ISMARA results: FOXA1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for FOXA1

Z-value: 0.48

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Transcription factors associated with FOXA1

Gene Symbol	Gene ID	Gene Info
FOXA1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000129514.4	forkhead box A1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXA1	hg19_v2_chr14_-_38064198_38064239	0.43	5.2e-11	Click!

Activity profile of FOXA1 motif

Sorted Z-values of FOXA1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_39684550 Show fit	34.90	ENST00000455635.1 ENST00000361566.3	KRT19 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 19
chr17_-_26695013 Show fit	23.97	ENST00000555059.2	CTB-96E2.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Homeobox protein SEBOX
chr19_+_18496957 Show fit	23.00	ENST00000252809.3	GDF15 Ensembl NCBI GeneCards UniProt NextProt Show fit	growth differentiation factor 15
chr17_-_26694979 Show fit	22.84	ENST00000438614.1	VTN Ensembl NCBI GeneCards UniProt NextProt Show fit	vitronectin
chr12_-_71551652 Show fit	18.16	ENST00000546561.1	TSPAN8 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 8
chr12_-_71551868 Show fit	16.82	ENST00000247829.3	TSPAN8 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 8
chr12_-_53343602 Show fit	15.50	ENST00000546897.1 ENST00000552551.1	KRT8 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 8
chr4_-_174256276 Show fit	12.86	ENST00000296503.5	HMGB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	high mobility group box 2
chr7_+_73242490 Show fit	12.52	ENST00000431918.1	CLDN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	claudin 4
chr7_+_116165754 Show fit	12.47	ENST00000405348.1	CAV1 Ensembl NCBI GeneCards UniProt NextProt Show fit	caveolin 1, caveolae protein, 22kDa

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	47.8	GO:0060706	cell differentiation involved in embryonic placenta development(GO:0060706)
0.7	44.2	GO:0030195	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
1.0	23.0	GO:1901741	positive regulation of myoblast fusion(GO:1901741)
2.5	22.8	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
1.2	22.0	GO:0071985	multivesicular body sorting pathway(GO:0071985)
1.7	17.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
2.1	14.4	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
1.1	14.2	GO:2000680	rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
1.3	12.9	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654)
4.2	12.5	GO:1900085	negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)

Showing 1 to 10 of 140 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	129.8	GO:0005615	extracellular space(GO:0005615)
7.8	46.6	GO:1990357	terminal web(GO:1990357)
0.0	45.4	GO:0005654	nucleoplasm(GO:0005654)
0.1	43.2	GO:0009986	cell surface(GO:0009986)
0.8	24.9	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.2	23.5	GO:0043202	lysosomal lumen(GO:0043202)
5.7	22.8	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.9	15.5	GO:0042589	zymogen granule membrane(GO:0042589)
1.0	15.0	GO:0030478	actin cap(GO:0030478)
0.1	14.8	GO:0031093	platelet alpha granule lumen(GO:0031093)

Showing 1 to 10 of 68 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	48.7	GO:0008307	structural constituent of muscle(GO:0008307)
0.3	48.5	GO:0005178	integrin binding(GO:0005178)
1.4	22.8	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3	21.1	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
0.2	21.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	19.0	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2	15.5	GO:0097110	scaffold protein binding(GO:0097110)
0.7	15.0	GO:0038187	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.5	15.0	GO:0005523	tropomyosin binding(GO:0005523)
0.8	14.4	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)

Showing 1 to 10 of 107 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	63.8	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.8	52.3	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	36.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	23.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.5	21.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.1	16.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	16.7	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	16.0	PID IL4 2PATHWAY	IL4-mediated signaling events
0.5	15.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.2	12.2	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Showing 1 to 10 of 33 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	25.5	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4	24.8	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.2	24.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	17.0	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.8	16.6	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.4	15.5	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.4	14.6	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.4	14.4	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.4	12.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.7	12.0	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation

Showing 1 to 10 of 54 entries

Results for FOXA1

Z-value: 0.48

Motif logo

Transcription factors associated with FOXA1

Activity-expression correlation:

Activity profile of FOXA1 motif

Sorted Z-values of FOXA1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: