST00000356033.4
ENST00000405458.3
ENST00000409753.3
hematological and neurological expressed 1
chr22_+_23134974 19.98 ENST00000390314.2
immunoglobulin lambda variable 2-11
chr1_-_159894319 19.84 ENST00000320307.4
transgelin 2
chr16_-_69760409 19.77 ENST00000561500.1
ENST00000439109.2
ENST00000564043.1
ENST00000379046.2
ENST00000379047.3
NAD(P)H dehydrogenase, quinone 1
chr2_+_89999259 19.57 ENST00000558026.1
immunoglobulin kappa variable 2D-28
chr2_-_89521942 19.18 ENST00000482769.1
immunoglobulin kappa variable 2-28
chr4_+_74606223 19.09 ENST00000307407.3
ENST00000401931.1
interleukin 8
chr7_-_96339132 18.72 ENST00000413065.1
split hand/foot malformation (ectrodactyly) type 1
chr1_+_27189631 18.69 ENST00000339276.4
stratifin
chr2_-_89340242 17.74 ENST00000480492.1
immunoglobulin kappa variable 1-12
chr18_+_21452964 17.56 ENST00000587184.1
laminin, alpha 3
chr2_-_89568263 17.10 ENST00000473726.1
immunoglobulin kappa variable 1-33
chr2_+_89923550 17.10 ENST00000509129.1
immunoglobulin kappa variable 1D-37 (non-functional)
chr17_+_35851570 17.03 ENST00000394386.1
dual specificity phosphatase 14
chr15_+_67420441 16.81 ENST00000558894.1
SMAD family member 3
chr1_-_152009460 16.59 ENST00000271638.2
S100 calcium binding protein A11
chr15_+_64428529 16.19 ENST00000560861.1
sorting nexin 1
chr3_-_149095652 16.16 ENST00000305366.3
transmembrane 4 L six family member 1
chr11_-_102668879 15.85 ENST00000315274.6
matrix metallopeptidase 1 (interstitial collagenase)
chr2_+_89952792 15.58 ENST00000390265.2
immunoglobulin kappa variable 1D-33
chr12_+_13349650 15.28 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
epithelial membrane protein 1
chr2_+_90198535 15.08 ENST00000390276.2
immunoglobulin kappa variable 1D-12
chr5_+_72143988 14.70 ENST00000506351.2
transportin 1
chr15_+_22892663 14.65 ENST00000313077.7
ENST00000561274.1
ENST00000560848.1
cytoplasmic FMR1 interacting protein 1
chr2_-_89619904 14.65 ENST00000498574.1
immunoglobulin kappa variable 1-39 (gene/pseudogene)
chr19_-_44174330 14.60 ENST00000340093.3
plasminogen activator, urokinase receptor
chr1_+_26605618 14.38 ENST00000270792.5
SH3 domain binding glutamic acid-rich protein like 3
chr19_+_36630855 14.14 ENST00000589146.1
calpain, small subunit 1
chr12_-_56122761 14.09 ENST00000552164.1
ENST00000420846.3
ENST00000257857.4
CD63 molecule
chr19_+_36630961 14.08 ENST00000587718.1
ENST00000592483.1
ENST00000590874.1
ENST00000588815.1
calpain, small subunit 1
chr5_+_150020214 13.84 ENST00000307662.4
synaptopodin
chr11_-_6341844 13.75 ENST00000303927.3
protein kinase C, delta binding protein
chr8_+_126442563 13.62 ENST00000311922.3
tribbles pseudokinase 1
chr7_-_107643674 13.53 ENST00000222399.6
laminin, beta 1
chr3_-_49395705 13.50 ENST00000419349.1
glutathione peroxidase 1
chrX_-_15511438 13.42 ENST00000380420.5
pirin (iron-binding nuclear protein)
chr6_+_83072923 13.37 ENST00000535040.1
trophoblast glycoprotein
chr19_+_36630454 13.26 ENST00000246533.3
calpain, small subunit 1
chr4_+_169753156 13.11 ENST00000393726.3
ENST00000507735.1
palladin, cytoskeletal associated protein
chr6_-_138428613 13.01 ENST00000421351.3
PERP, TP53 apoptosis effector
chr11_+_35198243 12.78 ENST00000528455.1
CD44 molecule (Indian blood group)
chr17_-_39942940 12.72 ENST00000310706.5
ENST00000393931.3
ENST00000424457.1
ENST00000591690.1
junction plakoglobin
chr2_-_85641162 12.69 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
capping protein (actin filament), gelsolin-like
chr11_+_35198118 12.57 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44 molecule (Indian blood group)
chr2_+_90192768 12.33 ENST00000390275.2
immunoglobulin kappa variable 1D-13
chr17_-_18161870 12.30 ENST00000579294.1
ENST00000545457.2
ENST00000379450.4
ENST00000578558.1
flightless I homolog (Drosophila)
chr1_-_24126023 12.27 ENST00000429356.1
UDP-galactose-4-epimerase
chr9_+_71819927 11.92 ENST00000535702.1
tight junction protein 2
chr22_+_23165153 11.69 ENST00000390317.2
immunoglobulin lambda variable 2-8
chr18_+_3449695 11.68 ENST00000343820.5
TGFB-induced factor homeobox 1
chr11_+_844406 11.58 ENST00000397404.1
tetraspanin 4
chr11_+_10326612 11.53 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
adrenomedullin
chr12_-_56120865 11.50 ENST00000548898.1
ENST00000552067.1
CD63 molecule
chr12_-_56120838 11.50 ENST00000548160.1
CD63 molecule
chr18_+_3449821 11.43 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGFB-induced factor homeobox 1
chr9_+_71820057 11.40 ENST00000539225.1
tight junction protein 2
chr6_-_159239257 11.39 ENST00000337147.7
ENST00000392177.4
ezrin
chr11_+_844067 11.38 ENST00000397406.1
ENST00000409543.2
ENST00000525201.1
tetraspanin 4
chr11_+_394196 11.36 ENST00000331563.2
ENST00000531857.1
plakophilin 3
chr11_+_67351019 11.35 ENST00000398606.3
glutathione S-transferase pi 1
chr3_+_30648066 11.27 ENST00000359013.4
transforming growth factor, beta receptor II (70/80kDa)
chr3_-_32022733 11.23 ENST00000438237.2
ENST00000396556.2
oxysterol binding protein-like 10
chr12_+_53491220 11.02 ENST00000548547.1
ENST00000301464.3
insulin-like growth factor binding protein 6
chr15_+_41136586 10.79 ENST00000431806.1
serine peptidase inhibitor, Kunitz type 1
chr17_+_75446819 10.76 ENST00000541152.2
ENST00000591704.1
septin 9
chr22_+_22735135 10.75 ENST00000390297.2
immunoglobulin lambda variable 1-44
chr6_+_44194762 10.71 ENST00000371708.1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr1_+_150480551 10.68 ENST00000369049.4
ENST00000369047.4
extracellular matrix protein 1
chr7_-_96339167 10.64 ENST00000444799.1
ENST00000417009.1
ENST00000248566.2
split hand/foot malformation (ectrodactyly) type 1
chr17_-_73781567 10.59 ENST00000586607.1
H3 histone, family 3B (H3.3B)
chr5_+_73980965 10.50 ENST00000261416.7
hexosaminidase B (beta polypeptide)
chr17_+_49230897 10.47 ENST00000393196.3
ENST00000336097.3
ENST00000480143.1
ENST00000511355.1
ENST00000013034.3
ENST00000393198.3
ENST00000608447.1
ENST00000393193.2
ENST00000376392.6
ENST00000555572.1
NME/NM23 nucleoside diphosphate kinase 1
NME1-NME2 readthrough
NME/NM23 nucleoside diphosphate kinase 2
chr11_+_46402297 10.29 ENST00000405308.2
midkine (neurite growth-promoting factor 2)
chr3_+_30647994 10.18 ENST00000295754.5
transforming growth factor, beta receptor II (70/80kDa)
chr22_+_23089870 10.00 ENST00000390311.2
immunoglobulin lambda variable 3-16
chr1_-_154943002 9.82 ENST00000606391.1
SHC (Src homology 2 domain containing) transforming protein 1
chr1_-_154943212 9.80 ENST00000368445.5
ENST00000448116.2
ENST00000368449.4
SHC (Src homology 2 domain containing) transforming protein 1
chr1_+_150480576 9.65 ENST00000346569.6
extracellular matrix protein 1
chr5_-_176923803 9.58 ENST00000506161.1
PDZ and LIM domain 7 (enigma)
chr20_+_44637526 9.55 ENST00000372330.3
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr8_-_141774467 9.54 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
protein tyrosine kinase 2
chr11_-_66103867 9.50 ENST00000424433.2
Ras and Rab interactor 1
chr2_+_90108504 9.49 ENST00000390271.2
immunoglobulin kappa variable 6D-41 (non-functional)
chrX_-_10851762 9.18 ENST00000380785.1
ENST00000380787.1
midline 1 (Opitz/BBB syndrome)
chr11_+_67351213 9.12 ENST00000398603.1
glutathione S-transferase pi 1
chr22_+_22707260 9.10 ENST00000390293.1
immunoglobulin lambda variable 5-48 (non-functional)
chr2_-_89597542 9.08 ENST00000465170.1
immunoglobulin kappa variable 1-37 (non-functional)
chr3_+_184038073 9.01 ENST00000428387.1
ENST00000434061.2
eukaryotic translation initiation factor 4 gamma, 1
chr12_+_64798095 8.98 ENST00000332707.5
exportin, tRNA
chr3_+_127771212 8.97 ENST00000243253.3
ENST00000481210.1
Sec61 alpha 1 subunit (S. cerevisiae)
chr22_+_23046750 8.95 ENST00000390307.2
immunoglobulin lambda variable 3-22 (gene/pseudogene)
chr6_-_84140757 8.92 ENST00000541327.1
ENST00000369705.3
ENST00000543031.1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr15_+_41136216 8.92 ENST00000562057.1
ENST00000344051.4
serine peptidase inhibitor, Kunitz type 1
chr20_+_33759854 8.81 ENST00000216968.4
protein C receptor, endothelial
chr5_-_176923846 8.81 ENST00000506537.1
PDZ and LIM domain 7 (enigma)
chr3_+_5020801 8.74 ENST00000256495.3
basic helix-loop-helix family, member e40
chr3_+_184037466 8.60 ENST00000441154.1
eukaryotic translation initiation factor 4 gamma, 1
chr3_+_100428316 8.48 ENST00000479672.1
ENST00000476228.1
ENST00000463568.1
TRK-fused gene
chr9_-_35685452 8.37 ENST00000607559.1
tropomyosin 2 (beta)
chr19_-_44174305 8.34 ENST00000601723.1
ENST00000339082.3
plasminogen activator, urokinase receptor
chr22_+_23029188 8.22 ENST00000390305.2
immunoglobulin lambda variable 3-25
chr7_+_129932974 8.08 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
carboxypeptidase A4
chr21_+_10862622 7.99 ENST00000302092.5
ENST00000559480.1
immunoglobulin heavy variable 1/OR21-1 (non-functional)
chr19_+_49377575 7.97 ENST00000600406.1
protein phosphatase 1, regulatory subunit 15A
chr1_-_150208363 7.74 ENST00000436748.2
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr10_+_75670862 7.74 ENST00000446342.1
ENST00000372764.3
ENST00000372762.4
plasminogen activator, urokinase
chr1_-_109968973 7.73 ENST00000271308.4
ENST00000538610.1
proteasome (prosome, macropain) subunit, alpha type, 5
chr3_+_100428268 7.72 ENST00000240851.4
TRK-fused gene
chr17_-_39743139 7.67 ENST00000167586.6
keratin 14
chr7_+_48128194 7.66 ENST00000416681.1
ENST00000331803.4
ENST00000432131.1
uridine phosphorylase 1
chr15_-_20170354 7.54 ENST00000338912.5
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr3_+_100428188 7.50 ENST00000418917.2
ENST00000490574.1
TRK-fused gene
chr2_+_89890533 7.50 ENST00000429992.2
immunoglobulin kappa variable 2D-40
chr7_+_48128316 7.31 ENST00000341253.4
uridine phosphorylase 1
chr10_+_88854926 7.18 ENST00000298784.1
ENST00000298786.4
family with sequence similarity 35, member A
chr12_+_123237321 7.17 ENST00000280557.6
ENST00000455982.2
density-regulated protein
chr3_+_69134080 7.13 ENST00000273258.3
ADP-ribosylation-like factor 6 interacting protein 5
chr22_+_23063100 7.04 ENST00000390309.2
immunoglobulin lambda variable 3-19
chr1_-_209824643 7.03 ENST00000391911.1
ENST00000415782.1
laminin, beta 3
chr7_-_55606346 6.98 ENST00000545390.1
vesicular, overexpressed in cancer, prosurvival protein 1
chrX_-_129244655 6.96 ENST00000335997.7
E74-like factor 4 (ets domain transcription factor)
chr13_+_102142296 6.90 ENST00000376162.3
integrin, beta-like 1 (with EGF-like repeat domains)
chr22_+_23154239 6.78 ENST00000390315.2
immunoglobulin lambda variable 3-10
chr8_-_82395461 6.71 ENST00000256104.4
fatty acid binding protein 4, adipocyte
chr17_-_7590745 6.68 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
tumor protein p53
chr6_+_63921351 6.67 ENST00000370659.1
FK506 binding protein 1C
chr3_+_187930719 6.63 ENST00000312675.4
LIM domain containing preferred translocation partner in lipoma
chr22_+_22712087 6.59 ENST00000390294.2
immunoglobulin lambda variable 1-47
chr6_+_63921399 6.59 ENST00000356170.3
FK506 binding protein 1C
chr22_-_30642782 6.56 ENST00000249075.3
leukemia inhibitory factor
chr2_+_201171064 6.56 ENST00000451764.2
spermatogenesis associated, serine-rich 2-like
chr10_-_98346801 6.51 ENST00000371142.4
transmembrane 9 superfamily member 3
chr1_-_150208291 6.44 ENST00000533654.1
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chrX_-_129244454 6.38 ENST00000308167.5
E74-like factor 4 (ets domain transcription factor)
chr1_-_150208412 6.37 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr17_+_21191341 6.37 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
mitogen-activated protein kinase kinase 3
chr2_-_219134822 6.29 ENST00000444053.1
ENST00000248450.4
angio-associated, migratory cell protein
chr3_-_149293990 6.23 ENST00000472417.1
WW domain containing transcription regulator 1
chr5_-_138534071 6.23 ENST00000394817.2
SIL1 nucleotide exchange factor
chr7_+_99006232 6.22 ENST00000403633.2
BUD31 homolog (S. cerevisiae)
chr17_+_7123125 6.17 ENST00000356839.5
ENST00000583312.1
ENST00000350303.5
acyl-CoA dehydrogenase, very long chain
chr7_+_112063192 6.15 ENST00000005558.4
interferon-related developmental regulator 1
chr14_+_103801140 6.13 ENST00000561325.1
ENST00000392715.2
ENST00000559130.1
ENST00000559532.1
ENST00000558506.1
eukaryotic translation initiation factor 5
chr3_-_151034734 6.09 ENST00000260843.4
G protein-coupled receptor 87
chr16_+_30077055 6.01 ENST00000564595.2
ENST00000569798.1
aldolase A, fructose-bisphosphate
chr11_-_62323702 5.96 ENST00000530285.1
AHNAK nucleoprotein
chr6_-_43027105 5.83 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
mitochondrial ribosomal protein L2
chr5_+_179247759 5.75 ENST00000389805.4
ENST00000504627.1
ENST00000402874.3
ENST00000510187.1
sequestosome 1
chr1_-_150208498 5.75 ENST00000314136.8
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr2_+_201981527 5.74 ENST00000441224.1
CASP8 and FADD-like apoptosis regulator
chr2_+_90248739 5.73 ENST00000468879.1
immunoglobulin kappa variable 1D-43
chr1_+_155107820 5.72 ENST00000484157.1
solute carrier family 50 (sugar efflux transporter), member 1
chr7_+_94023873 5.72 ENST00000297268.6
collagen, type I, alpha 2
chr1_-_27816641 5.67 ENST00000430629.2
WAS protein family, member 2
chr3_+_69134124 5.60 ENST00000478935.1
ADP-ribosylation-like factor 6 interacting protein 5
chr6_-_38670897 5.59 ENST00000373365.4
glyoxalase I
chr11_-_65430251 5.54 ENST00000534283.1
ENST00000527749.1
ENST00000533187.1
ENST00000525693.1
ENST00000534558.1
ENST00000532879.1
ENST00000532999.1
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr16_+_30751953 5.54 ENST00000483578.1
RP11-2C24.4

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL2_SMARCC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
23.4 117.2 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
11.9 71.6 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
9.3 27.9 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
8.7 26.0 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
8.6 51.3 GO:0007296 vitellogenesis(GO:0007296)
7.1 21.4 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
6.9 20.7 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
5.7 22.9 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
5.3 26.4 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
5.2 68.1 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
5.1 20.5 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
4.8 24.1 GO:0002159 desmosome assembly(GO:0002159)
4.8 23.9 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
4.5 13.6 GO:0045658 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
3.7 15.0 GO:0006218 uridine catabolic process(GO:0006218) uridine metabolic process(GO:0046108)
3.7 18.7 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
3.7 14.7 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
3.4 13.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
3.2 25.3 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
3.1 15.7 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
2.8 5.6 GO:0009438 methylglyoxal metabolic process(GO:0009438)
2.7 8.0 GO:1902310 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
2.6 21.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
2.6 7.7 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
2.5 73.2 GO:0031581 hemidesmosome assembly(GO:0031581)
2.5 50.2 GO:0016540 protein autoprocessing(GO:0016540)
2.4 7.3 GO:0001923 B-1 B cell differentiation(GO:0001923)
2.4 41.2 GO:0060712 spongiotrophoblast layer development(GO:0060712)
2.4 7.2 GO:0002188 translation reinitiation(GO:0002188)
2.4 9.6 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
2.4 2.4 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
2.3 23.3 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
2.3 25.2 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
2.3 11.4 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
2.3 31.8 GO:0051599 response to hydrostatic pressure(GO:0051599)
2.2 4.5 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
2.2 6.7 GO:0051097 negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252)
2.2 13.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
2.2 314.3 GO:0030449 regulation of complement activation(GO:0030449)
2.2 39.2 GO:0001765 membrane raft assembly(GO:0001765)
2.2 13.0 GO:0002934 desmosome organization(GO:0002934)
2.1 10.7 GO:0015862 uridine transport(GO:0015862)
2.1 10.5 GO:0007619 courtship behavior(GO:0007619)
2.1 6.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
2.1 6.2 GO:0007518 myoblast fate determination(GO:0007518)
2.0 17.6 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
1.9 13.5 GO:0018158 response to selenium ion(GO:0010269) protein oxidation(GO:0018158)
1.9 5.7 GO:1901656 glycoside transport(GO:1901656)
1.8 9.0 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
1.7 22.7 GO:0061436 establishment of skin barrier(GO:0061436)
1.7 13.8 GO:0099563 modification of synaptic structure(GO:0099563)
1.7 10.3 GO:0030421 defecation(GO:0030421)
1.7 26.5 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.6 1.6 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
1.6 12.7 GO:0002036 regulation of L-glutamate transport(GO:0002036)
1.6 6.3 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
1.5 8.9 GO:0006741 NADP biosynthetic process(GO:0006741)
1.4 4.3 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
1.4 5.5 GO:0033590 response to cobalamin(GO:0033590)
1.4 2.7 GO:0044111 development involved in symbiotic interaction(GO:0044111)
1.4 4.1 GO:2000364 response to prolactin(GO:1990637) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
1.3 5.3 GO:0097325 melanocyte proliferation(GO:0097325)
1.3 19.2 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
1.3 6.3 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
1.2 4.9 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
1.2 202.8 GO:0002377 immunoglobulin production(GO:0002377)
1.2 6.0 GO:0071874 response to norepinephrine(GO:0071873) cellular response to norepinephrine stimulus(GO:0071874)
1.2 4.8 GO:0034141 Toll signaling pathway(GO:0008063) positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
1.2 4.7 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
1.2 10.5 GO:0018202 peptidyl-histidine modification(GO:0018202)
1.2 16.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
1.1 3.4 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
1.1 9.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
1.0 6.2 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
1.0 1.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
1.0 4.1 GO:0044861 protein localization to plasma membrane raft(GO:0044860) protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
1.0 9.9 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
1.0 14.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
1.0 9.8 GO:0001866 NK T cell proliferation(GO:0001866)
1.0 4.9 GO:0060356 leucine import(GO:0060356)
1.0 21.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
1.0 3.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.0 3.8 GO:0019087 transformation of host cell by virus(GO:0019087)
0.9 12.3 GO:0019388 galactose catabolic process(GO:0019388)
0.9 9.4 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.9 6.4 GO:0035897 proteolysis in other organism(GO:0035897)
0.9 3.6 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.9 6.2 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.9 5.3 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.9 3.5 GO:1904378 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.9 2.6 GO:0010842 retina layer formation(GO:0010842)
0.9 80.7 GO:0070527 platelet aggregation(GO:0070527)
0.9 20.8 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.9 13.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.8 15.3 GO:0032060 bleb assembly(GO:0032060)
0.8 3.3 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.8 5.5 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.8 6.2 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.8 16.1 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.7 6.7 GO:0071285 cellular response to lithium ion(GO:0071285)
0.7 68.6 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.7 12.3 GO:0051014 actin filament severing(GO:0051014)
0.7 2.9 GO:0000023 maltose metabolic process(GO:0000023) diaphragm contraction(GO:0002086)
0.7 5.7 GO:0043589 skin morphogenesis(GO:0043589)
0.7 9.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.7 13.5 GO:0003334 keratinocyte development(GO:0003334)
0.7 1.3 GO:0023021 termination of signal transduction(GO:0023021)
0.7 2.0 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.6 30.1 GO:0043486 histone exchange(GO:0043486)
0.6 19.6 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.6 1.8 GO:0046521 sphingoid catabolic process(GO:0046521)
0.6 9.1 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.6 3.4 GO:0072719 cellular response to cisplatin(GO:0072719)
0.6 5.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.5 25.4 GO:0030834 regulation of actin filament depolymerization(GO:0030834)
0.5 1.5 GO:2000391 positive regulation of neutrophil extravasation(GO:2000391)
0.5 2.0 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.5 8.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 11.2 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.5 5.7 GO:0061635 regulation of protein complex stability(GO:0061635)
0.5 1.9 GO:0071492 cellular response to UV-A(GO:0071492)
0.4 7.4 GO:0050819 negative regulation of coagulation(GO:0050819)
0.4 37.8 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.4 2.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.4 0.8 GO:0032970 regulation of actin filament-based process(GO:0032970)
0.4 1.9 GO:0061143 alveolar primary septum development(GO:0061143)
0.4 5.7 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.4 5.1 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.4 4.7 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.4 12.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.3 8.7 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.3 2.5 GO:2000147 positive regulation of cellular component movement(GO:0051272) positive regulation of cell motility(GO:2000147)
0.3 20.8 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.3 0.9 GO:0015680 intracellular copper ion transport(GO:0015680)
0.3 4.5 GO:0043473 pigmentation(GO:0043473)
0.3 0.9 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002923) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.3 9.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.3 6.8 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.3 11.8 GO:0030224 monocyte differentiation(GO:0030224)
0.3 13.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 1.6 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.3 16.6 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.3 22.9 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.3 1.1 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.2 10.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 1.0 GO:0031099 regeneration(GO:0031099)
0.2 3.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 1.9 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 1.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.2 2.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.2 2.8 GO:1901072 glucosamine-containing compound catabolic process(GO:1901072)
0.2 4.9 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.2 1.3 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.2 14.2 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.2 1.4 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.2 1.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 19.0 GO:0002062 chondrocyte differentiation(GO:0002062)
0.2 1.1 GO:0051012 microtubule sliding(GO:0051012)
0.2 0.9 GO:0051036 regulation of endosome size(GO:0051036)
0.2 2.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 9.0 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 0.4 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.2 2.6 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.2 1.5 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.2 3.4 GO:0048745 smooth muscle tissue development(GO:0048745)
0.2 1.6 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.2 0.2 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.2 0.7 GO:0051043 regulation of membrane protein ectodomain proteolysis(GO:0051043)
0.2 5.3 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.2 1.2 GO:0010626 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) Schwann cell proliferation(GO:0014010)
0.2 0.8 GO:0031642 negative regulation of myelination(GO:0031642)
0.2 6.6 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.2 6.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 1.1 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.2 6.9 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.1 0.6 GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway(GO:0038089)
0.1 2.8 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 6.1 GO:0010595 positive regulation of endothelial cell migration(GO:0010595)
0.1 6.3 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 0.4 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.7 GO:1902172 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.1 0.8 GO:1901379 regulation of potassium ion transport(GO:0043266) regulation of potassium ion transmembrane transport(GO:1901379)
0.1 12.9 GO:0043542 endothelial cell migration(GO:0043542)
0.1 2.9 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 1.9 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 2.6 GO:0030728 ovulation(GO:0030728)
0.1 1.6 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 5.4 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 11.3 GO:0002576 platelet degranulation(GO:0002576)
0.1 0.2 GO:0002572 pro-T cell differentiation(GO:0002572)
0.1 3.1 GO:0017004 cytochrome complex assembly(GO:0017004)
0.1 3.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 3.3 GO:0006457 protein folding(GO:0006457)
0.1 9.8 GO:0006302 double-strand break repair(GO:0006302)
0.1 1.8 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 2.2 GO:0048240 sperm capacitation(GO:0048240)
0.1 1.8 GO:0006959 humoral immune response(GO:0006959)
0.1 6.6 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.1 5.8 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 0.3 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1 0.3 GO:2001223 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) negative regulation of neuron migration(GO:2001223)
0.1 6.1 GO:0006334 nucleosome assembly(GO:0006334)
0.1 2.9 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.1 11.1 GO:2001020 regulation of response to DNA damage stimulus(GO:2001020)
0.1 1.5 GO:0007398 ectoderm development(GO:0007398)
0.1 3.9 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 2.1 GO:0010107 potassium ion import(GO:0010107)
0.1 2.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.1 GO:0060763 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) mammary duct terminal end bud growth(GO:0060763) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.1 1.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 5.0 GO:0051225 spindle assembly(GO:0051225)
0.1 2.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.4 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:0006591 ornithine metabolic process(GO:0006591) positive regulation of cholesterol homeostasis(GO:2000189)
0.0 2.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 6.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 4.0 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.2 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 3.6 GO:0043462 regulation of ATPase activity(GO:0043462)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 1.5 GO:1902403 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in cell cycle checkpoint(GO:0072395) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in mitotic cell cycle checkpoint(GO:0072413) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) signal transduction involved in mitotic DNA damage checkpoint(GO:1902402) signal transduction involved in mitotic DNA integrity checkpoint(GO:1902403)
0.0 0.7 GO:0006298 mismatch repair(GO:0006298)
0.0 0.2 GO:0042940 D-amino acid transport(GO:0042940)
0.0 0.3 GO:0030890 positive regulation of B cell proliferation(GO:0030890)
0.0 1.2 GO:0006414 translational elongation(GO:0006414)
0.0 0.0 GO:0072069 DCT cell differentiation(GO:0072069) metanephric DCT cell differentiation(GO:0072240)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.6 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 1.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 0.8 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
13.0 117.2 GO:0005638 lamin filament(GO:0005638)
7.4 88.8 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
6.9 55.3 GO:0005610 laminin-5 complex(GO:0005610)
6.8 20.5 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
6.5 19.6 GO:0070435 Shc-EGFR complex(GO:0070435)
5.2 26.0 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
5.1 15.4 GO:0005607 laminin-2 complex(GO:0005607)
4.3 21.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
3.8 11.4 GO:0044393 microspike(GO:0044393)
3.6 25.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
3.4 40.7 GO:0005915 zonula adherens(GO:0005915)
3.3 26.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
2.7 16.2 GO:0030905 retromer, tubulation complex(GO:0030905)
2.6 28.3 GO:0071438 invadopodium membrane(GO:0071438)
2.5 30.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
2.4 21.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
2.2 40.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
2.0 72.2 GO:0032420 stereocilium(GO:0032420)
2.0 62.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
1.8 5.5 GO:0071159 NF-kappaB complex(GO:0071159)
1.8 14.7 GO:0044294 dendritic growth cone(GO:0044294)
1.7 22.2 GO:0097433 dense body(GO:0097433)
1.5 7.3 GO:0032449 CBM complex(GO:0032449)
1.4 30.1 GO:0000812 Swr1 complex(GO:0000812)
1.3 13.5 GO:0097413 Lewy body(GO:0097413)
1.1 20.0 GO:0031089 platelet dense granule lumen(GO:0031089)
1.1 11.0 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
1.0 21.1 GO:0031105 septin complex(GO:0031105)
0.9 27.8 GO:0030057 desmosome(GO:0030057)
0.9 13.4 GO:0090543 Flemming body(GO:0090543)
0.9 195.9 GO:0072562 blood microparticle(GO:0072562)
0.9 23.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.9 6.0 GO:0097449 astrocyte projection(GO:0097449)
0.8 3.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.8 3.3 GO:1990462 omegasome(GO:1990462)
0.8 17.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.7 5.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.6 9.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.6 5.0 GO:0070652 HAUS complex(GO:0070652)
0.5 1.6 GO:0033565 ESCRT-0 complex(GO:0033565)
0.5 5.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.5 10.7 GO:0098644 complex of collagen trimers(GO:0098644)
0.5 8.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.5 7.7 GO:0030056 hemidesmosome(GO:0030056)
0.4 8.9 GO:0005838 proteasome regulatory particle(GO:0005838)
0.4 8.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.4 5.7 GO:0031209 SCAR complex(GO:0031209)
0.4 34.7 GO:0005604 basement membrane(GO:0005604)
0.4 7.5 GO:0097342 ripoptosome(GO:0097342)
0.4 43.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.4 5.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.4 38.4 GO:0005882 intermediate filament(GO:0005882)
0.4 5.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.4 5.7 GO:0044754 autolysosome(GO:0044754)
0.4 1.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.4 35.6 GO:0042734 presynaptic membrane(GO:0042734)
0.3 9.0 GO:0009925 basal plasma membrane(GO:0009925)
0.3 14.3 GO:0002102 podosome(GO:0002102)
0.3 1.6 GO:0033553 rDNA heterochromatin(GO:0033553)
0.3 4.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.3 1.3 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.2 11.7 GO:0016235 aggresome(GO:0016235)
0.2 24.2 GO:0005923 bicellular tight junction(GO:0005923)
0.2 0.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2 1.1 GO:0030891 VCB complex(GO:0030891)
0.2 5.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 4.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 6.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 2.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 4.1 GO:0043034 costamere(GO:0043034)
0.2 2.0 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 13.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.2 36.8 GO:0030027 lamellipodium(GO:0030027)
0.2 4.9 GO:0042101 T cell receptor complex(GO:0042101)
0.2 9.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 17.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 71.5 GO:0030055 cell-substrate junction(GO:0030055)
0.1 5.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 9.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 3.5 GO:0001533 cornified envelope(GO:0001533)
0.1 10.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 177.0 GO:0005615 extracellular space(GO:0005615)
0.1 3.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 6.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 1.2 GO:0031528 microvillus membrane(GO:0031528)
0.1 6.2 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 11.4 GO:0016324 apical plasma membrane(GO:0016324)
0.1 26.1 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 9.0 GO:0005643 nuclear pore(GO:0005643)
0.1 13.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 1.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 3.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 3.4 GO:0000502 proteasome complex(GO:0000502)
0.1 5.1 GO:0015030 Cajal body(GO:0015030)
0.1 186.9 GO:0070062 extracellular exosome(GO:0070062)
0.1 0.6 GO:0016272 prefoldin complex(GO:0016272)
0.1 1.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 6.0 GO:0030018 Z disc(GO:0030018)
0.1 2.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.9 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 7.2 GO:0005840 ribosome(GO:0005840)
0.1 9.0 GO:0005681 spliceosomal complex(GO:0005681)
0.0 4.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.4 GO:0005657 replication fork(GO:0005657)
0.0 1.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.2 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 2.3 GO:0005795 Golgi stack(GO:0005795)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.3 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 22.9 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
6.2 18.7 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
5.8 34.9 GO:1990254 keratin filament binding(GO:1990254)
5.8 40.3 GO:0048408 epidermal growth factor binding(GO:0048408)
5.4 21.4 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
5.3 26.4 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
4.3 26.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
4.1 20.5 GO:0070026 nitric oxide binding(GO:0070026)
4.1 12.3 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
3.9 11.7 GO:0036317 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
3.7 15.0 GO:0004850 uridine phosphorylase activity(GO:0004850)
3.4 20.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
3.2 16.2 GO:1990460 leptin receptor binding(GO:1990460)
2.4 33.7 GO:0030215 semaphorin receptor binding(GO:0030215)
2.4 92.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
2.3 6.9 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
2.3 531.6 GO:0003823 antigen binding(GO:0003823)
2.2 19.5 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
2.1 6.3 GO:0008859 exoribonuclease II activity(GO:0008859)
2.0 4.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
1.9 33.9 GO:0044548 S100 protein binding(GO:0044548)
1.8 14.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
1.8 21.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
1.7 8.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.6 4.9 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
1.6 27.9 GO:0045295 gamma-catenin binding(GO:0045295)
1.6 21.2 GO:0045294 alpha-catenin binding(GO:0045294)
1.5 6.2 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
1.5 6.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
1.5 4.6 GO:0050613 delta14-sterol reductase activity(GO:0050613)
1.5 81.2 GO:0019212 phosphatase inhibitor activity(GO:0019212)
1.5 10.5 GO:0004673 protein histidine kinase activity(GO:0004673)
1.5 8.9 GO:0008948 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
1.3 10.5 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
1.2 59.4 GO:0004364 glutathione transferase activity(GO:0004364)
1.2 4.7 GO:1904408 dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408)
1.2 3.5 GO:1904288 BAT3 complex binding(GO:1904288)
1.2 34.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.2 17.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
1.1 8.0 GO:0072542 protein phosphatase activator activity(GO:0072542)
1.1 17.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.1 3.4 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
1.1 9.0 GO:0043022 ribosome binding(GO:0043022)
1.1 5.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
1.1 11.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
1.1 4.3 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
1.0 1.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.0 4.9 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
1.0 8.7 GO:0043426 MRF binding(GO:0043426)
1.0 23.1 GO:0070410 co-SMAD binding(GO:0070410)
1.0 2.9 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
1.0 3.8 GO:0033906 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.9 2.7 GO:0050816 phosphothreonine binding(GO:0050816)
0.9 13.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.9 24.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.8 13.6 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.8 3.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.8 8.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 6.7 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.7 1.4 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.7 9.5 GO:0008432 JUN kinase binding(GO:0008432)
0.7 4.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.7 6.0 GO:0051425 PTB domain binding(GO:0051425)
0.7 2.0 GO:0003883 CTP synthase activity(GO:0003883)
0.6 4.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.6 6.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.6 14.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 3.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.5 10.7 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.5 14.0 GO:0070064 proline-rich region binding(GO:0070064)
0.5 40.6 GO:0005518 collagen binding(GO:0005518)
0.5 4.9 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.5 13.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 21.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.4 5.6 GO:0038132 neuregulin binding(GO:0038132)
0.4 12.8 GO:0019956 chemokine binding(GO:0019956)
0.4 5.1 GO:0048156 tau protein binding(GO:0048156)
0.4 7.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.3 4.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.3 3.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 3.4 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.3 2.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.3 1.6 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.3 8.1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.3 1.8 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.3 4.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 15.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 27.5 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.3 3.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3 8.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 7.5 GO:0005123 death receptor binding(GO:0005123)
0.3 6.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.3 8.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 2.6 GO:0042731 PH domain binding(GO:0042731)
0.2 87.7 GO:0003924 GTPase activity(GO:0003924)
0.2 5.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 34.3 GO:0044325 ion channel binding(GO:0044325)
0.2 5.2 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 9.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 27.0 GO:0051082 unfolded protein binding(GO:0051082)
0.2 21.1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2 5.7 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.2 5.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 184.0 GO:0005198 structural molecule activity(GO:0005198)
0.2 6.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 0.6 GO:0004947 bradykinin receptor activity(GO:0004947)
0.2 11.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 3.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.2 19.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 2.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.2 1.6 GO:0030274 LIM domain binding(GO:0030274)
0.2 1.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.2 2.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 1.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 7.2 GO:0005504 fatty acid binding(GO:0005504)
0.1 2.2 GO:0016918 retinal binding(GO:0016918)
0.1 15.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.4 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.1 1.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.6 GO:0001164 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1 2.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 6.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.9 GO:0019863 IgE binding(GO:0019863)
0.1 7.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 53.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 3.9 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.0 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 1.9 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.5 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 17.4 GO:0045296 cadherin binding(GO:0045296)
0.1 2.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.1 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1 1.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 2.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 6.5 GO:0008201 heparin binding(GO:0008201)
0.1 0.2 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.0 0.6 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.2 GO:0001848 complement binding(GO:0001848)
0.0 1.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 4.7 GO:0005179 hormone activity(GO:0005179)
0.0 0.6 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.4 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.5 GO:0051400 BH domain binding(GO:0051400)
0.0 1.4 GO:0042562 hormone binding(GO:0042562)
0.0 0.6 GO:0030332 cyclin binding(GO:0030332)
0.0 0.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 74.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
2.4 150.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
2.0 61.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
2.0 68.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
1.3 140.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
1.2 65.1 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
1.0 52.6 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
1.0 82.2 PID TGFBR PATHWAY TGF-beta receptor signaling
1.0 30.7 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.9 24.7 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.8 57.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.7 44.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.6 8.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.6 10.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.6 22.6 PID FAS PATHWAY FAS (CD95) signaling pathway
0.6 38.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.5 36.7 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.5 12.8 PID CD40 PATHWAY CD40/CD40L signaling
0.4 25.9 PID AURORA B PATHWAY Aurora B signaling
0.4 27.7 PID AP1 PATHWAY AP-1 transcription factor network
0.4 30.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.4 15.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.4 8.8 PID IL1 PATHWAY IL1-mediated signaling events
0.3 7.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.3 5.2 PID ARF 3PATHWAY Arf1 pathway
0.3 23.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 5.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.2 7.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 16.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 7.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 3.6 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.1 10.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 24.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.5 PID FGF PATHWAY FGF signaling pathway
0.1 6.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.8 PID FOXO PATHWAY FoxO family signaling
0.1 3.1 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.0 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 10.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 3.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 2.7 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 3.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 3.1 PID LKB1 PATHWAY LKB1 signaling events
0.1 2.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 6.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 ST ADRENERGIC Adrenergic Pathway
0.0 1.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
2.0 38.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
1.9 166.6 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
1.7 87.1 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
1.7 15.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
1.5 27.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
1.5 39.8 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
1.4 39.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
1.2 13.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
1.2 44.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
1.1 43.9 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
1.1 85.6 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.9 68.6 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.9 14.7 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.8 17.6 REACTOME M