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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOXA2_FOXJ3
Z-value: 0.18
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Transcription factors associated with FOXA2_FOXJ3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXJ3 | hg19_v2_chr1_-_42800614_42800649, hg19_v2_chr1_-_42801540_42801562, hg19_v2_chr1_-_42800860_42800912 | 0.47 | 2.0e-13 | Click! |
| FOXA2 | hg19_v2_chr20_-_22565101_22565223, hg19_v2_chr20_-_22566089_22566097 | -0.38 | 4.3e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXA2_FOXJ3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 32.3 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
| 8.3 | 25.0 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 1.7 | 22.3 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.4 | 20.7 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.4 | 20.2 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 1.9 | 18.9 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.8 | 18.6 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
| 0.5 | 16.8 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 1.4 | 15.6 | GO:0042492 | gamma-delta T cell differentiation(GO:0042492) |
| 3.1 | 15.5 | GO:0048539 | immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 41.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 23.7 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 1.0 | 20.9 | GO:0042588 | zymogen granule(GO:0042588) |
| 1.1 | 19.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.6 | 17.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 1.4 | 16.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.2 | 16.3 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 16.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 15.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 14.2 | GO:0005769 | early endosome(GO:0005769) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.8 | 32.3 | GO:0004913 | interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917) |
| 0.1 | 28.5 | GO:0019900 | kinase binding(GO:0019900) |
| 0.1 | 26.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 22.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.9 | 20.3 | GO:0055103 | ligase regulator activity(GO:0055103) |
| 4.7 | 18.9 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 0.4 | 18.6 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 1.8 | 14.7 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.5 | 13.6 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 13.1 | GO:0044325 | ion channel binding(GO:0044325) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 30.5 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.3 | 23.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 19.5 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.3 | 19.2 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.4 | 17.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.3 | 9.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 9.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 9.0 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.2 | 8.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 8.1 | PID CD40 PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 52.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.5 | 32.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.7 | 20.2 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.9 | 18.9 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.4 | 17.8 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.2 | 17.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 16.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.6 | 15.5 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 13.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 13.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |