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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for FOXA1

Z-value: 0.48

Motif logo

Transcription factors associated with FOXA1

Gene Symbol Gene ID Gene Info
ENSG00000129514.4 forkhead box A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXA1hg19_v2_chr14_-_38064198_380642390.435.2e-11Click!

Activity profile of FOXA1 motif

Sorted Z-values of FOXA1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_39684550 34.90 ENST00000455635.1
ENST00000361566.3
keratin 19
chr17_-_26695013 23.97 ENST00000555059.2
Homeobox protein SEBOX
chr19_+_18496957 23.00 ENST00000252809.3
growth differentiation factor 15
chr17_-_26694979 22.84 ENST00000438614.1
vitronectin
chr12_-_71551652 18.16 ENST00000546561.1
tetraspanin 8
chr12_-_71551868 16.82 ENST00000247829.3
tetraspanin 8
chr12_-_53343602 15.50 ENST00000546897.1
ENST00000552551.1
keratin 8
chr4_-_174256276 12.86 ENST00000296503.5
high mobility group box 2
chr7_+_73242490 12.52 ENST00000431918.1
claudin 4
chr7_+_116165754 12.47 ENST00000405348.1
caveolin 1, caveolae protein, 22kDa
chr15_+_96869165 12.44 ENST00000421109.2
nuclear receptor subfamily 2, group F, member 2
chr3_+_142315225 11.75 ENST00000457734.2
ENST00000483373.1
ENST00000475296.1
ENST00000495744.1
ENST00000476044.1
ENST00000461644.1
plastin 1
chr4_-_72649763 11.46 ENST00000513476.1
group-specific component (vitamin D binding protein)
chr8_+_126442563 10.33 ENST00000311922.3
tribbles pseudokinase 1
chr19_-_48894104 10.28 ENST00000597017.1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr3_-_185538849 10.22 ENST00000421047.2
insulin-like growth factor 2 mRNA binding protein 2
chr3_+_52245458 9.88 ENST00000459884.1
aminolevulinate, delta-, synthase 1
chr22_+_21128167 9.79 ENST00000215727.5
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chrX_-_20236970 9.53 ENST00000379548.4
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr3_+_186330712 9.48 ENST00000411641.2
ENST00000273784.5
alpha-2-HS-glycoprotein
chr21_-_43735446 9.47 ENST00000398431.2
trefoil factor 3 (intestinal)
chr12_-_89746173 9.40 ENST00000308385.6
dual specificity phosphatase 6
chr11_-_108464465 9.32 ENST00000525344.1
exophilin 5
chr5_+_74011328 9.31 ENST00000513336.1
hexosaminidase B (beta polypeptide)
chr4_-_155533787 9.19 ENST00000407946.1
ENST00000405164.1
ENST00000336098.3
ENST00000393846.2
ENST00000404648.3
ENST00000443553.1
fibrinogen gamma chain
chr14_-_36988882 8.95 ENST00000498187.2
NK2 homeobox 1
chr14_-_38064198 8.88 ENST00000250448.2
forkhead box A1
chr12_+_96588143 8.02 ENST00000228741.3
ENST00000547249.1
ELK3, ETS-domain protein (SRF accessory protein 2)
chr5_+_179921430 7.98 ENST00000393356.1
CCR4-NOT transcription complex, subunit 6
chr11_+_844406 7.72 ENST00000397404.1
tetraspanin 4
chr17_-_19651668 7.60 ENST00000494157.2
ENST00000225740.6
aldehyde dehydrogenase 3 family, member A1
chr19_+_39214797 7.56 ENST00000440400.1
actinin, alpha 4
chr10_+_124320195 7.50 ENST00000359586.6
deleted in malignant brain tumors 1
chr10_+_124320156 7.48 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
deleted in malignant brain tumors 1
chr5_+_95998746 7.46 ENST00000508608.1
calpastatin
chr12_-_56123444 7.31 ENST00000546457.1
ENST00000549117.1
CD63 molecule
chr7_+_129906660 7.18 ENST00000222481.4
carboxypeptidase A2 (pancreatic)
chr11_-_108464321 7.14 ENST00000265843.4
exophilin 5
chr3_-_145878954 7.00 ENST00000282903.5
ENST00000360060.3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr12_+_10658489 6.94 ENST00000538173.1
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr12_-_56122761 6.94 ENST00000552164.1
ENST00000420846.3
ENST00000257857.4
CD63 molecule
chr7_-_99698338 6.83 ENST00000354230.3
ENST00000425308.1
minichromosome maintenance complex component 7
chr12_-_120765565 6.76 ENST00000423423.3
ENST00000308366.4
phospholipase A2, group IB (pancreas)
chr5_+_102201509 6.74 ENST00000348126.2
ENST00000379787.4
peptidylglycine alpha-amidating monooxygenase
chr10_+_104535994 6.74 ENST00000369889.4
WW domain binding protein 1-like
chr19_+_16178317 6.73 ENST00000344824.6
ENST00000538887.1
tropomyosin 4
chr11_+_62186498 6.62 ENST00000278282.2
secretoglobin, family 1A, member 1 (uteroglobin)
chr3_+_52811596 6.53 ENST00000542827.1
ENST00000273283.2
inter-alpha-trypsin inhibitor heavy chain 1
chr7_+_134576151 6.49 ENST00000393118.2
caldesmon 1
chr5_+_179921344 6.45 ENST00000261951.4
CCR4-NOT transcription complex, subunit 6
chr7_+_134576317 6.29 ENST00000424922.1
ENST00000495522.1
caldesmon 1
chr2_-_152146385 6.27 ENST00000414946.1
ENST00000243346.5
N-myc (and STAT) interactor
chr2_-_21266935 6.26 ENST00000233242.1
apolipoprotein B
chr5_+_32531893 6.03 ENST00000512913.1
SUB1 homolog (S. cerevisiae)
chr10_+_123923105 6.03 ENST00000368999.1
transforming, acidic coiled-coil containing protein 2
chr21_-_38445011 5.97 ENST00000464265.1
ENST00000399102.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr7_+_80231466 5.91 ENST00000309881.7
ENST00000534394.1
CD36 molecule (thrombospondin receptor)
chr3_+_148545586 5.83 ENST00000282957.4
ENST00000468341.1
carboxypeptidase B1 (tissue)
chr6_+_7107999 5.65 ENST00000491191.1
ENST00000379938.2
ENST00000471433.1
ras responsive element binding protein 1
chr5_-_41213607 5.59 ENST00000337836.5
ENST00000433294.1
complement component 6
chr15_-_55541227 5.56 ENST00000566877.1
RAB27A, member RAS oncogene family
chr11_-_102401469 5.46 ENST00000260227.4
matrix metallopeptidase 7 (matrilysin, uterine)
chr4_-_111119804 5.39 ENST00000394607.3
ENST00000302274.3
ELOVL fatty acid elongase 6
chr10_+_51549498 5.22 ENST00000358559.2
ENST00000298239.6
microseminoprotein, beta-
chr17_-_17485731 5.21 ENST00000395783.1
phosphatidylethanolamine N-methyltransferase
chr1_-_57431679 5.12 ENST00000371237.4
ENST00000535057.1
ENST00000543257.1
complement component 8, beta polypeptide
chr1_-_94079648 5.09 ENST00000370247.3
breast cancer anti-estrogen resistance 3
chr17_+_79953310 5.01 ENST00000582355.2
alveolar soft part sarcoma chromosome region, candidate 1
chr4_-_70080449 4.96 ENST00000446444.1
UDP glucuronosyltransferase 2 family, polypeptide B11
chr5_+_102201430 4.93 ENST00000438793.3
ENST00000346918.2
peptidylglycine alpha-amidating monooxygenase
chr17_-_46035187 4.85 ENST00000300557.2
proline rich 15-like
chr12_-_91572278 4.68 ENST00000425043.1
ENST00000420120.2
ENST00000441303.2
ENST00000456569.2
decorin
chr14_-_94789663 4.64 ENST00000557225.1
ENST00000341584.3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr10_-_81320151 4.63 ENST00000372325.2
ENST00000372327.5
ENST00000417041.1
surfactant protein A2
chr12_-_102872317 4.56 ENST00000424202.2
insulin-like growth factor 1 (somatomedin C)
chr7_+_112063192 4.49 ENST00000005558.4
interferon-related developmental regulator 1
chr13_+_76334795 4.48 ENST00000526202.1
ENST00000465261.2
LIM domain 7
chr6_+_33589161 4.36 ENST00000605930.1
inositol 1,4,5-trisphosphate receptor, type 3
chr1_-_43855444 4.34 ENST00000372455.4
mediator complex subunit 8
chr6_+_143929307 4.33 ENST00000427704.2
ENST00000305766.6
phosphatase and actin regulator 2
chr7_+_77469439 4.32 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
putative homeodomain transcription factor 2
chr13_+_76334567 4.27 ENST00000321797.8
LIM domain 7
chr20_+_306177 4.22 ENST00000544632.1
SRY (sex determining region Y)-box 12
chr17_+_8924837 4.09 ENST00000173229.2
netrin 1
chr6_-_87804815 4.07 ENST00000369582.2
glycoprotein hormones, alpha polypeptide
chr2_-_165424973 4.06 ENST00000543549.1
growth factor receptor-bound protein 14
chr17_+_72426891 4.04 ENST00000392627.1
G protein-coupled receptor, family C, group 5, member C
chr2_-_172017343 3.92 ENST00000431350.2
ENST00000360843.3
tousled-like kinase 1
chr5_-_137674000 3.75 ENST00000510119.1
ENST00000513970.1
cell division cycle 25C
chr13_-_31038370 3.72 ENST00000399489.1
ENST00000339872.4
high mobility group box 1
chr17_+_72427477 3.64 ENST00000342648.5
ENST00000481232.1
G protein-coupled receptor, family C, group 5, member C
chr4_-_186456652 3.63 ENST00000284767.5
ENST00000284770.5
PDZ and LIM domain 3
chr14_+_64970662 3.59 ENST00000556965.1
ENST00000554015.1
zinc finger and BTB domain containing 1
chr1_-_95391315 3.57 ENST00000545882.1
ENST00000415017.1
calponin 3, acidic
chr4_-_186456766 3.49 ENST00000284771.6
PDZ and LIM domain 3
chrX_+_135614293 3.42 ENST00000370634.3
vestigial like 1 (Drosophila)
chr18_+_66465302 3.36 ENST00000360242.5
ENST00000358653.5
coiled-coil domain containing 102B
chr12_+_21525818 3.29 ENST00000240652.3
ENST00000542023.1
ENST00000537593.1
islet amyloid polypeptide
chr1_-_246729544 3.29 ENST00000544618.1
ENST00000366514.4
transcription factor B2, mitochondrial
chr14_-_37051798 3.25 ENST00000258829.5
NK2 homeobox 8
chr10_-_90751038 3.16 ENST00000458159.1
ENST00000415557.1
ENST00000458208.1
actin, alpha 2, smooth muscle, aorta
chr19_-_15443318 3.15 ENST00000360016.5
bromodomain containing 4
chr1_+_104159999 3.13 ENST00000414303.2
ENST00000423678.1
amylase, alpha 2A (pancreatic)
chr1_+_198126093 3.07 ENST00000367385.4
ENST00000442588.1
ENST00000538004.1
NIMA-related kinase 7
chr3_-_113897899 3.06 ENST00000383673.2
ENST00000295881.7
dopamine receptor D3
chr6_+_135502466 2.98 ENST00000367814.4
v-myb avian myeloblastosis viral oncogene homolog
chr12_+_121416489 2.96 ENST00000541395.1
ENST00000544413.1
HNF1 homeobox A
chr9_-_89562104 2.88 ENST00000298743.7
growth arrest-specific 1
chr20_+_306221 2.87 ENST00000342665.2
SRY (sex determining region Y)-box 12
chr6_-_41715128 2.77 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
progastricsin (pepsinogen C)
chr2_-_192711968 2.76 ENST00000304141.4
serum deprivation response
chr3_+_137728842 2.75 ENST00000183605.5
claudin 18
chr10_-_32217717 2.73 ENST00000396144.4
ENST00000375245.4
ENST00000344936.2
ENST00000375250.5
Rho GTPase activating protein 12
chr11_+_120973375 2.69 ENST00000264037.2
tectorin alpha
chr6_-_43596899 2.63 ENST00000307126.5
ENST00000452781.1
GTP binding protein 2
chr4_+_55095264 2.60 ENST00000257290.5
platelet-derived growth factor receptor, alpha polypeptide
chr6_+_26251835 2.58 ENST00000356350.2
histone cluster 1, H2bh
chr13_+_78109804 2.58 ENST00000535157.1
sciellin
chr13_+_78109884 2.52 ENST00000377246.3
ENST00000349847.3
sciellin
chr2_+_47630255 2.48 ENST00000406134.1
mutS homolog 2
chr20_+_31823792 2.47 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
BPI fold containing family A, member 1
chr3_+_137717571 2.45 ENST00000343735.4
claudin 18
chr1_+_199996733 2.42 ENST00000236914.3
nuclear receptor subfamily 5, group A, member 2
chr14_+_64971292 2.40 ENST00000358738.3
ENST00000394712.2
zinc finger and BTB domain containing 1
chr2_+_152266392 2.39 ENST00000444746.2
ENST00000453091.2
ENST00000428287.2
ENST00000433166.2
ENST00000420714.3
ENST00000243326.5
ENST00000414861.2
RAP1 interacting factor homolog (yeast)
chr1_+_74701062 2.35 ENST00000326637.3
TNNI3 interacting kinase
chr1_-_216596738 2.33 ENST00000307340.3
ENST00000366943.2
ENST00000366942.3
Usher syndrome 2A (autosomal recessive, mild)
chr2_+_169757750 2.31 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
glucose-6-phosphatase, catalytic, 2
chr20_-_7921090 2.27 ENST00000378789.3
hydroxyacid oxidase (glycolate oxidase) 1
chr7_+_28452130 2.26 ENST00000357727.2
cAMP responsive element binding protein 5
chr2_+_47630108 2.21 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
mutS homolog 2
chr7_+_134430212 2.17 ENST00000436461.2
caldesmon 1
chr6_+_135502408 2.16 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
v-myb avian myeloblastosis viral oncogene homolog
chr1_-_111743285 2.15 ENST00000357640.4
DENN/MADD domain containing 2D
chr10_-_81708854 2.13 ENST00000372292.3
surfactant protein D
chr10_+_118350468 2.12 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
pancreatic lipase-related protein 1
chr8_+_11666649 2.12 ENST00000528643.1
ENST00000525777.1
farnesyl-diphosphate farnesyltransferase 1
chr15_+_75335604 2.10 ENST00000563393.1
phosphopantothenoylcysteine decarboxylase
chr2_-_172017393 1.95 ENST00000442919.2
tousled-like kinase 1
chrX_+_9431324 1.94 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr5_+_147774275 1.86 ENST00000513826.1
F-box protein 38
chr2_+_58655461 1.85 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
long intergenic non-protein coding RNA 1122
chr12_-_48398104 1.85 ENST00000337299.6
ENST00000380518.3
collagen, type II, alpha 1
chr5_-_135701164 1.82 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
transient receptor potential cation channel, subfamily C, member 7
chr2_-_89160770 1.76 ENST00000390240.2
immunoglobulin kappa joining 3
chr3_+_69985734 1.71 ENST00000314557.6
ENST00000394351.3
microphthalmia-associated transcription factor
chr11_+_71249071 1.69 ENST00000398534.3
keratin associated protein 5-8
chr7_+_116654935 1.66 ENST00000432298.1
ENST00000422922.1
suppression of tumorigenicity 7
chr1_-_203320617 1.61 ENST00000354955.4
fibromodulin
chr1_+_152486950 1.59 ENST00000368790.3
cysteine-rich C-terminal 1
chr3_-_148939835 1.56 ENST00000264613.6
ceruloplasmin (ferroxidase)
chr14_+_56127989 1.56 ENST00000555573.1
kinectin 1 (kinesin receptor)
chr6_-_111804393 1.55 ENST00000368802.3
ENST00000368805.1
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr1_+_12538594 1.53 ENST00000543710.1
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chrX_-_24665208 1.50 ENST00000356768.4
phosphate cytidylyltransferase 1, choline, beta
chrX_+_99839799 1.49 ENST00000373031.4
tenomodulin
chr20_+_62795827 1.46 ENST00000328439.1
ENST00000536311.1
myelin transcription factor 1
chr9_+_82187487 1.45 ENST00000435650.1
ENST00000414465.1
ENST00000376537.4
ENST00000376534.4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr16_-_67517716 1.42 ENST00000290953.2
agouti related protein homolog (mouse)
chr1_+_199996702 1.36 ENST00000367362.3
nuclear receptor subfamily 5, group A, member 2
chr1_+_214161854 1.33 ENST00000435016.1
prospero homeobox 1
chr2_+_204801471 1.30 ENST00000316386.6
ENST00000435193.1
inducible T-cell co-stimulator
chr4_+_187148556 1.27 ENST00000264690.6
ENST00000446598.2
ENST00000414291.1
ENST00000513864.1
kallikrein B, plasma (Fletcher factor) 1
chr14_+_37131058 1.24 ENST00000361487.6
paired box 9
chr9_+_27109133 1.24 ENST00000519097.1
ENST00000380036.4
TEK tyrosine kinase, endothelial
chr10_+_102891048 1.23 ENST00000467928.2
T-cell leukemia homeobox 1
chr15_+_60296421 1.20 ENST00000396057.4
forkhead box B1
chr7_-_81399438 1.17 ENST00000222390.5
hepatocyte growth factor (hepapoietin A; scatter factor)
chr6_+_161123270 1.15 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
plasminogen
chr9_+_136287444 1.14 ENST00000355699.2
ENST00000356589.2
ENST00000371911.3
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr9_-_98279241 1.14 ENST00000437951.1
ENST00000375274.2
ENST00000430669.2
ENST00000468211.2
patched 1
chr4_+_187187098 1.12 ENST00000403665.2
ENST00000264692.4
coagulation factor XI
chr6_-_89927151 1.10 ENST00000454853.2
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr7_+_134832808 1.08 ENST00000275767.3
transmembrane protein 140
chr9_-_95186739 1.07 ENST00000375550.4
osteomodulin
chr12_-_14849470 1.07 ENST00000261170.3
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr3_+_141106643 1.06 ENST00000514251.1
zinc finger and BTB domain containing 38
chr6_-_161085291 1.01 ENST00000316300.5
lipoprotein, Lp(a)
chr8_+_70404996 1.00 ENST00000402687.4
ENST00000419716.3
sulfatase 1
chr7_-_81399355 0.98 ENST00000457544.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr6_+_135502501 0.95 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
v-myb avian myeloblastosis viral oncogene homolog
chrX_+_24167746 0.93 ENST00000428571.1
ENST00000539115.1
zinc finger protein, X-linked
chr5_-_127674883 0.91 ENST00000507835.1
fibrillin 2
chr11_-_26743546 0.89 ENST00000280467.6
ENST00000396005.3
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr3_+_160394940 0.89 ENST00000320767.2
ADP-ribosylation factor-like 14
chr7_+_106505696 0.88 ENST00000440650.2
ENST00000496166.1
ENST00000473541.1
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chrX_-_15402498 0.85 ENST00000297904.3
c-fos induced growth factor (vascular endothelial growth factor D)
chr12_+_121416340 0.84 ENST00000257555.6
ENST00000400024.2
HNF1 homeobox A
chr14_-_64971288 0.82 ENST00000394715.1
zinc finger and BTB domain containing 25
chr7_+_106505912 0.82 ENST00000359195.3
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr22_-_40929812 0.82 ENST00000422851.1
megakaryoblastic leukemia (translocation) 1
chr1_+_145883868 0.76 ENST00000447947.2
G protein-coupled receptor 89C
chr5_-_148758839 0.76 ENST00000261796.3
interleukin 17B
chr8_-_131028869 0.76 ENST00000518283.1
ENST00000519110.1
family with sequence similarity 49, member B
chr17_-_48546324 0.75 ENST00000508540.1
chondroadherin
chr7_+_95115210 0.75 ENST00000428113.1
ENST00000325885.5
ankyrin repeat and SOCS box containing 4
chrX_-_124097620 0.69 ENST00000371130.3
ENST00000422452.2
teneurin transmembrane protein 1
chr7_+_31003621 0.67 ENST00000326139.2
growth hormone releasing hormone receptor
chr8_-_71316021 0.63 ENST00000452400.2
nuclear receptor coactivator 2
chr12_+_103981044 0.61 ENST00000388887.2
stabilin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.5 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
3.4 10.3 GO:0045658 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
3.1 12.4 GO:0009956 radial pattern formation(GO:0009956)
2.9 11.7 GO:0018032 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
2.5 22.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
2.5 7.6 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
2.3 11.7 GO:1902896 terminal web assembly(GO:1902896)
2.3 9.4 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
2.3 7.0 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
2.2 8.9 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
2.1 6.3 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
2.1 14.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
2.0 6.1 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
1.9 9.3 GO:0007619 courtship behavior(GO:0007619)
1.8 9.0 GO:0021759 globus pallidus development(GO:0021759)
1.7 17.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.7 6.8 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
1.5 6.0 GO:0002572 pro-T cell differentiation(GO:0002572)
1.5 4.5 GO:0007518 myoblast fate determination(GO:0007518)
1.5 4.4 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
1.4 9.8 GO:0008218 bioluminescence(GO:0008218)
1.4 5.6 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
1.4 4.2 GO:0035565 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
1.3 12.9 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
1.3 47.8 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
1.2 22.0 GO:0071985 multivesicular body sorting pathway(GO:0071985)
1.1 6.6 GO:0010193 response to ozone(GO:0010193)
1.1 14.2 GO:2000680 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
1.0 23.0 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
1.0 5.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.9 4.7 GO:0010520 meiotic gene conversion(GO:0006311) regulation of reciprocal meiotic recombination(GO:0010520)
0.9 10.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.9 3.7 GO:0002840 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.9 4.6 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.9 5.4 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.9 6.3 GO:0006642 triglyceride mobilization(GO:0006642) response to selenium ion(GO:0010269)
0.9 3.5 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.9 2.6 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.8 5.9 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.8 9.9 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.8 3.3 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.8 4.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.8 3.1 GO:0050883 negative regulation of sodium:proton antiporter activity(GO:0032416) gastric motility(GO:0035482) gastric emptying(GO:0035483) musculoskeletal movement, spinal reflex action(GO:0050883)
0.8 2.3 GO:0009441 glycolate metabolic process(GO:0009441)
0.7 44.2 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.7 6.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.7 5.9 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.7 5.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.6 3.2 GO:0072007 mesangial cell differentiation(GO:0072007) glomerular mesangial cell differentiation(GO:0072008) mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144)
0.6 12.5 GO:0061436 establishment of skin barrier(GO:0061436)
0.6 2.5 GO:0044010 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.6 8.5 GO:0045779 negative regulation of bone resorption(GO:0045779)
0.6 2.4 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.6 2.3 GO:0048496 maintenance of organ identity(GO:0048496)
0.5 7.6 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.5 1.6 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.5 9.5 GO:0006907 pinocytosis(GO:0006907)
0.5 2.4 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.5 2.8 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.4 3.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.4 4.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.4 2.1 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.4 11.5 GO:0042359 vitamin D metabolic process(GO:0042359)
0.4 1.2 GO:0007412 axon target recognition(GO:0007412)
0.4 1.9 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.4 1.1 GO:0010157 response to chlorate(GO:0010157)
0.4 1.5 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.4 7.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.3 9.5 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.3 1.2 GO:1900154 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.3 6.0 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.3 1.7 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897) secretory granule localization(GO:0032252)
0.3 0.5 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.3 3.2 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.2 5.5 GO:0044849 estrous cycle(GO:0044849)
0.2 5.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.7 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.2 5.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 2.3 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.2 2.9 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.2 3.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 1.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 6.0 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.2 1.8 GO:0060174 limb bud formation(GO:0060174)
0.2 0.8 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.2 1.9 GO:0006657 CDP-choline pathway(GO:0006657)
0.2 0.5 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 1.4 GO:0008343 adult feeding behavior(GO:0008343)
0.2 0.6 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016)
0.2 7.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 4.6 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.1 1.9 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 3.1 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.1 1.1 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 5.0 GO:0008210 estrogen metabolic process(GO:0008210)
0.1 0.8 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 3.8 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 0.5 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 1.0 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 2.4 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.1 0.9 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 2.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.9 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.1 1.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 4.1 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.1 7.6 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 1.1 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 1.8 GO:0006828 manganese ion transport(GO:0006828)
0.1 6.7 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 1.6 GO:0006825 copper ion transport(GO:0006825)
0.1 0.7 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 3.1 GO:0016486 peptide hormone processing(GO:0016486)
0.1 1.0 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.1 0.2 GO:0072709 cellular response to sorbitol(GO:0072709)
0.1 5.0 GO:0046324 regulation of glucose import(GO:0046324)
0.1 4.6 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.1 0.5 GO:0015705 iodide transport(GO:0015705)
0.1 1.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.8 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 1.2 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 10.2 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 7.0 GO:0002576 platelet degranulation(GO:0002576)
0.0 2.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 6.0 GO:0021987 cerebral cortex development(GO:0021987)
0.0 1.9 GO:0010976 positive regulation of neuron projection development(GO:0010976)
0.0 0.5 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 2.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.4 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 3.7 GO:0007586 digestion(GO:0007586)
0.0 12.1 GO:0006936 muscle contraction(GO:0006936)
0.0 0.4 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 6.9 GO:0006413 translational initiation(GO:0006413)
0.0 3.3 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)
0.0 0.7 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 2.6 GO:0007605 sensory perception of sound(GO:0007605)
0.0 5.9 GO:0043687 post-translational protein modification(GO:0043687)
0.0 3.6 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 1.3 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.3 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
7.8 46.6 GO:1990357 terminal web(GO:1990357)
5.7 22.8 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
1.6 4.7 GO:0032302 MutSbeta complex(GO:0032302)
1.2 10.7 GO:0005579 membrane attack complex(GO:0005579)
1.2 14.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.0 15.0 GO:0030478 actin cap(GO:0030478)
0.9 15.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.9 12.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.8 14.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.8 24.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.8 10.3 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.8 3.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.8 6.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.8 2.3 GO:0002139 stereocilia coupling link(GO:0002139)
0.8 4.6 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.7 9.2 GO:0005577 fibrinogen complex(GO:0005577)
0.6 6.0 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.6 1.7 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.5 6.8 GO:0042555 MCM complex(GO:0042555)
0.5 5.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.5 2.4 GO:0001940 male pronucleus(GO:0001940)
0.4 6.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.3 10.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 4.7 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.3 6.8 GO:0042599 lamellar body(GO:0042599)
0.3 7.0 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.3 7.6 GO:0031143 pseudopodium(GO:0031143)
0.3 4.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.2 1.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.2 23.5 GO:0043202 lysosomal lumen(GO:0043202)
0.2 13.4 GO:0005902 microvillus(GO:0005902)
0.2 1.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 14.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.1 GO:0044294 dendritic growth cone(GO:0044294)
0.1 4.1 GO:0005796 Golgi lumen(GO:0005796)
0.1 4.1 GO:0005604 basement membrane(GO:0005604)
0.1 0.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 4.6 GO:0016592 mediator complex(GO:0016592)
0.1 1.6 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 2.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 5.1 GO:0001533 cornified envelope(GO:0001533)
0.1 5.2 GO:0031526 brush border membrane(GO:0031526)
0.1 0.4 GO:0031905 early endosome lumen(GO:0031905)
0.1 5.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 129.8 GO:0005615 extracellular space(GO:0005615)
0.1 43.2 GO:0009986 cell surface(GO:0009986)
0.1 3.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 7.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 7.2 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 6.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.3 GO:0000786 nucleosome(GO:0000786)
0.0 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 3.2 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 1.9 GO:0005876 spindle microtubule(GO:0005876)
0.0 3.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 3.6 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 3.0 GO:0000922 spindle pole(GO:0000922)
0.0 3.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.5 GO:0070062 extracellular exosome(GO:0070062)
0.0 2.4 GO:0001650 fibrillar center(GO:0001650)
0.0 0.5 GO:0045171 intercellular bridge(GO:0045171)
0.0 45.4 GO:0005654 nucleoplasm(GO:0005654)
0.0 3.3 GO:0005925 focal adhesion(GO:0005925)
0.0 6.8 GO:0005768 endosome(GO:0005768)
0.0 1.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.5 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
3.3 9.9 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
3.2 12.9 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
2.9 11.7 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
2.6 10.3 GO:0005046 KDEL sequence binding(GO:0005046)
2.3 7.0 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
2.0 5.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.9 11.5 GO:0005499 vitamin D binding(GO:0005499)
1.7 5.2 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
1.6 6.3 GO:0035473 lipase binding(GO:0035473)
1.6 4.7 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
1.5 7.6 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
1.4 22.8 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
1.2 7.5 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
1.2 9.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
1.1 6.6 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
1.1 4.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.0 5.9 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.9 5.4 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.9 2.6 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.8 14.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.8 3.1 GO:0016160 amylase activity(GO:0016160)
0.8 2.3 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.7 15.0 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.7 6.8 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.7 3.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.6 9.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.6 9.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.6 3.7 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.6 10.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.6 6.0 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.6 2.3 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.6 6.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.5 15.0 GO:0005523 tropomyosin binding(GO:0005523)
0.5 2.1 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.5 48.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.5 2.4 GO:0031013 troponin I binding(GO:0031013)
0.4 3.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.4 12.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 1.9 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.4 1.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 10.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 21.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.3 12.4 GO:0001972 retinoic acid binding(GO:0001972)
0.3 6.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.3 48.5 GO:0005178 integrin binding(GO:0005178)
0.3 5.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.3 1.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 19.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 1.1 GO:0097108 hedgehog family protein binding(GO:0097108)
0.2 1.3 GO:0050692 DBD domain binding(GO:0050692)
0.2 5.6 GO:0031489 myosin V binding(GO:0031489)
0.2 21.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 0.8 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.2 15.5 GO:0097110 scaffold protein binding(GO:0097110)
0.2 0.9 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.2 3.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 1.6 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.7 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.2 0.5 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.2 6.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.2 GO:1990405 protein antigen binding(GO:1990405)
0.1 1.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 8.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 0.4 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 1.7 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 3.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 2.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 6.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 7.6 GO:0005518 collagen binding(GO:0005518)
0.1 4.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 6.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.5 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 3.8 GO:0050699 WW domain binding(GO:0050699)
0.1 9.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.1 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.1 0.5 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 9.2 GO:0030674 protein binding, bridging(GO:0030674)
0.1 1.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 10.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 4.3 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 1.1 GO:0015643 toxic substance binding(GO:0015643)
0.1 5.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 3.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.1 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.1 0.6 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 2.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 2.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 3.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.3 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 1.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 2.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 6.0 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 6.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 3.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.0 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 3.6 GO:0030246 carbohydrate binding(GO:0030246)
0.0 3.1 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 1.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 63.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.8 52.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.5 21.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.5 15.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.4 10.3 PID ARF 3PATHWAY Arf1 pathway
0.4 23.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 12.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 16.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 16.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 10.6 PID ATR PATHWAY ATR signaling pathway
0.1 36.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 4.6 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.1 4.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 5.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 4.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 0.9 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 6.5 PID BMP PATHWAY BMP receptor signaling
0.1 5.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 3.5 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 5.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 16.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 1.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.8 NABA COLLAGENS Genes encoding collagen proteins
0.1 1.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 1.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.0 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 16.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.7 12.0 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.6 9.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.6 4.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.6 9.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.5 6.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.5 6.8 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.4 2.6 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.4 9.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.4 12.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 6.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.4 15.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.4 6.3 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.4 14.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.4 24.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 14.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.4 9.9 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 3.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 25.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 7.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.3 6.0 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3 5.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 7.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.2 7.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 5.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 10.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 24.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 7.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 5.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.2 4.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.2 3.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 2.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 17.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 7.0 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.1 1.2 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 1.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 2.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 2.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 10.2 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.1 1.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 2.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 2.3 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.0 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.0 3.3 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 0.7 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.3 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.6 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1